5α-Tetrahydrocorticosterone is a potent glucocorticoid receptor agonist and a metabolite of corticosterone. It exhibits significant anti-inflammatory activity when applied topically, making it valuable for studying inflammatory skin conditions. In rat hepatocyte studies, it effectively reduces metabolites that bind to the glucocorticoid receptor, demonstrating a dissociation constant (Kd) of 268 nM. This compound is suitable for research focused on the mechanisms of glucocorticoid action and its therapeutic potential in skin inflammation.
5α-Tetrahydrocorticosterone is a potent glucocorticoid receptor agonist and a metabolite of corticosterone. It exhibits significant anti-inflammatory activity when applied topically, making it valuable for studying inflammatory skin conditions. In rat hepatocyte studies, it effectively reduces metabolites that bind to the glucocorticoid receptor, demonstrating a dissociation constant (Kd) of 268 nM. This compound is suitable for research focused on the mechanisms of glucocorticoid action and its therapeutic potential in skin inflammation.
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