Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
EIDD-1931-d2 is a deuterium-labeled derivative of 3,6-Dichloro-2-methoxybenzoic acid. This stable isotope is utilized in metabolic and pharmacokinetic studies to trace compounds in biological systems. EIDD-1931-d2 facilitates research into drug metabolism, providing insights into the biological fate of its parent compound in various applications. -
Stable Isotope
Vapendavir-d6 is a deuterium-labeled derivative of Vapendavir, functioning as a stable isotope. It is utilized in research applications requiring isotopic labeling to study viral replication and to trace metabolic pathways. This reagent aids in the investigation of antiviral mechanisms and supports the development of therapeutic strategies against viral infections. -
Stable Isotope
(Rac)-Tenofovir-d6 is a labeled isotopologue of Tenofovir, which functions as a nucleotide reverse transcriptase inhibitor. It is primarily used in the treatment of HIV and chronic Hepatitis B (HBV). This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and analytical applications involving mass spectrometry. -
Stable Isotope
Lamivudine-13C,d2 is a stable isotope-labeled form of Lamivudine, a potent nucleoside reverse transcriptase inhibitor (NRTI). This compound effectively inhibits the reverse transcriptase enzyme of both HIV and hepatitis B virus, making it valuable in antiviral research. Additionally, Lamivudine's ability to penetrate the central nervous system (CNS) enhances its significance in studies related to neurological implications of viral infections. -
Stable Isotope
Telbivudine-d4 is a deuterated form of Telbivudine, a thymidine nucleoside analog that serves as a potent antiviral agent targeting hepatitis B virus (HBV) replication. This stable isotope variant is essential for research applications requiring isotopic labeling, including pharmacokinetic studies and metabolic pathway investigations. Telbivudine-d4 provides a valuable tool for understanding the dynamics of HBV replication and the pharmacological properties of nucleoside analogs in antiviral therapy. -
Stable Isotope
Adefovir-d4 is a deuterium-labeled form of Adefovir, an adenosine monophosphate analog that serves as an antiviral agent. Upon intracellular conversion to Adefovir diphosphate, it effectively inhibits HBV DNA polymerase, exhibiting an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir demonstrates significant antiviral activity against a range of viruses, including hepatitis B virus (HBV) and various herpesviruses. Its isotopic label makes Adefovir-d4 ideal for tracer studies in viral research and pharmacokinetic evaluations. -
Stable Isotope
HBV-IN-39-d3 is a deuterated analog of the HBV inhibitor HBV-IN-39, designed to enhance oral bioavailability. This stable isotope-labeled compound is primarily used in pharmacokinetic studies and metabolic research related to hepatitis B virus (HBV) inhibition. Its unique isotopic composition allows for improved tracking and analysis in biological assays, facilitating further investigation into therapeutic strategies against HBV. -
Stable Isotope
Entecavir-13C2,15N-1 is a stable isotope-labeled form of Entecavir, which acts as a potent and selective inhibitor of hepatitis B virus (HBV) replication. This compound exhibits an EC50 of 3.75 nM in HepG2 cells, making it a valuable tool for studying HBV biology and antiviral mechanisms. Entecavir-13C2,15N-1 is ideally suited for applications in pharmacokinetic studies, drug metabolism research, and the development of HBV therapies. -
Stable Isotope
Penicillamine-d3 is a deuterium-labeled derivative of Penicillamine, a compound primarily known as a degradation product of penicillin antibiotics. This stable isotope serves as a valuable tool in metabolic and pharmacokinetic studies due to its ability to facilitate tracking and quantification in biological systems. Penicillamine has established roles in treating rheumatic diseases and as a chelating agent for copper in Wilson's disease, making Penicillamine-d3 useful for research applications in these areas. -
Stable Isotope
Hexadecanedioic acid-d28 is a stable isotope-labeled version of hexadecanedioic acid, which is known to be an orally active metabolite from Bacteroides uniformis. This compound functions as an inhibitor of the IRE1α-XBP1s pathway, effectively modulating flipogenesis and ferroptosis. Hexadecanedioic acid-d28 downregulates key targets, including XBP1 and Hrd1, while activating the Nrf2/SLC7A11/GPX4 pathway. It serves as a valuable tool for investigating mechanisms underlying metabolic-associated fatty liver disease and related metabolic disorders. -
Stable Isotope
