Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
LQB-118 is an orally active apoptosis inducer with a primary mechanism of regulating the AKT/GSK3β pathway. This compound exhibits significant potential in oncology research by inhibiting the migration of glioblastoma and prostate cancer cells, as well as inducing cell death through ROS-triggered and mitochondrial-dependent pathways. Additionally, LQB-118 has demonstrated efficacy in suppressing inflammation induced by yeast polysaccharides in both in vivo and in vitro models. Its diverse applications include investigations related to inflammation, cancer, and infectious diseases. -
Apoptosis Inducer
27-Methyl withaferin A is an apoptosis inducer that exhibits significant anticancer properties. This compound demonstrates potent antiproliferative effects against various human tumor cell lines, including HeLa, A-549, and MCF-7, with respective IC50 values of 3.2 μM, 4.2 μM, and 1.4 μM. Its ability to promote programmed cell death makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
27-O-(tert-Butyldimethylsilyl)withaferin A is a natural withanolide that acts as an apoptosis inducer. This compound exhibits potent antiproliferative effects across various human cancer cell lines, including HeLa, A-549, and MCF-7, while demonstrating a selective profile against normal Vero cells. Its unique mechanism of action makes it a valuable tool for research into cancer therapeutics and the regulation of programmed cell death. -
Apoptosis Inducer
MXC-017 is a potent apoptosis inducer that effectively penetrates the blood-brain barrier (BBB) and selectively targets Vimentin (VIM). This compound has demonstrated the ability to inhibit radiation-induced glioma stem cell formation while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects and negligible cytotoxicity, MXC-017 has been shown to significantly enhance median survival in glioblastoma mouse models when used in conjunction with radiation therapy, making it a valuable tool for cancer research. -
Apoptosis Inducer
Apoptosis Inducer 14 is a potent chemotherapeutic agent that initiates both intrinsic and extrinsic apoptosis pathways through the activation of P53. Exhibiting IC50 values of 193.93 μg/mL in A549 cells, 6.76 μg/mL in HCT116 cells, and 222.67 μg/mL in HF84 cells, this compound is a valuable tool for research focusing on cancer cell apoptosis and therapeutic efficacy. Applications include investigating mechanisms of cancer cell death and developing novel cancer treatments. -
Apoptosis Inducer
Apoptosis Inducer 24 targets the apoptosis pathway to inhibit proliferation in gastric cancer cells, with an IC50 ranging from 1.2 to 4.8 μM. This compound causes cell cycle arrest at the G2/M phase, induces apoptosis in the BGC-823 cell line, and disrupts mitochondrial function. Additionally, Apoptosis Inducer 24 demonstrates significant antitumor efficacy in murine models, exhibiting a favorable safety profile with an LD50 of 91.2 mg/kg. -
Apoptosis Inducer
Antitumor agent-44 is an apoptosis inducer that disrupts mitochondrial homeostasis, leading to cell cycle arrest and programmed cell death in human adenocarcinoma cells. This compound demonstrates significant anti-tumor activity in a lung cancer cell xenograft mouse model, making it a valuable tool for cancer research and therapeutic studies in oncology. -
Apoptosis Inducer
Apoptosis Inducer 3 is a potent compound that selectively initiates apoptosis in target cells, promoting both early and late apoptotic processes. It exhibits significant cytotoxic effects against various cancer cell lines, making it a valuable tool in cancer research and therapeutic studies. This reagent is crucial for investigating apoptotic mechanisms and developing novel cancer treatments. -
Apoptosis Inducer
Xanthoxyletin is a coumarin compound recognized for its role as an apoptosis inducer. Isolated from plants in the Genus Zanthoxylum and Clausena, it demonstrates significant antioxidant and anti-inflammatory properties. Xanthoxyletin exhibits cytotoxic effects on cancer cells, effectively inducing both apoptosis and necrosis. This compound is valuable for research focused on cancer therapies and the mechanisms underlying inflammation. -
Apoptosis Inducer
