Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
Bixin is a carotenoid derived from the seeds of Bixa orellana that acts as an apoptosis inducer. It has been shown to effectively induce cell death in cancer cells while also exhibiting notable anti-inflammatory, anti-tumor, and antioxidant properties. Additionally, Bixin treatment has demonstrated a protective effect on cardiac function by reducing fibrosis, inflammation, and the generation of reactive oxygen species (ROS), making it a valuable compound for research in cancer and cardiovascular diseases. -
Apoptosis Inducer
Euphorbia Factor L2 is a lathyrane diterpenoid that acts as an apoptosis inducer. Isolated from the seeds of Euphorbia lathyris L., it demonstrates potent cytotoxicity and triggers apoptosis through the mitochondrial pathway. This compound is a valuable tool for cancer research, providing insights into mechanisms of cell death and potential therapeutic applications in oncology. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Apoptosis Inducer
Ethylene dimethanesulfonate is a pro-apoptotic compound that functions as a mild alkylating agent. It selectively induces apoptosis in lymphocytes, making it a valuable tool for studying programmed cell death. This reagent is useful in research applications involving cancer biology, immunology, and cellular stress response mechanisms. -
Apoptosis Inducer
Delphinidin 3-rutinoside chloride is an active anthocyanin that functions as an apoptosis inducer, primarily targeting B cell chronic lymphocytic leukemia (B CLL). This compound demonstrates pro-apoptotic effects by promoting cell death in B CLL cells. Additionally, it exhibits phytoestrogen activity through its binding affinity for estrogen receptor beta (ERβ), with an IC50 value of 2.3 μM, making it a valuable tool for cancer research and apoptosis studies. -
Apoptosis Inducer
Leachianone A is a potent apoptosis inducer derived from Radix Sophorae. This compound exhibits notable anti-malarial, anti-inflammatory, and cytotoxic properties. Leachianone A effectively triggers apoptosis through both extrinsic and intrinsic pathways, making it a valuable reagent for research in therapeutic applications aimed at programmed cell death and disease modulation. -
Apoptosis Inducer
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
Apoptosis Inducer
(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties. -
Apoptosis Inducer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells. -
Apoptosis Inducer
Carubicin hydrochloride is an apoptosis inducer that targets cancer cell proliferation. Derived from microbial sources, it effectively inhibits the growth of VHL-defective clear cell renal cell carcinoma (CCRCC) cells. Notably, carubicin hydrochloride induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor HIF2. This compound holds significant potential for research applications in cancer biology. -
Apoptosis Inducer
Flavokawain C is a natural chalcone derived from Kava root, functioning as an apoptosis inducer. It demonstrates cytotoxic effects against human cancer cell lines, specifically exhibiting an IC50 value of 12.75 μM for HCT 116 cells. This compound is of significant interest in cancer research for its potential therapeutic applications in inducing programmed cell death in malignancies. -
Apoptosis Inducer
Euscaphic acid is a triterpene derived from the root of R. alceaefolius Poir, functioning as an apoptosis inducer. This compound inhibits DNA polymerases, specifically calf DNA polymerase α and rat DNA polymerase β, with IC50 values of 61 μM and 108 μM, respectively. Euscaphic acid's ability to induce apoptosis makes it a valuable reagent for research focused on cancer biology and cell death pathways. -
Apoptosis Inducer
Damnacanthal is an anthraquinone that primarily functions as an apoptosis inducer through selective inhibition of p56lck tyrosine kinase activity. Demonstrating significant anticancer properties, Damnacanthal effectively inhibits p56lck autophosphorylation and the phosphorylation of exogenous substrates, with IC50 values of 46 nM and 220 nM, respectively. Additionally, Damnacanthal exhibits antinociceptive and anti-inflammatory effects in murine models, along with antifungal activity against Candida albicans. This compound is valuable for research into cancer biology and related therapeutic pathways. -
Apoptosis Inducer
Glycidyl methacrylate is an apoptosis inducer that demonstrates concentration-dependent cytotoxicity and genotoxicity in human peripheral blood lymphocytes and CCRF-CEM leukemia cells. It induces DNA strand breaks and base oxidative damage through mechanisms associated with oxidative stress, although cellular repair systems can effectively mitigate the damage within two hours. This compound also has applications in the development of dental composite restorative materials. -
Apoptosis Inducer
