C108297 is a selective glucocorticoid receptor (GR) modulator, exhibiting a binding affinity (Ki) of 0.7 nM for GR and a functional Ki of 0.6 nM in reporter gene assays. It has demonstrated the ability to mitigate obesity by decreasing caloric intake while promoting lipolysis and fat oxidation, as well as reducing inflammation. This compound serves as a valuable tool for studying metabolic disorders and the inflammatory response in various biological contexts.
C108297 is a selective glucocorticoid receptor (GR) modulator, exhibiting a binding affinity (Ki) of 0.7 nM for GR and a functional Ki of 0.6 nM in reporter gene assays. It has demonstrated the ability to mitigate obesity by decreasing caloric intake while promoting lipolysis and fat oxidation, as well as reducing inflammation. This compound serves as a valuable tool for studying metabolic disorders and the inflammatory response in various biological contexts.
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