Catalog No.
Product Name
Application
Product Information
Citations
-
Sesquiterpene Lactone Dimer
Ainsliadimer A is a sesquiterpene lactone dimer derived from Ainsliaea macrocephala, characterized by its unique carbon skeleton. It functions as an inhibitor of nitric oxide production in cells stimulated by lipopolysaccharides (LPS). This compound is valuable for research applications involving inflammation and immune response modulation. -
Anti-inflammatory Agent
Balanophonin B is a selective inhibitor of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, exhibiting an IC50 of 1.46 μg/mL. Isolated from Lithocarpus pachylepis, this compound effectively reduces NO production in LPS-stimulated RAW264.7 macrophages, demonstrating significant anti-inflammatory activity. Balanophonin B is valuable for anti-inflammatory drug development and serves as a tool in the biological activity research of natural lignan compounds. -
Anti-inflammatory/Antitumor Agent
Rabdoternin E is an ent-kaurane-type diterpenoid known for its anti-inflammatory and antitumor properties. It effectively inhibits nitric oxide production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with an IC50 of 2.3 μM. Additionally, Rabdoternin E demonstrates cytotoxicity against human tumor cell lines, HL-60 and SW-480, with IC50 values of 2.6 μM and 4.1 μM, respectively. This compound can be naturally sourced from the aerial parts of Isodon rosthornii, a member of the Lamiaceae family. -
NO Synthase Inhibitor
Cycloneroside B is a novel sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase, effectively reducing nitric oxide production with an IC50 value of 50.7 µM. This compound is significant for research in the anti-inflammatory domain, providing valuable insight into pathways and mechanisms associated with inflammation. Its unique structure and activity make it a relevant tool for investigators exploring nitric oxide's role in various biological processes. -
NO Production Inhibitor
Idesin is a nitric oxide production inhibitor derived from the fruits of Idesia polycarpa. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide synthesis while exhibiting minimal cytotoxic effects. This compound is valuable in research applications focused on inflammation, immune response modulation, and studies exploring the roles of nitric oxide in various biological processes. -
Steroidal Compound
Cyathisterol is a steroidal compound that functions by inhibiting lipopolysaccharide (LPS)-induced nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research focused on inflammatory diseases. Its ability to modulate nitric oxide levels provides a potential therapeutic avenue for understanding and treating related pathologies. -
NO Synthase Inhibitor
KLYP961 is a selective, orally active dual inhibitor of inducible and neuronal nitric oxide synthase (IC50 = 50-400 nM). This compound effectively reduces endotoxin-induced increases in plasma nitrates and alleviates pain behaviors in a mouse formalin model. KLYP961 is also shown to mitigate carrageenan-induced edema and inflammatory hyperalgesia, as well as the writhing response provoked by phenylbenzoquinone. It is suitable for research focused on neurological diseases and related inflammatory conditions. -
iNOS Inhibitor
iNOs-IN-3 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 3.342 µM. This compound exhibits significant anti-inflammatory effects and is applicable in research related to LPS-induced acute lung injury (ALI). Its ability to modulate nitric oxide production makes it a valuable tool for exploring inflammatory pathways and potential therapeutic interventions. -
NO Production Inhibitor
iNOS-IN-2 is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing nitric oxide (NO) production with an IC50 of 6.4 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into chronic inflammatory conditions. Its ability to modulate NO levels positions iNOS-IN-2 as an important reagent for studying the roles of iNOS in various biological processes and potential therapeutic interventions. -
NOS Inhibitor
L-ENIPO hydrochloride is a selective inhibitor of nitric oxide synthases (NOS), specifically targeting inducible NOS (iNOS), neuronal NOS (nNOS), and endothelial NOS (eNOS) with Ki values of 17, 10.3, and 58.2 μM, respectively. It demonstrates reversible, tight-binding inhibition with a preference for iNOS, particularly at extended incubation periods. This compound is valuable in research applications focused on inflammation, neurodegenerative diseases, and vascular biology, providing insight into the role of nitric oxide in various physiological and pathological processes. -
Active Compound
Paneolilludinic acid is an active compound derived from the endolichenic fungus Cryptomarasmius aucubae. It is known to significantly inhibit the production of nitric oxide (NO), making it a valuable reagent for studies focused on inflammatory responses. This compound can be utilized in research applications exploring pathways involving nitric oxide and its role in various biological processes. -
Anti-inflammatory Agent
2-Oxostenine is a stenine-type alkaloid that exhibits anti-inflammatory properties. It has been shown to weakly inhibit lipopolysaccharide-induced nitric oxide production, thereby contributing to its potential role in managing inflammatory responses. This compound is suitable for research applications focused on understanding inflammation and evaluating novel anti-inflammatory agents. -
