5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research.
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research.
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