Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
(-)-Alkannin is a potent apoptosis inducer, extracted from Alkanna tinctoria, and has demonstrated significant anticancer activity. It effectively arrests the cell cycle and triggers apoptotic processes in various cancer cell lines. Additionally, (-)-Alkannin contributes to the reduction of hepatic inflammation through modulation of the Rho-kinase pathway, making it a valuable tool for research in cancer biology and inflammation studies. -
Apoptosis Inducer
Obacunone is a triterpenoid limonoid with potent apoptosis-inducing properties. It has demonstrated significant anticancer effects through the activation of programmed cell death pathways. Additionally, Obacunone offers protective benefits to retinal pigment epithelial (RPE) cells against oxidative damage caused by ultraviolet (UV) radiation, making it a valuable reagent for research in cancer biology and oxidative stress studies. -
Apoptosis Inducer
Icaritin is a prenylflavonoid derivative that functions as an apoptosis inducer. It has demonstrated potent inhibitory effects on the proliferation of K562 cells, with an IC50 of 8 µM, and primary chronic myeloid leukemia (CML) cells, exhibiting IC50 values of 13.4 µM for CML-chronic phase and 18 µM for CML-blast crisis. Icaritin modulates critical signaling pathways, including MAPK/ERK/JNK and JAK2/STAT3/AKT, and has been shown to enhance osteogenesis, making it a valuable compound for research in cancer and regenerative medicine. -
Apoptosis Inducer
Pimpinellin is an apoptosis inducer derived from Cyrtomium fortumei. It demonstrates significant antitumor activity by promoting apoptosis in tumor cells, thereby inhibiting cellular growth and proliferation. This compound has potential applications in cancer research, particularly in studies focused on mechanistic pathways of cell death and therapeutic strategies for tumor suppression. -
Apoptosis Inducer
9-Methoxycamptothecin (MCPT) is a potent apoptosis inducer that exerts its antitumor effects primarily through the inhibition of topoisomerase enzymes. Derived from Camptotheca acuminata, MCPT effectively induces G2/M cell cycle arrest and promotes apoptosis in various cancer cell lines. This compound is valuable for research applications focused on understanding cancer biology and therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
Linderalactone is a sesquiterpene lactone that acts as an apoptosis inducer by modulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. This compound has been shown to effectively inhibit the proliferation of lung cancer A-549 cells, displaying an IC50 of 15 µM. Its unique mechanism makes Linderalactone a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Melamine is an orally active apoptosis inducer that targets multiple biological pathways. It is effective in inducing disease models in animals, particularly concerning male reproductive function through its effects on Sertoli cells. Additionally, melamine exhibits neurotoxic and nephrotoxic properties, making it useful for research on cognitive impairment and acute kidney injury. Its potential to induce bladder cancer and urinary stone models further establishes melamine as a valuable tool in toxicological and cancer research. -
Apoptosis Inducer
Bucladesine calcium is a cell-permeable analog of cyclic AMP (cAMP), functioning as an apoptosis inducer primarily through the activation of cAMP-dependent protein kinase (PKA). By elevating intracellular cAMP levels, it inhibits phosphodiesterase (PDE) activity, thereby stabilizing cAMP concentrations and promoting apoptosis in targeted cells. This compound is widely utilized in research applications investigating cell signaling pathways, PKA-mediated processes, and mechanisms underlying programmed cell death. -
Apoptosis Inducer
13'-Carboxy-δ-tocopherol, a metabolite of long-chain vitamin E, serves as an apoptosis inducer by activating caspase-3 and caspase-9, leading to PARP-1 cleavage. This compound demonstrates significant antiproliferative effects in cancer cells by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) formation, ultimately driving apoptosis. 13'-Carboxy-δ-tocopherol is valuable in research focused on hepatocellular carcinoma and other cancer types. -
Mdm2-MdmX RING Domain Inhibitor
