Dopamine Receptors

Cat. No.

A45954

CAS No.

1217310-65-0

Quetiapine-d4 hemifumarate

Quetiapine-d4 hemifumarate is a deuterated form of Quetiapine, functioning as a 5-HT receptor agonist and a D2 dopamine receptor antagonist. This compound exhibits notable antidepressant and anxiolytic properties, making it valuable for research into mood disorders and anxiety treatment. Its unique isotopic labeling allows for advanced studies in pharmacokinetics and metabolic pathways of Quetiapine.

Cat. No.

A45968

CAS No.

54241-01-9

Clozapine hydrochloride

Synonyms: HF 1854 hydrochloride

Clozapine hydrochloride is an antipsychotic agent primarily targeting dopamine D2 receptors, where it acts as a potent antagonist with a Ki value of 75 nM. This compound also exhibits strong inhibitory activity against muscarinic M1 and serotonin 5HT2A receptors, with Kis of 9.5 nM and 4 nM, respectively. Additionally, clozapine hydrochloride serves as a selective agonist for the muscarinic M4 receptor, demonstrating an EC50 of 11 nM. This profile makes clozapine hydrochloride valuable for research related to schizophrenia and other neuropsychiatric disorders.

Cat. No.

A45975

CAS No.

851220-85-4

Aripiprazole monohydrate

Synonyms: OPC-14597 monohydrate

Aripiprazole monohydrate is a potent partial agonist of the dopamine D2 receptor and an inverse agonist at the 5-HT2B and 5-HT2A receptors. Additionally, it exhibits partial agonist functionality at 5-HT1A, 5-HT2C, D3, and D4 receptors. This compound is primarily utilized in research focused on schizophrenia and has also been explored for potential applications in treating COVID-19.

Cat. No.

A45980

CAS No.

37686-84-3

TDHL

Synonyms: Tergurid; Terguride; trans-Dihydrolisuride

TDHL (Tergurid) is a potent dopamine receptor agonist, exhibiting a Kd of 0.39 nM for the D2 receptor, and functions as an orally bioavailable 5-HT2 receptor antagonist. Its dual mechanism of action allows for comprehensive exploration in neuropharmacology studies. TDHL is suitable for investigating the role of dopamine signaling in various neurological and psychiatric disorders.

Cat. No.

A45986

CAS No.

2748605-29-8

Brexpiprazole S-oxide-d8

Synonyms: DM-3411 d8

Brexpiprazole S-oxide-d8 is a deuterium-labeled analog of Brexpiprazole S-oxide, the primary metabolite of the atypical antipsychotic Brexpiprazole. This compound acts as a partial agonist at human 5-HT1A and dopamine receptors, with inhibition constants (Kis) of 0.12 nM and 0.3 nM, respectively. Additionally, it functions as an antagonist at the 5-HT2A receptor, exhibiting a Ki of 0.47 nM. Brexpiprazole S-oxide-d8 is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on psychiatric disorders.

Cat. No.

A45999

CAS No.

71675-92-8

Esamisulpride

Synonyms: (S)-Amisulpride; (S)-Aramisulpride; (S)-DAN 2163

Esamisulpride is a potent antagonist of the dopamine D2 and D3 receptors, exhibiting Ki values of 4.43 nM for D2R and 0.72 nM for D3R. Additionally, it functions as a 5-HT7 receptor antagonist with a Ki of 900 nM. This compound is primarily employed in research related to schizophrenia and depression, providing valuable insights into dopaminergic and serotonergic system modulation.

Cat. No.

A46007

CAS No.

1159977-64-6

Ziprasidone amino acid

Synonyms: Ziprasidone Impurity C; Ziprasidone open ring impurity

Ziprasidone amino acid is a known impurity of Ziprasidone, functioning primarily as a 5-HT (serotonin) and dopamine receptor antagonist. This compound demonstrates significant antipsychotic activity, making it valuable in the study of neurological disorders. Its unique properties can aid researchers in investigating the mechanisms of antipsychotic effectiveness and receptor interactions in related drug development.

Cat. No.

A46012

CAS No.

1287376-15-1

Quetiapine-d4 fumarate

Quetiapine-d4 fumarate is a deuterium-labeled derivative of Quetiapine fumarate, primarily acting as a 5-HT receptor agonist and D2 dopamine receptor antagonist. This compound exhibits significant antidepressant and anxiolytic effects, making it valuable for research into mood disorders and anxiety-related conditions. Quetiapine-d4 fumarate is useful in pharmacokinetic studies and drug metabolism research, providing insights into the bioavailability and therapeutic potential of the parent compound.

