GPCR/G Protein

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  1. GLP-1 agonist

    Lixisenatide acetate is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM).
  2. μ-opioid receptor agonist

    Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.
  3. PAR-1 agonist

    Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.
  4. CRFR agonist

    Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.
  5. neuropeptide Y (NPY) Y5 receptor agonist

    [D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.
  6. opioid κ-receptor agonist

    Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.
  7. neurokinin (NK)-1 receptor agonist

    [Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.
  8. PAR-1 agonist

    iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. iso-TRAP-6 is an analog of TRAP-6 that refers to the use of isoserine instead of serine as first amino acid.
  9. mGluR II agonist

    Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
  10. 5-HT receptor agonist

    Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors.
  11. agonist of FPR2/ALX

    ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.
  12. CB1/CB2 agonist

    NMP-7 is a non-selective agonist of the CB1 and CB2 cannabinoid receptors that acts by blocking T-type calcium channels.
  13. alpha2-Adrenergic receptor agonist

    Flutonidine is an alpha2-Adrenergic receptor agonist.
  14. mGlu1 receptorsant agonist

    YM 298198 is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM).

  15. Galanin receptors GALR agonist

    Galnon is a selective, non-peptide agonist at the galanin receptors GALR.
  16. prostanoid agonist

    QCC-374 is prostanoid agonist potentially for the treatment of pulmonary arterial hypertension.
  17. central alpha 2-adrenoceptor agonist

    Guanabenz (GBZ, GA, Wytensin, Wy-8678) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.

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