MMRi6 is an Mdm2-MdmX RING domain inhibitor that disrupts the RING-RING interaction between Mdm2 and MdmX. This compound effectively inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated polyubiquitination of p53 in vitro, while sparing NEDD4-1 autoubiquitination. MMRi6 promotes stabilization and accumulation of p53, leading to PARP cleavage in wild-type p53 Emu-myc lymphoma cells. It demonstrates growth inhibition of wild-type p53 and p53-null Emu-myc lymphoma cells with IC50 values of approximately 0.5 μM and 3 μM, respectively, making it a valuable tool for studying leukemia and lymphoma. -
Apoptosis Inducer
6-Dehydrogingerdione serves as an apoptosis inducer by enhancing the sensitivity of human hepatoblastoma Hep G2 cells to TRAIL-induced cell death. This compound mediates its effects through the production of reactive oxygen species, which lead to an upregulation of death receptor 5 (DR5). Its ability to modulate apoptotic pathways makes it a valuable tool for research in cancer therapies and cell death mechanisms. -
Apoptosis Inducer
3-O-Acetyloleanolic acid (3AOA) is an oleanolic acid derivative that functions as an apoptosis inducer. It has demonstrated significant anti-cancer properties, promoting cell death in various cancer types, and displays anti-angiogenic activity, inhibiting the formation of new blood vessels. Research applications include studies on cancer therapy and the mechanisms of apoptosis and angiogenesis. -
Apoptosis Inducer
Desacetylcinobufotalin is a natural compound known for its role as an apoptosis inducer. It exhibits significant inhibitory effects on HepG2 cancer cells, with an IC50 value demonstrating potent cytotoxicity. This compound is primarily used in cancer research to explore mechanisms of programmed cell death and therapeutic strategies for hepatic carcinoma. -
p53 Activator
DPBQ is a potent p53 activator that promotes apoptosis specifically in polyploid cells. It induces the expression and phosphorylation of p53 without inhibiting topoisomerase or directly binding to DNA. This selective action makes DPBQ a valuable tool for research involving polyploidy and the modulation of p53 signaling pathways. -
Apoptosis Inducer
BMS 310705 (21-Aminoepothilone B) is an apoptosis inducer that targets malignancies, including ovarian, renal, bladder, and lung carcinoma. This compound promotes significant apoptotic activity through a mitochondrial-mediated pathway, making it a valuable tool for cancer research. Its effectiveness in inducing programmed cell death highlights its potential applications in studying tumor biology and developing novel therapeutic strategies. -
Apoptosis Inducer
(S)-(-)-Perillic acid is a terpenoid compound known for its role as an apoptosis inducer. It promotes cell apoptosis and cell cycle arrest while enhancing the levels of key proteins such as Bax, Bcl-2, p21, and caspase-3. This reagent is suitable for research applications related to cancer and infectious diseases, providing valuable insights into therapeutic mechanisms and cellular pathways. -
Apoptosis Inducer
Toddaculin is a natural coumarin known for its role as an apoptosis inducer. It effectively induces differentiation and apoptotic processes in leukemic cells while simultaneously suppressing excessive osteoclast activity. Additionally, Toddaculin promotes osteoblast differentiation and mineralization and demonstrates anti-inflammatory properties, making it a valuable reagent for research in cancer biology and bone metabolism. -
p53 Activator
STIMA-1 is a p53 activator that stimulates mutant p53 DNA binding in vitro. This compound induces the expression of p53 target proteins and promotes apoptosis in human tumor cells expressing mutant p53. It serves as a valuable tool for researching p53-driven pathways and potential therapeutic strategies for cancers associated with p53 mutations. -
Apoptosis Inducer
2,3-DCPE hydrochloride is an apoptosis inducer that promotes programmed cell death through the downregulation of Bcl-XL expression. This reagent exhibits anti-tumor activity, making it a valuable tool in cancer research, particularly in studies focused on cell survival mechanisms and therapeutic targets for malignancies. -
Apoptosis Inducer
(-)-Epipodophyllotoxin is an apoptosis inducer derived from the American mayapple, Podophyllum peltatum. Exhibiting potent antiproliferative activity, it demonstrates GI50 values of 0.36 and 0.24 μM against HeLa and MCF-7 cancer cell lines, respectively. Additionally, (-)-Epipodophyllotoxin has been shown to inhibit mitotic spindle assembly in vitro, making it a valuable reagent for cancer research and studies involving cell cycle dynamics. -