2-Mercaptoethanesulfonate-d4 sodium is a deuterated form of Sodium 2-mercaptoethanesulfonate, primarily utilized as a stable isotope in biochemical research. This compound exhibits antioxidant properties and serves as a cytoprotective agent against the toxic effects of chemotherapy. It is particularly effective in mitigating hemorrhagic cystitis caused by cyclophosphamide, making it valuable in oncology and pharmaceutical studies. -
Stable Isotope
Kevetrin-13C2,15N3 hydrochloride is a stable isotope-labeled version of Kevetrin, which functions as an activator of the tumor suppressor protein p53. This small molecule exhibits potential antineoplastic activity, making it relevant for cancer research. Its stable isotope labeling allows for advanced studies in metabolic tracking and pharmacokinetics, facilitating a deeper understanding of p53-related pathways in various biological contexts. -
Stable Isotope
2-Amino-3-methyl-imidazo[4,5-f]quinoline-13C is a stable isotope-labeled derivative of 2-Amino-3-methyl-imidazo[4,5-f]quinoline. This compound is recognized for its mutagenic properties, making it a valuable tool in studying mechanisms of mutagenesis and carcinogenesis. Its isotopic labeling enhances the accuracy of quantification in metabolic studies, as well as in the investigation of DNA damage and repair processes in various biological research applications. -
Stable Isotope
Benzophenone-d10 is a deuterium-labeled derivative of Benzophenone, functioning as a stable isotope for analytical applications. It serves as a photosensitizer, effectively absorbing UV light and facilitating energy transfer to DNA, which can induce DNA damage. This compound is utilized in a variety of research applications, including studies related to phototoxicity, environmental monitoring, and metabolic profiling of fragrances, plastics, and pharmaceuticals. Additionally, Benzophenone demonstrates estrogenic activity and potential carcinogenicity in long-term exposure studies. -
Stable Isotope
Benzophenone-d5 is a deuterated form of Benzophenone, which acts as a photosensitizer by absorbing UV light and facilitating energy transfer to DNA, leading to DNA damage. This compound is valuable in research applications that require metabolic tracing and analysis of environmental contaminants. Additionally, Benzophenone is utilized in various industries as a fragrance enhancer, ultraviolet curing agent, and an additive in plastics, as well as being involved in the development of insecticides and pharmaceuticals. Its estrogenic activity and potential carcinogenicity in animal models also make it pertinent for toxicological studies. -
Stable Isotope
Benzophenone-13C is a stable isotope-labeled form of benzophenone, which acts as a photosensitizer by absorbing UV light and transferring energy to DNA, leading to DNA damage. This compound plays a role in various research applications, including studies of DNA interactions, toxicology, and the investigation of its metabolic pathways. Additionally, benzophenone is used in diverse industrial applications as a fragrance enhancer, ultraviolet curing agent, and additive in plastics, as well as in the synthesis of insecticides, agricultural chemicals, and pharmaceuticals. Notably, benzophenone also exhibits estrogenic activity and potential carcinogenicity in long-term exposure studies in animal models. -
Stable Isotope
(-)-Aspartic acid-d3 is a deuterated form of (-)-Aspartic acid, serving as a stable isotope for biochemical research. This compound functions as a pyroptosis inhibitor and is known for its roles as a neurotransmitter and neuromodulator. It is involved in hormone synthesis and regulation, contributing to nervous system development and endocrine functions, making it valuable for studies in neurobiology and endocrinology. -
Stable Isotope
Quinidine-d3 is a deuterium-labeled derivative of Quinidine, primarily used as a stable isotope in research. Quinidine serves as an antiarrhythmic agent, effectively regulating abnormal heart rhythms, and has applications in malaria treatment. This isotope can be utilized in pharmacokinetic studies and metabolic research to trace the biochemical pathways of Quinidine and its effects on cardiovascular and infectious diseases. -
Stable Isotope
Hexamidine-d12 is a deuterium-labeled derivative of Hexamidine, a compound known for its amoebicidal properties. This reagent is particularly useful in the study of Acanthamoeba keratitis, facilitating research into its pathogenesis and treatment. The stable isotope labeling enhances the utility of Hexamidine in various analytical applications, including pharmacokinetics and metabolic studies. -
Stable Isotope
Ethopabate-d5 is a deuterium-labeled derivative of Ethopabate, a known orally active antiparasitic agent. This compound targets the prevention and treatment of infectious diseases in poultry, particularly coccidiosis and leucosis, often utilized in conjunction with other treatments such as Amprolium hydrochloride. Ethopabate-d5 serves as a stable isotope for research applications, assisting in the study of drug metabolism and pharmacokinetics in veterinary medicine. -
