Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
OTS514 hydrochloride is a potent inhibitor of the TOPK kinase, exhibiting an IC50 value of 2.6 nM. This compound effectively suppresses the proliferation of TOPK-positive cancer cells by inducing cell cycle arrest and apoptosis. OTS514 hydrochloride is a valuable tool for research focusing on cancer biology and potential therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
AlbA-DCA is a novel apoptosis inducer formed by conjugating Albiziabioside A (AlbA) with dichloroacetate acid (DCA). This compound triggers a significant increase in intracellular reactive oxygen species (ROS) while reducing lactic acid buildup in the tumor microenvironment (TME). AlbA-DCA selectively targets and eliminates cancer cells, effectively inducing apoptosis and making it a valuable tool for research in cancer biology and therapeutic development. -
p53-MDM2 Inhibitor
DS-5272 is an orally active inhibitor of the p53-MDM2 interaction, demonstrating an IC50 of 20 nM. This compound effectively inhibits the proliferation of SJSA-1 cells (wildtype p53, IC50 = 0.17 μM) as well as DLD-1 cells (mutant p53). DS-5272 induces cell cycle arrest and promotes apoptosis in SJSA-1 cells, while also exhibiting antitumor efficacy in vivo in mouse models. This makes DS-5272 a valuable tool for research in cancer therapeutics targeting the p53 pathway. -
Apoptosis Inducer
VDR Agonist 1 is a nonsteroidal agonist of the Vitamin D receptor (VDR), exhibiting an IC50 of 690 nM in MCF-7 cells. This compound induces apoptosis by enhancing the expression of pro-apoptotic protein BAX while reducing anti-apoptotic protein Bcl-2 levels. Additionally, VDR Agonist 1 triggers cell cycle arrest through the up-regulation of cyclin-dependent kinase inhibitors p21 and p27, making it a valuable tool for studies related to cancer biology and therapeutic interventions targeting apoptotic pathways. -
MDM2-NFAT1 Inhibitor
MA242 free base is a targeted inhibitor of MDM2 and NFAT1, effectively disrupting their interaction. By binding with high affinity, MA242 promotes degradation of both proteins and suppresses NFAT1-mediated transcription of MDM2. This compound has demonstrated the ability to induce apoptosis in pancreatic cancer cell lines, providing a valuable tool for research in cancer biology and therapeutic applications, particularly in contexts where p53 is either mutated or absent. -
Apoptosis Inducer
Fexapotide is an apoptosis inducer that selectively targets prostate cells, resulting in a reduction of prostate volume at the cellular level. This compound is primarily applied in research related to lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), providing insights into potential therapeutic interventions for these conditions. -
Apoptosis Inducer
Anticancer Agent 71 is a potent apoptosis inducer that targets the regulation of cell cycle and apoptotic pathways. This compound effectively arrests cells at the G2/M phase and promotes apoptosis by upregulating Bax, IkB-α, and cleaved PARP, while simultaneously downregulating Bcl-2 expression levels. Anticancer Agent 71 demonstrates significant antiproliferative activity, making it a valuable tool for cancer research applications focused on programmed cell death. -
Apoptosis Inducer
TJ08 is a 1,2,5-trisubstituted benzimidazole derivative that acts as an effective apoptosis inducer. It efficiently induces G1/S phase arrest while promoting apoptosis in a variety of cancer cell types. This compound is valuable for research applications focused on cancer biology and therapeutic development targeting apoptotic pathways. -
Apoptosis Inducer
Apiole is an apoptosis inducer that targets and inhibits human colon cancer cells, primarily by promoting G0/G1 cell cycle arrest. This compound demonstrates significant anti-tumor activity, as evidenced by its ability to inhibit colon tumor development in various in vivo mouse xenograft models. Apiole is valuable for research applications focused on cancer biology and therapeutic development. -
Apoptosis Inducer
Apoptosis Inducer 46 targets apoptotic pathways to induce cell death selectively in metastatic triple-negative breast cancer (TNBC) cells. It demonstrates potent growth inhibitory effects, specifically causing G2/M phase cell cycle arrest and promoting apoptotic cell death in MDA-MB-231 cells. Additionally, Apoptosis Inducer 46 inhibits NF-κB nuclear translocation, highlighting its potential for research applications in the study of TNBC. -