Apoptosis Inducer
3-Dehydrotrametenolic acid is an apoptosis inducer that functions as a lactate dehydrogenase (LDH) inhibitor. Isolated from the sclerotium of Poria cocos, it has been shown to promote adipocyte differentiation in vitro and to enhance insulin sensitivity in vivo. Additionally, 3-dehydrotrametenolic acid exhibits anticancer properties by inducing apoptosis in cancer cells, making it a valuable compound for research in cancer biology and metabolic disorders. -
ASK1 Inhibitor
TC ASK 10 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), exhibiting an IC50 of 14 nM. This compound demonstrates minimal inhibitory activity against a range of other kinases, with ASK2 being the only exception, showing an IC50 of 0.51 μM. TC ASK 10 is valuable for research applications focused on apoptosis regulation and cellular stress response pathways. -
Granzyme B/Caspase-8 Inhibitor
Ac-IETD-CHO is a potent, reversible inhibitor of granzyme B and caspase-8. By blocking these proteases, Ac-IETD-CHO effectively inhibits Fas-mediated apoptotic cell death, as well as preventing hemorrhage and liver failure. This compound is valuable for research in apoptosis, immune response, and the modulation of cytotoxic T lymphocyte-induced cell death. -
Apoptosis Inducer
Lucidenic acid B is a natural compound derived from Ganoderma lucidum that serves as an apoptosis inducer. It stimulates the activation of caspase-9 and caspase-3, leading to the cleavage of PARP in cancer cells. Notably, Lucidenic acid B does not alter the cell cycle profile or increase the number of necrotic cells, making it a valuable reagent for research in cancer biology and apoptosis studies. -
Apoptosis Inducer
Cantrixil, an active enantiomer of TRX-E-002, functions as a potent apoptosis inducer. It elevates phosphorylated c-Jun levels, leading to caspase-mediated apoptosis specifically in ovarian cancer cells. This second-generation super-benzopyran compound demonstrates significant pan anti-cancer activity across a variety of cancer phenotypes, making it a valuable tool for research into cancer therapeutics and mechanisms of cell death. -
MDM2 Inhibitor
Milademetan tosylate hydrate is a selective, orally active inhibitor of MDM2, primarily utilized in research focused on acute myeloid leukemia (AML) and solid tumors. This compound induces G1 cell cycle arrest, promotes cellular senescence, and triggers apoptosis, making it a valuable tool for studying the therapeutic potential in cancer treatment and the underlying mechanisms of tumor biology. -
Apoptosis Inducer
Diffractaic acid is a proapoptotic compound primarily derived from Usnea longissima. It is recognized for its ability to induce apoptosis in various cellular models, making it relevant for research in cell death and related disorders. Additionally, diffractaic acid exhibits analgesic and antipyretic properties, contributing to its potential applications in neurobiology and anti-inflammatory studies. -
p53 Activator
Condurango glycoside A is a potent p53 activator that initiates reactive oxygen species (ROS) generation and up-regulates p53 expression. This compound effectively induces apoptosis and promotes premature senescence associated with DNA damage in HeLa cells. Its biological activity makes it a valuable tool for research focused on cellular stress responses and cancer biology. -
Apoptosis Inducer
Rabeprazole-d4 is a deuterated derivative of Rabeprazole, primarily acting as an apoptosis inducer through its irreversible inhibition of gastric H+/K+-ATPase. This second-generation proton pump inhibitor also functions as a uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole-d4 is valuable for research focused on gastric ulcerations and gastroesophageal reflux diseases, facilitating studies on its mechanisms of action and therapeutic potential. -
Apoptosis Inducer
XL44 is an apoptosis inducer that targets hRpn13, facilitating hRpn13-dependent programmed cell death. This compound reduces cell viability through a PCLAF-dependent mechanism, promoting the ubiquitin-dependent degradation of hRpn13Pru and the ubiquitin-independent degradation of specific proteins containing KEN boxes. XL44 is utilized in research applications focused on understanding apoptosis pathways and protein degradation mechanisms. -