iNOS Inhibitor
Cindunistat (hydrochloride) maleate is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS). This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory diseases and associated pathways. Its oral bioavailability facilitates its use in in vivo studies, enabling deeper exploration of iNOS's role in various biological contexts. -
NO Synthase Inhibitor
Cycloneroside E is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. It demonstrates significant inhibitory activity on nitric oxide production, with an IC50 value of 48.0 µM in RAW 264.7 macrophage cells. This compound is valuable for research in the field of anti-inflammatory therapeutics, providing insights into the modulation of nitric oxide levels in inflammatory responses. -
NO Synthase Inhibitor
(-)-10,11-Dihydroxyfarnesol is a potent nitric oxide synthase inhibitor derived from the endolichenic fungus Cryptomarasmius aucubae. This compound demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying NO-related biological pathways and mechanisms. Its applications include research into vascular biology, neurobiology, and inflammation where modulation of nitric oxide signaling is critical. -
iNOS Inhibitor
Juncutol is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing iNOS protein expression stimulated by lipopolysaccharide (LPS). This compound plays a significant role in studies targeting inflammatory pathways, making it valuable for research in conditions characterized by excessive nitric oxide production, such as sepsis and neurodegenerative diseases. Its ability to modulate iNOS activity positions Juncutol as a crucial tool in understanding the regulation of nitric oxide in various biological contexts. -
Anti-Inflammatory Agent
PPM-18 (NSC 73233) is a potent anti-inflammatory agent that inhibits nitric oxide synthase (iNOS) expression by preventing NF-κB from binding to its promoter. This compound has demonstrated the ability to induce autophagy and apoptosis in bladder cancer cells, mediated through reactive oxygen species (ROS) and AMP-activated protein kinase (AMPK) signaling pathways. PPM-18 is valuable for researchers studying inflammation and cancer therapeutics. -
NO Synthase Inhibitor
Isophysalin A is a potent inhibitor of inducible nitric oxide synthase (iNOS), targeting multiple cysteine residues on IKKβ and effectively diminishing nitric oxide (NO) production. Its mechanism involves binding to glutathione (GSH), which contributes to its anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 46, a potent nitric oxide (NO) inhibitor, targets inducible nitric oxide synthase (iNOS) to modulate inflammatory responses. This compound demonstrates significant anti-inflammatory activity, effectively reducing swelling in murine models at a dosage of 10 mg/kg. It is a valuable tool for researching the mechanisms of inflammation and potential therapeutic applications in inflammatory diseases. -
NO Inhibitor
8A8 is a potent inhibitor of nitric oxide (NO) with an IC50 value of 4.7 μM. This compound effectively suppresses lipopolysaccharide (LPS)-induced proliferation of HaCat cells, demonstrating significant anti-inflammatory effects. 8A8 is useful for research applications focused on understanding NO's role in inflammatory processes and related cellular responses. -
NO Donor
BNN3 is a caged nitric oxide (NO) donor that is membrane-permeant and integrates into lipid membranes. This compound facilitates the controlled release of nitric oxide, allowing for precise modulation of NO-dependent signaling pathways. BNN3 is valuable for research applications focused on studying NO's role in various biological processes, including vascular biology and neurobiology. -
Anti-heart Failure Agent
Anti-Heart Failure Agent 2 targets inflammatory mechanisms associated with heart failure. Derived from processed Cornus officinalis, this compound exhibits significant anti-inflammatory activity by inhibiting nitric oxide release in LPS-induced RAW264.7 macrophages. It demonstrates protective effects against myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves histopathological changes in cardiac tissues. This agent is a valuable tool for research focused on heart failure mechanisms and therapeutic interventions. -
NO Synthase Inhibitor
Harzianol M is a potent nitric oxide synthase inhibitor derived from Trichoderma sp. SCSIOW21. This compound effectively reduces nitric oxide production, demonstrating significant anti-inflammatory properties. Harzianol M is useful in research applications focused on inflammation-related pathways and nitric oxide modulation. -
Stilbenoid Compound
Isoarundinin I is a stilbenoid compound known for its biological activity against various cellular targets. This compound exhibits antioxidant properties and has potential applications in research related to cancer biology and neuroprotection. Isoarundinin I can be isolated from Arundinaria bambusifolia, making it a valuable reagent for studies investigating the therapeutic potential of stilbenoids in disease models. -
NOS Inhibitor
S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain. -
NO Production Inhibitor