Apoptosis Inducer
Kusunokinin is a natural product isolated from Piper nigrum, functioning primarily as an apoptosis inducer. It demonstrates significant anticancer activity by arresting the cell cycle at the G2/M phase, leading to the activation of apoptotic pathways in cancer cells. This compound is useful for research applications focused on cancer biology and the mechanisms underlying cell cycle regulation and apoptosis. -
Apoptosis Inducer
NC-001 is a selective apoptosis inducer that primarily targets renal proximal tubular cells and renal cancer cells. This compound has demonstrated the ability to inhibit tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models, making it a valuable tool for investigating metastatic renal cell carcinoma. Its mechanism of action positions NC-001 as a promising candidate for research focused on renal cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 hydrochloride is a potent apoptosis inducer targeting PDE3A-SLFN12, exhibiting an IC50 of 0.3 μM. This compound binds to the enzyme pocket of PDE3A, facilitating the recruitment and stabilization of SLFN12, which inhibits protein translation and initiates apoptotic pathways. It serves as a valuable tool in oncology research, particularly in studies focused on apoptosis and antitumor mechanisms. -
ASK1 Inhibitor
ASK1-IN-4 is a selective inhibitor of Apoptosis Signal-regulating Kinase 1 (ASK1), demonstrating an IC50 of 0.2 μM. This compound effectively interacts with the ATP-binding site of ASK1, leading to the modulation of apoptotic signaling pathways. ASK1-IN-4 is primarily utilized in research focused on apoptosis regulation, oxidative stress response, and related therapeutic investigations. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Apoptosis Inducer
Griffipavixanthone is an apoptosis inducer that targets the mitochondrial apoptotic pathway, leading to increased reactive oxygen species (ROS) production within cells. Its primary biological activity is the induction of cell apoptosis, making it a valuable agent in anti-cancer research. Additionally, Griffipavixanthone exhibits weak inhibitory activity against sucrase, with an IC50 of 4.58 mM, suggesting potential implications in metabolic studies. -
Neural Apoptosis Inducer
NTR 368 is a peptide derived from the p75 neurotrophin receptor (p75NTR), specifically corresponding to residues 368-381 of the human protein. This compound exhibits a propensity to form alpha-helices in the presence of micellar lipids, enhancing its interaction with cellular membranes. NTR 368 serves as a potent inducer of neural apoptosis, making it a valuable tool for studying neurodegenerative processes and the mechanisms underlying neuronal cell death in research applications. -
Apoptosis Inducer
Asparanin A is an apoptosis inducer that exhibits significant anticancer activity. It triggers cell cycle arrest in the G0/G1 phase by targeting mitochondrial pathways and the PI3K/AKT signaling cascade, ultimately inhibiting the proliferation of cancer cells. Additionally, Asparanin A has showcased in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, where it substantially reduced tumor growth. -
Apoptosis Inducer
Amiloride is an inhibitor of epithelial sodium channels (ENaC) and the urokinase-type plasminogen activator receptor (uPAR). This compound has been shown to induce apoptosis through its modulation of sodium ion transport and intracellular signaling pathways. Research applications include studies on renal function, cancer cell metabolism, and the investigation of ion channel-related diseases. Additionally, Amiloride has been explored as a potential therapeutic agent in various pathophysiological conditions. -
Apoptosis Inducer
Silybin is a flavonolignan derived from the seeds of milk thistle (Silybum marianum) with a primary mechanism as an apoptosis inducer. It exhibits notable hepatoprotective, antioxidant, and anti-inflammatory properties, making it a valuable compound for cancer research. This compound's multifaceted biological activities support its potential applications in studies focused on cell death pathways and liver health. -
Apoptosis Inducer
