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Biological Activity
MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.55 mL | 127.75 mL | 255.5 mL |
| 0.5 mM | 5.11 mL | 25.55 mL | 51.1 mL |
| 1 mM | 2.55 mL | 12.77 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
*The above data is based on the productmolecular weight 391.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A20122 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1352817-76-5 |
| Formula | C17H24F3N3O4 |
| M. Wt | 391.39 |
| Purity | >98% |
| Synonyms | MIV247, MIV 247 |
| SMILES | FC1(-;@C-;@C-;@C-;@C-;@1)C[C@H](NC(C(F)(F)C)=O)C(NC2(-;@C-;@C-;@C-;@2)C(C(N)=O)=O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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