Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
Asparanin A is an apoptosis inducer that exhibits significant anticancer activity. It triggers cell cycle arrest in the G0/G1 phase by targeting mitochondrial pathways and the PI3K/AKT signaling cascade, ultimately inhibiting the proliferation of cancer cells. Additionally, Asparanin A has showcased in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, where it substantially reduced tumor growth. -
Apoptosis Inducer
Amiloride is an inhibitor of epithelial sodium channels (ENaC) and the urokinase-type plasminogen activator receptor (uPAR). This compound has been shown to induce apoptosis through its modulation of sodium ion transport and intracellular signaling pathways. Research applications include studies on renal function, cancer cell metabolism, and the investigation of ion channel-related diseases. Additionally, Amiloride has been explored as a potential therapeutic agent in various pathophysiological conditions. -
Apoptosis Inducer
Silybin is a flavonolignan derived from the seeds of milk thistle (Silybum marianum) with a primary mechanism as an apoptosis inducer. It exhibits notable hepatoprotective, antioxidant, and anti-inflammatory properties, making it a valuable compound for cancer research. This compound's multifaceted biological activities support its potential applications in studies focused on cell death pathways and liver health. -
Apoptosis Inducer
Pyridinium bisretinoid A2E TFA is an apoptosis inducer primarily involved in the study of retinal degenerative diseases. Isolated from lipofuscin in the retinal pigment epithelium, A2E TFA serves as a fluorophore that facilitates blue-light-induced apoptosis. Upon photoactivation, it mediates autophagy and stimulates the production of reactive oxygen species, making it a valuable tool in the investigation of cellular processes linked to retinal health and disease. -
Apoptosis Inducer
Procyanidin C1 is a natural polyphenol that functions as an apoptosis inducer. It induces DNA damage and induces cell cycle arrest, promoting apoptotic pathways by reducing Bcl-2 levels while enhancing BAX, caspase 3, and caspase 9 expression in cancer cells. Additionally, Procyanidin C1 exhibits senotherapeutic activity and has been shown to increase lifespan in murine models, making it a valuable tool for cancer research and studies on aging. -
Apoptosis Inducer
Bruceine D is an apoptosis inducer that targets the Notch signaling pathway, demonstrating significant anti-cancer activity in various human cancer cell lines. This compound effectively induces cell death, making it a valuable tool for cancer research. Additionally, Bruceine D exhibits potent anthelmintic properties against D. intermedius, with an EC50 value of 0.57 mg/L, highlighting its potential applications in both cancer biology and parasitology. -
Apoptosis Inducer
Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies. -
Apoptosis Inducer
Bacopaside II is an apoptosis inducer derived from the medicinal herb Bacopa monnieri. It functions as an inhibitor of AQP1 and demonstrates anti-angiogenesis activity. Bacopaside II exhibits significant cytotoxicity, effectively inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic exploration. -
Apoptosis Inducer
SM-164 hydrochloride is a potent Smac mimetic compound that functions as an apoptosis inducer by targeting the X-linked inhibitor of apoptosis protein (XIAP). It binds with high affinity to the BIR2 and BIR3 domains of XIAP, exhibiting an IC50 value of 1.39 nM. This compound is primarily utilized in research applications focused on dissecting apoptotic pathways and exploring therapeutic strategies for cancers that evade cell death mechanisms. -
Apoptosis Inducer
Enniatin A1 is a cyclic hexadepsipeptide that functions as an apoptosis inducer. Isolated from Fusarium mycotoxins, this compound exhibits anticarcinogenic properties primarily through the induction of apoptosis and disruption of the ERK signaling pathway. In addition, Enniatin A1 demonstrates inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 of 49 μM in rat liver microsomes, making it a valuable tool for research in cancer biology and lipid metabolism. -
Apoptosis Inducer
