Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid, also known as (+)-(R)-Proline, is an endogenous metabolite that plays a crucial role in amino acid metabolism. This compound exhibits significant renal and hepatotoxic effects in experimental models, making it valuable for research into amino acid metabolism and associated toxicity mechanisms. Its applications include investigations of metabolic pathways and the effects of amino acid dysregulation on cellular health. -
Endogenous Metabolite
4-Methoxycinnamic acid is an endogenous metabolite belonging to the class of phenylpropanoids. It exhibits biological activities including antioxidant and anti-inflammatory properties, making it a valuable compound in research focused on metabolic pathways and natural product chemistry. This compound is commonly studied for its role in plant defense mechanisms and its potential therapeutic applications in various diseases. -
Cysteinyl Leukotriene Pathway Marker
Leukotriene E4 (LTE4) serves as a marker in the cysteinyl leukotriene pathway, produced through the enzymatic conversion of leukotriene D4 (LTD4) by dipeptidase. This compound is a key component of the slow-reacting substance of anaphylaxis (SRS-A) and has been implicated in various inflammatory responses. Elevated urinary levels of leukotriene E4 are commonly utilized as a biomarker for asthma, making it valuable in both clinical and research applications related to respiratory diseases and allergic reactions. -
Endogenous Metabolite
H-HoArg-OH is an endogenous metabolite that acts as a potent inhibitor of human bone and liver alkaline phosphatase. This compound is valuable for investigating the role of alkaline phosphatase in bone and liver metabolism, providing insights into various biological processes and diseases. Its inhibitory properties make it a useful tool for studying related enzymatic pathways in biochemical research. -
Endogenous Metabolite
18:0,18:1 PS sodium is a phospholipid that plays a crucial role in the structure and function of synaptic vesicles and cholesterol metabolism. It is commonly utilized in metabolic research to investigate lipid interactions and cellular signaling pathways. This compound serves as an important tool for studying synaptic transmission and the biochemical networks associated with lipid metabolism. -
Endogenous Metabolite
N-Oleoyl Taurine is an endogenous metabolite that acts as an amino-acyl endocannabinoid. It is known to activate transient receptor potential (TRP) channels, specifically TRPV1 and TRPV4, implicating its role in calcium signaling. This compound has been isolated from rat brain and presents potential applications in research studying the physiological effects of TRP channel modulation and its involvement in neurological functions. -
Endogenous Metabolites
Methyl acetylacetate is a chemical reagent that serves as a versatile building block in the synthesis of α-substituted acetoacetates and cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives. This compound is particularly valuable in pharmaceutical research and holds potential for investigating inflammatory diseases, contributing to the understanding of metabolic pathways and disease mechanisms. -
Endogenous Metabolite
N-Acetylmannosamine 6-phosphate sodium salt is an endogenous metabolite that serves as a key metabolic intermediate in the degradation of sialic acid (Neu5Ac) by Staphylococcus aureus. This compound diminishes the affinity of the transcriptional regulator NanR for DNA, thereby modulating the metabolic pathway associated with sialic acid. It is useful for studies examining sialic acid metabolism and its regulatory mechanisms in microbial organisms. -
Endogenous Metabolite
(S)-(+)-1,2-Propanediol is an endogenous metabolite known for its role in various metabolic pathways. It serves as an organic solvent and diluent in pharmaceutical formulations and is utilized as a chiral synthetic intermediate in organic chemistry. Additionally, (S)-(+)-1,2-Propanediol is a valuable substrate for enzyme research, facilitating studies on enzyme kinetics and activity. -
Endogenous Metabolite
DL-Homocystine is a double-bonded derivative of homocysteine, serving as an endogenous metabolite. It is implicated in the pathogenesis and pathophysiology of schizophrenia, making it a relevant compound for research into neurodevelopmental disorders. This substance can provide insights into the biochemical mechanisms associated with mental health conditions and may aid in the exploration of potential therapeutic targets. -
Endogenous Metabolite
Sodium 2-hydroxybutanoate is an endogenous metabolite that plays a crucial role in cellular metabolism. It is involved in various biochemical pathways, including energy production and amino acid metabolism. This compound is primarily utilized in research applications studying metabolic processes and investigating disorders related to cellular energy regulation. -
Endogenous Metabolite
D(-)-2-Aminobutyric acid is an endogenous metabolite that serves as a substrate for D-amino acid oxidase. This compound is involved in various metabolic pathways and has been studied for its potential roles in neurological functions and disorders. Its application in research includes investigations into metabolic processes and the modulation of neurotransmitter activity. -
Endogenous Metabolite
