Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
N-Deacetylthiocolchicine is a potent tubulin inhibitor with an IC50 value of 2.2 nM in multidrug-resistant MDA-MB 231 breast cancer cells. This compound exerts its antiproliferative effects by binding to tubulin, disrupting microtubule assembly, and causing cell cycle arrest during mitosis. N-Deacetylthiocolchicine is a valuable tool for investigating therapeutic strategies in malignancies, particularly breast cancer. -
Epothilone Derivative
Cis-9,10-Dehydroepothilone D is an epothilone derivative that primarily targets tubulin to promote microtubule polymerization. This compound exhibits significant antiproliferative activity and is valuable in cancer research, particularly for the study of lung, colon, prostate, and breast cancers. Its role in disrupting cellular growth pathways makes it an important tool for investigating cancer biology and therapeutic strategies. -
Microtubule/Tubulin Inhibitor
Sudocetaxel is a microtubule depolymerization inhibitor that targets tubulin, impairing microtubule dynamics. This compound is particularly useful in drug delivery systems that are pH-sensitive, enhancing the therapeutic efficacy of docetaxel. It holds potential applications in cancer research, providing insights into microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-21 is a potent tubulin polymerization inhibitor that disrupts microtubule assembly, leading to compromised cellular integrity. This compound demonstrates significant anti-cancer activity by interfering with glucose metabolism and cellular proliferation. It is suitable for research applications aimed at understanding cancer biology and the mechanisms of tubulin-targeting therapies. -
Anticancer Agent
Anticancer Agent 40 (compound 3e) is a potent anticancer compound that targets various cancer cell lines. It demonstrates significant anticancer activities with IC50 values of 0.94, 0.98, 0.96, 0.95, and 2.13 nM against SKBR-3, SKOV-3, PC-3, U-87, and HDF cells, respectively. This compound is suitable for research applications focused on cancer biology and therapeutic development. -
PLK-1/Tubulin Inhibitor
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid compound that functions as an inhibitor of polo-like kinase-1 (PLK-1) and αβ-tubulin at the colchicine binding site. This compound disrupts microtubule assembly dynamics and modulates kinase activity, making it valuable for research into cancer cell proliferation and anti-nociceptive properties. Its unique biological activities make it a significant reagent for studies focused on cancer therapies and pain management. -
Tubulin Inhibitor
Tubulin-IN-52 is a potent tubulin inhibitor that exhibits notable cytotoxicity against various cancer cell lines, including prostate, lung, and ovarian cancers, with an impressive IC50 range of 0.9-3.8 mM in highly aggressive cancer models. This compound effectively inhibits the growth of established tumors while displaying minimal toxicity to normal cells. Tubulin-IN-52 serves as a valuable tool for investigating cancer biology and exploring potential therapeutic strategies in oncology research. -
Taxane Analog
Milataxel, a taxane analog, primarily targets tubulin to enhance polymerization rates. This compound demonstrates significant biological activity in the treatment of various cancers, particularly colorectal cancer and non-small cell lung cancer. Milataxel is a valuable reagent for research focused on cancer biology and therapeutic efficacy in oncology studies. -
Microtubule/Tubulin Control
CHM-1-P-Na is a sodium monophosphate salt of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one, targeting microtubule dynamics through tubulin interaction. This compound exhibits significant antitumor activity in both in vitro and in vivo models, demonstrating a distinct mechanism of action. CHM-1-P-Na offers promising applications in cancer research, particularly in studies focusing on tumor growth inhibition and the modulation of related enzymatic pathways. -
Tubulin Inhibitor
BKS3031A is a potent αβ-tubulin inhibitor that targets the colchicine binding site, effectively disrupting microtubule assembly dynamics. This compound demonstrates significant biological activity in modulating cellular processes such as mitosis and intracellular transport. BKS3031A is valuable for research applications in cancer biology and studies involving cytoskeletal dynamics. -
Microtubulin Inhibitor
Epothilone E is a microtubulin inhibitor that disrupts microtubule protein function, leading to the blockage of cell division. This compound exhibits significant anti-tumor activity and is valuable for research applications in cancer biology, particularly in studies focused on cell cycle regulation and mitotic progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-18 is a potent inhibitor of tubulin polymerization, targeting the microtubule dynamics essential for cellular structure and function. This compound exhibits significant anti-proliferative activity, making it valuable for research applications in breast cancer and chemoresistant colon cancer. Its ability to disrupt microtubule formation provides insights into the mechanisms of cancer cell growth and resistance, facilitating the development of new therapeutic strategies. -
Anticancer Agent