Apoptosis Inducer 42 is a potent agent that triggers late-stage apoptosis and inhibits interleukin-6 (IL-6) secretion. This compound demonstrates significant cytotoxic effects against various cancer cell lines, making it a valuable tool for cancer research, particularly in the study of colon cancer. Its mechanism of action and ability to modulate key cytokines enhance its utility in investigating apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Actisomide is a potent apoptosis inducer that primarily targets mitochondrial pathways to initiate programmed cell death. This compound demonstrates significant biological activity in various cellular models, making it a valuable tool for research on apoptosis and related signaling pathways. Its pH-dependent absorption in animal models and in vitro uptake in CaCo-2 cells highlight its relevance in pharmacological studies and drug development. Researchers can utilize Actisomide to elucidate mechanisms of apoptosis and investigate potential therapeutic applications in cancer and other diseases characterized by dysregulated cell death. -
Apoptosis Inducer
Uvarigrin is a potent apoptosis inducer targeting multidrug-resistant tumor cells. Isolated from the roots of Uvaria calamistrata, it effectively activates Caspase-9, leading to programmed cell death. This compound holds potential for research in cancer therapy and the mechanisms underlying drug resistance. -
Apoptosis Inducer
Ginsenoside Rs3 is a natural diol-type ginseng saponin that functions as an apoptosis inducer. It selectively enhances the protein levels of p53 and p21WAF1, leading to the induction of apoptosis in SK-HEP-1 cells. Ginsenoside Rs3 is utilized in cancer research to explore mechanisms of tumor cell death and the regulation of apoptosis-related pathways. -
Apoptosis Inducer
ABL-L is an apoptosis inducer that targets the p53-dependent pathway. This compound effectively promotes apoptosis in human laryngocarcinoma cells, making it a valuable tool for cancer research. Its ability to modulate apoptotic mechanisms supports investigations into therapeutic strategies for treating laryngeal cancer and related malignancies. -
Apoptosis Inducer
Telomerase-IN-4 is a potent telomerase inhibitor that induces apoptosis in targeted cells. It demonstrates significant antiproliferative activity, making it a valuable tool for research in cancer biology and therapeutic development. This compound can be utilized to explore mechanisms of cell death and the role of telomerase in tumor progression. -
Apoptosis Inducer
Apoptosis Inducer 4 (Compound 12b) primarily functions as an apoptosis inducer, targeting the apoptotic pathway to initiate programmed cell death. This compound exhibits significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the mechanisms of apoptosis. Its role in triggering apoptosis positions it as a potential candidate for investigating treatments aimed at tumor cell eradication and understanding the underlying processes of cell death in various cancer types. -
Apoptosis Inducer
Carubicin, a potent apoptosis inducer, is derived from microbial sources. This compound effectively inhibits the proliferation of VHL-deficient clear cell renal cell carcinoma (CCRCC) cells. Notably, Carubicin induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor 2 (HIF2), highlighting its unique mode of action. Its specific biological activity makes Carubicin a valuable tool for research into cancer therapeutics. -
Apoptosis Inducers
Antiangiogenic Agent 7 is an apoptosis inducer known for its ability to stimulate cell death through increased production of Reactive Oxygen Species and inhibition of thioredoxin reductase, an intracellular enzyme. This compound exhibits notable anti-cancer properties, displaying an IC50 range of 0.08-3.5 μM against various cancer cell lines, including HeLa (cervical), PC-3 (prostate), and A549 (non-small cell lung cancer). Additionally, Antiangiogenic Agent 7 demonstrates the potential to inhibit tumor growth in mouse xenograft models, making it a valuable tool for cancer research. -
Apoptosis Inducer
2-Deoxy-L-ribose functions as an apoptosis inducer by inhibiting the anti-apoptotic effects of its stereoisomer, 2-Deoxy-D-ribose. This compound has been shown to suppress the metastasis of tumor cells that overexpress thymidine phosphorylase, making it a valuable reagent for research in cancer biology and therapeutic applications targeting apoptosis pathways. -
