Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
7,8-Dihydroneopterin is an apoptosis inducer that enhances the expression of inducible nitric oxide synthase (iNOS) in astrocytes and neurons. This compound plays a significant role in the study of neurodegenerative diseases by promoting cellular apoptosis. Its biological activity provides valuable insights into mechanisms underlying neuroinflammation and neurodegeneration. -
Apoptosis Inducer/Insecticide
Dihydrorotenone is an irreversible inhibitor of mitochondrial complex I and serves as an apoptosis inducer. It demonstrates significant cytotoxicity to human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. Dihydrorotenone's insecticidal properties position it as a valuable tool in studies on neurodegenerative diseases, such as Parkinson's disease, as well as in safety assessments of natural pesticides and cancer chemoprevention research. -
Apoptosis Inducer
Prostaglandin A2 (PGA2) is a cyclopentenone prostaglandin that functions as an apoptosis inducer by activating caspase pathways and modulating the p53 signaling pathway. It also activates ERK2 and JNK1/SAPK pathways, contributing to its role in cell death and differentiation. Prostaglandin A2 exhibits antiviral properties against HSV-1 and demonstrates anti-tumor effects, making it relevant in research applications related to colorectal cancer, breast carcinoma, and herpetic keratitis. -
Apoptosis Inducer
Kahweol is a compound derived from Coffea arabica, functioning primarily as an apoptosis inducer. It exhibits anti-inflammatory, anti-angiogenic, and anti-cancer properties. Kahweol activates AMP-activated protein kinase (AMPK), leading to inhibition of adipogenesis and promotion of glucose uptake. Its biological activities make it valuable for research into cancer biology and metabolic disorders. -
Apoptosis Inducer
Ingenol 3,20-dibenzoate is a selective agonist of specific protein kinase C (PKC) isoforms, primarily targeting nPKC-delta, -epsilon, -theta, and PKC-mu. This compound induces morphologically characteristic apoptosis through the de novo synthesis of macromolecules and facilitates the translocation of these PKC isoforms from the cytosolic to the particulate fraction. Additionally, Ingenol 3,20-dibenzoate enhances interferon-gamma production and promotes the degranulation of natural killer (NK) cells, particularly in the context of non-small cell lung cancer (NSCLC) cell stimulation. Its applications are valuable in research focused on apoptosis and immune response modulation. -
Apoptosis Inducer
Bixin is a carotenoid derived from the seeds of Bixa orellana that acts as an apoptosis inducer. It has been shown to effectively induce cell death in cancer cells while also exhibiting notable anti-inflammatory, anti-tumor, and antioxidant properties. Additionally, Bixin treatment has demonstrated a protective effect on cardiac function by reducing fibrosis, inflammation, and the generation of reactive oxygen species (ROS), making it a valuable compound for research in cancer and cardiovascular diseases. -
Apoptosis Inducer
Euphorbia Factor L2 is a lathyrane diterpenoid that acts as an apoptosis inducer. Isolated from the seeds of Euphorbia lathyris L., it demonstrates potent cytotoxicity and triggers apoptosis through the mitochondrial pathway. This compound is a valuable tool for cancer research, providing insights into mechanisms of cell death and potential therapeutic applications in oncology. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Apoptosis Inducer
Ethylene dimethanesulfonate is a pro-apoptotic compound that functions as a mild alkylating agent. It selectively induces apoptosis in lymphocytes, making it a valuable tool for studying programmed cell death. This reagent is useful in research applications involving cancer biology, immunology, and cellular stress response mechanisms. -
Apoptosis Inducer
Delphinidin 3-rutinoside chloride is an active anthocyanin that functions as an apoptosis inducer, primarily targeting B cell chronic lymphocytic leukemia (B CLL). This compound demonstrates pro-apoptotic effects by promoting cell death in B CLL cells. Additionally, it exhibits phytoestrogen activity through its binding affinity for estrogen receptor beta (ERβ), with an IC50 value of 2.3 μM, making it a valuable tool for cancer research and apoptosis studies. -
Apoptosis Inducer
Leachianone A is a potent apoptosis inducer derived from Radix Sophorae. This compound exhibits notable anti-malarial, anti-inflammatory, and cytotoxic properties. Leachianone A effectively triggers apoptosis through both extrinsic and intrinsic pathways, making it a valuable reagent for research in therapeutic applications aimed at programmed cell death and disease modulation. -
Apoptosis Inducer
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
Apoptosis Inducer
(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties. -
ASK1 Inhibitor
ASK1-IN-2 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), demonstrating a potent inhibitory activity with an IC50 of 32.8 nM. This compound is valuable for research applications related to ulcerative colitis, as it modulates inflammatory pathways mediated by ASK1. Its orally active nature makes it suitable for in vivo studies aimed at exploring the therapeutic potential in gastrointestinal diseases. -
