Catalog No.
Product Name
Application
Product Information
Citations
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mPGES-1 Inhibitor
UK4b is a selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). This compound exhibits anti-inflammatory and analgesic properties, making it a valuable tool for research on pain and inflammation. Additionally, UK4b has demonstrated the ability to inhibit the growth of abdominal aortic aneurysms in murine models, highlighting its potential applications in cardiovascular research. -
mPGES-1 Inhibitor
PF-4693627 is a potent and selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 3 nM. This compound exhibits oral bioavailability and is designed for research into inflammatory conditions, particularly those related to osteoarthritis and rheumatoid arthritis. Its ability to inhibit mPGES-1 makes it a valuable tool for investigating pathways involved in inflammation. -
mPGES-1 Inhibitor
PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting an IC50 of 16.5 nM. It effectively inhibits IL-1β-induced prostaglandin E2 (PGE2) synthesis in vitro, making it a valuable tool for studying inflammatory processes. This compound is applicable in research focused on pain, inflammation, and other related pathways. -
mPGES-1 Inhibitor
CAY10589 is a selective inhibitor of the enzyme mPGES-1, which plays a critical role in inflammatory responses. This compound is primarily utilized in research to study the mechanisms of inflammation and its associated pathways. Importantly, CAY10589 does not significantly influence the differentiation of bone marrow myeloid precursor cells into M2-like tumor-associated macrophages (TAMs), making it a valuable tool for dissecting inflammatory processes without altering macrophage polarization. -
mPGES1 Inhibitor
mPGES1-IN-9 is a selective inhibitor of the microsomal prostaglandin E synthase-1 (mPGES1) enzyme, exhibiting an IC50 value of 0.5 μM. This compound is utilized in anti-inflammatory research, facilitating studies aimed at understanding the role of mPGES1 in various inflammatory processes. Its effective inhibition makes it a valuable tool for investigating potential therapeutic strategies in inflammatory diseases. -
PGE synthase Inhibitor
mPGES1-IN-4 is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), effectively reducing PGE2 production at submicromolar concentrations. This compound demonstrates notable anti-inflammatory activity, particularly in in vivo models of acute inflammation, by selectively targeting the mPGES-1 pathway. Its application in research includes investigating the role of PGE2 in inflammatory processes and potential therapeutic interventions. -
PGE2 Inhibitior
(+)–ε-Viniferin is a stilbene compound that acts as a PGE2 inhibitor, demonstrating significant anti-inflammatory properties. This compound is orally active and has been shown to reduce fat accumulation, making it a valuable tool for research focused on inflammation and obesity. -
mPGES-1 Inhibitor
AF3442 is a selective inhibitor of mPGES-1, exhibiting an IC50 value of 0.06 μM. This compound effectively reduces PGE2 generation from monocytes, even in the presence of plasma proteins, demonstrating its practical application in biological systems. AF3442's selectivity for mPGES-1 over other prostanoids such as TXB2, PGF2α, and 6-keto-PGF1α supports its use in research focused on analgesia and inflammation pathways. -
PGE Inhibitor
mPGES1-IN-6 is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 value of 0.03 μM. By effectively blocking mPGES-1, this compound plays a crucial role in reducing prostaglandin E2 synthesis, making it valuable for studies related to inflammation and pain modulation. mPGES1-IN-6 is suitable for research applications focused on anti-inflammatory drug discovery and the investigation of related signaling pathways. -
PGE2 Synthase Inhibitor
5-trans U-44069 is a selective inhibitor of prostaglandin E2 synthase, effectively modulating the synthesis of this key inflammatory mediator. Its primary mechanism of action involves the blockade of prostaglandin E2 formation, making it a valuable tool for investigating the role of PGE2 in various biological processes. This compound is suitable for research applications related to inflammation, pain, and cardiovascular studies. -
PGE synthase Inhibitor
Friluglanstat is a selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), targeting the synthesis of prostaglandin E2. This compound exhibits anti-inflammatory activity by reducing prostaglandin levels, making it a valuable tool for investigating inflammatory pathways. It is applicable in research focused on inflammation, pain relief, and related diseases. -