Apoptosis Inducer
c-Met/MEK1/Flt-3-IN-1 functions as an apoptosis inducer through the inhibition of key signaling pathways involved in cell proliferation and survival. It demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.21 µM in HeLa cells, 0.39 µM in A549 cells, and 0.33 µM in MCF-7 cells. This compound also induces apoptosis in A549 cells in a dose-dependent manner by causing cell cycle arrest at the G1 phase, making it a valuable tool for cancer research and therapeutic studies targeting apoptosis. -
Apoptosis Inducer
Apoptosis Inducer 6 is an agent that promotes apoptosis in cancer cells, serving as a valuable tool in anticancer research. It effectively initiates cell death by activating apoptotic pathways, demonstrating broad-spectrum anticancer activity across various cancer types. This compound is essential for studies investigating mechanisms of cell death and the development of novel cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 (compound A6) is an orally bioavailable apoptosis inducer targeting PDE3A and SLFN12, with an IC50 value of 0.3 μM. This compound functions by binding to the PDE3A enzyme pocket, effectively recruiting and stabilizing SLFN12, which disrupts protein translation and promotes apoptosis. Antitumor agent-100 demonstrates significant potential in cancer research applications, particularly in programs focusing on apoptosis regulation and tumor suppression mechanisms. -
Apoptosis Inducer
β-Apopicropodophyllin is a natural product known for its role as an apoptosis inducer. It exerts its effects through mechanisms that include microtubule disruption, DNA damage, cell cycle arrest, and endoplasmic reticulum stress. This compound is particularly relevant for research applications in cancer biology, facilitating studies on apoptotic pathways and potential therapeutic strategies. -
Apoptosis Inducer
JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies. -
Apoptosis Inducer
Momordicoside G is a cucurbitane-type triterpene glycoside that functions as an apoptosis inducer. It selectively triggers apoptosis in M1-like macrophages while sparing M2-like macrophages, thereby modulating immune responses. Additionally, Momordicoside G reduces intracellular reactive oxygen species (ROS) and promotes autophagy, contributing to its anticancer properties by inhibiting the growth of various cancer cell lines. Furthermore, it stimulates repair mechanisms in M2-associated lung injury and provides protective effects against inflammatory lung cancer damage. -
Apoptosis Inducer
Digallic acid is an apoptosis inducer that demonstrates antioxidant, antimutagenic, and antigenotoxic properties. This compound acts as a reverse transcriptase inhibitor and inhibits xanthine oxidase (XOD) and URAT1, with an IC50 of 5.34 μM. Additionally, digallic acid effectively scavenges DPPH· and O2·− radicals, making it valuable in cancer research and oxidative stress studies. It can be isolated from the fruits of Pistacia lentiscus, highlighting its natural sources. -
Apoptosis Inducer
Anticancer agent 173 is a potent thioxodihydroquinazolinone analog that functions as an apoptosis inducer. This compound enhances the efficacy of platinum-based chemotherapeutics, promoting apoptotic cell death in various cancer cell lines. Its ability to potentiate anticancer effects makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol is an apoptosis inducer that demonstrates significant antitumor activity across various tumor types. This compound, derived from medicinal mushrooms, inhibits the growth of HT29 colon cancer cells by inducing the expression of CDKN1A, leading to cell cycle arrest and subsequent apoptosis. Its unique mechanism makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
GKK1032B is an alkaloid compound derived from the endophytic fungus Penicillium sp. It functions as an apoptosis inducer, activating the caspase pathway to effectively induce cell death in human osteosarcoma MG63 cells. This compound holds potential for research applications in cancer studies and the exploration of therapeutic strategies targeting apoptotic mechanisms. -
Apoptosis Inducer
Telomerase-IN-5 is a selective inhibitor of telomerase, a key enzyme involved in cellular immortality and proliferation. This compound exhibits significant antiproliferative activity and effectively induces apoptosis in cancer cells. It serves as a valuable tool for research into telomerase-targeted therapies and the mechanisms underlying cell death and tumor suppression. -
