Catalog No.
Product Name
Application
Product Information
Citations
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DAT/NET/SERT Inhibitor
Amitifadine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that targets the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). It exhibits inhibitory concentrations of 12 nM for serotonin, 23 nM for norepinephrine, and 96 nM for dopamine in HEK 293 cells. This compound is pertinent for research applications exploring the modulation of monoaminergic systems and investigating potential therapeutic effects in mood disorders. -
D2R Antagonist
BRD5814 is a potent antagonist of the dopamine D2 receptor (D2R), a key target in the modulation of dopaminergic signaling. This compound demonstrates significant inhibitory activity, making it a valuable tool in research focused on schizophrenia and other neuropsychiatric disorders. Its application in studies of D2R-related pathways can aid in understanding the complex mechanisms underlying these conditions. -
Dopamine D4 Receptor Partial Agonist
FAUC-312 is a tetrahydropyrimidine that acts as a selective partial agonist of the dopamine D4 receptor, exhibiting a Ki value of 1.5 nM. This compound modulates dopaminergic signaling and has potential applications in researching neuropsychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder (ADHD). Its specificity towards the D4 receptor allows for the exploration of receptor-specific pathways and therapeutic interventions. -
Chlorpromazine Active Metabolite
7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine, primarily targeting dopamine receptors. This compound is known to increase prolactin levels and enhance dopamine turnover, exhibiting notable sedative effects. Research applications include studying psychosis and investigating its efficacy in inhibiting amphetamine-induced stereotyped behaviors in rodent models. -
Dopamine Agonist
PD 118440 is an orally active dopamine agonist that targets dopaminergic signaling pathways within the central nervous system. This compound demonstrates notable biological activity by inhibiting striatal dopamine synthesis and suppressing the firing of dopamine neurons. Additionally, PD 118440 has been shown to reverse Reserpine-induced depression in rodent models, making it a valuable tool for research in neuropharmacology and mood disorder studies. -
Dopamine Agonist
Lergotrile mesylate is a potent orally active dopamine agonist that functions primarily by activating dopamine receptors in the adenohypophysis, thereby inhibiting prolactin secretion. This mechanism contributes to its potential applications in the research of Parkinson's disease and related disorders. By modulating dopamine activity, Lergotrile mesylate serves as a valuable tool for exploring therapeutics targeting dopaminergic pathways. -
Dopamine Receptor Agonist
Disulergine is an ergot alkaloid that acts as a dopamine receptor agonist. It has been shown to inhibit prolactin secretion in rats and also suppress the release of growth hormone (GH). This compound is particularly relevant for research applications exploring the regulation of hormonal pathways and the physiological effects of dopamine receptor modulation. -
Central Dopamine Receptor Antagonist
Brl 20596 is a potent central dopamine receptor antagonist. This compound exhibits significant inhibitory activity at dopamine receptors, making it valuable for antipsychotic research. Its ability to modulate dopaminergic signaling can aid in the investigation of neuropsychiatric disorders related to dopamine dysregulation. -
DA2 Receptor Agonist
7-Hydroxy ropinirole bromide is a selective DA2 receptor agonist that demonstrates significant inhibitory effects on neurotransmitter release and sympathetic nerve responses. This compound, a derivative of N,N-di-n-propyldopamine (DPDA), has shown promise in isolated perfused rabbit ear artery models, making it a valuable tool for studying cardiovascular and neurological disorders. Its targeted mechanism of action underscores its relevance in exploring therapeutic interventions in these fields. -
CI-1007 Active Metabolite
PD-147693 is the active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, exhibiting antipsychotic activity akin to its parent compound. This reagent is utilized in neuropharmacological research to explore the mechanisms of dopaminergic signaling and evaluate potential therapeutic approaches for neuropsychiatric disorders. Its relevance extends to studies focused on dopamine receptor interactions and their implications in psychopharmacology. -
D3 Receptor Antagonist
(Rac)-GR218231 is a selective antagonist of the dopamine D3 receptor, exhibiting a pKi value of 8.9. This compound is valuable for studying the role of D3 receptors in various neurological and psychiatric disorders. Its pharmacological properties make it an important tool for research into dopamine-related pathways and potential therapeutic interventions. -
Antipsychotic Compound
A 23887 is a semirigid antipsychotic compound that primarily targets the dopamine D2 receptor. It exhibits significant affinity for this receptor, which is crucial for modulating dopaminergic signaling pathways. This compound is primarily utilized in research related to psychiatric disorders, particularly in the study of schizophrenia and other neuropsychiatric conditions. -
Stable Isotope