Lethedoside A is a natural flavonoid identified as an inhibitor of nitric oxide (NO) production, specifically targeting lipopolysaccharide (LPS)-induced pathways in RAW 264.7 cells. Its primary biological activity involves the modulation of inflammatory responses, making it a valuable tool for research into nitric oxide signaling and inflammatory diseases. This compound is applicable in studies exploring mechanisms of immune regulation and the development of anti-inflammatory strategies. -
NO and H₂S Dynamic Alternating Probe
BOD-NH-SC is a dual-response fluorescent reporter molecule designed for the simultaneous detection of nitric oxide (NO) and hydrogen sulfide (H₂S) in living cells through activatable near-infrared (NIR) II fluorescence, with a primary absorption peak at 664 nm. This reagent enables dynamic monitoring of NO and H₂S fluctuations, providing valuable insights into cellular signaling pathways. It is particularly suitable for applications in biochemistry, cell biology, and physiology related to redox biology and gasotransmitter research. -
Nitric Oxide Synthase Inhibitor
ONO-1714 is an orally active inhibitor of nitric oxide synthase, which plays a crucial role in nitric oxide production. This compound demonstrates significant biological activities, including the attenuation of endotoxin-induced acute lung injury, reduction of intestinal ischemia-reperfusion injury, and repression of biliary carcinogenesis. It is a valuable reagent for research applications focusing on inflammatory responses and tissue protection mechanisms. -
Anti-inflammatory Triterpenoid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is an anti-inflammatory triterpenoid that effectively inhibits nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated Raw264.7 macrophages. This compound is particularly relevant for research investigating the modulation of inflammatory pathways, making it a valuable tool for studies focused on inflammatory diseases and therapeutic development. Its mechanism of action supports exploration into potential anti-inflammatory therapies. -
NO Synthase Inhibitor
S-MTC is a selective inhibitor of type I nitric oxide synthase (NOS), primarily targeting the enzymatic production of nitric oxide. This compound has been shown to effectively modulate nitric oxide levels in various biological systems and is valuable for studies investigating vascular function, neurobiology, and inflammation. S-MTC serves as a crucial tool in research aimed at understanding the role of nitric oxide in physiological and pathological processes. -
NO Inhibitor
(-)-Cryptamide C is a potent inhibitor of nitric oxide (NO) production. Derived from the Periostracum cicadae, this dopamine enantiomer trimer demonstrates significant anti-inflammatory activity. It serves as a valuable tool for studying inflammatory diseases and their underlying mechanisms. -
NO Synthase Inhibitor
nNOS-IN-5 is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki value of 22 nM. This compound demonstrates remarkable selectivity, exhibiting a 900-fold preference for nNOS over human endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is suitable for research applications related to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, providing valuable insights into nNOS's role in neurobiology and associated pathologies. -
iNOS Inhibitor
2-Iminopiperidine hydrochloride is a potent inhibitor of inducible nitric oxide synthase (iNOS). This compound is utilized in research to explore nitric oxide-mediated processes in various conditions, including arthritis, inflammatory bowel disease, diabetes, allodynia, and cerebral ischemia, as well as other central nervous system disorders. Its role in modulating nitric oxide production makes it a valuable tool for investigating the underlying mechanisms of inflammation and neuroprotection. -
NOS Inhibitor
L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications. -
NO Releasing Agent
FR144420 is an orally active nitric oxide (NO)-releasing agent that primarily induces vasodilation and inhibits platelet aggregation through cGMP-mediated mechanisms. This compound demonstrates notable vasodilatory and antiplatelet effects, making it a valuable tool in cardiovascular research. Its potential applications include studies related to angina pectoris and coronary artery spasm, contributing to a better understanding of cardiovascular diseases. -
NO Production Inhibitor
Bisacurone is a natural terpenoid that acts as a nitric oxide production inhibitor. It demonstrates potent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production, with an IC50 value of 29.8 μM. Bisacurone is useful in research settings focused on inflammation and related pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes. -
NO Production Inhibitor
Nitric oxide production-IN-1 is a potent inhibitor of nitric oxide (NO) synthesis, isolated from Tupistra chinensis. It effectively reduces NO production in rat abdominal macrophages stimulated by lipopolysaccharide (LPS). This compound is valuable for research applications investigating inflammatory processes and the regulation of nitric oxide in various biological contexts. -
Anti-inflammatory Agent
