Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
Xanthoangelol is an apoptosis inducer derived from Angelica keiskei, known for its ability to trigger programmed cell death in neuroblastoma and leukemia cells. It also exhibits anti-inflammatory properties by suppressing obesity-related inflammatory responses and demonstrates antibacterial activity. Additionally, Xanthoangelol inhibits monoamine oxidases, contributing to its diverse biological effects, making it suitable for research in cancer therapeutics and inflammatory disease models. -
Apoptosis Inducer
28-Deoxonimbolide is a limonoid derived from Azadirachta indica, functioning as an apoptosis inducer. This compound exhibits significant anticancer activity by inducing apoptotic cell death in HL60 cells through both mitochondrial and death receptor-mediated pathways. Its ability to trigger these mechanisms makes it a valuable tool for research in cancer biology and apoptosis. -
Apoptosis Inducer
Gomisin N, a lignan compound derived from Schisandra chinensis, functions primarily as an apoptosis inducer. It has demonstrated the ability to activate key signaling pathways such as AMPK, Akt, MAPK/ERK, and Nrf2, while also promoting the activation of caspase-3 and PARP-1. Gomisin N exhibits a range of biological activities including anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis effects, and has shown potential in inhibiting proinflammatory cytokines. Additionally, it possesses anti-tumor properties, particularly against cervical and liver cancers, and may offer benefits in the context of Alzheimer’s disease research. -
Apoptosis Inducer
Hellebrigenin is an apoptosis inducer that selectively inhibits the MAPK signaling pathway, including ERK, p38, and JNK, as well as XIAP. It plays a critical role in activating intrinsic apoptosis mechanisms, including mitochondrial membrane potential disruption, activation of the Caspase family, PARP cleavage, and modulation of pro- and anti-apoptotic protein levels. Hellebrigenin also induces DNA double-strand breaks, thereby activating the ATM pathway. This compound is primarily utilized in cancer research, particularly in the study of oral squamous cell carcinoma, liver cancer, and other malignancies, due to its capacity to inhibit tumor cell proliferation and clonogenicity. -
Apoptosis Inducer
α-Santalol, a naturally occurring sesquiterpene, functions as an apoptosis inducer through the activation of caspase-3, leading to enhanced apoptotic processes. This compound has demonstrated the ability to reduce cell viability, induce PARP cleavage, and trigger apoptosis in human prostate cancer cells. Additionally, α-Santalol inhibits the Akt/Survivin signaling pathway to promote cellular death. This reagent is valuable for research focused on prostate cancer and diabetes mellitus. -
Apoptosis Inducer
Polyporenic acid C is a lanostane-type triterpenoid that functions as an apoptosis inducer. Isolated from Poria cocos, this compound activates key apoptotic pathways by cleaving caspase-8, caspase-3, and PARP, while modulating the phosphorylation status of Akt, PTEN, and p53. Additionally, Polyporenic acid C enhances JNK activation and exhibits significant anticancer activity against non-small cell lung cancer. This makes it a valuable reagent for research into cancer therapies and apoptotic mechanisms. -
Apoptosis Inducer
3-O-Methylgallic acid, a potent apoptosis inducer, is an anthocyanin metabolite known for its significant antioxidant properties. It effectively inhibits the proliferation of Caco-2 cells with an IC50 value of 24.1 μM, demonstrating its potential in cancer research. This compound is valuable for studying apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Glaucocalyxin A is an ent-kauranoid diterpene derived from Rabdosia japonica var. This compound acts as an apoptosis inducer by inhibiting the nuclear translocation of Five-zinc finger Glis 1 (GLI1), effectively modulating the PI3K/Akt signaling pathway. Its notable antitumor properties make Glaucocalyxin A a valuable reagent for research in cancer biology, particularly in studies focused on osteosarcoma. -
Apoptosis Inducer
Polygalacin D3 is a triterpenoid saponin extracted from the roots of the balloon flower and acts as an apoptosis inducer. It demonstrates significant biological activity by inhibiting the proliferation of non-small cell lung cancer (NSCLC) cell lines through the blockade of the PI3K/Akt signaling pathway. Additionally, Polygalacin D3 induces cell cycle arrest and apoptosis, making it a valuable reagent for cancer research applications. -