Apoptosis Inducer
Apoptosis Inducer 12 (Compound 3z) is a potent inducer of apoptosis via the mitochondrial pathway. It effectively triggers programmed cell death, making it a valuable tool for cancer research. This compound is particularly useful for studying mechanisms of tumor cell apoptosis and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Apoptosis Inducer 9 targets the apoptotic pathway to effectively promote cell death via the mitochondrial mechanism. It displays an IC50 value of 4.21 μM, leading to the activation of key apoptotic markers including cleaved caspase-3, cleaved caspase-9, and cleaved PARP. This compound offers substantial potential for the development of novel anti-proliferative agents, making it valuable for cancer research and studies focused on cell death mechanisms. -
Apoptosis Inducer
NSC308848 is a potent apoptosis inducer that operates through the inhibition of Myc transactivation. It disrupts the DNA-binding activity of Myc family proteins, leading to increased apoptosis in various cell types. This compound is valuable for research applications targeting Myc-dependent tumorigenesis and cellular stress responses. -
Apoptosis Inducer
Asperindole A is an indole-diterpene alkaloid that acts as an apoptosis inducer. This compound demonstrates cytotoxic properties and effectively induces apoptosis along with cell cycle arrest specifically at the S-phase. Asperindole A shows potential for research applications in the study of prostate cancer. -
Apoptosis Inducer
CIL-102 is an apoptosis inducer that functions as a MMP-2 and MMP-9 inhibitor, effectively reducing both protein expression and mRNA levels of these matrix metalloproteinases. This compound exhibits significant anti-cancer activity, making it a valuable tool for research focused on apoptosis mechanisms and cancer therapy development. Its ability to modulate MMP expression alters cellular environments, contributing to the understanding of tumor progression and metastasis. -
Apoptosis Inducer
L-2,5-Dihydrophenylalanine is an apoptosis inducer known for its ability to trigger programmed cell death in HL-60 human myeloblastoid leukemia cells. This compound facilitates research into mechanisms of apoptosis and may contribute to the development of therapeutic strategies for leukemia and other apoptosis-related disorders. Its role in cancer cell line studies makes it a valuable reagent for researchers focused on understanding cell death pathways. -
Apoptosis Inducer
TrxR1-IN-B19 is a covalent inhibitor of the enzyme thioredoxin reductase 1 (TrxR1). By inhibiting TrxR1 activity, it elevates oxidative stress, which triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and mitochondrial dysfunction. This cascade of events ultimately leads to cell cycle arrest and apoptosis, making TrxR1-IN-B19 a valuable tool for investigating apoptotic pathways in cellular models of disease. -
Apoptosis Inducer
2,2′-Dihydroxychalcone is a potent apoptosis inducer primarily targeting glutathione S-transferase (GST) with an IC50 of 28.9 μM in human colon cancer cells. This flavonoid has been shown to induce cell cycle arrest and apoptosis specifically in prostate cancer cells, highlighting its potential in cancer therapeutics. Additionally, 2,2′-Dihydroxychalcone exhibits significant anticancer and anti-inflammatory properties, making it a valuable reagent for cancer research and inflammation studies. -
Apoptosis Inducer
Formoxanthone A is an apoptosis inducer that effectively reduces cell viability in HeLa cells at a concentration of 25 μM. Its mechanism of action involves the activation of apoptotic pathways, making it a valuable tool for studying cell death processes. This compound can be utilized in research applications focused on cancer biology and therapeutic strategies targeting apoptosis. -
Apoptosis Inducer
γ-Eudesmol is a mitochondrial-mediated apoptosis inducer that effectively binds to mitochondrial membrane proteins, leading to depolarization of the mitochondrial membrane potential and the activation of caspase cascades. This compound exhibits significant cytotoxic effects against various tumor cell lines, including HepG2 and B16-F10, with IC50 values between 8.86 and 15.15 μg/mL. γ-Eudesmol is of particular interest for research applications in cancer biology, specifically in studies related to hepatocellular carcinoma and melanoma. -