Tubulin polymerization-IN-2 is a potent anticancer agent that specifically targets β-tubulin, exhibiting an IC50 value of 0.92 μM. This compound demonstrates significant biological activity across a range of cancer cell lines, including leukemia, non-small cell lung, renal, prostate, and breast cancers. Its mechanism of action makes it a valuable tool for research in cancer biology and therapeutic development. -
Anticancer Agent
CID-663143 is an anticancer agent that targets microtubule-associated proteins, inhibiting the polymerization of tubulin within cells. This compound demonstrates significant activity against cancer cell growth, with an IC50 value of less than 100 nM for HT-1080, BJeLR, and MCF10A cell lines. It is a valuable tool for investigating microtubule dynamics and the cellular mechanisms underlying cancer proliferation. -
Microtubule/Tubulin Inhibitor
Tubulin polymerization-IN-42 is an indole-substituted furanone that acts as a potent inhibitor of tubulin polymerization. Its primary mechanism targets microtubule dynamics, thereby interrupting the mitotic spindle formation. This compound exhibits significant anti-cancer activity, making it a valuable tool for research into cancer therapeutics and the study of microtubule-related cellular processes. -
Cytotoxic Chalcone
Calythropsin is a cytotoxic chalcone that primarily targets cell division processes. It exhibits a weak effect on mitosis, likely influencing tubulin polymerization, which is crucial for mitotic spindle formation. This compound can be utilized in research focusing on cell cycle regulation, cancer biology, and the investigation of microtubule dynamics. -
Microtubule Inhibitor
Microtubule Inhibitor 6 targets the microtubule assembly process, demonstrating strong inhibitory activity. It exhibits cytotoxic effects with IC50 values of 14.0 nM in NCI-H460 cells, 6.6 nM in BxPC-3 cells, and 7.0 nM in HT-29 cells. This compound effectively inhibits microtubule polymerization, making it a valuable reagent for cancer research focused on cell proliferation and mitosis. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-90 is a selective inhibitor of tubulin polymerization, targeting the nocodazole-binding site on β-tubulin. By disrupting microtubule formation, it induces the release of extracellular vesicles marked by CD63 and promotes IL-8 secretion from cells. This compound has demonstrated reduced viability in various cancer cell lines and is particularly relevant for research applications in acute T-lymphoblastic leukemia and other malignancies characterized by aberrant tubulin dynamics. -
Microtubule/Tubulin
Alestramustine is an antineoplastic cytostatic agent that primarily targets microtubules by binding to microtubule-associated proteins and β-tubulin via its active metabolites. This interaction disrupts microtubule function, leading to the inhibition of cell division. Alestramustine is utilized in research applications aimed at understanding cancer cell proliferation and the mechanisms of microtubule dynamics. -
Microtubule/Tubulin
Microtubule Inhibitor 7 targets tubulin, disrupting microtubule dynamics. This compound exhibits potent cytotoxic activity with IC50 values of 14.0 nM and 2.9 nM against the NCI-H460 human cancer cell line. It is valuable for research into cancer mechanisms and the evaluation of antiproliferative efficacy in various human cancer cell models. -
Microtubule/Tubulin Inhibitor
Dolastatinol is a synthetic analog of dolastatin 10 that acts as a potent inhibitor of tubulin polymerization. Its low nanomolar activity effectively disrupts microtubule formation, leading to significant effects on cell division and proliferation. This compound is valuable for research applications in cancer biology and studies investigating microtubule dynamics. -
Vascular Disrupting Agent
STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin to inhibit microtubule dynamics. It demonstrates significant antitumor activity in mouse xenograft models by selectively disrupting tumor-associated microvasculature, affecting both central and peripheral regions of tumors. STA-9584 is applicable in cancer research, particularly for studying prostate and breast cancer therapeutics. -
Tubulin Inhibitor
J-30 is a potent tubulin inhibitor that selectively interferes with microtubule polymerization, demonstrating an IC50 of 15-20 nM. By inducing G2/M phase arrest, J-30 exhibits significant potential in the study of solid tumors, including gastric and oral cancers. This compound serves as a valuable tool for researchers investigating the mechanisms of cancer cell proliferation and progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-7 is an effective inhibitor of tubulin polymerization, disrupting microtubule dynamics. This compound demonstrates significant potential in cancer research by interfering with cellular division and tumor growth. It is a valuable tool for investigating mechanisms of tumorigenesis and evaluating therapeutic strategies targeting tubulin. -
Anticancer Agent
Anticancer agent 139 (Compound 6h) primarily targets tubulin through π-cationic interactions with the lysine residue Lys352, demonstrating strong anticancer activity. This compound exhibits significant efficacy against various cancer cell lines, including SNB-19, OVCAR-8, and NCI-H40, with proliferation growth inhibition (PGI) values of 86.61, 85.26, and 75.99, respectively. Additionally, anticancer agent 139 shows moderate activity against HOP-62, SNB-75, and others, making it a valuable tool for cancer research and drug discovery applications. -