Apoptosis Inducer
Dehydroxy-oridonin-vinyl ester is a potent apoptosis inducer that targets the PI3K/Akt signaling pathway. This compound demonstrates strong anti-proliferative activity against SU-DHL-6 lymphoma cells, with an IC₅₀ value of 0.12 μM. Dehydroxy-oridonin-vinyl ester selectively induces cell apoptosis while not interfering with cell cycle progression, making it a valuable tool for research in cancer therapy, particularly in the study of lymphoma. -
Apoptosis Inducer
BIBU1361 dihydrochloride is an apoptosis inducer that primarily targets pro-survival pathways, including Akt/mTOR and gp130/JAK/STAT3. This compound effectively promotes apoptosis while inhibiting autophagy, leading to a reduction in pro-inflammatory cytokine levels, particularly IL-6. BIBU1361 dihydrochloride is valuable for research applications focused on cancer therapy and the modulation of inflammatory responses. -
Apoptosis Inducer
DCZ3301 is a potent apoptosis inducer that functions as an aryl-guanidino inhibitor. It effectively inhibits cell proliferation, induces G2/M cell cycle arrest, and facilitates apoptosis. By downregulating PI3K protein expression and inhibiting AKT phosphorylation, DCZ3301 targets the PI3K/AKT signaling pathway, making it a valuable reagent for cancer research. -
Apoptosis Inducer
Licoricidin (LCD) is a potent apoptosis inducer derived from Glycyrrhiza uralensis Fisch, demonstrating significant anti-cancer properties. It effectively inhibits SW480 colorectal cancer cells with an IC50 of 7.2 μM by promoting cell cycle arrest, apoptosis, and autophagy, making it a promising candidate for chemoprevention and chemotherapy. Additionally, Licoricidin suppresses lung metastasis through the inhibition of tumor angiogenesis and lymphangiogenesis, while improving the tumor microenvironment. In osteosarcoma models, Licoricidin enhances the cytotoxic effects of gemcitabine by inactivating the Akt and NF-κB signaling pathways. Furthermore, Licoricidin alleviates UVA-induced photoaging by scavenging reactive oxygen species and inhibiting MMP-1 activity, indicating its potential in topical anti-aging formulations. -
Autophagy/Apoptosis Inducer
Autophagy Inducer 7 is an effective modulator of autophagy and apoptosis, primarily targeting the Akt/mTOR signaling pathway. This compound promotes autophagy by inhibiting pathway activity and downregulating associated proteins, leading to a reduction in DNA synthesis and inducing G0-G1 cell cycle arrest. Additionally, Autophagy Inducer 7 has demonstrated the ability to inhibit tumor cell proliferation, making it a valuable tool for research in cancer biology and therapeutic strategies involving autophagy. -
Apoptosis Inducer
Crebanine is an isoquinoline-like alkaloid that acts as an apoptosis inducer through antagonism of the α7-nAChR, exhibiting an IC50 value of 19.1 μM. This compound suppresses cancer cell proliferation, migration, and invasion while triggering a reactive oxygen species (ROS) burst that promotes apoptosis. Additionally, Crebanine modulates critical signaling pathways including AKT/FoxO3a, NF-κB, and MAPK, and demonstrates antioxidant properties in microglia by reducing ROS and lipid peroxidation. With applications in studying hepatocellular carcinoma, cerebral ischemia, and Alzheimer's disease, Crebanine may also ameliorate cognitive deficits and ischemia-reperfusion brain damage in rodent models. -
Apoptosis Inducer
Alphitolic acid, an apoptosis inducer, is a triterpene isolated from Quercus aliena. It functions by inhibiting Akt–NF-κB signaling pathways, promoting apoptosis and autophagy. Additionally, Alphitolic acid exhibits anti-inflammatory properties by down-regulating nitric oxide and TNF-α production. This compound is applicable in cancer and inflammation research. -
Apoptosis Inducer
Tributyrin, a triglyceride variant of butyric acid, functions as a stable proagent that induces apoptosis. Upon diffusion through biological membranes, it is metabolized by intracellular lipases to release butyrate, which exerts significant antiproliferative and pro-apoptotic effects within cells. This compound serves as a valuable reagent for research into cell differentiation and apoptosis pathways. -
Apoptosis Inducer
6-Dehydrogingerdione serves as an apoptosis inducer by enhancing the sensitivity of human hepatoblastoma Hep G2 cells to TRAIL-induced cell death. This compound mediates its effects through the production of reactive oxygen species, which lead to an upregulation of death receptor 5 (DR5). Its ability to modulate apoptotic pathways makes it a valuable tool for research in cancer therapies and cell death mechanisms. -