Ropinirole-d3 hydrochloride is a deuterium-labeled derivative of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors, with a Ki value of 29 nM for the D2 receptor. It exhibits pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is primarily utilized in research related to dopamine receptor signaling and has potential implications for therapies targeting Parkinson's disease. -
Dopamine D2 Receptor Antagonist
ADR 851 free base is a potent antagonist of the dopamine D2 receptor, making it valuable for research applications focused on antiemetic effects. This compound demonstrates significant potential in modulating dopamine-related pathways, contributing to the understanding of various neurological and psychiatric disorders. Its utilization in experimental studies may provide insights into therapeutic strategies targeting nausea and vomiting. -
D1 Receptor Agonist
SKF-80723 acts as a selective agonist for the dopamine D1 receptor, playing a crucial role in neurotransmitter signaling. This compound is primarily utilized in neuroscience research, particularly in studies related to Parkinson's disease and dopaminergic dysfunction. Its activation of D1 receptors offers insights into potential therapeutic strategies for neurodegenerative conditions associated with dopaminergic signaling deficits. -
Dopamine Receptor Agonist
Aplindore fumarate is a partial agonist of the dopamine D2 receptor, primarily utilized in neurological research. This compound has shown potential in studies related to Parkinson's disease and schizophrenia, offering insights into dopaminergic signaling pathways. Its activity makes it a valuable tool for investigating therapeutic strategies and understanding the underlying mechanisms of these disorders. -
D3R agonist
7-Hydroxy-PIPAT is a selective agonist of the D3 dopamine receptor, exhibiting a high binding affinity with a Ki value of 0.99 nM. This compound is utilized in research to explore mechanisms related to dopaminergic signaling and may offer insights into the pathology of neuropsychiatric disorders. Its potent activity makes it a valuable tool for studying D3 receptor-mediated pathways in various biological contexts. -
Atypical Dopamine Agonist
S3608 is an atypical dopamine agonist that selectively activates dopamine receptors, contributing to enhanced locomotor activity. This compound has been shown to dose-dependently increase locomotor activity in rodent models, making it a valuable tool for studying dopaminergic signaling and its implications in neuropharmacology. S3608 can be utilized in research applications focused on movement disorders, addiction, and behavioral studies related to dopamine modulation. -
D4 Receptor Antagonist
Sonepiprazole mesylate is a selective D4 dopamine receptor antagonist that exhibits inhibition constants (Kis) of 3.6 nM for rD4-Dopamine and 10.1 nM for hD4.2-Dopamine, indicating potent activity at these targets. Additionally, it shows significantly lower affinity for rD2-Dopamine (5147 nM) and Histamine-H1 receptors (7430 nM). This compound is valuable for research applications focused on neurobiology, particularly in studies related to dopamine receptor signaling and its implications in psychiatric disorders. -
Dopamine D-2 Receptors Antagonist
A31472 is a potent antagonist of dopamine D-2 receptors, making it a valuable tool for studying the pharmacology of antipsychotic agents. Its mechanism of action is critical for exploring the underlying pathways associated with dopamine dysregulation. Researchers can utilize A31472 to investigate its effects on behavioral and neurochemical processes relevant to psychiatric disorders. -
Dopamine Antagonist
Clothixamide is a dopamine antagonist that primarily targets dopamine receptors in the central nervous system. It exhibits biological activity relevant to the modulation of dopaminergic signaling and is useful for investigating various psychiatric disorders, including schizophrenia and depression. Research applications include studying the effects of dopamine inhibition on behavior and neurotransmitter pathways. -
Dopamine Receptor Antagonist
Org-10490 is a potent antagonist of dopamine D1 and D2 receptors, primarily utilized in neurological and psychiatric research. It plays a critical role in studies related to disorders such as schizophrenia and bipolar disorder by modulating dopaminergic signaling pathways. Its efficacy in receptor inhibition makes Org-10490 valuable for investigating therapeutic strategies targeting dopamine-related conditions. -
Dopamine D2 Receptor Antagonist
Lensiprazine is a potent dopamine D2 receptor antagonist that also functions as a serotonin reuptake inhibitor. This compound is primarily utilized in research focusing on psychiatric disorders, including bipolar disorder and schizophrenia, facilitating the exploration of neurochemical pathways involved in these conditions. Its dual action provides valuable insights into the modulation of neurotransmitter systems. -
D2 Dopamine Receptor Blocker
Savoxepin mesylate is a selective antagonist of the D2 dopamine receptor, exhibiting antipsychotic properties. It specifically targets dopamine D2 receptors in the hippocampus while sparing those in the striatum, thereby minimizing the likelihood of extrapyramidal side effects. This selective action makes Savoxepin mesylate a valuable tool for research addressing dopaminergic signaling and its implications in neuropsychiatric disorders. -