d-Sophoridine is a quinolizidine alkaloid derived from the Leguminous plant Sophora flavescens, acting as a potent apoptosis inducer. This compound demonstrates significant antitumor activity, particularly as a candidate for pancreatic cancer treatment, while exhibiting favorable toxicity profiles. d-Sophoridine is valuable for research aimed at understanding apoptosis mechanisms and developing targeted cancer therapies. -
Apoptosis Inducer
Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that functions as an apoptosis inducer. It effectively promotes programmed cell death in rhabdomyosarcoma cells by inhibiting protein synthesis. This compound is valuable for research applications focused on cancer biology and the mechanisms of apoptosis. -
Apoptosis Inducer
R24 is a flavonoid derivative that functions as an apoptosis inducer. It exhibits significant anti-angiogenic and anti-proliferative properties, effectively inducing apoptosis in cancer cells while promoting the production of reactive oxygen species (ROS). R24 is particularly useful in research applications focused on cancer biology, including studies on lung cancer and colorectal cancer. -
Apoptosis Inducer
TBP-134 is an apoptosis inducer that primarily targets the death receptor DR5, leading to G2/M phase cell cycle arrest. This compound is particularly relevant for research applications in pancreatic tumor studies, facilitating investigations into apoptotic pathways and therapeutic strategies. Its ability to selectively trigger apoptosis makes TBP-134 a valuable tool for cancer research. -
Apoptosis Inducer
Galgravin is an apoptosis inducer derived from Nectandra megapotamica, exhibiting potent cytotoxic effects in vitro. This compound triggers programmed cell death in leukemia cells, making it a valuable tool for studying cancer biology and therapeutic applications. Its anti-inflammatory properties further emphasize its potential in cancer research and drug development. -
Apoptosis Inducer
Anticancer agent 136 is a C17-triazole analogue of Geldanamycin that functions as an apoptosis inducer by targeting Hsp90. It demonstrates an IC50 of 3.38 μM in human dermal fibroblasts (HDF) and a dissociation constant (Kd) of 3.86 μM for Hsp90. This compound is useful for research investigating apoptosis pathways and the therapeutic potential of Hsp90 inhibition in cancer treatment. -
Apoptosis Inducer
Antitumor agent-110 is an imidazotetrazine compound that functions as an apoptosis inducer primarily by arresting the cell cycle at the G2/M phase. This reagent exhibits favorable permeability properties and is suitable for applications in cancer research. Additionally, Antitumor agent-110 contains an alkyne functional group, facilitating its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
Apoptosis Inducer
[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol is an apoptosis inducer that targets cell cycle progression by blocking the transition from G0 to G1 phase. As a terphenyl derivative, it effectively induces differentiation in leukemia cells while exhibiting a strong apoptotic effect. This compound serves as a valuable tool in cancer research, particularly in studies focused on leukemia differentiation and apoptosis mechanisms. -
Apoptosis Inducer
Lepidozin G is an apoptosis inducer that effectively inhibits the growth of various cancer cell lines, exhibiting IC50 values between 4.2 ± 0.2 and 5.7 ± 0.5 μM. This compound induces cell death in PC-3 prostate cancer cells through mechanisms related to mitochondrial apoptosis, making it a valuable tool for cancer research and drug development investigations focused on apoptosis pathways. -
Apoptosis Inducer
MPI-0441138 is an apoptosis inducer that functions as a mitosis inhibitor. It promotes DNA breaks and facilitates the translocation of cytochrome c, which culminates in the death of tumor cells. This compound is valuable for research applications focused on cancer biology and therapeutic strategies aimed at inducing apoptosis in malignancies. -
Apoptosis Inducer
IVHD-valtrate is a derivative of Valeriana jatamansi that functions as an apoptosis inducer. This compound has demonstrated efficacy against human ovarian cancer cells both in vitro and in vivo, promoting apoptosis and causing cell cycle arrest in the G2/M phase. IVHD-valtrate holds promise as a novel chemotherapeutic agent for research in ovarian cancer treatment. -
Apoptosis Inducer