Stable Isotope
Closantel-13C6 is a stable isotope-labeled form of Closantel, a halogenated salicylanilide known for its potent anti-parasitic properties. It selectively inhibits Onchocerca volvulus chitinase (OvCHT1) with an IC50 of 1.6 μM and a Ki of 468 nM, effectively disrupting the development of larvae from the L3 to L4 stage. This compound is valuable in research focused on treatments for river blindness and other helminth infections. -
Stable Isotope
Aldicarb sulfone-13C2,d3 is a labeled version of Aldicarb sulfone, incorporating both deuterium and carbon-13 isotopes. This compound acts as a cholinesterase inhibitor and is one of the primary metabolites of the carbamate pesticide Aldicarb, showcasing notable insecticidal activity. Aldicarb sulfone-13C2,d3 is valuable for chemical research applications, particularly in studies involving pesticide metabolism and its impact on cholinergic signaling pathways. -
Stable Isotope
Albendazole sulfone-d3 is a deuterium-labeled derivative of Albendazole sulfone, serving as a stable isotope for analytical studies. This compound is a metabolite of Albendazole and demonstrates significant anti-parasitic activity against Echinococcus multilocularis metacestodes. It is primarily used in pharmacokinetic studies and metabolic tracking of Albendazole in biological systems, facilitating research on parasitic infections and drug metabolism. -
Stable Isotope
α-Artemether-d3 is a deuterium-labeled derivative of α-Artemether, a prominent antimalarial agent. This stable isotope is utilized in pharmacokinetic studies to trace the metabolic pathways of the parent compound. Its application in research facilitates a deeper understanding of drug efficacy and metabolism, enhancing the study of antimalarial therapies. -
Stable Isotope
Thiabendazole-13C6 is a stable isotope-labeled compound used for research involving the inhibition of mitochondrial helminth-specific fumarate reductase. Its primary mechanism targets this enzyme, contributing to its anthelminthic properties. This reagent is valuable for studies related to parasitic infections, metabolic pathways in helminths, and the development of anthelminthic therapies. -
Stable Isotope
Amitraz-d6 is a deuterium-labeled derivative of Amitraz, an acaricide and insecticide that exhibits alpha-adrenergic agonist activity. It primarily targets octopamine receptors in the central nervous system, leading to its biological effects, including inhibition of monoamine oxidases and prostaglandin synthesis. Amitraz-d6 is valuable in research applications involving metabolic studies, pharmacokinetics, and the elucidation of the compound's action mechanisms. -
Stable Isotope
5-Hydroxymebendazole-d3, a deuterium-labeled derivative of 5-Hydroxymebendazole, serves as a stable isotope for research applications. It is a significant metabolite of benzimidazole compounds, contributing to studies on drug metabolism and pharmacokinetics. This reagent is ideal for tracing and quantifying metabolic pathways in biochemical and pharmaceutical research. -
Stable Isotope
Piperaquine-d6 is a stable isotope-labeled derivative of the bisquinoline antimalarial agent Piperaquine. It serves as a valuable tool in malaria research, particularly when used in combination with Artemisinin, to study pharmacokinetics and drug metabolism. This labeled compound aids in tracing metabolic pathways and enhancing the understanding of antimalarial efficacy. Piperaquine-d6 is essential for advancing research in malaria treatment and therapeutic strategies. -
Stable Isotope
Clofentezine-d8 is a stable isotope-labeled form of Clofentezine, which functions as a potent growth inhibitor primarily targeting mite populations. Its deuterium labeling enhances tracking and quantification in chemical research applications, particularly in studies involving pesticide efficacy and metabolic pathways. This reagent is valuable for understanding the mechanisms of action of mite control agents in agricultural sciences. -
Stable Isotope
DL-Methionine-13C is a stable isotope-labeled form of the essential sulfur-containing amino acid, DL-Methionine. It plays a crucial role in mitigating oxidative stress and contributes to cellular antioxidant defenses. This compound is applicable in animal nutrition as a feed additive and may serve as a biocidal agent against Heterodera rostochiensis in potato cultivation, aiding in agricultural research. Its isotopic labeling allows for advanced tracking and metabolic studies in various biological systems. -
Stable Isotope