D2 Receptor Antagonist
(S)-Remoxipride hydrochloride hydrate is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in the study of psychotic disorders, providing a valuable tool for understanding the mechanisms underlying dopamine-related pathologies and developing therapeutic strategies. Its specificity for the D2 receptor makes it an important reagent in neuropharmacology research. -
Dopamine Antagonist
Milenperone is a potent dopamine antagonist that primarily targets dopamine receptors. Its biological activity allows for the modulation of dopaminergic signaling, making it valuable in research focusing on neurological disorders. Milenperone is particularly useful in studies investigating the mechanisms underlying conditions related to dopamine dysregulation. -
Drug Derivative
4-EEC hydrochloride is a synthetic stimulant that acts as a releasing agent for norepinephrine and dopamine. It exhibits neurochemical properties that can influence mood and cognitive function. This compound is primarily used in research applications related to neuropharmacology and the study of stimulant drugs. -
D2 Receptor Antagonist
Desethoxy Quetiapine dihydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1330 nM. This compound effectively inhibits Apomorphine-induced climbing and swimming behavior in murine models, making it valuable for investigating neuropharmacological activity and the modulation of dopaminergic signaling. Its utility in behavioral studies supports research into the therapeutic effects of D2 receptor antagonism in psychiatric disorders. -
Dopamine D1 Antagonist
SKF 83509 is a selective dopamine D1 antagonist with a Ki value of 70.2 nM, demonstrating no activity at dopamine D2 receptors. This compound is primarily utilized in neuropharmacological research to investigate the role of dopamine D1 receptors in various neurological conditions. SKF 83509 aids in the exploration of dopaminergic signaling pathways and contributes to studies focused on drug addiction, schizophrenia, and other dopamine-related disorders. -
D4 Receptor Antagonist
Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research. -
Dopamine D2 Receptor Agonist
FR 64822 is a potent dopamine D2 receptor agonist that demonstrates significant antinociceptive activity in preclinical models, such as rats and mice, via indirect stimulation of these receptors. In addition to its analgesic properties, FR 64822 has been shown to facilitate penile erection in juvenile rats and mitigate scopolamine-induced amnesia during passive avoidance tasks. Its diverse biological activities make it a valuable tool for research in neuropharmacology and behavioral studies. -
D3 Receptor Agonist
(+)-UH 232 is a partially selective agonist of the D3 dopamine receptor, exhibiting an intrinsic activity of 0.2-0.4. This compound effectively antagonizes quinpirole-induced mitogenesis, with a reported Ki value of 9.4 nM. It is utilized in research to explore D3 receptor signaling and its implications in various neurobiological processes. -
Antipsychotic Agent
Butaclamol is an antipsychotic agent that functions primarily as a D2 dopamine receptor antagonist. This compound exhibits significant neuroleptic activity, making it a valuable tool in the study of psychotic disorders. It is utilized in research to explore the mechanisms underlying dopaminergic signaling and its implications in various neuropsychiatric conditions. -
Haloperidol Analogue
Deschlorohaloperidol is a potent analogue of Haloperidol, primarily acting as a dopamine D2 receptor (D2R) antagonist. This compound exhibits significant antipsychotic activity, making it valuable in research focused on schizophrenia and related disorders. Its structural modifications enhance its efficacy for investigating dopamine signaling pathways and therapeutic interventions in psychiatric conditions. -
D4 Receptor Ligand
U-101958 maleate is a highly selective antagonist for the dopamine D4 receptor, exhibiting an IC50 of 2.7 nM. In HEK-293 cells expressing the human recombinant D4.4 receptor, U-101958 behaves as an agonist, demonstrating its versatile interaction with this target. This compound is primarily utilized in research related to antipsychotic effects and the modulation of dopaminergic signaling pathways. -
Dopamine Receptor Modulator
Ordopidine hydrochloride is a modulator of dopamine receptors that demonstrates an ED50 of 68 μmol/kg for increasing DOPAC levels in the rat striatum. This compound is valuable in research applications focused on neurological disorders and dopamine-related signaling pathways. Its ability to influence dopamine metabolism makes it a useful tool for exploring the role of dopamine in various physiological and pathological conditions. -
Dopamine Receptor Agonist
PF-592379 is a selective agonist of the dopamine D3 receptor, exhibiting an EC50 of 21 nM. This compound demonstrates significant potential in modulating dopaminergic signaling pathways, making it valuable for research applications related to neuroinflammatory disorders and addiction. Its ability to influence dopamine receptor activity makes PF-592379 a useful tool for studying the role of dopamine in various physiological and pathological processes. -
Dopamine Receptor Antagonist