mPGES-1Inhibitor
AGU661 is a potent inhibitor of Microsomal Prostaglandin E2 Synthase 1 (mPGES-1) with an IC50 of 0.22 nM. It effectively reduces PGE2 production in human pro-inflammatory M1 macrophages and activated monocytes, while sparing other lipid mediator pathways. Although AGU661 exhibits poor metabolic stability and high plasma protein binding, its incorporation into PLGA-based nanoparticles significantly enhances its bioactivity. This compound is suited for research related to inflammatory disorders. -
PGE synthase Inhibitor
mPGES1-IN-5 is a polysubstituted pyrimidine compound that serves as a selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). This compound demonstrates potent submicromolar inhibition of PGE2 production, primarily exerting its anti-inflammatory effects through mPGES-1 blockade. It is particularly useful in research related to inflammation and can be applied in various acute inflammation models in vivo to study its therapeutic potential. -
PGE Inhibitor
BRP-201 is a selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating an IC50 value of 0.42 μM. This compound exhibits potent anti-inflammatory properties, making it a valuable tool for research in inflammatory diseases. Its specificity for mPGES-1 supports its potential application in the development of next-generation anti-inflammatory therapeutics. -
5-LO/mPGES-1 Inhibitor
5-LO/mPGES1-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), exhibiting IC50 values of 0.3 μM and 0.4 μM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory pathways. Applications include studies focused on the modulation of inflammatory responses, providing insights into potential therapeutic strategies for related diseases. -
mPGES-1 Inhibitor
AGU654 is a selective mPGES-1 inhibitor with an IC50 of 2.9 nM, acting primarily on the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme. By inhibiting this enzyme, AGU654 disrupts the conversion of arachidonic acid to prostaglandin E2 (PGE2), thereby reducing inflammatory responses, pain, and fever. In cellular models, AGU654 effectively suppresses PGE2 production in response to bacterial exotoxins while maintaining the synthesis of other prostaglandins. Furthermore, in guinea pig models, it demonstrates significant anti-inflammatory, analgesic, and antipyretic properties, highlighting its potential for research in inflammatory diseases and pain management. -
PGE synthase Inhibitor
Fagaramide is a potent inhibitor of prostaglandin E synthase, demonstrating significant anti-inflammatory properties. Extracted from Zanthoxylum bungeanum, it effectively reduces carrageenan-induced foot swelling in rat models. This compound serves as a valuable tool for research into inflammation mechanisms and potential therapeutic applications targeting prostaglandin synthesis. Its biological activity is approximately 1/20 that of indomethacin, making it a noteworthy candidate for further exploration in inflammatory studies. -
PGE synthase Inhibitor
Cryogenine is an alkaloid that functions as a selective inhibitor of prostaglandin E synthase, exhibiting significant anti-inflammatory properties. With an IC50 value of 424 μM, Cryogenine effectively attenuates inflammatory responses. In experimental models, administration at doses of 100 mg/kg per day has shown a reduction in paw edema and a decreased mean arthritic index in rats with adjuvant-induced polyarthritis. This makes Cryogenine a valuable reagent for researching inflammation and related disorders. -
Pge Synthase Inhibitor
5-trans U-46619 is an inhibitor of prostaglandin E synthase, which plays a critical role in the biosynthesis of prostaglandins. At a concentration of 10 μM, 5-trans U-46619 demonstrates an inhibition of less than 20% on PGE synthase activity. This compound is suitable for research applications investigating the modulation of inflammatory pathways and the role of prostaglandins in various biological processes. -
PGE synthase Inhibitor
Suprofen L-lysine is a non-steroidal anti-inflammatory drug (NSAID) that functions primarily as a prostaglandin E synthase inhibitor. This compound exhibits significant anti-inflammatory activity, making it suitable for research applications aimed at understanding inflammation pathways and evaluating potential therapeutic strategies for inflammatory diseases. Its mechanistic insights can contribute to the development of new anti-inflammatory agents in pharmaceutical research. -
