Fig. 1 · Structure
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Nisoldipine-d6
Stable Isotope
Nisoldipine-d6 is the deuterium-labeled derivative of Nisoldipine, a potent calcium channel blocker that selectively targets L-type voltage-gated calcium channels, specifically Cav1.2, with an IC50 of 10 nM. This stable isotope is valuable for pharmacokinetic studies, enabling the investigation of drug metabolism and distribution in biological systems. Researchers can utilize Nisoldipine-d6 for determining precise drug concentrations and tracing its metabolic pathways in various experimental setups.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1285910-03-3 |
| Applications | Stable Isotope |
| Formula | C20H18D6N2O6 |
| Molecular Weight | 394.45 |
| Synonyms | BAY-k 5552-d6 |
| SMILES | O=C(C(C(C(C=CC=C1)=C1[N](=O)=O)C(C(OC)=O)=C2C)=C(N2)C)OCC(C([2H])([2H])[2H])C([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.