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L-873724

Name: L-873724
Brand: Adooq Bioscience
SKU: A12487
Availability: InStock

Cat. No. A12487 CAS 603139-12-4

Cathepsin K inhibitor

L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HepG2	IC50	1221 nM	Potency against Cathepsin L in HepG2 cells by whole cell enzyme occupancy assay	[PMID: 16413777]
HepG2	IC50	4807 nM	Potency against Cathepsin B in HepG2 cells by whole cell enzyme occupancy assay	[PMID: 16413777]
Osteoclast	IC50	13 nM	Activity in rabbit osteoclasts by bone resorption assay	[PMID: 16413777]
Ramos	IC50	95 nM	Potency against Cathepsin S in Ramos cells by whole cell enzyme occupancy assay	[PMID: 16413777]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	603139-12-4
Applications	Cathepsin K inhibitor
Formula	C₂₃H₂₆F₃N₃O₃S
Molecular Weight	481.53
SMILES	O=S(C1=CC=C(C2=CC=C([C@@H](C(F)(F)F)N[C@@H](CC(C)C)C(NCC#N)=O)C=C2)C=C1)(C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.