Cat. No.

A46013

CAS No.

2587360-22-1

Ecopipam hydrobromide

Synonyms: SCH 39166 hydrobromide

Ecopipam hydrobromide is a highly selective antagonist of dopamine D1 and D5 receptors, exhibiting dissociation constants (Kis) of 1.2 nM and 2.0 nM, respectively. It demonstrates over 40-fold selectivity compared to D2, D4, 5-HT, and α2a receptors. This compound is valuable for research investigating the pathophysiology of schizophrenia and obesity, making it a useful tool for studying dopaminergic signaling pathways and related disorders.

Cat. No.

A46016

CAS No.

314-19-2

Apomorphine hydrochloride

Synonyms: (-)-Apomorphine hydrochloride

Apomorphine hydrochloride is a potent dopamine receptor agonist and a known activator of the 20S proteasome. It enhances proteasomal and insulin-degrading enzyme activities, facilitating the degradation of intracellular amyloid-beta (Aβ), phosphorylated tau (p-tau), and p53, thereby reducing their levels in neuronal cells. This compound is particularly relevant for research focused on neurodegenerative disorders such as Alzheimer's disease and psychiatric conditions including schizophrenia.

Cat. No.

A46025

CAS No.

108179-91-5

SKF-83566 hydrobromide

SKF-83566 hydrobromide is a selective antagonist of the D1-like dopamine receptors, exhibiting high blood-brain barrier permeability and oral bioavailability. This compound functions as a competitive inhibitor of the dopamine transporter (DAT), with an IC50 of 5.7 μM, and demonstrates a weaker antagonistic effect on the vascular 5-HT2 receptor (Ki=11 nM). Additionally, SKF-83566 selectively inhibits adenylyl cyclase 2 (AC2) over AC1 and AC5, making it a valuable tool for studying Parkinson's disease and nicotine dependence.

Cat. No.

A46080

CAS No.

898532-85-9

D3/5-HT receptor modulator-1

D3/5-HT receptor modulator-1 is a selective antagonist for dopamine D3 receptors and 5-HT2A receptors, while also functioning as a partial agonist at 5-HT1A receptors. With measured Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the respective targets, this compound exhibits a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels. Its unique pharmacological profile suggests potential applications in the development of atypical antipsychotic therapies and for studying dopaminergic and serotonergic signaling pathways.

Cat. No.

A46091

CAS No.

884305-07-1

Keto Ziprasidone

Keto Ziprasidone is a known impurity of the antipsychotic agent Ziprasidone, which functions primarily as a combined antagonist of serotonin (5-HT) and dopamine receptors. This compound is crucial for research applications focusing on drug metabolism and pharmacokinetics, particularly in understanding the potential effects of impurities on therapeutic efficacy and safety profiles. Its analysis can aid in the development of quality control measures in pharmaceutical formulations.

Cat. No.

A46093

CAS No.

131999-28-5

5-HT6/7 antagonist 1

5-HT6/7 Antagonist 1 is a potent antagonist of the 5-HT6, 5-HT7, and D2 receptors, exhibiting selectivity that spares M1 receptors and hERG channels. This compound's multifunctional activity makes it valuable for research into neuropharmacology and the modulation of serotonergic and dopaminergic systems. It provides a useful tool for studying disorders related to these receptor pathways, including anxiety, depression, and schizophrenia.

Cat. No.

A46100

CAS No.

884305-08-2

Hydroxy ziprasidone

Hydroxy ziprasidone is a known impurity of the antipsychotic agent ziprasidone, which functions primarily as a combined antagonist of both serotonin (5-HT) and dopamine receptors. This compound is useful for researchers studying the pharmacological properties and metabolic pathways of ziprasidone, as well as for quality control in the synthesis of pharmaceutical formulations. Its presence can provide insights into the drug's safety, efficacy, and potential side effects.

Cat. No.

A46106

CAS No.

2227154-23-4

LB-102

LB-102 is an orally bioavailable inhibitor of dopamine D2, D3, and 5-HT7 receptors. It exhibits significant antagonistic activity, making it a valuable tool for investigating the neurochemical pathways involved in schizophrenia and other psychiatric disorders. This compound is useful for studies aimed at understanding the role of these receptors in various neuropsychiatric conditions.

Cat. No.

A46109

CAS No.

47739-98-0

Clocapramine

Synonyms: Clocarpramine; 3-Chlorocarpipramine

Clocapramine is a selective antagonist of the 5-HT2A receptor, with additional inhibitory effects on D2 dopamine receptors. This compound exhibits notable properties in modulating serotonin and dopamine signaling, making it relevant for neuropharmacological research. Clocapramine can be utilized in studies related to psychiatric disorders, including depression and schizophrenia, as well as the characterization of receptor interactions in neural pathways.