Apoptosis Inducer
3-O-Acetyloleanolic acid (3AOA) is an oleanolic acid derivative that functions as an apoptosis inducer. It has demonstrated significant anti-cancer properties, promoting cell death in various cancer types, and displays anti-angiogenic activity, inhibiting the formation of new blood vessels. Research applications include studies on cancer therapy and the mechanisms of apoptosis and angiogenesis. -
Apoptosis Inducer
Desacetylcinobufotalin is a natural compound known for its role as an apoptosis inducer. It exhibits significant inhibitory effects on HepG2 cancer cells, with an IC50 value demonstrating potent cytotoxicity. This compound is primarily used in cancer research to explore mechanisms of programmed cell death and therapeutic strategies for hepatic carcinoma. -
Apoptosis Inducer
BMS 310705 (21-Aminoepothilone B) is an apoptosis inducer that targets malignancies, including ovarian, renal, bladder, and lung carcinoma. This compound promotes significant apoptotic activity through a mitochondrial-mediated pathway, making it a valuable tool for cancer research. Its effectiveness in inducing programmed cell death highlights its potential applications in studying tumor biology and developing novel therapeutic strategies. -
Apoptosis Inducer
(S)-(-)-Perillic acid is a terpenoid compound known for its role as an apoptosis inducer. It promotes cell apoptosis and cell cycle arrest while enhancing the levels of key proteins such as Bax, Bcl-2, p21, and caspase-3. This reagent is suitable for research applications related to cancer and infectious diseases, providing valuable insights into therapeutic mechanisms and cellular pathways. -
Apoptosis Inducer
Toddaculin is a natural coumarin known for its role as an apoptosis inducer. It effectively induces differentiation and apoptotic processes in leukemic cells while simultaneously suppressing excessive osteoclast activity. Additionally, Toddaculin promotes osteoblast differentiation and mineralization and demonstrates anti-inflammatory properties, making it a valuable reagent for research in cancer biology and bone metabolism. -
Apoptosis Inducer
2,3-DCPE hydrochloride is an apoptosis inducer that promotes programmed cell death through the downregulation of Bcl-XL expression. This reagent exhibits anti-tumor activity, making it a valuable tool in cancer research, particularly in studies focused on cell survival mechanisms and therapeutic targets for malignancies. -
Apoptosis Inducer
(-)-Epipodophyllotoxin is an apoptosis inducer derived from the American mayapple, Podophyllum peltatum. Exhibiting potent antiproliferative activity, it demonstrates GI50 values of 0.36 and 0.24 μM against HeLa and MCF-7 cancer cell lines, respectively. Additionally, (-)-Epipodophyllotoxin has been shown to inhibit mitotic spindle assembly in vitro, making it a valuable reagent for cancer research and studies involving cell cycle dynamics. -
Apoptosis Inducer
3-Dehydrotrametenolic acid is an apoptosis inducer that functions as a lactate dehydrogenase (LDH) inhibitor. Isolated from the sclerotium of Poria cocos, it has been shown to promote adipocyte differentiation in vitro and to enhance insulin sensitivity in vivo. Additionally, 3-dehydrotrametenolic acid exhibits anticancer properties by inducing apoptosis in cancer cells, making it a valuable compound for research in cancer biology and metabolic disorders. -
Apoptosis Inducer
Lucidenic acid B is a natural compound derived from Ganoderma lucidum that serves as an apoptosis inducer. It stimulates the activation of caspase-9 and caspase-3, leading to the cleavage of PARP in cancer cells. Notably, Lucidenic acid B does not alter the cell cycle profile or increase the number of necrotic cells, making it a valuable reagent for research in cancer biology and apoptosis studies. -
Apoptosis Inducer
Cantrixil, an active enantiomer of TRX-E-002, functions as a potent apoptosis inducer. It elevates phosphorylated c-Jun levels, leading to caspase-mediated apoptosis specifically in ovarian cancer cells. This second-generation super-benzopyran compound demonstrates significant pan anti-cancer activity across a variety of cancer phenotypes, making it a valuable tool for research into cancer therapeutics and mechanisms of cell death. -
Apoptosis Inducer