Pyridinium bisretinoid A2E TFA is an apoptosis inducer primarily involved in the study of retinal degenerative diseases. Isolated from lipofuscin in the retinal pigment epithelium, A2E TFA serves as a fluorophore that facilitates blue-light-induced apoptosis. Upon photoactivation, it mediates autophagy and stimulates the production of reactive oxygen species, making it a valuable tool in the investigation of cellular processes linked to retinal health and disease. -
Apoptosis Inducer
Procyanidin C1 is a natural polyphenol that functions as an apoptosis inducer. It induces DNA damage and induces cell cycle arrest, promoting apoptotic pathways by reducing Bcl-2 levels while enhancing BAX, caspase 3, and caspase 9 expression in cancer cells. Additionally, Procyanidin C1 exhibits senotherapeutic activity and has been shown to increase lifespan in murine models, making it a valuable tool for cancer research and studies on aging. -
Survivin Inhibitor
FL118, a potent survivin inhibitor, is a synthetic analogue of camptothecin (10,11-(Methylenedioxy)-20(S)-camptothecin). It functions by binding to the oncoprotein DDX5 (p68), leading to its dephosphorylation and degradation. FL118 is instrumental for cancer research, providing valuable insights into therapeutic strategies targeting survivin-related pathways. -
Apoptosis Inducer
Bruceine D is an apoptosis inducer that targets the Notch signaling pathway, demonstrating significant anti-cancer activity in various human cancer cell lines. This compound effectively induces cell death, making it a valuable tool for cancer research. Additionally, Bruceine D exhibits potent anthelmintic properties against D. intermedius, with an EC50 value of 0.57 mg/L, highlighting its potential applications in both cancer biology and parasitology. -
p53 Stabilizer/MDM2 PROTAC Degrader
Seldegamadlin is a selective p53 stabilizer and an MDM2 PROTAC degrader with a DC50 of 0.4 nM. It effectively inhibits the proliferation of RS4;11 cancer cells, demonstrating an IC50 of 0.3 nM, and induces cell cycle arrest at the G2/M phase while promoting apoptosis. By upregulating p53 activity, Seldegamadlin overcomes the p53-MDM2 feedback loop, making it a valuable tool for research in hematologic and solid tumors, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). -
Apoptosis Inducer
Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies. -
Apoptosis Inducer
Bacopaside II is an apoptosis inducer derived from the medicinal herb Bacopa monnieri. It functions as an inhibitor of AQP1 and demonstrates anti-angiogenesis activity. Bacopaside II exhibits significant cytotoxicity, effectively inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic exploration. -
PKD/PIM2 Inhibitor
CRT0066101 is a potent and orally active inhibitor of Protein Kinase D (PKD) with IC50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively. Additionally, it serves as an effective PIM2 inhibitor with an IC50 of approximately 135.7 nM. This compound exhibits notable anti-inflammatory activity demonstrated in LPS-induced lung injury models in mice, as well as anticancer effects, making it a valuable tool for research in cancer and inflammation-related studies. -
Apoptosis Inducer
SM-164 hydrochloride is a potent Smac mimetic compound that functions as an apoptosis inducer by targeting the X-linked inhibitor of apoptosis protein (XIAP). It binds with high affinity to the BIR2 and BIR3 domains of XIAP, exhibiting an IC50 value of 1.39 nM. This compound is primarily utilized in research applications focused on dissecting apoptotic pathways and exploring therapeutic strategies for cancers that evade cell death mechanisms. -
Apoptosis Inducer
Thonningianin A is an ellagitannin that serves as an apoptosis inducer. Isolated from the methanolic extract of the African medicinal herb Thonningia sanguinea, this compound demonstrates significant antioxidant properties, including radical scavenging, anti-superoxide formation, and metal chelation. Thonningianin A is recognized for its potential anti-cancer activities, making it relevant for research in oncology and cellular signaling pathways related to apoptosis. -
Apoptosis Inducer
Hirsutine, an indole alkaloid derived from Uncaria rhynchophylla, serves as an apoptosis inducer with notable anti-cancer properties. It effectively triggers apoptotic pathways while demonstrating significant inhibitory effects against Dengue virus, all with low cytotoxicity. This compound is valuable for research in cancer biology and virology, enabling studies on apoptotic mechanisms and antiviral strategies. -
Apoptosis Inducer
Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications. -
