Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
Apoptosis Inducer 46 targets apoptotic pathways to induce cell death selectively in metastatic triple-negative breast cancer (TNBC) cells. It demonstrates potent growth inhibitory effects, specifically causing G2/M phase cell cycle arrest and promoting apoptotic cell death in MDA-MB-231 cells. Additionally, Apoptosis Inducer 46 inhibits NF-κB nuclear translocation, highlighting its potential for research applications in the study of TNBC. -
Apoptosis Inducer
Kusunokinin is a natural product isolated from Piper nigrum, functioning primarily as an apoptosis inducer. It demonstrates significant anticancer activity by arresting the cell cycle at the G2/M phase, leading to the activation of apoptotic pathways in cancer cells. This compound is useful for research applications focused on cancer biology and the mechanisms underlying cell cycle regulation and apoptosis. -
Apoptosis Inducer
NC-001 is a selective apoptosis inducer that primarily targets renal proximal tubular cells and renal cancer cells. This compound has demonstrated the ability to inhibit tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models, making it a valuable tool for investigating metastatic renal cell carcinoma. Its mechanism of action positions NC-001 as a promising candidate for research focused on renal cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 hydrochloride is a potent apoptosis inducer targeting PDE3A-SLFN12, exhibiting an IC50 of 0.3 μM. This compound binds to the enzyme pocket of PDE3A, facilitating the recruitment and stabilization of SLFN12, which inhibits protein translation and initiates apoptotic pathways. It serves as a valuable tool in oncology research, particularly in studies focused on apoptosis and antitumor mechanisms. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Apoptosis Inducer
Griffipavixanthone is an apoptosis inducer that targets the mitochondrial apoptotic pathway, leading to increased reactive oxygen species (ROS) production within cells. Its primary biological activity is the induction of cell apoptosis, making it a valuable agent in anti-cancer research. Additionally, Griffipavixanthone exhibits weak inhibitory activity against sucrase, with an IC50 of 4.58 mM, suggesting potential implications in metabolic studies. -
Neural Apoptosis Inducer
NTR 368 is a peptide derived from the p75 neurotrophin receptor (p75NTR), specifically corresponding to residues 368-381 of the human protein. This compound exhibits a propensity to form alpha-helices in the presence of micellar lipids, enhancing its interaction with cellular membranes. NTR 368 serves as a potent inducer of neural apoptosis, making it a valuable tool for studying neurodegenerative processes and the mechanisms underlying neuronal cell death in research applications. -
Apoptosis Inducer
Asparanin A is an apoptosis inducer that exhibits significant anticancer activity. It triggers cell cycle arrest in the G0/G1 phase by targeting mitochondrial pathways and the PI3K/AKT signaling cascade, ultimately inhibiting the proliferation of cancer cells. Additionally, Asparanin A has showcased in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, where it substantially reduced tumor growth. -
Apoptosis Inducer
Amiloride is an inhibitor of epithelial sodium channels (ENaC) and the urokinase-type plasminogen activator receptor (uPAR). This compound has been shown to induce apoptosis through its modulation of sodium ion transport and intracellular signaling pathways. Research applications include studies on renal function, cancer cell metabolism, and the investigation of ion channel-related diseases. Additionally, Amiloride has been explored as a potential therapeutic agent in various pathophysiological conditions. -
Apoptosis Inducer
Silybin is a flavonolignan derived from the seeds of milk thistle (Silybum marianum) with a primary mechanism as an apoptosis inducer. It exhibits notable hepatoprotective, antioxidant, and anti-inflammatory properties, making it a valuable compound for cancer research. This compound's multifaceted biological activities support its potential applications in studies focused on cell death pathways and liver health. -
Apoptosis Inducer
