JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies.
JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies.
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