Catalog No.
Product Name
Application
Product Information
Citations
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TpoR Agonist
Totrombopag choline is a potent thrombopoietin receptor (TpoR) agonist that effectively stimulates megakaryocyte growth and platelet production. By activating TpoR, it triggers a signaling cascade involving JAK2 kinase and Stat5, which plays a crucial role in megakaryocyte differentiation. This compound is valuable for research focused on platelet biology and the mechanisms regulating thrombopoiesis. -
TLR7 Agonist
SMU-L11 is a selective TLR7 agonist with an EC50 of 0.024 μM, which engages the MyD88 adapter protein to activate downstream NF-κB and MAPK signaling pathways. This compound significantly enhances immune cell activation in murine models, promoting the proliferation of CD4+ T and CD8+ T cells, leading to direct tumor cell lysis and inhibition of tumor growth. SMU-L11 is a valuable reagent for cancer research and can also be utilized for investigations into immune system-related diseases. -
TLR4/HCN Inhibitor
HCN-IN-1 is a TLR4 inhibitor and modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, specifically targeting HCN2 and HCN4. It effectively inhibits TLR4-mediated signaling, evidenced by reduced alkaline phosphatase activity. HCN-IN-1 modulates HCN2 currents by shifting the voltage-dependent activation to hyperpolarized potentials and slowing activation kinetics, while also blocking currents through HCN4 channels. This compound demonstrates significant analgesic, anti-inflammatory, and anti-anginal properties, making it valuable for research into inflammatory pain, neuropathic pain, heart failure, and related inflammatory conditions. -
Anti-CD33 Antibidy
Vadastuximab is a humanized monoclonal antibody that selectively targets CD33, a cell surface protein predominantly expressed on myeloid cells and acute myeloid leukemia (AML) cells. This antibody is instrumental in the development of antibody-drug conjugates (ADCs) designed for targeted therapeutic applications. Research indicates that Vadastuximab can enhance the efficacy of cancer treatments by delivering cytotoxic agents directly to CD33-expressing tumors, thereby promoting precise tumor eradication while minimizing off-target effects. -
CD33 Splicing Modulator
CD33 Splicing Modulator 1 is an innovative agent that targets the CD33/Siglec 3 receptor, a crucial regulator of microglial activity in the myeloid lineage. This compound enhances exon 2 skipping in cellular mRNA, thereby altering CD33 expression. It holds promise as a research tool in neurodegenerative disease studies, particularly in the context of Alzheimer's disease, facilitating a deeper understanding of the underlying mechanisms of these conditions. -
FKBPL Peptide
AD 01 is a 24-amino acid peptide derived from FKBPL (FK506-binding protein like), targeting the CD44 receptor to exert significant anti-angiogenic effects. By binding to CD44, AD 01 effectively inhibits tumor cell migration in a manner dependent on this receptor. This peptide is valuable for research applications focused on cancer biology, particularly in studies related to angiogenesis and tumor metastasis. -
MR1 Antigen
Photolumazine III is an MR1 (MHC class I-related molecule 1) antigen, which plays a crucial role in the immune response by presenting antigenic metabolites to T cells. This compound exhibits biological activity related to the activation of MR1-restricted T cell responses, thus serving as a valuable tool for studying immune mechanisms and developing immunotherapies. Research applications include the investigation of microbial and tumor-associated antigens, as well as the modulation of immune responses in various disease models. -
Anti-EpCAM/TROP1/CD326 Antibody
Varsetatug is a humanized IgG1κ monoclonal antibody that targets the epithelial cell adhesion molecule (EpCAM), also known as TROP1 or CD326. This antibody exhibits significant antitumor activity, making it a valuable tool for studying various malignancies, including breast, prostate, and ovarian cancers. Varsetatug is instrumental in cancer research, particularly in investigating therapeutic approaches that exploit EpCAM pathways. -
CD8 T Cell Epitope
TYVPANASL is a MHC I-binding CD8 T cell epitope derived from the HER2/neu protein. This nine-amino-acid peptide plays a crucial role in stimulating CD8 T cell responses, making it valuable in immunological studies and vaccine development. TYVPANASL can be utilized in the preparation of J-LEAPS vaccines, contributing to cancer immunotherapy research. -