Pyridinium bisretinoid A2E TFA is an apoptosis inducer primarily involved in the study of retinal degenerative diseases. Isolated from lipofuscin in the retinal pigment epithelium, A2E TFA serves as a fluorophore that facilitates blue-light-induced apoptosis. Upon photoactivation, it mediates autophagy and stimulates the production of reactive oxygen species, making it a valuable tool in the investigation of cellular processes linked to retinal health and disease. -
Apoptosis Inducer
Procyanidin C1 is a natural polyphenol that functions as an apoptosis inducer. It induces DNA damage and induces cell cycle arrest, promoting apoptotic pathways by reducing Bcl-2 levels while enhancing BAX, caspase 3, and caspase 9 expression in cancer cells. Additionally, Procyanidin C1 exhibits senotherapeutic activity and has been shown to increase lifespan in murine models, making it a valuable tool for cancer research and studies on aging. -
Apoptosis Inducer
Bruceine D is an apoptosis inducer that targets the Notch signaling pathway, demonstrating significant anti-cancer activity in various human cancer cell lines. This compound effectively induces cell death, making it a valuable tool for cancer research. Additionally, Bruceine D exhibits potent anthelmintic properties against D. intermedius, with an EC50 value of 0.57 mg/L, highlighting its potential applications in both cancer biology and parasitology. -
Apoptosis Inducer
Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies. -
Apoptosis Inducer
Bacopaside II is an apoptosis inducer derived from the medicinal herb Bacopa monnieri. It functions as an inhibitor of AQP1 and demonstrates anti-angiogenesis activity. Bacopaside II exhibits significant cytotoxicity, effectively inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic exploration. -
Apoptosis Inducer
SM-164 hydrochloride is a potent Smac mimetic compound that functions as an apoptosis inducer by targeting the X-linked inhibitor of apoptosis protein (XIAP). It binds with high affinity to the BIR2 and BIR3 domains of XIAP, exhibiting an IC50 value of 1.39 nM. This compound is primarily utilized in research applications focused on dissecting apoptotic pathways and exploring therapeutic strategies for cancers that evade cell death mechanisms. -
Apoptosis Inducer
Glaucocalyxin A is an ent-kauranoid diterpene derived from Rabdosia japonica var. This compound acts as an apoptosis inducer by inhibiting the nuclear translocation of Five-zinc finger Glis 1 (GLI1), effectively modulating the PI3K/Akt signaling pathway. Its notable antitumor properties make Glaucocalyxin A a valuable reagent for research in cancer biology, particularly in studies focused on osteosarcoma. -
Apoptosis Inducer
Polygalacin D3 is a triterpenoid saponin extracted from the roots of the balloon flower and acts as an apoptosis inducer. It demonstrates significant biological activity by inhibiting the proliferation of non-small cell lung cancer (NSCLC) cell lines through the blockade of the PI3K/Akt signaling pathway. Additionally, Polygalacin D3 induces cell cycle arrest and apoptosis, making it a valuable reagent for cancer research applications. -
Apoptosis Inducer
Dehydroxy-oridonin-vinyl ester is a potent apoptosis inducer that targets the PI3K/Akt signaling pathway. This compound demonstrates strong anti-proliferative activity against SU-DHL-6 lymphoma cells, with an IC₅₀ value of 0.12 μM. Dehydroxy-oridonin-vinyl ester selectively induces cell apoptosis while not interfering with cell cycle progression, making it a valuable tool for research in cancer therapy, particularly in the study of lymphoma. -
Apoptosis Inducer
BIBU1361 dihydrochloride is an apoptosis inducer that primarily targets pro-survival pathways, including Akt/mTOR and gp130/JAK/STAT3. This compound effectively promotes apoptosis while inhibiting autophagy, leading to a reduction in pro-inflammatory cytokine levels, particularly IL-6. BIBU1361 dihydrochloride is valuable for research applications focused on cancer therapy and the modulation of inflammatory responses. -
Apoptosis Inducer
DCZ3301 is a potent apoptosis inducer that functions as an aryl-guanidino inhibitor. It effectively inhibits cell proliferation, induces G2/M cell cycle arrest, and facilitates apoptosis. By downregulating PI3K protein expression and inhibiting AKT phosphorylation, DCZ3301 targets the PI3K/AKT signaling pathway, making it a valuable reagent for cancer research. -
Apoptosis Inducer
