Boc-MIF-1-Am is a potent enhancer of the human dopamine D2 receptor, exhibiting an EC50 value of 17.82 nM. This bioconjugate of melanostatin (MIF-1) and amantadine is primarily utilized in the study of dopaminergic signaling pathways and their implications in neurological disorders. Although Boc-MIF-1-Am demonstrates key biological activity, it has been noted to exhibit mild neurotoxicity at a concentration of 200 μM in SH-SY5Y cells, making careful consideration necessary in experimental designs.
Boc-MIF-1-Am is a potent enhancer of the human dopamine D2 receptor, exhibiting an EC50 value of 17.82 nM. This bioconjugate of melanostatin (MIF-1) and amantadine is primarily utilized in the study of dopaminergic signaling pathways and their implications in neurological disorders. Although Boc-MIF-1-Am demonstrates key biological activity, it has been noted to exhibit mild neurotoxicity at a concentration of 200 μM in SH-SY5Y cells, making careful consideration necessary in experimental designs.
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