CD36 Ligand
KDdiA-PC is a highly potent ligand for CD36, primarily targeting the receptor that mediates the cellular response to oxidized low-density lipoprotein (oxLDL). Its significant biological activity facilitates studies on lipid metabolism, inflammation, and atherosclerosis. KDdiA-PC is valuable for researchers investigating the role of CD36 in various physiological and pathological processes. -
CD63-binding Peptide
CP05 is a CD63-binding peptide that specifically interacts with the exosome surface marker CD63. This interaction facilitates the anchoring of exosomes to target tissues, enhancing in vivo delivery of exosomal payloads. CP05 is useful in research applications focused on drug delivery, therapeutic targeting, and the study of exosome biology. -
CD36 Peptide
CD36 Peptide P (139-155), Cys conjugated targets the CD36 protein and serves as a crucial tool for studying its function. This Cys-conjugated peptide is effective in inhibiting the immunoadsorption of CD36 by the OKM5 antibody, making it valuable for research applications focused on immune responses and metabolic processes. The peptide can aid in the investigation of CD36-related pathways and its role in various biological contexts. -
Anti-PD-1/TIGIT Antibody
Nilvanstomig is an anti-PD-1/TIGIT antibody that targets the PD-1/TIGIT pathway, thereby facilitating T cell activation and enhancing natural killer (NK) cell anti-tumor activity. This compound is particularly relevant in the study of advanced cervical cancer and contributes to research focused on immune modulation and cancer immunotherapy. Its mechanism of action underscores its potential for strengthening anti-tumor responses in various oncological contexts. -
CD36 Peptide
CD36 Peptide P (93-110), Cys conjugated specifically targets CD36, a multifunctional receptor involved in cellular adhesion and lipid metabolism. This peptide has been shown to block the binding of CD36 to immobilized thrombospondin, thereby providing valuable insights into CD36-mediated pathways. Additionally, it partially inhibits collagen-induced platelet aggregation, making it useful for research applications related to cardiovascular function and cell signaling. -
Anti-CD326/EPCAM Antibody
Anti-CD326/EPCAM Antibody (3622W94) is a humanized antibody that specifically targets the epithelial cell adhesion molecule (EpCAM/CD326), a key player in cell-cell adhesion and signaling. This antibody is suitable for research applications focused on various epithelial cancers, including pancreatic, prostate, and breast cancer. Its ability to interfere with tumor progression and metastasis makes it a valuable tool for studies in cancer biology and therapeutic development. -
Anti-CEACAM5/CEA/CD66e Antibody
Altumomab is a human monoclonal antibody that selectively targets CEACAM5 (carcinoembryonic antigen, CEA) and CD66e. This antibody is primarily utilized in cancer research, particularly for tumor identification and immunotherapy applications. Its specificity for CEACAM5 makes it a valuable tool in the study of various malignancies, enabling enhanced detection and therapeutic strategies against CEA-expressing tumors. -
CD33 Splicing Modulator
CD33 splicing modulator 1 hydrochloride is a small molecule modulator that targets CD33/Siglec 3, a myeloid cell surface receptor that regulates microglial activity. This compound promotes exon 2 skipping in cellular mRNA, making it a valuable tool for investigating the molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease. It provides researchers with a means to explore potential therapeutic approaches through modulation of splicing events related to CD33. -
COX Inhibitor
SC57666 is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 26 nM. This compound exhibits anti-inflammatory activity by specifically blocking COX-2, thereby reducing prostaglandin synthesis. SC57666 is valuable for research applications focused on understanding inflammation and pain mechanisms, as well as for screening in drug discovery efforts targeting COX-2 related conditions. -
COX Inhibitor
FR-188582 is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 17 nM. This compound exhibits potent anti-inflammatory activity, making it a valuable tool for studies related to pain and inflammation pathways. Its specificity for COX-2 allows for the exploration of therapeutic applications in conditions such as arthritis and other inflammatory diseases. -
COX Inhibitor