Licoricidin (LCD) is a potent apoptosis inducer derived from Glycyrrhiza uralensis Fisch, demonstrating significant anti-cancer properties. It effectively inhibits SW480 colorectal cancer cells with an IC50 of 7.2 μM by promoting cell cycle arrest, apoptosis, and autophagy, making it a promising candidate for chemoprevention and chemotherapy. Additionally, Licoricidin suppresses lung metastasis through the inhibition of tumor angiogenesis and lymphangiogenesis, while improving the tumor microenvironment. In osteosarcoma models, Licoricidin enhances the cytotoxic effects of gemcitabine by inactivating the Akt and NF-κB signaling pathways. Furthermore, Licoricidin alleviates UVA-induced photoaging by scavenging reactive oxygen species and inhibiting MMP-1 activity, indicating its potential in topical anti-aging formulations. -
Autophagy/Apoptosis Inducer
Autophagy Inducer 7 is an effective modulator of autophagy and apoptosis, primarily targeting the Akt/mTOR signaling pathway. This compound promotes autophagy by inhibiting pathway activity and downregulating associated proteins, leading to a reduction in DNA synthesis and inducing G0-G1 cell cycle arrest. Additionally, Autophagy Inducer 7 has demonstrated the ability to inhibit tumor cell proliferation, making it a valuable tool for research in cancer biology and therapeutic strategies involving autophagy. -
Apoptosis Inducer
Crebanine is an isoquinoline-like alkaloid that acts as an apoptosis inducer through antagonism of the α7-nAChR, exhibiting an IC50 value of 19.1 μM. This compound suppresses cancer cell proliferation, migration, and invasion while triggering a reactive oxygen species (ROS) burst that promotes apoptosis. Additionally, Crebanine modulates critical signaling pathways including AKT/FoxO3a, NF-κB, and MAPK, and demonstrates antioxidant properties in microglia by reducing ROS and lipid peroxidation. With applications in studying hepatocellular carcinoma, cerebral ischemia, and Alzheimer's disease, Crebanine may also ameliorate cognitive deficits and ischemia-reperfusion brain damage in rodent models. -
Apoptosis Inducer
Alphitolic acid, an apoptosis inducer, is a triterpene isolated from Quercus aliena. It functions by inhibiting Akt–NF-κB signaling pathways, promoting apoptosis and autophagy. Additionally, Alphitolic acid exhibits anti-inflammatory properties by down-regulating nitric oxide and TNF-α production. This compound is applicable in cancer and inflammation research. -
Apoptosis Inducer
Tributyrin, a triglyceride variant of butyric acid, functions as a stable proagent that induces apoptosis. Upon diffusion through biological membranes, it is metabolized by intracellular lipases to release butyrate, which exerts significant antiproliferative and pro-apoptotic effects within cells. This compound serves as a valuable reagent for research into cell differentiation and apoptosis pathways. -
Apoptosis Inducer
6-Dehydrogingerdione serves as an apoptosis inducer by enhancing the sensitivity of human hepatoblastoma Hep G2 cells to TRAIL-induced cell death. This compound mediates its effects through the production of reactive oxygen species, which lead to an upregulation of death receptor 5 (DR5). Its ability to modulate apoptotic pathways makes it a valuable tool for research in cancer therapies and cell death mechanisms. -
Apoptosis Inducer
3-O-Acetyloleanolic acid (3AOA) is an oleanolic acid derivative that functions as an apoptosis inducer. It has demonstrated significant anti-cancer properties, promoting cell death in various cancer types, and displays anti-angiogenic activity, inhibiting the formation of new blood vessels. Research applications include studies on cancer therapy and the mechanisms of apoptosis and angiogenesis. -
Apoptosis Inducer
Desacetylcinobufotalin is a natural compound known for its role as an apoptosis inducer. It exhibits significant inhibitory effects on HepG2 cancer cells, with an IC50 value demonstrating potent cytotoxicity. This compound is primarily used in cancer research to explore mechanisms of programmed cell death and therapeutic strategies for hepatic carcinoma. -
Apoptosis Inducer
BMS 310705 (21-Aminoepothilone B) is an apoptosis inducer that targets malignancies, including ovarian, renal, bladder, and lung carcinoma. This compound promotes significant apoptotic activity through a mitochondrial-mediated pathway, making it a valuable tool for cancer research. Its effectiveness in inducing programmed cell death highlights its potential applications in studying tumor biology and developing novel therapeutic strategies. -