Cytidine-5'-triphosphate disodium dihydrate (5'-CTP disodium dihydrate) is an endogenous metabolite that functions as a high-energy coenzyme in critical biological processes. It plays a vital role in glycerophospholipid biosynthesis and protein glycosylation, facilitating cellular membrane dynamics and post-translational modifications. This compound is valuable for research applications studying metabolic pathways, cellular signaling, and the synthesis of nucleotides and lipids. -
Endogenous Metabolite
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE is a plasmalogen composed of 1(Z)-octadecenoic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. This compound acts as an endogenous metabolite and is essential for maintaining membrane integrity and fluidity. It plays a critical role in signaling pathways and lipid metabolism, making it a valuable tool for research in cell biology, neurobiology, and inflammation studies. -
Endogenous Metabolite
AubipyOMe is a selective inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme implicated in osteoclast and macrophage activity. It exhibits IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, effectively inhibiting TRAP activity in murine macrophage extracts and human lung tissue. This compound is valuable for studying bone resorption and macrophage function in various biological contexts. -
Endogenous Metabolite
Mevalonic acid 5-pyrophosphate tetralithium is an endogenous metabolite involved in the mevalonate pathway, which plays a crucial role in synthesizing isoprenoids and cholesterol. This compound is pertinent for research into metabolic processes and the regulation of lipid biosynthesis. Its use can facilitate the study of cellular signaling and metabolism, enhancing understanding of various biological systems and disease states. -
Endogenous Metabolite
CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia. -
Endogenous Metabolite
Dibenzyl disulfide is an endogenous metabolite that plays a significant role in various biological processes. This compound exhibits antioxidant properties and may contribute to cellular defense mechanisms. It is utilized in research to explore metabolic pathways and the biochemical impacts of sulfur-containing compounds in biological systems. -
Endogenous Metabolite
(R)-(-)-1,3-Butanediol is the R-enantiomer of 1,3-Butanediol, functioning as an endogenous metabolite. It demonstrates anti-diabetic properties in animal models, showcasing potential for metabolic regulation. This compound is also utilized in the flavoring and fragrance industries, contributing to the modulation of carbohydrate and lipid metabolism in biological systems. Its diverse applications make it a valuable reagent for research in metabolic studies. -
Endogenous Metabolite
3-Oxo-4,6-choladien-24-oic acid is an endogenous metabolite associated with hepatobiliary disease. This compound is typically found in the urine of affected individuals and serves as a potential biomarker for liver function. Its study may contribute to the understanding of metabolic pathways and disease mechanisms related to liver health. -
Endogenous Metabolite
8-Isoprostaglandin F2α is an isoprostane resulting from the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. This compound exists in human plasma in two forms: esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α functions primarily as a weak thromboxane receptor (TP) agonist in vascular smooth muscle, making it relevant in studies of vascular biology and cardiovascular research. -
Endogenous Metabolite
L-Lysine hydrate is an essential amino acid that acts as an endogenous metabolite. It plays a crucial role in protein synthesis and is implicated in various biological processes. Research applications include studies on vascular calcification and acute pancreatitis, making it a valuable reagent for investigating metabolic disorders and related pathologies. -
Endogenous Metabolite
α-D-Glucose-1-phosphate disodium hydrate serves as a crucial endogenous metabolite, acting primarily as a building block in the synthesis of glucuronic acid. This compound exhibits cytostatic properties, making it essential for cardiopathic therapy, while also demonstrating potential as an antibiotic and immunosuppressive agent. Its versatile applications in circulatory system therapies underscore its significance in various biochemical and pharmaceutical research contexts. -
Endogenous Metabolite
3-Hydroxymandelic Acid is an endogenous metabolite derived from Phenylephrine, which functions as an α-receptor agonist. This compound is instrumental in research related to catecholamine metabolism and autonomic nervous system regulation. It can be utilized for studying the biochemical pathways of adrenergic signaling and the physiological effects of α-receptor activation. -
Endogenous Metabolite
L-Allothreonine is an endogenous metabolite that plays a role in various metabolic pathways. This amino acid is involved in protein synthesis and may influence cellular functions through its contributions to metabolic processes. Research applications include studies on metabolism, amino acid profiling, and investigations into its physiological roles in human health and disease. -
Endogenous Metabolite
L-Prolylglycine is an endogenous metabolite that serves as an important modulator of cellular signaling pathways. This compound is known to exhibit neuroprotective effects and plays a role in cognitive function. It is utilized in research applications focused on neurobiology, metabolism, and the study of related disorders. -