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor known for its nitric oxide (NO)-donating properties. It effectively modulates increased intrahepatic vascular tone, making it a valuable tool in studying portal hypertension and liver diseases. This compound is utilized in research contexts focused on the therapeutic mechanisms of COX inhibition and its impact on hepatic vascular dynamics. -
Anti-Inflammatory Agent
Apyramide is an anti-inflammatory agent that acts as a prodrug of indomethacin. It serves as a potent and nonselective inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting significant blood-brain barrier permeability. Apyramide is primarily utilized in research applications focused on inflammation modulation and pain relief. -
COX Inhibitor
RWJ 63556 is an orally active inhibitor of cyclooxygenase-2 (COX-2) and a 5-lipoxygenase inhibitor, exhibiting significant anti-inflammatory properties. This compound is utilized in research to explore its potential therapeutic effects in conditions characterized by inflammation, such as arthritis and other inflammatory diseases. Its selective inhibition may provide insights into the role of COX-2 and lipoxygenase pathways in various biological processes. -
Anti-inflammatory agent
Ketoprofen (lysinate) is a non-steroidal anti-inflammatory agent primarily targeting cyclooxygenase enzymes. It exhibits potent inhibitory activity with IC50 values of 2 nM for COX-1 and 26 nM for COX-2. This compound is valuable for research applications in inflammation, immunology, and metabolic diseases such as obesity, making it an essential tool for exploring pathways in these biological contexts. -
COX Inhibitor
COX-2-IN-6 is a selective cyclooxygenase-2 (COX-2) inhibitor, specifically designed for oral administration and exhibiting gut-restricted properties. With an IC50 value of 0.84 μM and a Ki of 69 nM, COX-2-IN-6 effectively targets COX-2, inhibiting COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM. This compound is utilized in research focused on colorectal cancer chemoprevention, offering valuable insights into inflammatory processes and therapeutic strategies. -
COX-2 Inhibitor
COX-2-IN-28 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting an IC50 of 0.054 µM for COX-2, while demonstrating significantly lower inhibitory activity against 15-lipoxygenase (2.14 µM) and cyclooxygenase-1 (13.21 µM). This selective inhibition positions COX-2-IN-28 as a valuable tool for investigating the role of COX-2 in inflammation and pain pathways. It is suitable for research applications focused on inflammatory diseases and therapeutic development targeting COX-2 pathways. -
COX Inhibitor
Tolmetin sodium is a potent inhibitor of cyclooxygenase (COX), demonstrating IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2. As a non-steroidal anti-inflammatory drug (NSAID), it is primarily used for its analgesic and anti-inflammatory properties. Tolmetin sodium is valuable in research applications focused on pain management, inflammation, and associated disorders. -
Anti-inflammatory Compound
Amfenac sodium is an orally active anti-inflammatory compound known for its potent analgesic and antipyretic properties. It acts by inhibiting the cyclooxygenase enzymes, thereby reducing inflammatory responses. This reagent is valuable for research applications related to both acute and chronic inflammation, facilitating a deeper understanding of inflammatory pathways and potential therapeutic interventions. -
COX-2 Inhibitor
SD 8381 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2). It demonstrates an IC50 value of 0.0098 μM against human COX-2 and 0.69 μM against human COX-1, indicating a high degree of selectivity. This compound is valuable for research applications focused on inflammation and pain management, as well as studies examining the role of COX-2 in various disease states. -
COX2 Inhibitor
COX-2-IN-56 is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating minimal inhibition of cyclooxygenase-1 (COX-1). This compound is valuable for investigating COX-2-dependent disorders, particularly in the context of inflammatory processes. Its specificity makes it suitable for research applications focused on understanding the role of COX-2 in various pathological conditions. -
COX Inhibitor
Benzoylgomisin O is a selective inhibitor of cyclooxygenase enzymes COX-1 and COX-2, as well as 15-lipoxygenase (15-LOX). This compound, isolated from Schisandra rubriflora, exhibits significant anti-inflammatory activity, making it a valuable reagent for research into inflammatory diseases and related pathways. Its ability to modulate lipid mediators positions it as a potential tool in the study of pathophysiological conditions where COX and LOX pathways are implicated. -
