DNA Damage

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  1. Purine Nucleoside Analog

    2-Thiopseudouridine is a purine nucleoside analog with significant potential in cancer research. It exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. The compound's anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for studying cancer biology and developing therapeutic strategies.
  2. Thymidine Analog

    5-N-Boc-aminomethyluridine is a thymidine analog known for its incorporation into replicated DNA. This compound exhibits insertional activity, making it valuable for cellular labeling and tracking DNA synthesis in various biological research applications. Its unique properties facilitate the study of nucleic acid metabolism and cellular processes.
  3. Purine Nucleoside Analog

    2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-fluorouridine is a purine nucleoside analog with significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is essential for studies aimed at developing therapies for hematological malignancies and understanding the biochemical pathways involved in tumor progression.
  4. Purine Nucleoside Analog

    5-Methyl-2-thio-xylo-uridine is a purine nucleoside analog that exhibits broad antitumor activity primarily against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound aids in the study of therapeutic strategies for various hematological cancers, contributing to the understanding of cellular responses and treatment efficacy.
  5. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoroarabino-O6-methyl inosine is a purine nucleoside analog that exerts its biological activity primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor effects, making it particularly relevant in the study of indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis, which further enhances its potential in cancer research applications.
  6. Purine Nucleoside Analog

    N6-Benzoyl-3'-fluoro-2',3'-dideoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies aimed at exploring its potential therapeutic applications in oncology.
  7. Purine Nucleoside Analog

    5-Azidomethyl-2’-beta-methyl uridine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. In addition, this compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This makes it an invaluable tool for chemical biology and medicinal chemistry applications.
  8. Purine Nucleoside Analog

    8-Aza-7-deazguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic exploration. This compound is suitable for studies aimed at understanding the molecular pathways involved in tumorigenesis and for developing potential anticancer strategies.
  9. Purine Nucleoside Analog

    N4-Benzoyl-2'-deoxy-5'-O-DMTr-2'-fluoro-5-methylcytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in the treatment of indolent lymphoid malignancies. Its primary mechanisms of action involve inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for cancer research, enabling the study of nucleoside metabolism and the development of novel therapeutic strategies.
  10. Cytidine Analog

    5’(R)-C-Methylcytidine is a synthetic cytidine nucleoside analog that inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to interfere with DNA methylation processes provides insights into gene regulation and potential therapeutic interventions.
  11. Nucleoside Metabolite

    5-O-(1-Carboxyvinyl)-3-phosphoshikimic acid is a nucleoside metabolite that acts as an intermediate in the shikimic acid pathway. This compound is pivotal in the biosynthesis of aromatic amino acids and phenylpropanoids, contributing to essential metabolic processes in plants and microorganisms. Its utilization in research includes studies on metabolic engineering and the development of herbicides, as well as exploring its role in secondary metabolite production.
  12. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoroinosine is a purine nucleoside analog that primarily inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular proliferation. Its research applications include studying cancer cell biology and exploring therapeutic strategies for hematological cancers.
  13. Purine Nucleoside Analog

    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(pyridine-4-yl)purine is a purine nucleoside analog that effectively inhibits DNA synthesis and induces apoptosis. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its application in research underscores its potential as a therapeutic agent in cancer treatment strategies.
  14. Purine Nucleoside Analog

    2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside is a purine nucleoside analog that primarily inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular proliferation. Its potential applications in cancer research make it a valuable tool for studying mechanisms of tumorigenesis and evaluating therapeutic strategies.
  15. Purine Nucleoside Analog

    2'-Deoxy-5,N4,N4-trimethylcytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer properties are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, helping to elucidate mechanisms of tumor growth and potential therapeutic strategies.
  16. Nucleoside Metabolite

    Prostaglandin C2 is a nucleoside metabolite that plays a critical role in various physiological processes, including inflammatory responses and vascular regulation. This compound is involved in modulating cellular signaling pathways and may offer insights into the mechanisms underlying diseases linked to dysregulated prostaglandin levels. Prostaglandin C2 can be utilized in research applications focused on inflammation, cardiovascular health, and metabolic disorders.
  17. Purine Nucleoside Analog

    3’-Deoxy-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is instrumental in various research applications aimed at understanding and developing therapies for malignancies resistant to conventional treatments.
  18. Purine Nucleoside Analog