(-)-Fucose-13C-3 is a stable isotope-labeled form of (-)-Fucose, a hexose sugar crucial for determining A and B blood group antigen substructures. This compound is involved in selectin-mediated leukocyte-endothelial adhesion and various host-microbe interactions. Its unique isotopic labeling makes it an essential tool for metabolic studies and tracking biosynthetic pathways in biological research. -
Stable Isotope
Triclabendazole-d3 is the deuterated form of Triclabendazole, a potent orally active antiparasitic agent. It exhibits significant anti-Leishmania activity and promotes gasdermin E (GSDME)-dependent pyroptosis through the activation of caspase-3. This stable isotope-labeled compound is valuable for investigating the effects of Triclabendazole on Fasciola hepatica and studying its biochemical pathways in parasitic infections. -
Stable Isotope
Flufenamic acid-d4 is a deuterium-labeled derivative of Flufenamic acid, a non-steroidal anti-inflammatory drug. It primarily functions as a cyclooxygenase (COX) inhibitor while also activating AMP-activated protein kinase (AMPK) and modulating various ion channels, including chloride channels and L-type Ca2+ channels. This compound inhibits TEAD2 YBD functionality, affecting YAP-dependent processes such as cell migration and proliferation. Flufenamic acid-d4 is thus a valuable tool for studies in inflammation, cell signaling, and cancer research. -
Stable Isotope
(-)-Fucose-13C-1 is a stable isotope-labeled form of (-)-Fucose. This hexose is essential for determining A and B blood group antigen substructures and is involved in selectin-mediated leukocyte-endothelial adhesion and host-microbe interactions. Researchers use (-)-Fucose-13C-1 in metabolic studies, glycoprotein synthesis investigations, and to trace carbohydrate metabolism in various biological systems. -
Stable Isotope
Diethyltoluamide-d10 is a deuterium-labeled derivative of Diethyltoluamide, widely recognized as the primary active ingredient in insect repellents. Its stable isotope labeling enables precise tracking and quantification in various biological studies. This compound is essential for research applications focused on evaluating insect repellent efficacy, studying environmental exposure, and understanding the metabolism of insect repellents in biological systems. -
Stable Isotope
Triclabendazole-13C,d3 is a stable isotope-labeled form of Triclabendazole, incorporating both carbon-13 and deuterium. It serves as a useful tool in pharmacokinetic studies and metabolic research, enabling the tracing of drug metabolism and distribution in biological systems. This isotopically labeled reagent is valuable for elucidating the pharmacodynamics and pharmacological profiles of Triclabendazole in various biological contexts. -
Stable Isotope
(-)-Fucose-13C is a stable isotope-labeled form of (-)-Fucose, classified among the hexoses. This compound plays a crucial role in determining the structural composition of A and B blood group antigens, mediates selectin-dependent adhesion between leukocytes and endothelial cells, and is involved in host-microbe interactions. Its isotopic labeling makes it valuable for metabolic flux analysis and tracking studies in cellular biology and biochemistry research. -
Stable Isotope
DL-Methionine-d is a deuterium-labeled form of the essential amino acid DL-Methionine, which plays a crucial role in cellular defense against oxidative stress. This compound is utilized in various research applications, including metabolic studies and the investigation of sulfur's role in biological systems. Additionally, it has demonstrated efficacy in controlling Heterodera rostochiensis in potato plants, indicating its potential in agricultural research and pest management. -
Stable Isotope
Albendazole sulfoxide-d7 is a deuterium-labeled form of Albendazole sulfoxide, the primary active metabolite of Albendazole. It displays significant anthelmintic activity against Echinococcus multilocularis metacestodes, making it invaluable in parasitology research. This stable isotope can be utilized in pharmacokinetic studies and metabolic profiling to trace the metabolism and distribution of Albendazole sulfoxide in biological systems. -
Isotope-Labeled Compounds
2,3-Diphosphoglyceric acid-d3 ammonium is a deuterium-labeled form of 2,3-Diphosphoglyceric acid (2,3-DPG), an important intermediate in glycolysis. It functions by stabilizing deoxygenated hemoglobin through allosteric binding, thereby enhancing oxygen release in tissues. Additionally, 2,3-DPG exhibits antiparasitic properties and is utilized in research related to Alzheimer’s disease, providing insights into its biochemical pathways and potential therapeutic strategies. -
Stable Isotope
Perfluorobutanesulfonic acid-13C3 sodium is a stable isotope-labeled variant of perfluorobutanesulfonic acid (PFBS-13C3), targeting surfactant properties. This compound exhibits significant biological activity, disrupting pancreatic organ development and lipid metabolism in zebrafish models. Additionally, it impairs reproductive capabilities in nematodes (Caenorhabditis elegans) and induces alterations in the physiological functions of their progeny, making it valuable for research in environmental toxicology and developmental biology. -
