BMS-754807

Catalog No.: A11059

IGF-1R inhibitor

BMS-754807

BMS-754807 Chemical Structure

CAS NO. 1001350-96-4

BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.

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5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

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50 mg

Regular Price: $350.00

Special Price $280.00

100 mg

Regular Price: $600.00

Special Price $480.00

10mM * 1mL in DMSO

Regular Price: $65.00

Special Price $52.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Biological Activity

BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
Targets
Target Value
Insulin ReceptorIC50: 1.7nM
IGF-1RIC50: 1.8nM
TrkBIC50: 4.1nM
MetIC50: 5.6nM
TrkAIC50: 7.4nM
AuroraAIC50: 9nM
AuroraBIC50: 25nM
RONIC50: 44nM
FLT3IC50: 170nM
JAK2IC50: 347nM
GSK-3βIC50: 785nM
CDK2EIC50: 795nM
MK2IC50: 919nM
LCKIC50: 1.218μM
SrcIC50: 1.527μM
PKAIC50: 1.605μM
PKCαIC50: 2.53μM
BTKIC50: 3.797μM
CSKIC50: 5μM
PKCδIC50: 12μM
PKCζIC50: >50μM
PKCιIC50: >50μM
p38αIC50: >50μM
p38βIC50: >50μM
HER1IC50: >50μM
IKK1IC50: >50μM
IKK2IC50: >50μM
In vitro (25°C) DMSO 86 mg/mL (186.35 mM)
Water Insoluble
Ethanol 86 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.34 mL 216.68 mL
0.5 mM 4.33 mL 21.67 mL 43.34 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11059
Actions Inhibitor
CAS No. 1001350-96-4
Formula C23H24FN9O
M. Wt 461.5
Purity >98%
Synonyms BMS754807, BMS 754807
SMILES C[[email protected]]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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