Anticancer Compound
7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone that primarily targets β-tubulin, inhibiting its polymerization along with α-tubulin. This compound exhibits significant anticancer properties by triggering a DNA damage response that leads to cell cycle arrest in the G2/M phase. Its potential applications in cancer research make it a valuable tool for exploring microtubule dynamics and therapeutic strategies in oncology. Isolated from members of the Asteraceae family, 7a-Hydroxyfrullanolide offers insights into natural product-based anticancer mechanisms. -
Tubulin inhibitor
Tubulin inhibitor 16 is a potent compound targeting tubulin, effectively disrupting microtubule dynamics. It demonstrates significant antiproliferative activity and exhibits cytotoxic effects in HepG2 hepatic cancer cells. This reagent is valuable for research applications focusing on cancer cell biology and the mechanistic study of tubulin modulation. -
Tubulin Inhibitor
Tubulin Inhibitor 25 is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.98 μM. It demonstrates significant activity against the HT29 cancer cell line, effectively inhibiting cell migration and tube formation, which are critical processes in angiogenesis. This compound is valuable for research applications related to cancer biology and investigations into anti-angiogenic therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-50 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells. This compound effectively induces cell cycle arrest in the G2/M phase, making it a valuable tool for studying the mechanisms of cell division and tumor biology. Its application in research can aid in the development of novel therapeutic strategies targeting proliferative diseases. -
Microtubule Inhibitor
BMS-184476 is a selective microtubule inhibitor that demonstrates potent antitumor activity. It effectively induces G2/M phase arrest and promotes apoptosis in tumor cells, making it a valuable tool for investigating mechanisms of cancer cell proliferation and survival. This compound shows promise for research into solid tumors, particularly non-small cell lung cancer. -
Microtubule/Tubulin Inhibitor
Ceratamine A is a microtubule/tubulin inhibitor derived from the marine sponge Pseudoceratina sp. This antimitotic heterocyclic alkaloid demonstrates significant cytotoxicity against various human cancer cell lines, making it a valuable tool for cancer research. Its ability to interfere with microtubule dynamics underscores its potential for studying cancer cell proliferation and treatment responses. -
EVs Inducer
EVs inducer-1 is an extracellular vesicle (EV) release inducer that targets tubulin polymerization. This compound enhances the secretion of immunostimulatory EVs from antigen-presenting cells, particularly increasing EV particle release from dendritic cells and elevating CD63 reporter gene activity. Additionally, EVs inducer-1 inhibits the viability of proliferating cells, making it a valuable tool for research in immune regulation and EV biology. -
Intermediate Reactant
Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (MMAE), which functions as a microtubule/tubulin inhibitor. MMAE exhibits significant anticancer activity and is frequently utilized as the cytotoxic component in antibody-drug conjugates (ADCs). This compound plays a crucial role in the development of novel therapeutics aimed at targeting cancer cells. -
Microtubule Inhibitor
Erbulozole is a microtubule inhibitor that disrupts the dynamic instability of microtubules, leading to impaired cell division and potential antitumoral effects. This compound has been utilized in research focused on cancer biology and may serve as a prototype for developing novel therapeutics targeting microtubule dynamics in tumor cells. -
Antimicrotubule Agent,
KPU-300 is a potent antimicrotubule agent targeting tubulin, demonstrating significant cytotoxicity with an IC50 value of 7.0 nM against HT-29 colorectal cancer cells. Its mechanism of action involves disruption of microtubule dynamics, leading to cell cycle arrest and subsequent apoptosis. KPU-300 is valuable for research applications focused on cancer therapeutics and the study of microtubule-targeting agents. -
Stilbenoid
Blestriarene B is a stilbenoid that exhibits inhibitory effects on tubulin polymerization, making it a significant compound in cancer research. Isolated from the tubers of Bletilla striata (Orchidaceae), it offers potential applications in studying cytoskeletal dynamics and cell division. This compound serves as a valuable tool for investigating therapeutic strategies targeting microtubule function. -
Microtubule Depolymerization Inhibitor
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor that effectively prevents calcium-induced microtubule depolymerization. This compound demonstrates a significant reduction in the growth of J774.2 macrophages, with an IC50 of approximately 60 nM, and promotes elevated levels of nitric oxide (NO) and tumor necrosis factor (TNF) in isolated mouse peritoneal macrophages. Its pharmacological properties make it a valuable tool for investigating microtubule dynamics and immune response modulation in experimental settings. -
Microtubule stabilizer
