Total item
Cart Subtotal
$0.00 - Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Biological Activity
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
Targets
| Target | Value |
|---|---|
| Insulin Receptor | IC50: 1.7nM |
| IGF-1R | IC50: 1.8nM |
| TrkB | IC50: 4.1nM |
| Met | IC50: 5.6nM |
| TrkA | IC50: 7.4nM |
| AuroraA | IC50: 9nM |
| AuroraB | IC50: 25nM |
| RON | IC50: 44nM |
| FLT3 | IC50: 170nM |
| JAK2 | IC50: 347nM |
| GSK-3β | IC50: 785nM |
| CDK2E | IC50: 795nM |
| MK2 | IC50: 919nM |
| LCK | IC50: 1.218μM |
| Src | IC50: 1.527μM |
| PKA | IC50: 1.605μM |
| PKCα | IC50: 2.53μM |
| BTK | IC50: 3.797μM |
| CSK | IC50: 5μM |
| PKCδ | IC50: 12μM |
| PKCζ | IC50: >50μM |
| PKCι | IC50: >50μM |
| p38α | IC50: >50μM |
| p38β | IC50: >50μM |
| HER1 | IC50: >50μM |
| IKK1 | IC50: >50μM |
| IKK2 | IC50: >50μM |
| In vitro (25°C) | DMSO | 92 mg/mL (199.35 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 92 mg/mL (199.35 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 20 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.67 mL | 108.34 mL | 216.68 mL |
| 0.5 mM | 4.33 mL | 21.67 mL | 43.34 mL |
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11059 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 461.5 |
| Formula | C23H24FN9O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1001350-96-4 |
| Synonyms | BMS754807, BMS 754807 |
| SMILES | C[[email protected]]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
NVP-AEW541
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IG…
Picropodophyllin
Picropodophyllin (AXL1717) is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor.
NVP-ADW742
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
GSK1904529A
GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.
OSI-906
OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R)…
XL-228
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor…
PQ 401
PQ 401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation.
AG-1024 (Tyrphostin)
AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits…
Keywords:buy BMS-754807 | BMS-754807 Supplier | purchase | cost | manufacturer | order | distributor | buy 1001350-96-4| 1001350-96-4 Supplier | purchase 1001350-96-4 | 1001350-96-4 cost | 1001350-96-4 manufacturer | order 1001350-96-4 | 1001350-96-4 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.