EpoY is an irreversible inhibitor of tubulin tyrosine carboxypeptidase (TCP), a critical enzyme complex involving vasohibin-1 (VASH1) and small vasohibin binding protein (SVBP). It exhibits an IC50 of approximately 500 nM, leading to a reduction in detyrosinated alpha-tubulin levels, which impacts microtubule dynamics and neuronal differentiation. EpoY's inhibition of TCP is significant for research into neuronal differentiation defects and associated pathologies, including cancer and cardiomyopathies.
EpoY is an irreversible inhibitor of tubulin tyrosine carboxypeptidase (TCP), a critical enzyme complex involving vasohibin-1 (VASH1) and small vasohibin binding protein (SVBP). It exhibits an IC50 of approximately 500 nM, leading to a reduction in detyrosinated alpha-tubulin levels, which impacts microtubule dynamics and neuronal differentiation. EpoY's inhibition of TCP is significant for research into neuronal differentiation defects and associated pathologies, including cancer and cardiomyopathies.
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