mPGES-1 Inhibitor
α-Gracinoic acid is a selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), which plays a crucial role in the synthesis of pro-inflammatory prostaglandins. This compound exhibits significant anti-inflammatory activity, making it a valuable tool in research focused on chronic inflammatory diseases. It can be utilized to explore the molecular mechanisms underlying inflammation and the potential therapeutic strategies targeting the mPGES-1 pathway. -
PGE synthase Inhibitor
FR20 is a potent inhibitor of human microsomal prostaglandin synthase 1 (mPGES-1). By selectively targeting this enzyme, FR20 effectively reduces the synthesis of pro-inflammatory prostaglandins, making it valuable in research focused on inflammation and pain pathways. This reagent is ideal for studies exploring the role of mPGES-1 in various biochemical and cellular contexts. -
PGE synthase Inhibitor
AF3485 is an inhibitor of the human microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating significant antitumor activity both in vitro and in vivo. This compound effectively targets tumor-associated angiogenesis by lowering prostaglandin E2 (PGE2) levels, inhibiting epidermal growth factor receptor (EGFR) signaling, and decreasing the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Subchronic administration of AF3485 has been shown to reduce tumor growth in mice with human A431 xenograft tumors, making it a valuable tool for cancer research. -
PGE synthase Inhibitor
mPGES1-IN-8 is a selective inhibitor of microsomal prostaglandin E synthase 1 (mPGES1), which plays a crucial role in the biosynthesis of prostaglandin E2. This compound exhibits significant anti-inflammatory properties by inhibiting the production of pro-inflammatory mediators. It is useful in research applications focused on inflammation, pain, and related pathological conditions. -
PGE synthase Inhibitor
Gingerdione is a selective inhibitor of prostaglandin E synthase, a key enzyme in the inflammatory pathway. This compound, extracted from ginger rhizomes, has demonstrated anti-inflammatory properties and can be utilized in research focused on the modulation of pain and inflammation. Its ability to inhibit prostaglandin synthesis makes it a valuable tool for studying the therapeutic potential in various inflammatory conditions. -
PGE synthase Inhibitor
Zomepirac is a potent inhibitor of prostaglandin E synthase, acting as a non-steroidal anti-inflammatory drug (NSAID). It effectively suppresses prostaglandin biosynthesis, which is integral to inflammatory processes. Zomepirac has been used in research to explore its anti-inflammatory properties and may be relevant in studies assessing immune-mediated liver injury. -
PSMA Inhibitor
Zadavotide guraxetan is a potent inhibitor of prostate-specific membrane antigen (PSMA). This compound is utilized in SPECT/CT imaging, providing valuable insights into the cellular profiles of triple-negative breast cancer and prostate cancer. Its application in radionuclide studies underscores its significance in cancer research and therapeutic development. -
PSMA Inhibitor
Tert-Butyl-DCL is a potent inhibitor of Prostate-Specific Membrane Antigen (PSMA), a crucial target in prostate cancer research. Its inhibition of PSMA activity makes Tert-Butyl-DCL a valuable tool for studying the molecular mechanisms of prostate cancer progression and therapeutic interventions. This compound is ideal for applications in cancer biology and the development of PSMA-targeted therapies. -
PSMA Imaging Agent
EC0652 is a potent PSMA imaging agent designed for SPECT imaging applications. It enables the detection and visualization of prostate-specific membrane antigen (PSMA) expression, making it a valuable tool in research focused on metastatic castration-resistant prostate cancer. This compound enhances the understanding of tumor biology and may aid in the development of targeted therapeutic strategies. -
PSMA Modulator
Flotufolastat is a prostate-specific membrane antigen (PSMA) modulator that serves as a radiodiagnostic agent for imaging prostate cancer. This compound is instrumental in enhancing the detection and characterization of prostate cancer lesions. Flotufolastat is valuable for research applications focused on prostate cancer and other malignancies associated with PSMA expression. -
PSMA Ligand