Apoptosis Inducer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells. -
Survivin Dimerization Inhibitor
LQZ-7F is a potent survivin dimerization inhibitor that promotes spontaneous apoptosis in prostate cancer cells. It demonstrates dose-dependent cytotoxicity against PC-3 and C4-2 cell lines, with IC50 values of 2.99 µM and 2.47 µM, respectively. Additionally, LQZ-7F exhibits synergistic effects when combined with Docetaxel, making it valuable for research into therapeutic strategies targeting survivin in cancer treatment. -
Apoptosis Inducer
Carubicin hydrochloride is an apoptosis inducer that targets cancer cell proliferation. Derived from microbial sources, it effectively inhibits the growth of VHL-defective clear cell renal cell carcinoma (CCRCC) cells. Notably, carubicin hydrochloride induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor HIF2. This compound holds significant potential for research applications in cancer biology. -
Mutant p53 Reactivator
SLMP53-2 is a mutant p53 reactivator that restores the wild-type conformation and DNA-binding capabilities of the mutp53-Y220C variant by enhancing its interaction with Hsp70. This mechanism reestablishes p53 transcriptional activity, contributing to important biological processes such as cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress. SLMP53-2 demonstrates significant antitumor activity, making it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Flavokawain C is a natural chalcone derived from Kava root, functioning as an apoptosis inducer. It demonstrates cytotoxic effects against human cancer cell lines, specifically exhibiting an IC50 value of 12.75 μM for HCT 116 cells. This compound is of significant interest in cancer research for its potential therapeutic applications in inducing programmed cell death in malignancies. -
Apoptosis Inducer
Euscaphic acid is a triterpene derived from the root of R. alceaefolius Poir, functioning as an apoptosis inducer. This compound inhibits DNA polymerases, specifically calf DNA polymerase α and rat DNA polymerase β, with IC50 values of 61 μM and 108 μM, respectively. Euscaphic acid's ability to induce apoptosis makes it a valuable reagent for research focused on cancer biology and cell death pathways. -
Apoptosis Inducer
Damnacanthal is an anthraquinone that primarily functions as an apoptosis inducer through selective inhibition of p56lck tyrosine kinase activity. Demonstrating significant anticancer properties, Damnacanthal effectively inhibits p56lck autophosphorylation and the phosphorylation of exogenous substrates, with IC50 values of 46 nM and 220 nM, respectively. Additionally, Damnacanthal exhibits antinociceptive and anti-inflammatory effects in murine models, along with antifungal activity against Candida albicans. This compound is valuable for research into cancer biology and related therapeutic pathways. -
p53Y220C Transcriptional Activator
TRAP-1 is a selective p53Y220C transcriptional activator that engages with p53Y220C and BRD4 to form a ternary complex, leading to enhanced transcription of mutant p53 target genes. It effectively upregulates p21 and other p53 target genes in pancreatic cell lines harboring the p53Y220C mutation. Notably, TRAP-1 demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.531 μM in BxPC-3 cells (p53Y220C) compared to 3.94 μM in A549 cells (p53WT). TRAP-1 is a valuable tool for investigating cancer associated with the p53Y220C mutation. -
Survivin/XIAP Modulator
UC-112 is a selective modulator of survivin and XIAP, with notable anticancer properties. It induces the degradation of survivin through the ubiquitin-mediated proteasomal pathway, while also decreasing XIAP levels in in vivo tumor models. This compound activates caspase-3/7 and caspase-9, promoting apoptosis in cancer cells. UC-112 is relevant for research into melanoma, prostate cancer, and various cancer-related studies. -
Apoptosis Inducer
Glycidyl methacrylate is an apoptosis inducer that demonstrates concentration-dependent cytotoxicity and genotoxicity in human peripheral blood lymphocytes and CCRF-CEM leukemia cells. It induces DNA strand breaks and base oxidative damage through mechanisms associated with oxidative stress, although cellular repair systems can effectively mitigate the damage within two hours. This compound also has applications in the development of dental composite restorative materials. -
Apoptosis Inducer
8-Hydroxyefavirenz is a potent apoptosis inducer through a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Its ability to trigger programmed cell death positions it as a valuable tool in cancer research. Additionally, 8-Hydroxyefavirenz features an alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), enhancing its utility in click chemistry applications. -
Apoptosis Inducer
Taccalonolide A is a microtubule stabilizer derived from the plant Tacca chantrieri, known for its ability to induce apoptosis. This compound demonstrates significant cytotoxic effects, particularly in cancer cell lines, including those that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7). Taccalonolide A initiates apoptosis through mechanisms such as G2-M phase cell cycle accumulation and Bcl-2 phosphorylation, exhibiting an IC50 of 622 nM against SK-OV-3 cells. Its distinct properties make it a valuable tool for research in cancer biology and drug resistance. -