    7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine is a purine nucleoside analog known for its anticancer properties. This compound exhibits significant biological activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and the induction of apoptosis. It represents a valuable tool for research in cancer therapeutics and the study of purine metabolism.
  19. Purine Nucleoside Analog

    MMT-2'-O-Methyl adenosine (n-bz) CED phosphoramidite is a purine nucleoside analog that serves as a versatile building block in oligonucleotide synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. It is primarily utilized in research focused on the development of novel therapeutics and the study of nucleic acid interactions.
  20. Purine Nucleoside Analog

    2'-Bromo-2'-deoxy-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism of action involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on anticancer therapeutics and the study of nucleoside metabolism.
  21. Nucleoside Metabolite

    10-OPDA is a nucleoside metabolite that plays a pivotal role in nucleotide biosynthesis and cellular signaling. It participates in various biological processes, making it valuable for research applications in cell biology and metabolic studies. Investigating 10-OPDA can provide insights into nucleoside metabolism and related pathways in various organisms.
  22. Purine Nucleoside Analog

    2’,3’-Dideoxy-5-fluorocytidine is a purine nucleoside analog that exhibits substantial antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is instrumental for studies focusing on the development of targeted therapies and the understanding of nucleoside metabolism in tumor biology.
  23. Purine Nucleoside Analog

    3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a purine nucleoside analog that targets DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA replication and the induction of apoptosis. Its applications in cancer research make it a valuable tool for studying purine metabolism and therapeutic strategies in oncology.
  24. Uridine Analog

    5’(R)-C-Methyluridine is a uridine analog that serves as a valuable tool in biochemical research. This compound is primarily employed to investigate potential antiepileptic effects, as well as to assess anticonvulsant and anxiolytic activities. Additionally, it holds promise in the development of novel antihypertensive agents, expanding the understanding of uridine's therapeutic applications.
  25. Purine Nucleoside Analog

    5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets the inhibition of DNA synthesis and induces apoptosis, making it valuable in the study of indolent lymphoid malignancies. Its unique structural modifications enhance its effectiveness in various cancer research applications, particularly in understanding the biology of tumor cell proliferation and survival.
  26. Purine Nucleoside Analog

    N2-iBu-2’,3’-bis-O-TBDMS guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This reagent can be utilized to elucidate the effects of nucleoside modifications on cellular processes and therapeutic responses.
  27. Purine Nucleoside Analog

    2'-Deoxy-N6-(4-methoxybenzyl)adenosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. This reagent serves as a crucial compound for studying cellular responses to nucleoside analogs and their potential in oncology.
  28. Nucleoside Metabolite

    N6-(5-Oxo-D-isoleucyl)-L-lysine is a nucleoside metabolite that serves as a key intermediate in nucleotide biosynthesis. This compound is utilized in research applications focused on metabolic pathways involving nucleotides and amino acids. Its biological activity offers insights into cellular metabolism and potential therapeutic targets for metabolic disorders.
  29. Thymidine Analog

    1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analog that targets DNA replication processes. This compound exhibits insertional activity within replicated DNA, making it a valuable tool for labeling cells and monitoring DNA synthesis. It is applicable in studies of nucleic acid dynamics and cellular proliferation.
  30. Purine Nucleoside Analog

    1,2-Di-O-acetyl-3,5-di-O-benzyl-D-xylofuranose is a purine nucleoside analog. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. The compound's anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic studies.
  31. Purine Nucleoside Analog

    1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)uridine is a purine nucleoside analog that exhibits significant antitumor activity, specifically targeting indolent lymphoid malignancies. Its primary mechanisms of action include inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic strategies against various malignancies.
  32. Purine Nucleoside Analog

    5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog known for its significant antitumor activity, particularly against indolent lymphoid malignancies. This compound primarily exerts its effects by inhibiting DNA synthesis and inducing apoptosis in cancer cells. It serves as a valuable tool in cancer research, aiding in the exploration of therapeutic strategies and the development of novel anti-cancer agents.
  33. Purine Nucleoside Analog

    2′,3′-Dideoxy-3′-fluoroadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is useful in studies focused on the therapeutic potential of nucleoside analogs and their roles in cancer treatment strategies.
  34. Purine Nucleoside Analog

    2-Amino-6-chloropurine-9-beta-D-(2’-deoxy-3’,5’-di-O-(p-toluoyl))riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound primarily functions by inhibiting DNA synthesis and promoting apoptosis, making it a valuable tool in cancer research. Its unique structural features also enable exploration of therapeutic strategies targeting purine metabolism in neoplastic cells.
  35. Cytidine Analog