PSMA binder-1 is a potent ligand targeting Prostate-Specific Membrane Antigen (PSMA). It facilitates the synthesis of PSMA-targeting molecules, such as Ac-PSMA-trillium, providing a valuable tool for research in prostate cancer diagnosis and therapy. This compound is essential for studies focused on imaging and targeted treatment strategies aimed at PSMA-expressing tumors. -
Contrast Agent
Piflufolastat is a positron emission tomography (PET) imaging agent that specifically targets prostate-specific membrane antigen (PSMA). Labeled with fluorine-18, Piflufolastat F-18 serves as a diagnostic tool for the visualization of prostate cancer. Its application in molecular imaging enables enhanced detection and monitoring of prostate malignancies, supporting research and clinical decision-making in oncology. -
PSMA Ligand
PSMA-azide is a ligand targeting prostate-specific membrane antigen (PSMA). It effectively inhibits PSMA-dependent hydrolysis of N-acetylaspartylglutamic acid (NAAG) with an IC50 of 9 nM and a Ki of 1 nM, making it a valuable tool for studying PSMA-related pathways. Additionally, PSMA-azide features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkynyl-containing molecules, facilitating various biochemical labeling and conjugation applications in research. -
Active Intermediate
Glu-urea-Glu-NHS ester is an activated N-hydroxysuccinamide (NHS) ester of the Glu-urea-Glu compound. It serves as a versatile active intermediate in the synthesis of small-molecule inhibitors targeting prostate-specific membrane antigen (PSMA). This reagent is valuable for developing imaging agents, such as PSMAi-PEG conjugates, and enhancing the efficacy of targeted drug delivery systems in research applications. -
GCPII Inhibitor
GCPII-IN-1 is a potent inhibitor of the gene carboxypeptidase II (GCPII), also recognized as prostate-specific membrane antigen (PSMA), with a Ki value of 44.3 nM. This compound is primarily utilized in the research of prostate cancer, facilitating studies aimed at understanding tumor biology and developing potential therapeutic strategies. Its mechanism of action makes it a valuable tool for elucidating the role of GCPII in cancer progression. -
GCPII Inhibitor
GCPII-IN-1 TFA is a selective inhibitor of GCPII (glutamate carboxypeptidase II), also known as prostate-specific membrane antigen (PSMA), exhibiting a Ki value of 44.3 nM. This compound is instrumental in the investigation of prostate cancer, facilitating studies on the modulation of GCPII activity and its potential therapeutic applications in oncology. Researchers can utilize GCPII-IN-1 TFA to explore mechanisms of tumor growth and treatment resistance in prostate cancer models. -
PSA Substrate
Prostate Specific Antigen Substrate is a fluorescent substrate utilized for the detection of enzymatic activity associated with prostate specific antigen (PSA). This reagent enables researchers to effectively measure PSA activity, aiding in the study of prostate cancer and other related conditions. Its application in various assays facilitates enhanced understanding of PSA's role in oncology research. -
PSMA-Targeted Maytansinoid
EC1169 is a PSMA-targeted maytansinoid conjugate that selectively binds to prostate-specific membrane antigen (PSMA). This compound delivers the cytotoxic maytansinoid B hydrazide payload directly to PSMA-positive tumor cells, demonstrating significant antitumor activity while sparing PSMA-negative cells. In preclinical models, EC1169 promotes complete recovery in mice with PSMA-positive tumors, exhibiting a favorable safety profile without inducing body weight loss or major organ damage. This reagent is valuable for research focused on prostate cancer and other PSMA-expressing malignancies. -
PSMA ligand
PNT2001 is a potent prostate-specific membrane antigen (PSMA) ligand, exhibiting an IC50 of 3.1 nM. This compound enhances cellular internalization, making it a valuable tool for targeting PSMA in prostate cancer research. Additionally, PNT2001 can be labeled with 177Lu and 225Ac, facilitating the development of radiolabeled therapies for prostate cancer treatment and diagnostic applications. -
Precursor
PSMA I&S is a key precursor for the synthesis of 99mTc-labeled PSMA-targeting ligands. This compound facilitates the generation of radiolabeled agents that selectively bind to the prostate-specific membrane antigen (PSMA), making it valuable for imaging and therapeutic applications in prostate cancer research. Its role in the development of novel radiopharmaceuticals enhances the ability to study PSMA expression in various biological contexts. -
PSMA Near-infrared Optical Probe