Apoptosis Inducer
Chaetoglobosin A is a potent apoptosis inducer derived from the extract of Penicillium aquamarinium and belongs to the cytochalasan family. It selectively targets filamentous actin in chronic lymphocytic leukemia (CLL) cells, leading to cell-cycle arrest and inhibition of membrane ruffling and cell migration. This compound is valuable for research in apoptosis mechanisms and cancer therapeutics. -
Apoptosis Inducer
Justicidin A is a natural compound isolated from Justicia procumbens that acts as an apoptosis inducer. It induces programmed cell death by decreasing Ku70 levels, which facilitates the translocation of Bax from the cytosol to the mitochondria. Justicidin A is valuable for researching cancer mechanisms and therapeutic strategies targeting apoptosis pathways. -
Apoptosis Inducer
Beta-Zearalanol is a mycotoxin derived from the Fusarium species, known for its role as an apoptosis inducer. This compound induces oxidative stress in mammalian reproductive cells, making it a valuable reagent for studies focused on cellular apoptosis and reproductive toxicology. Its ability to conjugate with glucuronic acid further supports its relevance in biochemical and pharmacological research. -
Apoptosis Inducer
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research. -
Apoptosis Inducer
Tetrahydroxyquinone, a redox-active benzoquinone, primarily induces apoptosis through the generation of reactive oxygen species (ROS). By participating in a redox cycle with semiquinone radicals, Tetrahydroxyquinone enhances oxidative stress within cells, making it a valuable tool for studying cellular mechanisms related to cell death and oxidative damage. Its ability to trigger apoptotic pathways positions it as a relevant compound for research in cancer biology and oxidative stress-related studies. -
Apoptosis Inducer
Rubropunctatin is an orange azaphilone pigment that functions as an apoptosis inducer. Isolated from Monascus pilosus-fermented rice, it displays notable anti-inflammatory, immunosuppressive, and antioxidative properties. Additionally, Rubropunctatin has demonstrated anti-tumor activity, making it a promising candidate for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Citreoviridin is a potent apoptosis inducer derived from Penicillium citreoviride NRRL 2579, primarily targeting Na+/K+-ATPase in brain synaptosomes. This compound exhibits a dose-dependent inhibition of cell proliferation and promotes apoptosis in human umbilical vein endothelial cells. Its unique mechanism of action and effects on ATPase activities make it a valuable reagent for research applications studying cellular apoptotic pathways and endothelial cell function. -
Apoptosis Inducer
Falcarinol is a natural compound that functions as an apoptosis inducer, primarily through its inhibition of the heat shock protein 90 (Hsp90) in both the N-terminal and C-terminal regions. Its selective mechanism showcases limited toxicity, making it a valuable tool for studying apoptotic pathways. Additionally, Falcarinol contains an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc), which enables its use in click chemistry applications for the conjugation of azide-containing compounds. -
Apoptosis Inducer
Ganglioside GD3 diammonium is an acidic glycosphingolipid that serves as an effective apoptosis inducer through its interaction with the mitochondrial permeability transition pore (PTPC). This compound inhibits the proliferation of cancer cells and activates the caspase family, facilitating apoptosis. Ganglioside GD3 diammonium is valuable for research into cancer biology and neurodegenerative diseases, providing insights into cell death mechanisms and potential therapeutic interventions. -
Apoptosis Inducer
Enniatin A1 is a cyclic hexadepsipeptide that functions as an apoptosis inducer. Isolated from Fusarium mycotoxins, this compound exhibits anticarcinogenic properties primarily through the induction of apoptosis and disruption of the ERK signaling pathway. In addition, Enniatin A1 demonstrates inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 of 49 μM in rat liver microsomes, making it a valuable tool for research in cancer biology and lipid metabolism. -
Apoptosis Inducer
Apoptosis Inducer 42 is a potent agent that triggers late-stage apoptosis and inhibits interleukin-6 (IL-6) secretion. This compound demonstrates significant cytotoxic effects against various cancer cell lines, making it a valuable tool for cancer research, particularly in the study of colon cancer. Its mechanism of action and ability to modulate key cytokines enhance its utility in investigating apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Actisomide is a potent apoptosis inducer that primarily targets mitochondrial pathways to initiate programmed cell death. This compound demonstrates significant biological activity in various cellular models, making it a valuable tool for research on apoptosis and related signaling pathways. Its pH-dependent absorption in animal models and in vitro uptake in CaCo-2 cells highlight its relevance in pharmacological studies and drug development. Researchers can utilize Actisomide to elucidate mechanisms of apoptosis and investigate potential therapeutic applications in cancer and other diseases characterized by dysregulated cell death. -