Apoptosis Inducer
(S)-(-)-Perillic acid is a terpenoid compound known for its role as an apoptosis inducer. It promotes cell apoptosis and cell cycle arrest while enhancing the levels of key proteins such as Bax, Bcl-2, p21, and caspase-3. This reagent is suitable for research applications related to cancer and infectious diseases, providing valuable insights into therapeutic mechanisms and cellular pathways. -
Apoptosis Inducer
Toddaculin is a natural coumarin known for its role as an apoptosis inducer. It effectively induces differentiation and apoptotic processes in leukemic cells while simultaneously suppressing excessive osteoclast activity. Additionally, Toddaculin promotes osteoblast differentiation and mineralization and demonstrates anti-inflammatory properties, making it a valuable reagent for research in cancer biology and bone metabolism. -
Apoptosis Inducer
2,3-DCPE hydrochloride is an apoptosis inducer that promotes programmed cell death through the downregulation of Bcl-XL expression. This reagent exhibits anti-tumor activity, making it a valuable tool in cancer research, particularly in studies focused on cell survival mechanisms and therapeutic targets for malignancies. -
Apoptosis Inducer
(-)-Epipodophyllotoxin is an apoptosis inducer derived from the American mayapple, Podophyllum peltatum. Exhibiting potent antiproliferative activity, it demonstrates GI50 values of 0.36 and 0.24 μM against HeLa and MCF-7 cancer cell lines, respectively. Additionally, (-)-Epipodophyllotoxin has been shown to inhibit mitotic spindle assembly in vitro, making it a valuable reagent for cancer research and studies involving cell cycle dynamics. -
Apoptosis Inducer
3-Dehydrotrametenolic acid is an apoptosis inducer that functions as a lactate dehydrogenase (LDH) inhibitor. Isolated from the sclerotium of Poria cocos, it has been shown to promote adipocyte differentiation in vitro and to enhance insulin sensitivity in vivo. Additionally, 3-dehydrotrametenolic acid exhibits anticancer properties by inducing apoptosis in cancer cells, making it a valuable compound for research in cancer biology and metabolic disorders. -
Apoptosis Inducer
Lucidenic acid B is a natural compound derived from Ganoderma lucidum that serves as an apoptosis inducer. It stimulates the activation of caspase-9 and caspase-3, leading to the cleavage of PARP in cancer cells. Notably, Lucidenic acid B does not alter the cell cycle profile or increase the number of necrotic cells, making it a valuable reagent for research in cancer biology and apoptosis studies. -
Apoptosis Inducer
Cantrixil, an active enantiomer of TRX-E-002, functions as a potent apoptosis inducer. It elevates phosphorylated c-Jun levels, leading to caspase-mediated apoptosis specifically in ovarian cancer cells. This second-generation super-benzopyran compound demonstrates significant pan anti-cancer activity across a variety of cancer phenotypes, making it a valuable tool for research into cancer therapeutics and mechanisms of cell death. -
Apoptosis Inducer
13'-Carboxy-δ-tocopherol, a metabolite of long-chain vitamin E, serves as an apoptosis inducer by activating caspase-3 and caspase-9, leading to PARP-1 cleavage. This compound demonstrates significant antiproliferative effects in cancer cells by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) formation, ultimately driving apoptosis. 13'-Carboxy-δ-tocopherol is valuable in research focused on hepatocellular carcinoma and other cancer types. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Apoptosis Inducer
α-Eleostearic acid is a conjugated linolenic acid that functions as an apoptosis inducer, demonstrating its role in prompting programmed cell death. Additionally, it acts as a ferroptosis inducer, contributing to a unique mechanism of cell death associated with iron metabolism. This compound exhibits notable antioxidant properties and displays antitumor activity, making it a valuable reagent for research in cancer biology and cell death mechanisms. -
Apoptosis Inducer