13'-Carboxy-δ-tocopherol, a metabolite of long-chain vitamin E, serves as an apoptosis inducer by activating caspase-3 and caspase-9, leading to PARP-1 cleavage. This compound demonstrates significant antiproliferative effects in cancer cells by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) formation, ultimately driving apoptosis. 13'-Carboxy-δ-tocopherol is valuable in research focused on hepatocellular carcinoma and other cancer types. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Apoptosis Inducer
α-Eleostearic acid is a conjugated linolenic acid that functions as an apoptosis inducer, demonstrating its role in prompting programmed cell death. Additionally, it acts as a ferroptosis inducer, contributing to a unique mechanism of cell death associated with iron metabolism. This compound exhibits notable antioxidant properties and displays antitumor activity, making it a valuable reagent for research in cancer biology and cell death mechanisms. -
Apoptosis Inducer
(-)-Alkannin is a potent apoptosis inducer, extracted from Alkanna tinctoria, and has demonstrated significant anticancer activity. It effectively arrests the cell cycle and triggers apoptotic processes in various cancer cell lines. Additionally, (-)-Alkannin contributes to the reduction of hepatic inflammation through modulation of the Rho-kinase pathway, making it a valuable tool for research in cancer biology and inflammation studies. -
Apoptosis Inducer
Obacunone is a triterpenoid limonoid with potent apoptosis-inducing properties. It has demonstrated significant anticancer effects through the activation of programmed cell death pathways. Additionally, Obacunone offers protective benefits to retinal pigment epithelial (RPE) cells against oxidative damage caused by ultraviolet (UV) radiation, making it a valuable reagent for research in cancer biology and oxidative stress studies. -
Apoptosis Inducer
Icaritin is a prenylflavonoid derivative that functions as an apoptosis inducer. It has demonstrated potent inhibitory effects on the proliferation of K562 cells, with an IC50 of 8 µM, and primary chronic myeloid leukemia (CML) cells, exhibiting IC50 values of 13.4 µM for CML-chronic phase and 18 µM for CML-blast crisis. Icaritin modulates critical signaling pathways, including MAPK/ERK/JNK and JAK2/STAT3/AKT, and has been shown to enhance osteogenesis, making it a valuable compound for research in cancer and regenerative medicine. -
Apoptosis Inducer
Pimpinellin is an apoptosis inducer derived from Cyrtomium fortumei. It demonstrates significant antitumor activity by promoting apoptosis in tumor cells, thereby inhibiting cellular growth and proliferation. This compound has potential applications in cancer research, particularly in studies focused on mechanistic pathways of cell death and therapeutic strategies for tumor suppression. -
Apoptosis Inducer
9-Methoxycamptothecin (MCPT) is a potent apoptosis inducer that exerts its antitumor effects primarily through the inhibition of topoisomerase enzymes. Derived from Camptotheca acuminata, MCPT effectively induces G2/M cell cycle arrest and promotes apoptosis in various cancer cell lines. This compound is valuable for research applications focused on understanding cancer biology and therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
Linderalactone is a sesquiterpene lactone that acts as an apoptosis inducer by modulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. This compound has been shown to effectively inhibit the proliferation of lung cancer A-549 cells, displaying an IC50 of 15 µM. Its unique mechanism makes Linderalactone a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Melamine is an orally active apoptosis inducer that targets multiple biological pathways. It is effective in inducing disease models in animals, particularly concerning male reproductive function through its effects on Sertoli cells. Additionally, melamine exhibits neurotoxic and nephrotoxic properties, making it useful for research on cognitive impairment and acute kidney injury. Its potential to induce bladder cancer and urinary stone models further establishes melamine as a valuable tool in toxicological and cancer research. -
Apoptosis Inducer
Bucladesine calcium is a cell-permeable analog of cyclic AMP (cAMP), functioning as an apoptosis inducer primarily through the activation of cAMP-dependent protein kinase (PKA). By elevating intracellular cAMP levels, it inhibits phosphodiesterase (PDE) activity, thereby stabilizing cAMP concentrations and promoting apoptosis in targeted cells. This compound is widely utilized in research applications investigating cell signaling pathways, PKA-mediated processes, and mechanisms underlying programmed cell death. -
Apoptosis Inducer
