Fig. 1 · Structure
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Glyburide-d3
Stable Isotope
Glyburide-d3 is a deuterium-labeled derivative of Glibenclamide, an orally active inhibitor of ATP-sensitive K+ channels (KATP). This compound is instrumental in research related to diabetes and obesity, as it modulates insulin secretion through KATP inhibition. Glyburide-d3 also interacts with P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR), and it influences mitochondrial bioenergetics by altering membrane ion permeability. Additionally, it has been shown to induce autophagy, making it a valuable tool in cellular metabolism studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1219803-02-7 |
| Applications | Stable Isotope |
| Formula | C23H25D3ClN3O5S |
| Molecular Weight | 497.02 |
| SMILES | O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.