MK-0674

Catalog No.: A21558

cathepsin K inhibitor

MK-0674

MK-0674 Chemical Structure

CAS NO. 887781-62-6

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.

Availability: In stock

Package Price Qty
1 mg

Regular Price: $320.00

Special Price $256.00

5 mg

Regular Price: $960.00

Special Price $768.00

10 mg

Regular Price: $1,600.00

Special Price $1,280.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.96 mL 94.79 mL 189.57 mL
0.5 mM 3.79 mL 18.96 mL 37.91 mL
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21558
Actions Inhibitor
CAS No. 887781-62-6
Formula C26H27F6N3O2
M. Wt 527.5
Purity >98%
Synonyms MK0674, MK 0674
SMILES N#CC1(CC1)NC([[email protected]](CC(C)(C)F)N[[email protected]@H](C2=CC=C(C3=CC=C(C=C3)[[email protected]@H](O)C(F)F)C=C2)C(F)(F)F)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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