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Guanylate cyclase C agonist
Linaclotide is a peptide agonist of the guanylate cyclase 2C.- Tessa A Groeneweg, .et al. , Ann N Y Acad Sci, 2026, Feb;1556(1):e70152 PMID: 41400434
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GC-C receptor agonist
Plecanatide acetate is a guanylate cyclase-C (GC-C) receptor agonist, with an EC50 of 190 nM in T84 cells. Plecanatide acetate shows anti-inflammatory activity in models of murine colitis.