Stable Isotope
Permethrin-d6 is a deuterium-labeled derivative of the insecticide and acaricide Permethrin, which targets mitochondrial complex I. This compound exhibits significant estrogenic and anti-estrogenic activities, demonstrating its potential in endocrine disruption studies. Additionally, Permethrin acts as a neurotoxin by prolonging sodium channel activation in neuronal membranes, and it has been shown to reduce bacterial infection resistance in the medaka fish model (Oryzias latipes). Its stable isotope labeling makes Permethrin-d6 suitable for environmental monitoring and metabolic studies in chemical research. -
Stable Isotope
Pirimiphos-methyl-d6 is a deuterium-labeled derivative of Pirimiphos-methyl, an organophosphorus insecticide and acaricide that acts primarily through the inhibition of acetylcholinesterase (AChE) in target organisms. This compound is utilized in research for the development of analytical methods and for studying the biological activities of organophosphates. Its applications extend to the investigation of pest control mechanisms and the management of storage pests in agricultural grains. -
Stable Isotope
Pirimicarb-d6 is a deuterium-labeled derivative of Pirimicarb, serving as a stable isotope for analytical research. Pirimicarb functions as a selective carbamate insecticide, effectively inhibiting acetylcholinesterase (AChE) and displaying acaricidal properties. This reagent is widely applicable in studies related to insecticide action mechanisms and environmental fate assessments of carbamate pesticides in agricultural settings. -
Stable Isotope
Thiacloprid-d4 is a deuterium-labeled derivative of Thiacloprid, a chloronicotinyl insecticide primarily employed for the control of aphid pests in agricultural settings. This compound is notable for its ability to destabilize DNA through interactions that modify its structure and stability, particularly by binding to the minor groove via hydrophobic and hydrogen interactions. Thiacloprid-d4 serves as a valuable stable isotope for research applications in environmental chemistry and toxicology, facilitating the study of pesticide behavior and biological impact. -
Stable Isotope
Fmoc-L-Lys (Boc)-OH-13C6,15N2 is a stable isotope-labeled derivative of lysine featuring both 15N and 13C isotopes. This compound serves as a valuable building block for peptide synthesis and can be utilized in quantitative proteomics studies. Its isotopic labeling facilitates the analysis of protein structure and dynamics, enabling researchers to enhance their understanding of metabolic pathways and biochemical interactions. -
Stable Isotope
Proguanil-d4 hydrochloride is the deuterium-labeled form of Proguanil hydrochloride, primarily used as a stable isotope in research. As an antimalarial proagent, Proguanil is metabolized to the active metabolite Cycloguanil, which inhibits dihydrofolate reductase (DHFR). This reagent is valuable for studying the pharmacokinetics of antimalarial compounds and exploring their metabolic pathways in various biological contexts. -
Stable Isotope
Triazophos-d5 is a deuterium-labeled derivative of Triazophos, a non-systemic insecticide and acaricide that primarily targets acetylcholinesterase (AChE). By covalently and irreversibly binding to the acetylcholine binding site, Triazophos-d5 inhibits the hydrolysis of acetylcholine, resulting in increased neuromuscular activity and hyperexcitability in target pests. This compound is widely utilized in research to study insect resistance and as a tracer in ecological and environmental studies, particularly concerning its effects on various soil insects and mites affecting major crops such as cotton, rice, and soybeans. -
Stable Isotope
Atovaquone-d4 is the deuterium-labeled derivative of Atovaquone, designed for use as a stable isotope tracer in biological research. Atovaquone functions primarily as a mitochondrial electron transport inhibitor, effective in the treatment and prevention of Pneumocystis pneumonia, toxoplasmosis, malaria, and Babesiosis. Its stable isotope form enables enhanced tracking and quantification in studies involving drug metabolism and pharmacokinetics. -
Stable Isotope
Pyridoxal phosphate-d5 is a deuterium-labeled form of Pyridoxal phosphate, the active coenzyme of vitamin B6. This compound acts as an inhibitor of reverse transcriptases and is utilized in research related to neurological disorders, including tardive dyskinesia. Its application in stable isotope studies enhances the understanding of metabolic pathways involving vitamin B6 metabolism and its biological functions.