RIPK1 Binder
Ponicidin is a selective RIPK1 binder with an affinity of 135 nM for mouse RIPK1, functioning primarily as an apoptosis inducer and cell growth inhibitor. This compound modulates the JAK2/STAT3 signaling pathway to promote apoptosis, activates the PI3K/Akt pathway, and enhances SIRT1 expression. Additionally, Ponicidin exerts neuroprotective effects by alleviating oxidative stress, inhibiting inflammatory responses, and blocking necroptosis, while also increasing ROS production for antiproliferative and antiviral activity. It has significant implications for research in hepatocellular carcinoma, Alzheimer's disease, and gastric cancer. -
Apoptosis Inducer/Autophagy Inhibitor
Kumatakenin is a potent apoptosis inducer and autophagy inhibitor that targets ATG5 with a Kd value of 2.94 μM. It effectively enhances the activity of caspases 3, 8, and 9, leading to caspase-dependent apoptosis in ovarian cancer cells while modulating chemokines and pro-oncogenic factors. Kumatakenin also reduces M2 macrophage polarization, inhibits tumor progression in esophageal cancer by targeting FASN, and interacts with Eno3 to mitigate ferroptosis and alleviate intestinal inflammation. This compound is valuable for studies in ovarian cancer, esophageal cancer, depression, and colitis research. -
Apoptosis
Custirsen is a targeted antisense oligonucleotide that inhibits the expression of clusterin, an antiapoptotic protein often upregulated in response to chemotherapy. By downregulating clusterin, custirsen enhances apoptosis in cancer cells, thereby overcoming treatment resistance. This compound is primarily utilized in cancer research, particularly in studies focused on improving therapeutic efficacy and understanding apoptotic mechanisms in tumor biology. -
Apoptosis Inducer
Mepazine is a selective inhibitor of MALT1 protease, demonstrating IC50 values of 0.83 and 0.42 μM for full-length GSTMALT1 and the GSTMALT1 325-760 fragment, respectively. This compound effectively enhances apoptosis and reduces the viability of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cells. Mepazine serves as a valuable tool for investigating apoptosis mechanisms and potential therapeutic applications in cancer research. -
σ2 Receptor Agonist
PB28 dihydrochloride is a potent σ2 receptor agonist, exhibiting high affinity with a Ki of 0.68 nM, and also acts as a σ1 antagonist with a Ki of 0.38 nM. This compound demonstrates significant biological activity by inhibiting electrically evoked twitch responses in guinea pig bladder and ileum, with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride has been shown to modulate SARS-CoV-2-human protein-protein interactions, induce caspase-independent apoptosis, and display antitumor effects, making it a valuable tool for research in neuropharmacology and cancer biology. -
Apoptosis Inducer
Medicarpin is a flavonoid derived from Medicago sativa that functions as an apoptosis inducer. It has been shown to effectively induce apoptosis and counteract multidrug resistance in leukemia P388 cells by modulating the P-glycoprotein-mediated efflux of chemotherapeutic agents. This compound serves as a valuable tool for research into cancer treatment and the mechanisms underlying drug resistance. -
IAP Antagonist
Dasminapant is a bivalent SMAC mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs), specifically targeting XIAP, cIAP-1, cIAP-2, and ML-IAP. This compound induces the degradation of cIAP-1 and XIAP, resulting in the activation of caspase-3 and subsequent PARP cleavage, ultimately leading to programmed cell death (apoptosis). Dasminapant is valuable in research applications concerning hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma, providing insights into novel therapeutic strategies. -
Apoptosis Inducer
Bromelain is an apoptosis inducer derived from pineapple stem that exhibits anti-inflammatory properties. It functions by down-regulating plasma kininogen, inhibiting Prostaglandin E2 expression, and degrading advanced glycation end product receptors, alongside modulating angiogenic biomarkers and displaying antioxidant activity in the COX pathway. Bromelain demonstrates fibrinolytic, antiedematous, and antithrombotic effects, while also showcasing potential anticancer activities through the promotion of apoptotic cell death, making it a valuable tool for cancer research and inflammation studies. -