Cat. No.

A49400

CAS No.

59453-24-6

Bromperidol hydrochloride

Synonyms: R-11333 hydrochloride

Bromperidol hydrochloride is an antipsychotic agent that primarily functions as a potent antagonist of central dopamine D2 receptors. It exhibits significant antipsychotic activity, making it valuable in the treatment of various psychotic disorders. Additionally, Bromperidol hydrochloride has demonstrated synergistic effects in combination with Spectinomycin, highlighting its potential in antimicrobial research against Mycobacteria.

Cat. No.

A49447

CAS No.

61241-59-6

A32390A

A32390A is a potent inhibitor of dopamine β-hydroxylase, functioning primarily to decrease norepinephrine synthesis. This reduction can lead to lowered blood pressure, making A32390A valuable in studies related to hypertension, particularly in models such as DOCA hypertensive rats. Additionally, the compound's properties as a copper chelator allow for exploration in the context of bacterial infections and metabolic disorders, providing versatile applications in chemical research.

Cat. No.

A49540

CAS No.

122898-67-3

Itopride

Synonyms: HSR803 free base

Itopride is a potent dopamine D2 receptor antagonist and an acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its dual mechanisms of action, promoting both antidopaminergic and anti-acetylcholinesterase effects. This compound is primarily utilized in research related to gastrointestinal disorders, particularly gastroesophageal reflux disease (GERD), offering insights into prokinetic therapies.

Cat. No.

A53294

CAS No.

1323633-98-2

Fluphenazine-d8

Fluphenazine-d8 is a deuterium-labeled derivative of fluphenazine, functioning primarily as a dopamine receptor antagonist. It effectively inhibits postsynaptic dopamine-2 receptors in key neural pathways, including the mesolimbic, nigrostriatal, and tuberoinfundibular systems. This reagent is valuable in research areas such as psychosis and diabetic peripheral neuropathy, and it has shown potential in studies related to SARS-CoV-2 inhibition. Fluphenazine-d8 serves as a useful tool for elucidating the pharmacodynamics of dopaminergic activity and its downstream effects.

Cat. No.

A53338

CAS No.

1254-47-3

Fluphenazine hydrochloride

Fluphenazine hydrochloride functions as a potent dopamine receptor antagonist, primarily targeting postsynaptic dopamine-2 receptors within mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This compound exhibits significant biological activity by blocking neuronal voltage-gated sodium channels, leading to effects on behavior, such as the antagonism of methylphenidate-induced stereotyped gnawing and inhibition of climbing behavior in murine models. Fluphenazine hydrochloride is valuable for research into psychotic disorders and painful peripheral neuropathy related to diabetes, and it has demonstrated potential for inhibition of SARS-CoV-2.

Cat. No.

A53458

CAS No.

3093-66-1

Fluphenazine dimaleate

Fluphenazine dimaleate is a potent dopamine receptor antagonist primarily targeting postsynaptic dopamine-2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. Its ability to antagonize neuronal voltage-gated sodium channels contributes to its effectiveness in modulating dopaminergic activity. Fluphenazine dimaleate is valuable in research addressing psychosis, diabetic neuropathy, and behavioral studies, including the inhibition of Methylphenidate-induced stereotyped behaviors in animal models. Emerging studies also suggest its potential in inhibiting SARS-CoV-2, positioning it as a multifaceted tool in scientific investigation.

Cat. No.

A53540

CAS No.

81968-16-3

Mergocriptine

Synonyms: CBM36-733

Mergocriptine is a dopamine receptor agonist that has been identified as a ligand for the SARS-CoV-2 main protease (Mpro). This compound plays a significant role in modulating ambulatory activity and may be utilized in research focused on neurological disorders and viral pathogenesis. Its dual action positions it as a valuable tool in studying dopamine-related pathways and potential antiviral mechanisms.

Cat. No.

A53945

CAS No.

2138330-43-3

Photosensitizer-2

Photosensitizer-2 is an organic D-π-A sensitizer designed to mitigate phototoxicity. Featuring an acrylic acid moiety, it exhibits significant phototoxic effects and demonstrates robust antitumor activity against HeLa cells, with observed IC50 values of 20.9 ± 4.5 μM in the dark and 0.046 ± 0.012 μM upon irradiation. This compound is suitable for applications in photodynamic therapy research and cancer treatment studies.