Artocarpin is a potent apoptosis inducer that targets various signaling molecules, including NF-κB, Erk1/2, p38 MAPK, and Akt kinases. It stimulates the production of reactive oxygen species (ROS) and activates both p53-dependent and independent apoptotic pathways, resulting in G1-phase cell cycle arrest and autophagic cell death. Artocarpin displays significant cytotoxic and bactericidal effects against cancer cells, reduces bacterial burden, and possesses anti-inflammatory, analgesic, and anti-angiogenic properties, making it valuable for cancer and inflammatory research applications. -
Apoptosis Inducer
Kuanoniamine A is a pyridoacridine alkaloid that functions as an apoptosis inducer. Its primary mechanism involves the inhibition of DNA synthesis and regulation of the cell cycle, effectively decreasing the number of cells in the G2/M phase. Kuanoniamine A demonstrates significant anti-proliferative effects on human lymphocytes and is utilized in research focused on breast cancer, glioma, non-small cell lung cancer, and melanoma. -
Apoptosis Inducer
Tubulysin M is a potent apoptosis inducer that targets microtubules by inhibiting tubulin polymerization. This highly cytotoxic anti-microtubule agent exhibits exceptional activity against mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce cell cycle arrest and subsequent apoptosis makes Tubulysin M a valuable tool for research in cancer biology and drug resistance mechanisms. -
Apoptosis Inducer
Tubulysin F is a potent apoptosis inducer that functions as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits strong cytotoxic activity across various mammalian cell types, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin F effectively leads to cell cycle arrest and subsequent apoptosis, making it a valuable reagent for research in cancer biology and drug resistance mechanisms. -
Apoptosis Inducer
Tubulysin I is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin I exhibits significant cytotoxicity against mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin I disrupts cellular processes, leading to cell cycle arrest and subsequent apoptosis, making it a valuable tool for cancer research and studies on cell death mechanisms. -
Apoptosis Inducer
Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms. -
Apoptosis Inducer
Tubulysin H is a potent apoptosis inducer that functions as an anti-microtubule toxin by inhibiting tubulin polymerization. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin H exhibits exceptional cytotoxicity in mammalian cells, including those that are multidrug-resistant, with low nanomolar IC50 values. Its ability to disrupt microtubule dynamics results in cell cycle arrest and subsequent induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Tubulysin E is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin E exhibits remarkable cytotoxicity in mammalian cells, including those resistant to multiple drugs, with calculated IC50 values in the low nanomolar range. The compound effectively disrupts microtubule dynamics by inhibiting tubulin polymerization, leading to cell cycle arrest and subsequent apoptotic cell death. This makes Tubulysin E a valuable tool in cancer research and studies focused on apoptosis mechanisms. -
Apoptosis Inducer
Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that functions through both p53-dependent and p53-independent mechanisms. It activates and stabilizes the p53 protein in TP53 wild-type models by modulating MDM2 processing, leading to cell cycle arrest and apoptosis. Additionally, Kevetrin demonstrates enhanced efficacy in models with mutated TP53. This compound is valuable for research applications in various cancers, including acute myeloid leukemia and breast cancer. -
p53 Modulator, Apoptosis Inducer
Safrole oxide is a p53 modulator that enhances the expression of the p53 tumor suppressor protein, facilitating cell cycle arrest and promoting apoptosis. This compound effectively induces apoptosis in lung cancer cells while avoiding necrotic cell death. Safrole oxide is valuable for research focused on lung cancer mechanisms and therapeutic strategies. -
Cell-cycle Inhibitor, Senescence Inducer, Apoptosis Inducer, Antiproliferative Agent
Anticancer agent 299 is a cell-cycle inhibitor that functions as a senescence and apoptosis inducer, exhibiting significant antiproliferative effects on cancer cells. This compound demonstrates selective cytotoxicity against cancerous cells with minimal impact on non-tumoral chondrocyte cells at therapeutic concentrations. Anticancer agent 299 is particularly useful for research related to ER+/HER2− breast cancer and BRAF-mutant melanoma.