cpm-1285 is an apoptosis inducer that functionally inhibits intracellular Bcl-2 and related death antagonists. It demonstrates a strong binding affinity to Bcl-2, with an IC50 value of 130 nM. In preclinical studies, cpm-1285 effectively reduces tumor burden in murine models, making it a valuable tool for research on cancer therapies and the mechanisms of programmed cell death. -
Apoptosis Inducer
MYRA-A is a potent apoptosis inducer that targets the Myc pathway. It functions by inhibiting Myc transactivation and interfering with the DNA-binding activity of Myc family proteins, leading to decreased cell viability. MYRA-A is valuable for research in cancer biology, particularly in studies related to Myc-driven malignancies and the mechanisms of apoptosis. -
NF-κB p65 Inhibitor, Apoptosis Inducer
N-Desmethyldauricine is an inhibitor of NF-κB p65 with significant apoptotic effects. It effectively reduces p65 protein expression, induces apoptosis, and arrests the cell cycle at the G0/G1 phase. Additionally, N-Desmethyldauricine attenuates intercellular adhesion and inhibits the growth of 3D spheroids derived from triple-negative breast cancer. This compound is useful for research involving triple-negative breast cancer dynamics and therapeutic strategies. -
Apoptosis Inducer
Antitumor agent-149 is an apoptosis inducer that functions by inhibiting HIF-1α-mediated transcription. This compound effectively promotes apoptosis in cancer cells, thereby contributing to the suppression of tumor growth. In preclinical studies, Antitumor agent-149 demonstrated significant efficacy in inhibiting tumor progression in the SW620 xenograft mouse model, making it a valuable tool for cancer research. -
Apoptosis Inducer
Ganoderic acid Mf is a triterpenoid that acts as an apoptosis inducer, specifically targeting cancer cells. It promotes cell cycle arrest in the G1 phase, demonstrating significant selectivity for tumor versus normal cells. This compound induces apoptosis through a mitochondria-mediated pathway, making it a valuable reagent for cancer research and therapeutic studies. -
Apoptosis Inducer
Sanguinarine (gluconate) is a benzophenanthridine alkaloid that functions as an apoptosis inducer. It promotes apoptosis through the generation of reactive oxygen species (ROS) and is linked to the activation of key signaling pathways, including JNK and NF-κB. This compound is utilized in research exploring mechanisms of apoptosis and oxidative stress responses in various cell types. -
Apoptosis Inducer
Alpha-tocopheryloxyacetic acid (alpha-TEA) acts as an apoptosis inducer, specifically targeting pathways involved in programmed cell death. This compound demonstrates significant biological activity in promoting apoptosis in cancer cells, making it a valuable tool for research into both solid tumors and hematological malignancies. Its mechanism and application in oncological studies provide insights into potential therapeutic strategies for cancer treatment. -
Apoptosis Inducer
Apoptosis Inducer 8 is a compound that acts as a galectin-1 (gal-1) mediated apoptosis inducer, specifically designed to target and initiate cell death in lung cancer cells. This reagent has demonstrated a significant reduction in gal-1 protein levels, contributing to its efficacy as an anti-cancer agent. Additionally, Apoptosis Inducer 8 serves as a positron emission tomography (PET) imaging agent, facilitating research applications in cancer diagnosis and therapy monitoring. -
Apoptosis Inducer
Apoptosis Inducer 25 is a potent apoptosis inducer that specifically targets cell proliferation. It effectively inhibits the growth of BGC-823 cells with an IC50 of 0.37 μM, leading to cell cycle arrest in the G2/M phase. This compound further promotes apoptosis and triggers mitochondrial dysfunction, making it a valuable tool in cancer research. Its favorable pharmacokinetic profile in rat models underscores its potential for further investigation in therapeutic applications. -
Apoptosis Inducer
Apoptosis Inducer 41 targets the mitochondrial pathway to trigger apoptosis in cancer cells. It displays potent inhibitory effects on MCF-7 cells, with an IC50 of 6.2 μM, and effectively induces cell cycle arrest in the G2/M phase. Additionally, Apoptosis Inducer 41 increases reactive oxygen species (ROS) accumulation and causes depolarization of the mitochondrial membrane potential. This compound is suitable for research focused on breast cancer and the mechanisms of programmed cell death. -
Apoptosis Inducer