    3’-beta-C-Methylcytidine is a cytidine nucleoside analog that primarily targets DNA methyltransferases. This compound demonstrates significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. It is suitable for studies focused on epigenetic regulation and therapeutic interventions aimed at altering DNA methylation patterns.
  36. Adenosine Analog

    3’-O-(2-Methoxyethyl)-2-aminoadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory properties and has demonstrated potential in inhibiting cancer progression. Research applications include studying vascular biology, exploring therapeutic avenues in oncology, and investigating the signaling pathways mediated by adenosine receptors.
  37. Purine Nucleoside Analog

    2′-Deoxy-2-hydrazinyladenosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suitable for investigating therapeutic approaches in oncology and understanding the molecular pathways involved in tumor cell proliferation and survival.
  38. Nucleoside Metabolite

    3α,7α-Dihydroxy-5β-cholestan-26-al is a nucleoside metabolite that plays a role in various biochemical pathways. This compound is involved in the metabolism of nucleosides and may exhibit significant biological activity in cellular processes. It is suitable for research applications focused on metabolic studies and the investigation of nucleoside-related mechanisms.
  39. Purine Nucleoside Analog

    TLR7 agonist 10 is a purine nucleoside analog that functions as a TLR7 activator. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. TLR7 agonist 10 is essential for research focused on cancer biology and therapeutic development.
  40. Purine Nucleoside Analog

    3’-Deoxy-O6-methyl inosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on understanding cancer biology and developing novel therapeutic strategies.
  41. Purine Nucleoside Analog

    3’-Deoxy-3’-fluoro-2-thiouridine is a purine nucleoside analog known for its significant antitumor activity. It targets indolent lymphoid malignancies and exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, enabling studies on therapeutic strategies against various malignancies.
  42. Purine Nucleoside Analog

    6-Chloro-2-iodopurine-9-riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on understanding cancer biology and developing targeted therapies.
  43. Uridine Analog

    3'-Azido-3'-deoxy-4-deoxyuridine is a uridine analog featuring an azide functional group. This compound is utilized in click chemistry applications, specifically in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. It may be instrumental in the study of anticonvulsant and anxiolytic activities, as well as in the development of new antihypertensive agents.
  44. Purine Nucleoside Analog

    2-Amino-3’-deoxy-3’-fluoroadenosine is a purine nucleoside analog that exhibits significant anticancer activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and the development of novel anticancer therapeutics.
  45. Nucleoside Metabolite

    α-Phocaecholic acid is a nucleoside metabolite that serves as a critical component in various biochemical pathways. This compound is known for its role in cellular signaling and metabolism, making it a valuable tool in research related to nucleoside functions. Its applications extend to studies in metabolic disorders and cellular processes, aiding researchers in understanding the underlying mechanisms of nucleoside metabolism.
  46. Purine Nucleoside Analog

    3′-Azido-2′,3′-dideoxy-5-hydroxyuridine is a purine nucleoside analog that exerts its effects by inhibiting DNA synthesis, thereby disrupting cellular replication. It demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies, and promotes apoptosis in cancerous cells. This compound is useful in research focused on cancer treatment and the mechanisms of chemotherapeutic agents.
  47. Purine Nucleoside Analog

    5-(Aminomethyl)-2′,3′-O-(1-methylethylidene)-2-thiouridine is a purine nucleoside analog known for its significant antitumor activity. This compound targets indolent lymphoid malignancies through mechanisms such as inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable reagent for cancer research aimed at understanding and developing therapies for lymphoid cancers.
  48. Hypoxanthine Analog

    2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog that serves as a potent modulator of various biological pathways. This compound exhibits significant anti-inflammatory properties and functions as a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor, providing cytoprotection by inhibiting PARP activity and mitigating peroxynitrite-induced mitochondrial depolarization and superoxide production. Additionally, this analog can be utilized as an indicator of hypoxia in research settings, making it valuable for studies related to cellular response under low oxygen conditions.
  49. Adenosine Analog

    3',5'-TIPS-N-Ac-Adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has potential applications in inhibiting cancer progression. It is valuable for research related to vascular biology and oncology, facilitating the study of adenosine receptor signaling pathways and their therapeutic implications.
  50. Purine Nucleoside Analog

    5-(Trifluoromethyl)cytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which can lead to apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of novel therapeutic strategies.

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