Anti-inflammatory Agent
Daturaolone is a natural triterpenoid known for its anti-inflammatory properties. It primarily exerts its biological activity through inhibitory effects on COX-1, which plays a crucial role in inflammatory responses. This compound is of interest in research applications focused on understanding and developing therapies for pain management and various inflammatory conditions. -
COX-1 inhibitor
COX-1-IN-1 is a selective inhibitor of cyclooxygenase-1 (COX-1) with an IC50 value of 0.23 μM, demonstrating a high degree of selectivity over COX-2 (IC50 > 50 μM), resulting in a selectivity index of 217. This compound effectively inhibits platelet aggregation, making it a useful tool in the study of inflammatory processes and cardiovascular research applications. COX-1-IN-1 can aid in understanding the role of COX-1 in various physiological and pathological conditions. -
COX-2 Inhibitor
Desmethyl etoricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 1 μM in whole blood, demonstrating significant potential in modulating inflammatory responses. It exhibits a lower affinity for COX-1, with an IC50 of 16 μM in U937 cells, highlighting its selectivity. This compound is valuable for research applications targeting inflammatory pathways and exploring therapeutic effects in various inflammatory conditions. -
COX1/2 Inhibitor
COX-1/2-IN-2 is a selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), demonstrating potent activity with IC50 values of 9.7 ± 0.09 µM for COX-1 and 4.6 ± 1.45 µM for COX-2. This compound is useful in research applications involving inflammation and pain modulation, as it effectively reduces the synthesis of pro-inflammatory prostaglandins. Its utility in pharmacological studies makes it a valuable reagent for exploring COX-related pathways. -
COX-2 Inhibitor
Cassiatannin A is a proanthocyanidin tetramer that acts as a selective COX-2 inhibitor. It has demonstrated significant inhibition rates of 38%, 52%, and 97% at concentrations of 10, 100, and 1000 μg/mL, respectively. This compound is valuable for research into inflammatory processes and the molecular pathways associated with COX-2-mediated responses. -
COX-2 Inhibitor
COX-2-IN-21 is a selective, orally active inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.039 μM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory diseases and pain management. Its selectivity for COX-2 over COX-1 enhances its therapeutic potential while minimizing side effects associated with non-selective NSAIDs. -
iNOS/COX-2 Inhibitor
Longiferone B is a daucane sesquiterpene derived from the rhizomes of Boesenbergia longiflora, acting as an inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). It exhibits significant anti-inflammatory properties, effectively reducing nitric oxide production with an IC50 value of 21.0 μM. Longiferone B also suppresses the mRNA expression of iNOS and COX-2, making it a valuable compound for research in inflammation-related studies. -
COX-2 Inhibitor
COX-2-IN-27 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting an IC50 of 0.045 µM against COX-2, while demonstrating significantly higher IC50 values of 13.22 µM for COX-1 and 1.67 µM for 15-lipoxygenase (15-LOX). This compound exhibits notable anti-inflammatory activity, making it a valuable tool for research in inflammation-related pathways and the study of COX-2 mediated processes. Its selectivity enables detailed investigations into the role of COX-2 in disease and therapeutic applications. -
COX-1 Inhibitor
VU0487836 is a selective inhibitor of cyclooxygenase-1 (COX-1), exhibiting an IC50 value of 0.36 μM against ovine-derived COX-1. This compound is being investigated as a prototype for developing radiological imaging agents aimed at COX-1 in ovarian cancer. VU0487836 is relevant for research focused on ovarian cancer and may provide insights into therapeutic strategies targeting COX-1 pathways. -
COX-2 Inhibitor
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active inhibitor of COX-2, demonstrating an IC50 of 0.06 μM against purified human COX-2. This compound exhibits significant anti-inflammatory properties and has potential applications in cancer prevention. The metabolic stability of LM-4108 varies across species, with half-lives of 11 minutes in rat, 21 minutes in human, and 51 minutes in mouse liver microsomes. -
COX-2 Inhibitor