8-Hydroxyefavirenz is a potent apoptosis inducer through a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Its ability to trigger programmed cell death positions it as a valuable tool in cancer research. Additionally, 8-Hydroxyefavirenz features an alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), enhancing its utility in click chemistry applications. -
Apoptosis Inducer
Taccalonolide A is a microtubule stabilizer derived from the plant Tacca chantrieri, known for its ability to induce apoptosis. This compound demonstrates significant cytotoxic effects, particularly in cancer cell lines, including those that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7). Taccalonolide A initiates apoptosis through mechanisms such as G2-M phase cell cycle accumulation and Bcl-2 phosphorylation, exhibiting an IC50 of 622 nM against SK-OV-3 cells. Its distinct properties make it a valuable tool for research in cancer biology and drug resistance. -
Apoptosis Inducer
Chaetoglobosin A is a potent apoptosis inducer derived from the extract of Penicillium aquamarinium and belongs to the cytochalasan family. It selectively targets filamentous actin in chronic lymphocytic leukemia (CLL) cells, leading to cell-cycle arrest and inhibition of membrane ruffling and cell migration. This compound is valuable for research in apoptosis mechanisms and cancer therapeutics. -
Apoptosis Inducer
Justicidin A is a natural compound isolated from Justicia procumbens that acts as an apoptosis inducer. It induces programmed cell death by decreasing Ku70 levels, which facilitates the translocation of Bax from the cytosol to the mitochondria. Justicidin A is valuable for researching cancer mechanisms and therapeutic strategies targeting apoptosis pathways. -
Apoptosis Inducer
Beta-Zearalanol is a mycotoxin derived from the Fusarium species, known for its role as an apoptosis inducer. This compound induces oxidative stress in mammalian reproductive cells, making it a valuable reagent for studies focused on cellular apoptosis and reproductive toxicology. Its ability to conjugate with glucuronic acid further supports its relevance in biochemical and pharmacological research. -
Apoptosis Inducer
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research. -
Apoptosis Inducer
Tetrahydroxyquinone, a redox-active benzoquinone, primarily induces apoptosis through the generation of reactive oxygen species (ROS). By participating in a redox cycle with semiquinone radicals, Tetrahydroxyquinone enhances oxidative stress within cells, making it a valuable tool for studying cellular mechanisms related to cell death and oxidative damage. Its ability to trigger apoptotic pathways positions it as a relevant compound for research in cancer biology and oxidative stress-related studies. -
Apoptosis Inducer
Rubropunctatin is an orange azaphilone pigment that functions as an apoptosis inducer. Isolated from Monascus pilosus-fermented rice, it displays notable anti-inflammatory, immunosuppressive, and antioxidative properties. Additionally, Rubropunctatin has demonstrated anti-tumor activity, making it a promising candidate for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Citreoviridin is a potent apoptosis inducer derived from Penicillium citreoviride NRRL 2579, primarily targeting Na+/K+-ATPase in brain synaptosomes. This compound exhibits a dose-dependent inhibition of cell proliferation and promotes apoptosis in human umbilical vein endothelial cells. Its unique mechanism of action and effects on ATPase activities make it a valuable reagent for research applications studying cellular apoptotic pathways and endothelial cell function. -
Apoptosis Inducer
Falcarinol is a natural compound that functions as an apoptosis inducer, primarily through its inhibition of the heat shock protein 90 (Hsp90) in both the N-terminal and C-terminal regions. Its selective mechanism showcases limited toxicity, making it a valuable tool for studying apoptotic pathways. Additionally, Falcarinol contains an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc), which enables its use in click chemistry applications for the conjugation of azide-containing compounds. -
Apoptosis Inducer
Ganglioside GD3 diammonium is an acidic glycosphingolipid that serves as an effective apoptosis inducer through its interaction with the mitochondrial permeability transition pore (PTPC). This compound inhibits the proliferation of cancer cells and activates the caspase family, facilitating apoptosis. Ganglioside GD3 diammonium is valuable for research into cancer biology and neurodegenerative diseases, providing insights into cell death mechanisms and potential therapeutic interventions. -
Apoptosis Inducer
Enniatin A1 is a cyclic hexadepsipeptide that functions as an apoptosis inducer. Isolated from Fusarium mycotoxins, this compound exhibits anticarcinogenic properties primarily through the induction of apoptosis and disruption of the ERK signaling pathway. In addition, Enniatin A1 demonstrates inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 of 49 μM in rat liver microsomes, making it a valuable tool for research in cancer biology and lipid metabolism. -
