Nicotinoyl azide serves as a versatile synthetic intermediate, notable for its ability to form high-energy intermediates that generate C-8 adducts with adenosine and guanosine. The compound contains an azide functional group and is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds featuring DBCO or BCN functionalities, making it valuable for diverse applications in chemical biology and medicinal chemistry.
Nicotinoyl azide serves as a versatile synthetic intermediate, notable for its ability to form high-energy intermediates that generate C-8 adducts with adenosine and guanosine. The compound contains an azide functional group and is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds featuring DBCO or BCN functionalities, making it valuable for diverse applications in chemical biology and medicinal chemistry.
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