Apoptosis Inducer
Chrysosplenol D is a methoxy flavonoid that functions as an apoptosis inducer, specifically targeting ERK1/2 signaling pathways in triple-negative human breast cancer cells. In addition to its pro-apoptotic effects, Chrysosplenol D displays anti-inflammatory properties and moderate antitrypanosomal activity, making it a valuable candidate for cancer research and studies focused on inflammation and parasitic infections. -
MDM2-p53 Interaction Inhibitor
MI-1061 TFA is a potent inhibitor of the MDM2-p53 interaction, exhibiting an IC50 of 4.4 nM and a Ki of 0.16 nM. This orally bioavailable and chemically stable compound effectively activates p53, leading to apoptosis in SJSA-1 xenograft tumor tissues in murine models. MI-1061 TFA demonstrates significant anti-tumor activity, making it a valuable tool for cancer research focused on the modulation of the p53 signaling pathway. -
Apoptosis Inducer
Genistein 8-c-glucoside (G8CG) acts as an apoptosis inducer by promoting mitochondrial membrane depolarization. This compound facilitates programmed cell death, making it a valuable tool for research applications focused on cancer biology and therapeutic interventions. G8CG’s mechanisms can be explored in various cellular models to better understand apoptosis and its regulation. -
Apoptosis Inducer
Phellamurin is a plant flavonoid glycoside derived from the leaves of Phellodendron amurense, primarily functioning as an apoptosis inducer. It has been shown to inhibit intestinal P-glycoprotein and demonstrates anti-tumor activity by promoting programmed cell death in various cancer cell lines. Additionally, Phellamurin affects the reproductive behavior of Papilio protenor by inhibiting egg-laying, indicating its potential applications in biological research related to apoptosis and cancer therapy. -
Apoptosis Inducer
Ganglioside GD3 disodium salt is an acidic glycosphingolipid that functions as an apoptosis inducer. It has been shown to inhibit the proliferation of cancer cells, influence the mitochondrial permeability transition pore (mPTP), and activate the caspase family, leading to programmed cell death. This compound is valuable for research applications focused on cancer biology and neurodegenerative diseases. -
Apoptosis Inducer
Zeylenone is a naturally occurring cyclohexene oxide that acts as an apoptosis inducer. It effectively inhibits cell proliferation and promotes apoptotic cell death in cervical carcinoma cells through the modulation of the PI3K/AKT/mTOR and MAPK/ERK signaling pathways. This compound serves as a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Mepazine acetate is an apoptosis inducer that inhibits the protease activity of MALT1, making it a valuable tool for investigating the role of MALT1 in various biological processes. In studies with mouse bone marrow precursor cells, treatment with mepazine acetate significantly reduced RANK ligand (RANKL)-induced osteoclast formation and suppressed the expression of key osteoclast markers, including TRAP and feline hepsin K. Notably, its protective effects were found to be independent of MALT1 deficiency, suggesting the involvement of alternative mechanisms. This compound is essential for research focused on apoptosis, osteoclast differentiation, and related signaling pathways. -
Apoptosis Inducer
Vitamin K2 is an apoptosis inducer that exerts its effects by promoting autophagy and inhibiting cell proliferation. It has demonstrated the ability to reduce proinflammatory cytokine levels, including IL-1β, TNF-α, and IL-6, making it relevant in studies related to inflammatory processes. Vitamin K2 is valuable for research into conditions such as involutional osteoporosis, non-alcoholic fatty liver disease, ulcerative colitis, acute myeloid leukemia, myelodysplastic syndromes, and hepatocellular carcinoma. -
Mdm2-MdmX Inhibitor
MMRi64 is a selective inhibitor of the Mdm2-MdmX protein interactions. This compound downregulates Mdm2 and MdmX levels in leukemia cells, leading to increased accumulation of p53 and activation of the apoptotic pathways associated with p53. MMRi64 is a valuable tool for cancer research, particularly in the study of leukemias and lymphomas, where modulation of the p53 signaling axis is critical. -
Apoptosis Inducer