Isofludelone is a microtubule stabilizer that demonstrates significant antitumor activity, making it a valuable compound for cancer research, particularly in the study of solid tumors. By promoting microtubule stabilization, isofludelone can disrupt normal cellular mechanisms, leading to potential therapeutic advances in oncology. Its application in research may provide insights into the pathological processes associated with tumorigenesis and aid in the development of effective treatments. -
Intermediate Reactant
Monomethyl auristatin E intermediate-9 serves as a crucial intermediate reagent for the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor known for its anticancer properties. MMAE is primarily utilized as the cytotoxic agent in antibody-drug conjugates (ADCs), enhancing therapeutic efficacy in targeted cancer treatments. This intermediate is essential for researchers exploring the development of novel ADCs and studying their mechanisms of action in cancer biology. -
Mitotic Arrest Inducer
Centmitor-1 is a potent mitotic arrest inducer that targets microtubule dynamics by modulating microtubule plus-ends. Its application in cell studies reveals significant phenotypes, including chromosome alignment defects, multipolar spindle formation, centrosome fragmentation, and activation of the spindle assembly checkpoint. Centmitor-1 serves as a valuable tool for investigating mitotic processes and exploring therapeutic strategies in cancer research. -
Intermediate Reactant
Monomethyl auristatin E intermediate-13 is a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with demonstrated anticancer activity. MMAE is commonly employed as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted cancer therapy. This intermediate is essential for research applications focused on the development and optimization of ADCs in cancer treatment. -
BNC105 Prodrug
BNC105P is a phosphate prodrug of BNC105 that functions as a vascular disrupting agent (VDA) and an antitumor agent upon conversion to the active form, BNC105. This compound selectively targets tumor vasculature, leading to disruption of blood flow and subsequent tumor cell death. BNC105P is utilized in cancer research to investigate therapeutic strategies aimed at targeting tumor microenvironments and enhancing treatment efficacy. -
Cytochalasin
Cytochalasin J is a cytochalasin derivative that targets microtubule organization. It disrupts mitotic spindle formation and alters kinetochore structure, demonstrating cytotoxic effects in human leukemia K562 cells with an IC50 of 1.5 μM. This compound is valuable for research applications in cancer biology, particularly in the study of cell division and cancer cell dynamics. -
Intermediate Reactant
Monomethyl auristatin E intermediate-12 serves as an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor known for its anticancer properties. This compound plays a crucial role as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted delivery in cancer therapy. Its use in research applications contributes to the development of innovative therapeutic strategies in oncology. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-57 is a potent tubulin polymerization inhibitor affecting microtubule dynamics. This α-naphthoxy-substituted carbendazim derivative induces mitotic arrest, effectively inhibiting proliferation in cancer cells. It demonstrates promising potential for research applications in cancer biology and therapeutic development. -
Antimitotic Agent
Alfalone is an antimitotic agent that inhibits cell division by disrupting microtubule dynamics, leading to cleavage arrest and the formation of tuberculate eggs. This compound is valuable for research applications in cell biology and developmental studies, particularly in understanding the mechanisms of mitotic regulation and the effects on embryonic development. -
Intermediate Reactant
Monomethyl auristatin E intermediate-4 serves as a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor exhibiting significant anticancer activity. MMAE is commonly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted delivery and efficacy in cancer therapy. Researchers use this intermediate for developing ADCs and studying microtubule dynamics in cancer cell biology. -
Microtubule/Tubulin Inhibitor
Tubulin Inhibitor 9 is a microtubule-targeting compound that selectively inhibits tubulin polymerization. Demonstrating potent anticancer activity, this compound achieves an IC50 of 0.9 nM in the MDA-MB 231 breast cancer cell line. It serves as a valuable tool for investigating microtubule dynamics and evaluating potential therapeutic strategies in cancer research. -
Microtubule/Tubulin Inhibitor
Cis-Trismethoxy resveratrol acts as a microtubule/tubulin inhibitor, demonstrating potent anti-mitotic properties. It effectively inhibits tubulin polymerization with an IC50 value of 4 μM. This compound is valuable for research applications focused on cell division, cancer biology, and the study of microtubule dynamics. -
Mitotic Inhibitor
MT-7 is a potent mitotic inhibitor that exhibits significant antiproliferative activity. It effectively induces cell cycle arrest at the G2/M phase, leading to a specific and reversible mitotic arrest. Additionally, MT-7 inhibits the polymerization of cellular microtubules, making it a valuable tool for researchers investigating cell division and cancer biology.
