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Dopamine Receptors

Dopamine receptor agonists and antagonists act on the five G protein-coupled receptors that respond to dopamine. The receptors form two groups, with D1 and D5 in the D1-like class and D2, D3 and D4 in the D2-like class. D1-like receptors stimulate adenylyl cyclase, whereas D2-like receptors inhibit it and lower cyclic adenosine monophosphate (cAMP) levels. Dopamine signaling controls movement, reward, motivation and hormone release, and is studied in Parkinson's disease and psychiatric research. Ligands here include the agonist rotigotine HCl, the D2 antagonists L-741626 and domperidone, and the D3-preferring ligand BP897.

2 Items

  • ACR 16 hydrochloride
    Cat. No.
    A16074
    CAS No.
    882737-42-0

    ACR 16 hydrochloride

    Synonyms: Pridopidine hydrochloride

    ACR 16 hydrochloride is a dopaminergic stabilizer (Ki values 17550 nM and 7521 for D2(low) and D2(high), respectively) that state-dependently stabilizes psychomotor activity by the dual actions of functional dopamine D2 receptor antagonism and strengthening of cortical glutamate functions in various settings of perturbed neurotransmission.

    In stock View Details
    1 mg
    $120.00
    2 mg
    $180.00
    All 3 sizes
  • (-)-OSU6162 hydrochloride
    Cat. No.
    A29927
    CAS No.
    156907-84-5

    (-)-OSU6162 hydrochloride

    Synonyms: PNU96391 hydrochloride

    (-)-OSU6162 hydrochloride is a dopamine stabilizer that functions as a partial agonist at the 5-HT2A receptor while acting as a dopamine D2 antagonist. This compound exhibits significant effects on modulating dopaminergic activity and is relevant for studies exploring aggression and irritability. Its unique mechanism makes it a valuable tool in research investigating neuropsychiatric disorders and dopaminergic regulation.

    In stock View Details
    5 mg
    $290.00
    50 mg
    $2,855.00
    All 2 sizes

2 Items

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