Zopocianine is a near-infrared optical probe targeting prostate-specific membrane antigen (PSMA). This compound selectively binds to PSMA expressed on the surface of cancer cells, facilitating receptor-mediated endocytosis and subsequent accumulation within acidic endosomes. Zopocianine is particularly effective for visualizing small tumors, primary prostate tumors, and locoregional metastases, making it a valuable tool in fluorescence-guided surgery for achieving negative tumor margins. Its applications are primarily in the field of prostate cancer research. -
PSMA Ligand
PSMA binder-2 is a potent ligand targeting Prostate-Specific Membrane Antigen (PSMA), facilitating the synthesis of Ac-PSMA-trillium, which exhibits enhanced binding and pharmacokinetic properties. This versatile compound can be modified with various radioactive isotopes for different applications; when labeled with 111In, it serves effectively as a DOTA chelating and imaging agent. Alternatively, when conjugated with 225Ac, it acts as a Macropa chelator, proving valuable for targeted radionuclide therapy (TRT) in the research of metastatic castration-resistant prostate cancer (mCRPC). -
PSMA Radioactive Inhibitor
PSMA–DA1 is a radioactive inhibitor targeting Prostate-Specific Membrane Antigen (PSMA). It serves as a promising radiotheranostic agent for imaging and treating PSMA-expressing tumors. Its specificity for PSMA makes it a valuable tool in the research of prostate cancer diagnosis and therapy, enabling the development of effective targeted treatment strategies. -
PSMA Inhibitor
MIP-1072 is a selective inhibitor of prostate-specific membrane antigen (PSMA) that targets the enzyme's glutamate carboxypeptidase activity. With a Ki value of 4.6 nM, MIP-1072 demonstrates significant potency in inhibiting PSMA, making it a valuable tool in prostate cancer research. Its application is particularly relevant for studies focused on the role of PSMA in tumor progression and targeted therapies. -
PSA-activated Protoxin
Topsalysin is a PSA-activated protoxin that functions as a pore-forming protein, specifically a synthetic proaerolysin fusion protein modified to target human prostate-specific antigen (PSA). It demonstrates significant tumor-suppressive effects in mouse models, making it a valuable tool for studying prostate cancer biology. Its unique mechanism allows for selective targeting of PSA-expressing tissues, providing insights into therapeutic approaches for prostate cancer treatment. -
PSMA Ligand
PSMA Ligand 1 is a potent PSMA ligand that exhibits an IC50 of 26.74 nM. This compound has been radiolabeled with [18F], making it a suitable candidate for use as a PET tracer in imaging studies. Its primary applications include aiding in the diagnosis and monitoring of prostate cancer, facilitating innovative research in oncology and molecular imaging. -
PSMA Ligand
PDI2 (PSMA-DOTA-PEI2) is a prostate-specific membrane antigen (PSMA) ligand that functions as a tumor retention agent and imaging agent while reducing renal uptake. It selectively binds to PSMA on prostate cancer cells, facilitating entry through clathrin-dependent endocytosis, which results in increased tumor retention and decreased renal accumulation. PDI2 is valuable for research in prostate cancer and castration-resistant metastatic prostate cancer, particularly in the context of SPECT diagnostic imaging and radiotheranostics. -
PSMA Inhibitor
MIP-1095 is a potent inhibitor of prostate-specific membrane antigen (PSMA), specifically targeting its glutamate carboxypeptidase activity with a Ki of 0.24 nM. This compound is valuable in research applications focused on prostate cancer, facilitating studies on PSMA's role in tumor progression and its potential as a therapeutic target. MIP-1095 is essential for the development of PSMA-targeted diagnostics and therapeutics. -
PSMA Inhibitor
PSMA-IN-4 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting an IC50 value of 1.2 μM. This compound effectively interferes with PSMA activity, making it a valuable tool in research focused on prostate cancer diagnostics and therapeutics. Its specificity and potency support investigations into PSMA's role in tumor biology and its potential as a therapeutic target. -
Anti-PSMA Antibody
Capromab is a monoclonal antibody targeting the intracellular domain of prostate-specific membrane antigen (PSMA). It exhibits specificity for necrotic cells with compromised membranes and does not undergo internalization upon binding. Capromab is utilized in research focused on prostate cancer, aiding in studies related to tumor progression and targeted therapies.