Endogenous Metabolite
3-Amino-4-hydroxybenzoic acid is an endogenous metabolite known for its role in various biochemical pathways. It functions as an intermediate in the synthesis of important compounds such as catecholamines and can influence metabolic processes. This compound is utilized in research applications involving metabolic studies, enzyme activity assessment, and the exploration of its therapeutic potential in various physiological contexts. -
Endogenous Metabolite
ATP dipotassium, or Adenosine 5'-triphosphate dipotassium, serves as a crucial endogenous metabolite involved in energy storage and metabolic processes. It provides the necessary energy for various metabolic pumps and functions as a key coenzyme in cellular activities. Additionally, ATP dipotassium plays a significant role as a signaling molecule in immune responses and inflammatory pathways, making it valuable for research in cellular biology, immunology, and inflammation studies. -
Endogenous Metabolite
alpha-D-glucose, an endogenous metabolite, primarily functions as an essential monosaccharide in glucose metabolism. It exhibits a pronounced insulin-stimulating effect compared to beta-D-glucose, making it critical for studies related to diabetes, carbohydrate metabolism, and insulin signaling pathways. This compound is integral in research exploring energy metabolism and cellular respiration. -
Endogenous Metabolite
2-(2-Methylbenzamido)acetic acid is an endogenous metabolite identified in urine. This compound is significant for its role in metabolic studies and can be used as a biomarker in various physiological and pathological conditions. It serves as a useful tool for researchers examining metabolic profiles and renal function. -
Endogenous Metabolite
1,4-D-Gulonolactone is an endogenous metabolite that serves as a precursor in the biosynthesis of ascorbic acid (vitamin C). It plays a crucial role in redox biology and cellular antioxidant defense mechanisms. This compound is commonly utilized in research to investigate its physiological functions and potential implications in metabolic disorders, aging, and oxidative stress. -
Endogenous Metabolite
Thiotaurine is an endogenous metabolite of cystine that acts as a sulfur donor. It plays a role in modulating the activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is important for neutrophil activation and leukocyte energy metabolism. Thiotaurine exhibits potential anti-inflammatory properties and may serve as an immunomodulator in various biological research applications. -
Endogenous Metabolite
Methylmalonyl-CoA tetralithium is an endogenous metabolite involved in the catabolism of branched-chain amino acids, odd-chain fatty acids, and cholesterol. It acts as a substrate for methylmalonyl-CoA mutase (MCM) in the conversion to succinyl-CoA, a crucial step in cellular energy metabolism. This reagent is valuable in research applications focused on metabolic pathways, mitochondrial function, and the study of related metabolic disorders. -
Endogenous Metabolite
N-Formylglycine, an endogenous metabolite, plays a pivotal role in various biological processes. It is involved in the regulation of cellular metabolism and can act as a precursor in the biosynthesis of important biomolecules. Research applications include studies on metabolic pathways and the exploration of its function in cellular signaling and regulation. -
Endogenous Metabolite
NSC 90469 is an endogenous metabolite involved in various biological processes. It plays a crucial role in metabolic pathways and can be utilized in research applications related to cellular metabolism and biochemical assays. Its investigation aids in understanding metabolic dysregulation in diseases and potential therapeutic targets. -
Endogenous Metabolite
Phenyl acetate is an endogenous metabolite derived from 2-phenylethylamine, commonly found in urine. It plays a role in the regulation of glutamine metabolism and has potential applications in disease detection, particularly in relation to conditions such as depression. Its measurement may serve as a biomarker, offering insights into metabolic disturbances associated with various health conditions. -
Endogenous Metabolite
Euphol is a tetracyclic triterpene alcohol derived from the sap of Euphorbia tirucalli, primarily targeting monoacylglycerol lipase (MGL). This compound exhibits anti-mutagenic, anti-inflammatory, and immunomodulatory properties, making it relevant in pain research and the study of the endocannabinoid system. Euphol reversibly inhibits MGL activity, with an IC50 of 315 nM, thereby modulating inflammatory pain pathways in peripheral tissues. -
Endogenous Metabolite
Palmitoyldocosahexaenoyl phosphatidylcholine is an endogenous metabolite that serves as a critical component of cellular membranes. This compound plays a significant role in promoting membrane fluidity and functionality, influencing various biological processes, including cell signaling and inflammation. Its research applications extend to studies involving lipid metabolism, neuroprotection, and the modulation of inflammatory pathways. -
Endogenous Metabolite
