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Simvastatin acid-d6

Stable Isotope

Simvastatin acid-d6 is a deuterium-labeled derivative of Simvastatin acid, primarily targeting HMG-CoA reductase (HMGCR). This compound exhibits robust biological activity by reducing Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Furthermore, Simvastatin acid-d6 is instrumental in modulating OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene, making it valuable for research in cardiovascular health and drug transport studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2747915-75-7
Applications	Stable Isotope
Formula	C₂₅H₃₄D₆O₆
Molecular Weight	442.62
Synonyms	Tenivastatin-d6
SMILES	O=C(O)C[C@H](O)C[C@H](O)CC[C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@H](OC(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@]12[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.