Apoptosis Inducer 36 is a potent apoptosis inducer targeting leukemia cells. It demonstrates significant anti-leukemic activity by reducing leukemia stem cells and promoting differentiation. This compound inhibits the proliferation of acute myeloid leukemia (AML) cells, causes cell cycle arrest at the G1 phase, and stimulates PANoptosis, encompassing apoptosis, pyroptosis, and necrosis. A prodrug form of Apoptosis Inducer 36 shows orally active antitumor efficacy in mouse models, making it a valuable tool for research in cancer therapeutics. -
Apoptosis Inducer
Apoptosis Inducer 7 (Compound 5I) primarily targets apoptotic pathways to promote cell death in cancer cells. It activates the cleavage of PARP and caspases, while down-regulating the anti-apoptotic protein c-Flip and up-regulating the pro-apoptotic protein Noxa. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research focused on apoptosis mechanisms and therapeutic strategies. -
Apoptosis Inducer
Mechercharmycin A is a potent apoptosis inducer derived from the marine bacterium Thermoactinomyces sp. YM3-251. This compound demonstrates significant cytotoxicity and has shown strong antitumor activity in various biological models. It is utilized in research applications focusing on cancer cell apoptosis and the exploration of novel therapeutic strategies for tumor treatment. -
Apoptosis Inducer
Camellianin A, a potent apoptosis inducer, primarily targets cancer cell proliferation. Derived from the leaves of A. nitida, it exhibits significant anticancer activity, particularly in human Hep G2 and MCF-7 cell lines. Additionally, Camellianin A demonstrates angiotensin-converting enzyme (ACE) inhibitory effects, making it relevant for research in cancer therapy and cardiovascular studies. -
Apoptosis Inducer
Apoptosis Inducer 40 is a potent apoptosis inducer that primarily targets programmed cell death mechanisms. It demonstrates significant cytotoxic activity against Jurkat and NB4 cells, with IC50 values of 4.5 μM and 3.6 μM, respectively. By promoting apoptosis and cell cycle arrest, Apoptosis Inducer 40 is valuable for cancer research, particularly in studies focused on acute myeloid leukemia (AML). -
Apoptosis Inducer
Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide derived from the BH3 domain of Bax, a pro-apoptotic protein that promotes cell death through mitochondrial pathway activation. This peptide is effective in inducing apoptosis across various cell line models and serves as a valuable tool for studying apoptosis mechanisms and the role of BH3-only proteins in cellular processes. Researchers can utilize this peptide for investigations into cancer therapeutics and programmed cell death pathways. -
Apoptosis Inducer
Antitumor agent-92 is an Icaritin derivative that functions as an apoptosis inducer. It effectively induces cell cycle arrest at the G0/G1 phase, leading to programmed cell death. This compound has significant potential for research applications in hepatocellular carcinoma (HCC) studies, providing a valuable tool for investigations into novel cancer therapies. -
Apoptosis Inducer
Anticancer agent 153 functions as an apoptosis inducer through the generation of reactive oxygen species (ROS). This compound disrupts mitochondrial membrane potential (MMP), leading to the initiation of programmed cell death and effectively inhibiting cancer cell proliferation. Anticancer agent 153 is a valuable tool for research applications focused on understanding apoptosis mechanisms and evaluating potential therapeutic strategies against cancer. -
Hsp70 Binder, Apoptosis Inducer
EV206 is a selective binder to the N-terminal domain of Hsp70, functioning as an apoptosis inducer. It promotes the degradation of Hsp70 through the ubiquitin-proteasome pathway, leading to reduced protein stability and inhibition of cellular growth. EV206 effectively induces apoptotic cell death in non-small cell lung cancer cells, suppresses colony formation, and downregulates markers associated with cancer stem cells. Additionally, it demonstrates anti-tumor activity in H460 xenograft models. This compound serves as a valuable tool for research in non-small cell lung cancer. -
Apoptosis Inducer