Benzamide Derivative 1 is a dopamine receptor antagonist with potential applications in the treatment of gastrointestinal disorders. This compound, derived from patent EP0213775A1, compound 18, exhibits key biological activity by modulating dopamine signaling pathways. Its role in gastrointestinal function makes it a valuable tool for researchers investigating the interplay between dopamine receptors and gut health. -
Dopamine Receptor Agonist
U91356 is a selective dopamine receptor agonist that targets D1-like receptors. This compound has been shown to enhance dopaminergic signaling, making it useful in studies investigating neurological disorders such as schizophrenia and Parkinson's disease. U91356 facilitates the exploration of dopamine-related pathways and receptor interactions in various biological systems. -
Stable Isotope
Quetiapine Sulfoxide-d8 is a deuterated analog of Quetiapine sulfoxide, a primary metabolite of the second-generation antipsychotic Quetiapine. This compound acts as a 5-HT receptor agonist and dopamine receptor antagonist, playing a critical role in the pharmacokinetic studies of Quetiapine metabolism. Quetiapine Sulfoxide-d8 is commonly utilized in research applications involving drug metabolism, pharmacology, and analytical chemistry, particularly in the development and validation of quantitation methods in biological samples. -
Pergolide Metabolite
Pergolide sulfone is a metabolite of Pergolide, primarily acting as a dopamine receptor agonist. This compound exhibits significant dopaminergic activity, making it relevant for research into Parkinson's disease and other neurological disorders. Pergolide sulfone can be utilized in studies investigating the pharmacological profiles of dopamine receptor interactions and their implications in neurodegenerative conditions. -
Drug Metabolite
Reduced Haloperidol, a primary metabolite of Haloperidol, functions as a dopamine receptor antagonist. It exhibits significant antipsychotic activity, primarily utilized in research related to schizophrenia and other psychotic disorders. This compound is instrumental in studies investigating the modulation of neurotransmitter systems, aiding in the reduction of hallucinations and delusions associated with these conditions. -
Drug Metabolite
Quetiapine sulfoxide dihydrochloride is a primary metabolite of the second-generation antipsychotic quetiapine. This compound functions as a 5-HT receptor agonist and a dopamine receptor antagonist, contributing to its pharmacological effects. It is commonly utilized in research related to neuropharmacology and metabolic profiling of antipsychotic drugs, offering insights into the drug's therapeutic activity and safety profile. -
Lurasidone Metabolite
Lurasidone Metabolite 14283 hydrochloride is a significant active metabolite of the antipsychotic agent Lurasidone, which targets serotonin and dopamine receptors. This compound plays a crucial role in the pharmacological activity of Lurasidone, contributing to its efficacy in the treatment of schizophrenia. Research applications include studying the metabolic profile of Lurasidone and its pharmacodynamics in neural systems. -
Drug Metabolite
Quetiapine sulfoxide hydrochloride is a primary metabolite of Quetiapine, a second-generation antipsychotic. This compound acts primarily as a 5-HT receptor agonist and dopamine receptor antagonist, contributing to the pharmacological profile of Quetiapine. It is valuable in research focusing on the metabolism and pharmacokinetics of antipsychotic medications, providing insights into their therapeutic effects and potential side effects. -
Quetiapine Metabolite
7-Hydroxyquetiapine is the primary active metabolite of the antipsychotic agent Quetiapine. It functions by modulating various neurotransmitter systems, particularly serotonin and dopamine receptors, contributing to its therapeutic effects in managing psychiatric disorders. This compound is valuable for studying the pharmacological profile of Quetiapine and investigating its metabolic pathways in both in vitro and in vivo research settings. -
Racemate of NNC 55-0396
(Rac)-NNC 55-0396 is a racemic mixture that targets the dopamine D2 receptor. This compound is of significant interest in neurological research due to its potential role in modulating dopaminergic signaling pathways. It is commonly utilized in studies investigating the pharmacological effects of dopamine receptor antagonists in various neurological disorders. -
Drug Derivative
Bmapn is a drug derivative with impactful interactions on dopamine signaling pathways. It exhibits rewarding and reinforcing properties by decreasing dopamine transporter levels and enhancing dopamine receptor D2 gene expression specifically in the striatum. This compound is valuable for research applications studying addiction, neuropharmacology, and the modulation of dopaminergic systems. -
Stable Isotope
Boc-Leu-OH·H2O-13C is a stable isotope-labeled derivative of N-Boc-L-leucine, featuring a carbon-13 (13C) label. This amino acid derivative, protected with a Boc group, serves as an essential building block for the synthesis of peptides, such as L-prolyl-L-leucyl-glycinamide, which exhibit modulatory activity on dopamine receptors. It is valuable for applications in peptide research, metabolic studies, and tracer experiments utilizing stable isotopes. -
Amino Acid Derivatives
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics.