Pyridinium bisretinoid A2E is an apoptosis inducer primarily found in lipofuscin within the retinal pigment epithelium. This compound triggers blue-light-induced apoptosis, facilitating autophagy and generating reactive oxygen species upon photoactivation. A2E is employed in research to investigate mechanisms underlying retinal degenerative diseases. -
Apoptosis Inducer
Resistomycin is a pentacyclic polyketide antibiotic that serves as an apoptosis inducer. It exhibits significant anticancer activity by promoting programmed cell death in various cancer cell lines. This compound is valuable for research applications focused on understanding apoptotic mechanisms and developing cancer therapeutics. -
Apoptosis Inducer
Secalonic acid D is a potent apoptosis inducer that targets GSK3-β, leading to the degradation of β-catenin. Isolated from the metabolites of Aspergillus aculeatus, this compound effectively down-regulates c-Myc expression and induces cell cycle arrest at the G1 phase. Its mechanism of action makes Secalonic acid D valuable for research on tumor cell apoptosis and cell cycle regulation in cancer studies. -
Apoptosis Inducer
Icariside D2 is an apoptosis inducer isolated from Annona glabra fruit that inhibits angiotensin-converting enzyme. It exhibits notable cytotoxicity against the HL-60 cell line with an IC50 value of 9.0 ± 1.0 μM. This compound is valuable in research focused on cancer biology, particularly in studies exploring mechanisms of programmed cell death and potential therapeutic interventions. -
Apoptosis Inducer
Girinimbine is a carbazole alkaloid recognized for its ability to induce apoptosis. This compound exhibits a range of biological activities including antitrypanosomal, antibacterial, antiplatelet, anti-inflammatory, antioxidant, and antitumor effects. It is valuable in research applications focused on cell death mechanisms and potential therapeutic strategies against various diseases. -
Apoptosis Inducer
Rotundifuran is a labdane-type diterpene isolated from Vitex rotundifolia, known for its role as an apoptosis inducer. This compound has been demonstrated to inhibit cell cycle progression and promote apoptosis in human myeloid leukemia cells, making it a valuable tool for cancer research. Its effects on cell viability and mechanisms of action provide insight into potential therapeutic applications targeting cancer cell survival. -
Apoptosis Inducer
Ganoderenic acid D is a triterpene that acts as an apoptosis inducer. Isolated from the extract of Ganoderma lucidum, this compound effectively inhibits the proliferation of cancer cells by promoting cell cycle arrest and triggering apoptotic pathways. It serves as a valuable tool in cancer research, particularly in studies focused on mechanisms of cell death and therapeutic interventions in oncology. -
Apoptosis Inducer
QN523 is an innovative apoptosis inducer that exhibits potent cytotoxicity across a diverse panel of 12 cancer cell lines. This compound facilitates programmed cell death and autophagy, making it a valuable tool for cancer research. Utilizing QN523 can enhance the understanding of apoptotic pathways and contribute to the development of targeted cancer therapies. -
Apoptosis Inducer
Soyasaponin III is a monodesmodic oleanane triterpenoid that acts as an apoptosis inducer. Derived from soy (Glycine max), this bioactive saponin demonstrates significant cytotoxicity in Hep-G2 cells, making it a valuable tool for research into cancer biology and therapeutic strategies targeting apoptosis. Its unique mechanism provides insights into the modulation of cell death pathways and potential applications in developing anticancer agents. -
Apoptosis Inducer
Kauran-16,17-diol is a natural diterpene that functions as an apoptosis inducer. This compound demonstrates significant anti-tumor activity, exhibiting an IC50 of 17 μM in inhibiting nitric oxide production in LPS-stimulated RAW 264.7 macrophages. Kauran-16,17-diol is valuable for research focused on cancer biology and mechanisms of apoptosis. -
Apoptosis Inducer
Dehydroleucodine, a sesquiterpene lactone derived from Artemisia douglasiana, acts as an apoptosis inducer. This compound exhibits significant antileukemic activity and has been shown to inhibit gastric ulcer formation. Additionally, Dehydroleucodine stabilizes mast cells by preventing degranulation triggered by compound 48/80, making it a valuable reagent for exploring mechanisms of cell death and inflammation in research applications.
