ZK 216348 is a selective nonsteroidal glucocorticoid receptor agonist, exhibiting an IC50 of 20.3 nM. This compound also interacts with progesterone and mineralocorticoid receptors, with IC50 values of 20.4 nM and 79.9 nM, respectively. ZK 216348 demonstrates significant anti-inflammatory properties comparable to those of Prednisolone while minimizing transactivation-related side effects, making it a valuable tool for research in inflammation and related conditions.
ZK 216348 is a selective nonsteroidal glucocorticoid receptor agonist, exhibiting an IC50 of 20.3 nM. This compound also interacts with progesterone and mineralocorticoid receptors, with IC50 values of 20.4 nM and 79.9 nM, respectively. ZK 216348 demonstrates significant anti-inflammatory properties comparable to those of Prednisolone while minimizing transactivation-related side effects, making it a valuable tool for research in inflammation and related conditions.
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