ASK1 Inhibitor
Selonsertib hydrochloride is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1). This compound exerts anti-inflammatory, anti-tumor, and anti-fibrotic effects by blocking the phosphorylation and activation of ASK1 through its binding to the catalytic kinase domain. It also attenuates the production of inflammatory cytokines and decreases the expression of fibrosis-related genes, thereby inhibiting excessive apoptosis and limiting cell proliferation. These properties make selonsertib hydrochloride a valuable tool for research in inflammation and fibrotic diseases. -
p53 Stabilizer
p53 Stabilizer 2 (Compound 17a16) is a potent p53 stabilizer that enhances the stability and function of the p53 protein. This compound induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells, demonstrating its broad therapeutic potential. Mechanistically, p53 Stabilizer 2 triggers mitochondrial stress and activates critical checkpoint pathways, including NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. Additionally, it has shown efficacy in inhibiting tumor growth in p53-deficient xenograft models, making it a valuable tool for cancer research. -
Apoptosis Inducer
Uvarigrin is a potent apoptosis inducer targeting multidrug-resistant tumor cells. Isolated from the roots of Uvaria calamistrata, it effectively activates Caspase-9, leading to programmed cell death. This compound holds potential for research in cancer therapy and the mechanisms underlying drug resistance. -
Apoptosis Inducer
Ginsenoside Rs3 is a natural diol-type ginseng saponin that functions as an apoptosis inducer. It selectively enhances the protein levels of p53 and p21WAF1, leading to the induction of apoptosis in SK-HEP-1 cells. Ginsenoside Rs3 is utilized in cancer research to explore mechanisms of tumor cell death and the regulation of apoptosis-related pathways. -
Apoptosis Inducer
ABL-L is an apoptosis inducer that targets the p53-dependent pathway. This compound effectively promotes apoptosis in human laryngocarcinoma cells, making it a valuable tool for cancer research. Its ability to modulate apoptotic mechanisms supports investigations into therapeutic strategies for treating laryngeal cancer and related malignancies. -
Apoptosis Inducer
Telomerase-IN-4 is a potent telomerase inhibitor that induces apoptosis in targeted cells. It demonstrates significant antiproliferative activity, making it a valuable tool for research in cancer biology and therapeutic development. This compound can be utilized to explore mechanisms of cell death and the role of telomerase in tumor progression. -
Apoptosis Inducer
Apoptosis Inducer 4 (Compound 12b) primarily functions as an apoptosis inducer, targeting the apoptotic pathway to initiate programmed cell death. This compound exhibits significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the mechanisms of apoptosis. Its role in triggering apoptosis positions it as a potential candidate for investigating treatments aimed at tumor cell eradication and understanding the underlying processes of cell death in various cancer types. -
Apoptosis Inducer
Carubicin, a potent apoptosis inducer, is derived from microbial sources. This compound effectively inhibits the proliferation of VHL-deficient clear cell renal cell carcinoma (CCRCC) cells. Notably, Carubicin induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor 2 (HIF2), highlighting its unique mode of action. Its specific biological activity makes Carubicin a valuable tool for research into cancer therapeutics. -
ASK1 Inhibitor
ASK1-IN-3 is a selective inhibitor of the apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 33.8 nM. This compound demonstrates significant apoptotic induction in HepG2 cancer cells and exhibits effective cell cycle arrest. Its ability to modulate the activity of several cell cycle regulating kinases renders ASK1-IN-3 valuable for research applications related to cancer therapy and cell cycle regulation studies. -
Apoptosis Inducers
Antiangiogenic Agent 7 is an apoptosis inducer known for its ability to stimulate cell death through increased production of Reactive Oxygen Species and inhibition of thioredoxin reductase, an intracellular enzyme. This compound exhibits notable anti-cancer properties, displaying an IC50 range of 0.08-3.5 μM against various cancer cell lines, including HeLa (cervical), PC-3 (prostate), and A549 (non-small cell lung cancer). Additionally, Antiangiogenic Agent 7 demonstrates the potential to inhibit tumor growth in mouse xenograft models, making it a valuable tool for cancer research. -
PKD Inhibitor
CRT0066101 trihydrochloride is a potent inhibitor of Protein Kinase D (PKD), exhibiting IC50 values of 1 nM, 2.5 nM, and 2 nM against PKD1, PKD2, and PKD3, respectively. In addition to its PKD-inhibitory properties, it also targets PIM2 with an IC50 of approximately 135.7 nM. This compound demonstrates significant anti-inflammatory effects in lipopolysaccharide (LPS)-induced lung injury models in mice and exhibits potential anticancer activity, making it a valuable reagent for research in oncology and inflammation.