Apoptosis Inducer
Flaccidoside II is a potent apoptosis inducer that targets malignant peripheral nerve sheath tumors (MPNSTs). This active triterpenoid saponin, derived from the rhizome of Anemone flaccida, effectively inhibits proliferation and triggers apoptotic pathways in cancer cell lines. Additionally, Flaccidoside II demonstrates therapeutic potential in mitigating collagen-induced arthritis in murine models, making it a valuable reagent for research in cancer and inflammatory diseases. -
Apoptosis Inducer
Mel56 is an apoptosis inducer that acts on human melanoma cells. This melanogenin analogue demonstrates cytotoxicity by promoting melanin production and facilitating apoptosis in cancerous cells. It serves as a valuable reagent for research applications aimed at understanding melanoma progression and therapeutic strategies. -
Apoptosis Inducers
C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that serves as an apoptosis inducer. It effectively triggers apoptotic pathways in U937 cells, leading to the fragmentation of nucleosomal DNA. This compound is utilized in research focused on understanding ceramide-mediated apoptosis and its implications in cancer biology. -
Apoptosis Inducer
Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent that induces apoptosis through the promotion of DNA alkylation. This compound plays a significant role in cancer research by facilitating cell death in malignant cells, making it valuable for studies focused on tumor biology and therapeutic strategies. Its mechanism of action may provide insights into the development of novel anticancer therapies. -
Apoptosis Inducer
LQB-118 is an orally active apoptosis inducer with a primary mechanism of regulating the AKT/GSK3β pathway. This compound exhibits significant potential in oncology research by inhibiting the migration of glioblastoma and prostate cancer cells, as well as inducing cell death through ROS-triggered and mitochondrial-dependent pathways. Additionally, LQB-118 has demonstrated efficacy in suppressing inflammation induced by yeast polysaccharides in both in vivo and in vitro models. Its diverse applications include investigations related to inflammation, cancer, and infectious diseases. -
Apoptosis Inducer
27-Methyl withaferin A is an apoptosis inducer that exhibits significant anticancer properties. This compound demonstrates potent antiproliferative effects against various human tumor cell lines, including HeLa, A-549, and MCF-7, with respective IC50 values of 3.2 μM, 4.2 μM, and 1.4 μM. Its ability to promote programmed cell death makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
27-O-(tert-Butyldimethylsilyl)withaferin A is a natural withanolide that acts as an apoptosis inducer. This compound exhibits potent antiproliferative effects across various human cancer cell lines, including HeLa, A-549, and MCF-7, while demonstrating a selective profile against normal Vero cells. Its unique mechanism of action makes it a valuable tool for research into cancer therapeutics and the regulation of programmed cell death. -
Apoptosis Inducer
MXC-017 is a potent apoptosis inducer that effectively penetrates the blood-brain barrier (BBB) and selectively targets Vimentin (VIM). This compound has demonstrated the ability to inhibit radiation-induced glioma stem cell formation while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects and negligible cytotoxicity, MXC-017 has been shown to significantly enhance median survival in glioblastoma mouse models when used in conjunction with radiation therapy, making it a valuable tool for cancer research. -
Apoptosis Inducer
Apoptosis Inducer 14 is a potent chemotherapeutic agent that initiates both intrinsic and extrinsic apoptosis pathways through the activation of P53. Exhibiting IC50 values of 193.93 μg/mL in A549 cells, 6.76 μg/mL in HCT116 cells, and 222.67 μg/mL in HF84 cells, this compound is a valuable tool for research focusing on cancer cell apoptosis and therapeutic efficacy. Applications include investigating mechanisms of cancer cell death and developing novel cancer treatments.