Formiminoglutamic acid is an endogenous metabolite that serves as a potential biomarker of folate deficiency. It is involved in amino acid metabolism and plays a role in the assessment of various metabolic disorders. This compound is particularly useful in research applications focused on understanding folate metabolism and its associated health implications. -
Endogenous Metabolite
Inosine 5′-diphosphate sodium is an endogenous metabolite that plays a crucial role in intracellular energy metabolism and signal transduction pathways. As a purine ribonucleoside 5′-diphosphate, it serves as a derivative of inosine, facilitating important cellular functions. This compound is employed in research related to nucleotide metabolism, cellular signaling mechanisms, and the modulation of enzymatic activities in various biological systems. -
Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate sodium is an endogenous metabolite that serves as an a-site substrate analogue. It significantly inhibits the reaction rate of indole and nucleophilic indole analogues with E(A-A) upon binding to the a-site. This compound is valuable for studying enzymatic mechanisms and metabolic pathways, particularly those involving glycerol 3-phosphate dehydrogenase and related enzymes in biochemical research. -
Endogenous Metabolite,Cancer Inhibitor
Protoporphyrin IX (disodium) is a key metabolite in the heme biosynthetic pathway, functioning primarily as a radiation sensitizer. It enhances the generation of reactive oxygen species (ROS) even under hypoxic conditions, thereby inducing DNA damage. This compound also serves as a photosensitizer, undergoing photodegradation when exposed to light. Notably, Protoporphyrin IX (disodium) accumulates in tumor cells following administration of 5-aminolevulinic acid (5-ALA) and demonstrates selective efficacy against basal cell carcinoma when activated at a wavelength of 405 nm. Its properties make it a valuable candidate for research into sonodynamic and photodynamic therapies for various cancers, including bladder cancer. -
Endogenous Metabolite
(±)-Coriolic acid is an endogenous metabolite formed from the non-enzymatic oxidation of linoleic acid, classified as a racemic monohydroxy fatty acid. This compound serves as a significant hydroxy fatty acid in psoriatic skin scales, where it is found at a mean concentration of 17 ng/mg. Research applications include the study of lipid metabolism and skin pathology, particularly in relation to inflammatory skin disorders. -
Endogenous Metabolite
N-Palmitoyl Taurine is an endogenous metabolite identified as a prominent acyl amino acid in lipidomic studies of rat brain tissue. This compound plays a role in modulating endocannabinoid signaling pathways, which are critical for various neurophysiological processes. Research applications of N-Palmitoyl Taurine include investigating its potential neuroprotective effects and implications in neurodegenerative disorders. Further studies are ongoing to elucidate its biological functions and mechanisms of action. -
Endogenous Metabolite
15(S)-HETE is an endogenous metabolite that serves as a biomarker for Zellweger Syndrome. This compound is primarily involved in lipid metabolism and signaling pathways related to cellular function and inflammation. It is valuable for researchers investigating the biochemical and physiological processes affected in Zellweger Syndrome and other related disorders. -
Endogenous Metabolite
Phytic acid potassium is an endogenous metabolite known for its role as a chelator of metal ions. It has been shown to exhibit antioxidant properties and can influence cellular signaling pathways. This compound is utilized in biochemical research to study its effects on mineral bioavailability and its potential role in various physiological processes. -
Endogenous Metabolite
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a key structural glycoprotein that plays an essential role in tissue architecture and cellular interactions. It serves as a scaffold by interacting with type IV collagen, facilitating cell adhesion through integrin receptors, and promoting neurite outgrowth. Its various functional domains are critical for collagen binding and heparin interaction, making it a vital component in studies related to cell behavior, tissue engineering, and developmental biology. -
Endogenous Metabolite
NSC 13138 is an endogenous metabolite that plays a crucial role in various metabolic pathways. Its biological activity is linked to influencing intracellular signaling processes, making it relevant for research in metabolic regulation and homeostasis. This compound serves as a valuable tool for studying metabolic changes in disease models and understanding its implications in cellular functions. -
Endogenous Metabolite
2'-Deoxycytidine-5'-monophosphoric acid disodium (dCMP disodium) is an essential endogenous metabolite involved in nucleic acid metabolism. It serves as a precursor for DNA synthesis and plays a crucial role in cellular processes including DNA repair and replication. dCMP disodium is utilized in biochemical research to study DNA-related activities and pathways, enhancing the understanding of cellular functions and genetic regulation. -
Endogenous Metabolite
D-Xylulose is an endogenous metabolite that plays a key role in carbohydrate metabolism. It serves as a precursor for the pentitol D-arabitol, contributing to various metabolic pathways. D-Xylulose is valuable for research applications focused on metabolic disorders and the physiological roles of sugar alcohols.