COX-2-IN-5 is a selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting an IC50 value of 0.65 µM. This compound is primarily utilized in research focused on inflammation and related pathways. Its potent inhibitory activity makes it an invaluable tool for studying COX-2 mediated processes in various biological contexts. -
COX-2/5-LOX Inhibitor
COX-2/5-LOX-IN-2 is a potent dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). This benzothiophen-2-yl pyrazole carboxylic acid derivative demonstrates significant analgesic and anti-inflammatory properties, exhibiting COX-2 inhibitory activity with an IC50 of 0.01 μM and 5-LOX inhibitory activity with an IC50 of 1.78 μM. COX-2/5-LOX-IN-2 is a valuable tool for research applications aimed at understanding and modulating inflammatory pathways. -
Anti-inflammatory Agent
AHR-6293 is a potent anti-inflammatory agent that functions primarily through modulation of the aryl hydrocarbon receptor (AhR). This compound demonstrates superior anti-inflammatory effects compared to its predecessor AHR-5850, making it a valuable tool in the study of inflammatory pathways. AHR-6293 is not indicated for the inhibition of platelet aggregation, allowing for specific applications in inflammation research and therapeutic exploration. -
COX Inhibitor
Plantanone A is a selective cyclooxygenase (COX) inhibitor, demonstrating an IC50 of 33.37 μM for ovine COX-1 and 46.16 μM for ovine COX-2. This compound exhibits limited DPPH radical scavenging activity with an IC50 of 467.7 μM. Plantanone A serves as a valuable tool for investigating inflammation-related diseases and their underlying mechanisms. -
COX-2 Inhibitor
COX-2-IN-17 is a potent inhibitor of cyclooxygenase-2 (COX-2) with a remarkable ability to penetrate the blood-brain barrier (BBB), exhibiting an IC50 of 0.02 μM. This compound demonstrates significant anti-inflammatory and analgesic properties, effectively reducing hyperalgesia during both the neurogenic and inflammatory phases. COX-2-IN-17 is suitable for research applications aimed at understanding pain mechanisms and exploring potential therapeutic interventions for inflammatory conditions. -
COX-1/2 Inhibitor
N-Acetyl-2-carboxybenzenesulfonamide is a potent inhibitor of COX-1 and COX-2, exhibiting IC50 values of 0.06 μM and 0.25 μM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for the study of inflammatory pathways and the development of anti-inflammatory therapies. Its ability to selectively inhibit cyclooxygenase enzymes positions it as a useful agent in pharmacological research. -
COX-2 Inhibitor
COX-2-IN-51 is a selective COX-2 inhibitor exhibiting an IC50 of 70.7 nM. It effectively reduces LPS-induced release of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as the expression of COX-2 and inducible nitric oxide synthase (iNOS), and inhibits the NF-κB signaling pathway. This compound demonstrates anti-inflammatory and analgesic properties in various murine models by targeting the NF-κB cascade, while presenting a lower risk of gastrointestinal side effects compared to traditional nonsteroidal anti-inflammatory drugs. -
COX-I Inhibitor
2,5-Dimethoxy-3-glucopyranosylcinnamic alcohol is a selective inhibitor of the cyclooxygenase-1 (COX-I) enzyme. This compound exhibits notable anti-inflammatory properties, making it a valuable tool for research in inflammation-related pathways. It is isolated from the plant species P. crocatum and Dirca palustris and can be utilized in studies investigating the modulation of inflammatory responses and related signaling mechanisms. -
COX Inhibitor
Pemedolac is a selective inhibitor of cyclooxygenase (COX), demonstrating potent analgesic activity while minimizing anti-inflammatory effects. This compound exhibits significant efficacy in alleviating chemically induced and inflammatory pain in preclinical models, with effective pain relief achieved at lower doses than those typically associated with anti-inflammatory or gastric irritant effects. Pemedolac has a reduced ulcerogenic potential, suggesting a safer profile compared to standard nonsteroidal anti-inflammatory drugs (NSAIDs), making it a valuable candidate in the treatment of neurological, dermatological, and musculoskeletal disorders. -
COX-1 Inhibitor
COX-1-IN-4 is a selective inhibitor of cyclooxygenase-1 (COX-1), demonstrating an IC50 of 0.09 μM for COX-1 and 2.49 μM for COX-2. This compound effectively reduces nitric oxide production and decreases the expression of the inducible nitric oxide synthase (iNOS) protein. COX-1-IN-4 is valuable for exploring mechanisms associated with neuroinflammation in research settings.