(-)-Alkannin is a potent apoptosis inducer, extracted from Alkanna tinctoria, and has demonstrated significant anticancer activity. It effectively arrests the cell cycle and triggers apoptotic processes in various cancer cell lines. Additionally, (-)-Alkannin contributes to the reduction of hepatic inflammation through modulation of the Rho-kinase pathway, making it a valuable tool for research in cancer biology and inflammation studies. -
Apoptosis Inducer
Obacunone is a triterpenoid limonoid with potent apoptosis-inducing properties. It has demonstrated significant anticancer effects through the activation of programmed cell death pathways. Additionally, Obacunone offers protective benefits to retinal pigment epithelial (RPE) cells against oxidative damage caused by ultraviolet (UV) radiation, making it a valuable reagent for research in cancer biology and oxidative stress studies. -
Apoptosis Inducer
Icaritin is a prenylflavonoid derivative that functions as an apoptosis inducer. It has demonstrated potent inhibitory effects on the proliferation of K562 cells, with an IC50 of 8 µM, and primary chronic myeloid leukemia (CML) cells, exhibiting IC50 values of 13.4 µM for CML-chronic phase and 18 µM for CML-blast crisis. Icaritin modulates critical signaling pathways, including MAPK/ERK/JNK and JAK2/STAT3/AKT, and has been shown to enhance osteogenesis, making it a valuable compound for research in cancer and regenerative medicine. -
Apoptosis Inducer
Pimpinellin is an apoptosis inducer derived from Cyrtomium fortumei. It demonstrates significant antitumor activity by promoting apoptosis in tumor cells, thereby inhibiting cellular growth and proliferation. This compound has potential applications in cancer research, particularly in studies focused on mechanistic pathways of cell death and therapeutic strategies for tumor suppression. -
Apoptosis Inducer
9-Methoxycamptothecin (MCPT) is a potent apoptosis inducer that exerts its antitumor effects primarily through the inhibition of topoisomerase enzymes. Derived from Camptotheca acuminata, MCPT effectively induces G2/M cell cycle arrest and promotes apoptosis in various cancer cell lines. This compound is valuable for research applications focused on understanding cancer biology and therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
Linderalactone is a sesquiterpene lactone that acts as an apoptosis inducer by modulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. This compound has been shown to effectively inhibit the proliferation of lung cancer A-549 cells, displaying an IC50 of 15 µM. Its unique mechanism makes Linderalactone a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Melamine is an orally active apoptosis inducer that targets multiple biological pathways. It is effective in inducing disease models in animals, particularly concerning male reproductive function through its effects on Sertoli cells. Additionally, melamine exhibits neurotoxic and nephrotoxic properties, making it useful for research on cognitive impairment and acute kidney injury. Its potential to induce bladder cancer and urinary stone models further establishes melamine as a valuable tool in toxicological and cancer research. -
Apoptosis Inducer
Bucladesine calcium is a cell-permeable analog of cyclic AMP (cAMP), functioning as an apoptosis inducer primarily through the activation of cAMP-dependent protein kinase (PKA). By elevating intracellular cAMP levels, it inhibits phosphodiesterase (PDE) activity, thereby stabilizing cAMP concentrations and promoting apoptosis in targeted cells. This compound is widely utilized in research applications investigating cell signaling pathways, PKA-mediated processes, and mechanisms underlying programmed cell death. -
Apoptosis Inducer
Tubulysin M is a potent apoptosis inducer that targets microtubules by inhibiting tubulin polymerization. This highly cytotoxic anti-microtubule agent exhibits exceptional activity against mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce cell cycle arrest and subsequent apoptosis makes Tubulysin M a valuable tool for research in cancer biology and drug resistance mechanisms. -
Apoptosis Inducer
Tubulysin F is a potent apoptosis inducer that functions as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits strong cytotoxic activity across various mammalian cell types, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin F effectively leads to cell cycle arrest and subsequent apoptosis, making it a valuable reagent for research in cancer biology and drug resistance mechanisms.