Apoptosis Inducer
Apoptosis Inducer 42 is a potent agent that triggers late-stage apoptosis and inhibits interleukin-6 (IL-6) secretion. This compound demonstrates significant cytotoxic effects against various cancer cell lines, making it a valuable tool for cancer research, particularly in the study of colon cancer. Its mechanism of action and ability to modulate key cytokines enhance its utility in investigating apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Actisomide is a potent apoptosis inducer that primarily targets mitochondrial pathways to initiate programmed cell death. This compound demonstrates significant biological activity in various cellular models, making it a valuable tool for research on apoptosis and related signaling pathways. Its pH-dependent absorption in animal models and in vitro uptake in CaCo-2 cells highlight its relevance in pharmacological studies and drug development. Researchers can utilize Actisomide to elucidate mechanisms of apoptosis and investigate potential therapeutic applications in cancer and other diseases characterized by dysregulated cell death. -
Apoptosis Inducer
Uvarigrin is a potent apoptosis inducer targeting multidrug-resistant tumor cells. Isolated from the roots of Uvaria calamistrata, it effectively activates Caspase-9, leading to programmed cell death. This compound holds potential for research in cancer therapy and the mechanisms underlying drug resistance. -
Apoptosis Inducer
Ginsenoside Rs3 is a natural diol-type ginseng saponin that functions as an apoptosis inducer. It selectively enhances the protein levels of p53 and p21WAF1, leading to the induction of apoptosis in SK-HEP-1 cells. Ginsenoside Rs3 is utilized in cancer research to explore mechanisms of tumor cell death and the regulation of apoptosis-related pathways. -
Apoptosis Inducer
ABL-L is an apoptosis inducer that targets the p53-dependent pathway. This compound effectively promotes apoptosis in human laryngocarcinoma cells, making it a valuable tool for cancer research. Its ability to modulate apoptotic mechanisms supports investigations into therapeutic strategies for treating laryngeal cancer and related malignancies. -
Apoptosis Inducer
Telomerase-IN-4 is a potent telomerase inhibitor that induces apoptosis in targeted cells. It demonstrates significant antiproliferative activity, making it a valuable tool for research in cancer biology and therapeutic development. This compound can be utilized to explore mechanisms of cell death and the role of telomerase in tumor progression. -
Apoptosis Inducer
Apoptosis Inducer 4 (Compound 12b) primarily functions as an apoptosis inducer, targeting the apoptotic pathway to initiate programmed cell death. This compound exhibits significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the mechanisms of apoptosis. Its role in triggering apoptosis positions it as a potential candidate for investigating treatments aimed at tumor cell eradication and understanding the underlying processes of cell death in various cancer types. -
Apoptosis Inducer
Carubicin, a potent apoptosis inducer, is derived from microbial sources. This compound effectively inhibits the proliferation of VHL-deficient clear cell renal cell carcinoma (CCRCC) cells. Notably, Carubicin induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor 2 (HIF2), highlighting its unique mode of action. Its specific biological activity makes Carubicin a valuable tool for research into cancer therapeutics. -
Apoptosis Inducers
Antiangiogenic Agent 7 is an apoptosis inducer known for its ability to stimulate cell death through increased production of Reactive Oxygen Species and inhibition of thioredoxin reductase, an intracellular enzyme. This compound exhibits notable anti-cancer properties, displaying an IC50 range of 0.08-3.5 μM against various cancer cell lines, including HeLa (cervical), PC-3 (prostate), and A549 (non-small cell lung cancer). Additionally, Antiangiogenic Agent 7 demonstrates the potential to inhibit tumor growth in mouse xenograft models, making it a valuable tool for cancer research. -
Apoptosis Inducer
2-Deoxy-L-ribose functions as an apoptosis inducer by inhibiting the anti-apoptotic effects of its stereoisomer, 2-Deoxy-D-ribose. This compound has been shown to suppress the metastasis of tumor cells that overexpress thymidine phosphorylase, making it a valuable reagent for research in cancer biology and therapeutic applications targeting apoptosis pathways. -
Apoptosis Inducer
c-Met/MEK1/Flt-3-IN-1 functions as an apoptosis inducer through the inhibition of key signaling pathways involved in cell proliferation and survival. It demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.21 µM in HeLa cells, 0.39 µM in A549 cells, and 0.33 µM in MCF-7 cells. This compound also induces apoptosis in A549 cells in a dose-dependent manner by causing cell cycle arrest at the G1 phase, making it a valuable tool for cancer research and therapeutic studies targeting apoptosis. -