Anti-inflammatory agent 80 (Compound 2/2f) is an effective anti-inflammatory compound that also exhibits notable anti-tumor activity. Isolated from Cynanchum limprichtii Schltr., this agent is valuable for research in inflammation and cancer biology. Its ability to modulate inflammatory responses makes it a potential candidate for further studies in therapeutic applications related to inflammatory diseases and tumor progression. -
iNOs Inhibitor
iNOs-IN-7 is a potent inhibitor of inducible nitric oxide synthase (iNOS), a critical enzyme involved in the production of nitric oxide during inflammatory responses. This compound has demonstrated efficacy in modulating inflammatory pathways and is valuable for research applications related to inflammatory diseases and pain management. Its use may facilitate the exploration of therapeutic strategies targeting iNOS in various pathological conditions. -
Metabolic Agent
Tiazotic acid is a metabolic agent that primarily functions as an immunomodulator. It exhibits significant anti-inflammatory, antioxidant, and cardioprotective properties while enhancing endothelial nitric oxide synthase (eNOS) levels. Additionally, Tiazotic acid lowers D-dimer levels in circulation, mitigating the risks associated with thromboembolic events, such as heart attacks and strokes, particularly in post-COVID syndrome. Its diverse biological activities make it a valuable tool in cardiovascular and metabolic research. -
NO Production Inhibitor
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide is a potent nitric oxide (NO) production inhibitor, primarily targeting lipopolysaccharide-activated macrophages. As a metabolite of Neoandrographolide, it exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory responses and related pathways. Its ability to modulate NO levels in immune cells supports investigations into various conditions involving excessive inflammation and immune dysregulation. -
iNOS Inhibitor
Hirundigoside E is an iNOS inhibitor that exhibits significant anti-inflammatory activity. It effectively suppresses lipopolysaccharide (LPS)-induced iNOS protein expression in macrophages. This compound is suitable for research focused on understanding and mitigating inflammatory diseases. -
Anti-Inflammatory Agent
Randaiol is an anti-inflammatory agent derived from the stem bark of Magnolia officinalis, exhibiting significant antioxidant properties. This compound effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production, thereby mitigating inflammatory responses. Randaiol is valuable for research applications focused on inflammation pathways and oxidative stress regulation. -
Anti-heart Failure Agent
Anti-Heart Failure Agent 3 is an anti-heart failure compound that exhibits anti-inflammatory properties derived from processed Cornus officinalis. This agent effectively inhibits nitric oxide (NO) release in LPS-induced RAW264.7 macrophage cells. Additionally, Anti-Heart Failure Agent 3 mitigates myocardial ischemia-reperfusion injury, decreases myocardial infarction size, and enhances histopathological outcomes in cardiac tissues. It presents significant potential for research focused on heart failure mechanisms and therapeutic approaches. -
NO Synthase Inhibitor
Inflexuside B is an abietane diterpenoid that functions as a potent inhibitor of nitric oxide (NO) synthase. Isolated from the aerial parts of Isodon inflexus, Inflexuside B demonstrates significant inhibitory activity against LPS-activated NO synthase in RAW264.7 macrophages. This compound serves as a valuable tool in research focused on inflammatory pathways and nitric oxide-related signaling mechanisms. -
NOS Inhibitor
hnNOS-IN-2 is a selective inhibitor of human neuronal nitric oxide synthase (hnNOS), demonstrating excellent metabolic stability. This compound is primarily utilized in research focusing on neurodegenerative diseases, offering insights into the role of nitric oxide in neuronal function and pathology. Its inhibition capability provides a valuable tool for studying the therapeutic potential in various neurological disorders. -
nNOS Inhibitor
NOS-IN-4 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with an IC50 value of 4.00 μM, effectively reducing nNOS enzyme activity. It has been shown to offer neuroprotective effects, particularly in the context of MPTP-induced dopamine depletion in murine models. This compound is valuable for studying neurodegenerative disorders and the associated pathophysiological mechanisms. -
NO Inhibitor
Physalin O is a natural compound derived from Physalis angulata, functioning primarily as a nitric oxide (NO) inhibitor. It exhibits notable cytotoxicity against Hep G2 and MCF-7 cancer cell lines, with IC50 values of 31.1 µM and 11.4 µM, respectively. In addition to its anti-cancer properties, Physalin O demonstrates significant anti-inflammatory activities through the inhibition of NO production, making it a valuable tool in related research applications. -
Inactive Isomer
D-NMMA acetate is an inactive isomer of L-NMMA, which functions as a nitric oxide synthase inhibitor. While D-NMMA acetate does not exhibit the same biological activity as its active counterpart, it serves as a useful tool in research applications aimed at understanding nitric oxide signaling pathways and the physiological effects of nitric oxide modulation. Its role is significant in studies evaluating the impact of L-NMMA in various experimental settings.