Apoptosis Inducer
ATH686 is a potent apoptosis inducer that selectively inhibits the mutant FLT3 protein kinase. By targeting ATP-binding sites, ATH686 effectively disrupts the proliferation of cells harboring FLT3 mutations, leading to apoptosis and cell cycle arrest. This compound is particularly relevant for research applications in the study of leukemic cell signaling and therapeutic interventions for FLT3-mutant leukemias. -
Apoptosis Inducer
Pinoresinol is a lignan that acts as an apoptosis inducer through the sensitization of cancer cells. It has been shown to enhance the susceptibility of these cells to TNF-related apoptosis-inducing ligand (TRAIL), thereby promoting apoptotic cell death. This compound is widely used in cancer research, particularly in studies aimed at elucidating mechanisms of TRAIL-induced apoptosis and developing potential therapeutic strategies. -
Apoptosis Inducer
Cycloartenol, a phytosterol compound, functions as an apoptosis inducer, exerting significant influence on cellular processes. It has been shown to inhibit glioma cell migration and suppress p38 MAP kinase phosphorylation, making it valuable for cancer research. Additionally, cycloartenol exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and anti-tumor properties, as well as potential applications in neurodegenerative disease studies. This compound also contributes to essential processes in plant growth and development. -
Apoptosis Inducer
Pulsatilla saponin D is an apoptosis inducer derived from the root of Pulsatilla chinensis. It exhibits potent anti-tumor activity by promoting programmed cell death in cancer cells. This compound is primarily used in research applications focused on understanding the mechanisms of apoptosis and evaluating potential therapeutic strategies in oncology. -
Apoptosis Inducer
Physalin F is a secosteroid that acts as an apoptosis inducer. It effectively induces apoptosis in peripheral blood mononuclear cells (PBMCs), leading to a reduction in spontaneous proliferation and cytokine production associated with Human T-lymphotropic virus type 1 (HTLV-1) infection. This compound demonstrates significant anti-inflammatory and immunomodulatory properties, making it valuable for research in viral pathogenesis and cellular immune responses. -
Apoptosis Inducer
Mepazine hydrochloride is a potent apoptosis inducer that selectively inhibits MALT1 protease, exhibiting IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. This compound effectively enhances apoptosis in ABC-DLBCL cells, making it a valuable tool for research into apoptotic mechanisms and therapeutic strategies in cancer biology. -
Apoptosis Inducer
SW106065 is an apoptosis inducer that targets malignant peripheral nerve sheath tumors (MPNST). It effectively inhibits ATP consumption in sMPNST models with an EC50 of 1 µM. This compound is a valuable tool for investigating the molecular mechanisms of MPNST and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Furanodienone is an apoptosis inducer derived from the bioactive constituents of Rhizoma Curcumae. It has been shown to effectively promote programmed cell death in various cell types, making it a candidate for research in cancer therapy and related fields. Its ability to modulate apoptotic pathways highlights its potential in studies exploring therapeutic interventions and cancer treatment strategies. -
Apoptosis Inducer
2'-Aminoacetophenone is an apoptosis inducer that functions primarily by disrupting mitochondrial activity through the induction of oxidative stress. This compound has demonstrated efficacy in regulating autophagy by inhibiting the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR. Additionally, it serves as a respiratory biomarker for detecting Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients, providing valuable insights into disease mechanisms. Its ability to induce apoptosis signals also contributes to its utility in investigating skeletal muscle dysfunction in murine models. -
Apoptosis Inducer
(E)-Flavokawain A is a chalcone derived from Kava that functions as an apoptosis inducer. It has demonstrated anticarcinogenic properties by inducing apoptosis in bladder cancer cells through a Bax protein-dependent and mitochondria-dependent pathway. Additionally, (E)-Flavokawain A has been shown to suppress tumor growth in murine models, making it a valuable compound for cancer research and therapeutic studies.