Apoptosis Inducer
Apoptosis Inducer 6 is an agent that promotes apoptosis in cancer cells, serving as a valuable tool in anticancer research. It effectively initiates cell death by activating apoptotic pathways, demonstrating broad-spectrum anticancer activity across various cancer types. This compound is essential for studies investigating mechanisms of cell death and the development of novel cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 (compound A6) is an orally bioavailable apoptosis inducer targeting PDE3A and SLFN12, with an IC50 value of 0.3 μM. This compound functions by binding to the PDE3A enzyme pocket, effectively recruiting and stabilizing SLFN12, which disrupts protein translation and promotes apoptosis. Antitumor agent-100 demonstrates significant potential in cancer research applications, particularly in programs focusing on apoptosis regulation and tumor suppression mechanisms. -
Apoptosis Inducer
β-Apopicropodophyllin is a natural product known for its role as an apoptosis inducer. It exerts its effects through mechanisms that include microtubule disruption, DNA damage, cell cycle arrest, and endoplasmic reticulum stress. This compound is particularly relevant for research applications in cancer biology, facilitating studies on apoptotic pathways and potential therapeutic strategies. -
Apoptosis Inducer
JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies. -
Apoptosis Inducer
Momordicoside G is a cucurbitane-type triterpene glycoside that functions as an apoptosis inducer. It selectively triggers apoptosis in M1-like macrophages while sparing M2-like macrophages, thereby modulating immune responses. Additionally, Momordicoside G reduces intracellular reactive oxygen species (ROS) and promotes autophagy, contributing to its anticancer properties by inhibiting the growth of various cancer cell lines. Furthermore, it stimulates repair mechanisms in M2-associated lung injury and provides protective effects against inflammatory lung cancer damage. -
Apoptosis Inducer
Digallic acid is an apoptosis inducer that demonstrates antioxidant, antimutagenic, and antigenotoxic properties. This compound acts as a reverse transcriptase inhibitor and inhibits xanthine oxidase (XOD) and URAT1, with an IC50 of 5.34 μM. Additionally, digallic acid effectively scavenges DPPH· and O2·− radicals, making it valuable in cancer research and oxidative stress studies. It can be isolated from the fruits of Pistacia lentiscus, highlighting its natural sources. -
Apoptosis Inducer
Anticancer agent 173 is a potent thioxodihydroquinazolinone analog that functions as an apoptosis inducer. This compound enhances the efficacy of platinum-based chemotherapeutics, promoting apoptotic cell death in various cancer cell lines. Its ability to potentiate anticancer effects makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol is an apoptosis inducer that demonstrates significant antitumor activity across various tumor types. This compound, derived from medicinal mushrooms, inhibits the growth of HT29 colon cancer cells by inducing the expression of CDKN1A, leading to cell cycle arrest and subsequent apoptosis. Its unique mechanism makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
GKK1032B is an alkaloid compound derived from the endophytic fungus Penicillium sp. It functions as an apoptosis inducer, activating the caspase pathway to effectively induce cell death in human osteosarcoma MG63 cells. This compound holds potential for research applications in cancer studies and the exploration of therapeutic strategies targeting apoptotic mechanisms. -
Apoptosis Inducer
Telomerase-IN-5 is a selective inhibitor of telomerase, a key enzyme involved in cellular immortality and proliferation. This compound exhibits significant antiproliferative activity and effectively induces apoptosis in cancer cells. It serves as a valuable tool for research into telomerase-targeted therapies and the mechanisms underlying cell death and tumor suppression. -
Apoptosis Inducer
Apoptosis Inducer 12 (Compound 3z) is a potent inducer of apoptosis via the mitochondrial pathway. It effectively triggers programmed cell death, making it a valuable tool for cancer research. This compound is particularly useful for studying mechanisms of tumor cell apoptosis and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Apoptosis Inducer 9 targets the apoptotic pathway to effectively promote cell death via the mitochondrial mechanism. It displays an IC50 value of 4.21 μM, leading to the activation of key apoptotic markers including cleaved caspase-3, cleaved caspase-9, and cleaved PARP. This compound offers substantial potential for the development of novel anti-proliferative agents, making it valuable for cancer research and studies focused on cell death mechanisms.
