Fig. 1 · Structure
Documents & Downloads
JNJ 10329670
Cat. No.
A39850
CAS
400797-24-2
Cathepsin S Inhibitor
JNJ 10329670 is a selective noncovalent inhibitor of cathepsin S, exhibiting a Ki value of 34 nM for human cathepsin S. This compound effectively inhibits invariant chain proteolysis in B cells and dendritic cells, leading to the modulation of antigen-induced T cell proliferation. It serves as a valuable tool in immunological research and studies focused on autoimmune diseases and cancer immunotherapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 400797-24-2 |
| Applications | Cathepsin S Inhibitor |
| Formula | C30H34ClF3N6O3S |
| Molecular Weight | 651.14 |
| SMILES | FC(F)(F)C1=CC=C(C=C1)C2=NN(C3=C2CN(CC3)S(=O)(C)=O)CCCN4CCC(CC4)N5C6=CC(Cl)=CC=C6N(C5=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.