Artocarpin is a potent apoptosis inducer that targets various signaling molecules, including NF-κB, Erk1/2, p38 MAPK, and Akt kinases. It stimulates the production of reactive oxygen species (ROS) and activates both p53-dependent and independent apoptotic pathways, resulting in G1-phase cell cycle arrest and autophagic cell death. Artocarpin displays significant cytotoxic and bactericidal effects against cancer cells, reduces bacterial burden, and possesses anti-inflammatory, analgesic, and anti-angiogenic properties, making it valuable for cancer and inflammatory research applications. -
Apoptosis Inducer
Kuanoniamine A is a pyridoacridine alkaloid that functions as an apoptosis inducer. Its primary mechanism involves the inhibition of DNA synthesis and regulation of the cell cycle, effectively decreasing the number of cells in the G2/M phase. Kuanoniamine A demonstrates significant anti-proliferative effects on human lymphocytes and is utilized in research focused on breast cancer, glioma, non-small cell lung cancer, and melanoma. -
Apoptosis Inducer
Tubulysin M is a potent apoptosis inducer that targets microtubules by inhibiting tubulin polymerization. This highly cytotoxic anti-microtubule agent exhibits exceptional activity against mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce cell cycle arrest and subsequent apoptosis makes Tubulysin M a valuable tool for research in cancer biology and drug resistance mechanisms. -
Apoptosis Inducer
Tubulysin F is a potent apoptosis inducer that functions as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits strong cytotoxic activity across various mammalian cell types, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin F effectively leads to cell cycle arrest and subsequent apoptosis, making it a valuable reagent for research in cancer biology and drug resistance mechanisms. -
Apoptosis Inducer
Tubulysin I is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin I exhibits significant cytotoxicity against mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin I disrupts cellular processes, leading to cell cycle arrest and subsequent apoptosis, making it a valuable tool for cancer research and studies on cell death mechanisms. -
Apoptosis Inducer
Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms. -
Apoptosis Inducer
Tubulysin H is a potent apoptosis inducer that functions as an anti-microtubule toxin by inhibiting tubulin polymerization. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin H exhibits exceptional cytotoxicity in mammalian cells, including those that are multidrug-resistant, with low nanomolar IC50 values. Its ability to disrupt microtubule dynamics results in cell cycle arrest and subsequent induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Tubulysin E is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin E exhibits remarkable cytotoxicity in mammalian cells, including those resistant to multiple drugs, with calculated IC50 values in the low nanomolar range. The compound effectively disrupts microtubule dynamics by inhibiting tubulin polymerization, leading to cell cycle arrest and subsequent apoptotic cell death. This makes Tubulysin E a valuable tool in cancer research and studies focused on apoptosis mechanisms. -
Cell-cycle Inhibitor, Senescence Inducer, Apoptosis Inducer, Antiproliferative Agent
Anticancer agent 299 is a cell-cycle inhibitor that functions as a senescence and apoptosis inducer, exhibiting significant antiproliferative effects on cancer cells. This compound demonstrates selective cytotoxicity against cancerous cells with minimal impact on non-tumoral chondrocyte cells at therapeutic concentrations. Anticancer agent 299 is particularly useful for research related to ER+/HER2− breast cancer and BRAF-mutant melanoma. -
Apoptosis Inducer
Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that functions through both p53-dependent and p53-independent mechanisms. It activates and stabilizes the p53 protein in TP53 wild-type models by modulating MDM2 processing, leading to cell cycle arrest and apoptosis. Additionally, Kevetrin demonstrates enhanced efficacy in models with mutated TP53. This compound is valuable for research applications in various cancers, including acute myeloid leukemia and breast cancer. -
p53 Modulator, Apoptosis Inducer
Safrole oxide is a p53 modulator that enhances the expression of the p53 tumor suppressor protein, facilitating cell cycle arrest and promoting apoptosis. This compound effectively induces apoptosis in lung cancer cells while avoiding necrotic cell death. Safrole oxide is valuable for research focused on lung cancer mechanisms and therapeutic strategies.
