Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Vemurafenib-d5 is a deuterium-labeled analogue of Vemurafenib, a selective and potent inhibitor of B-RAF kinase, targeting the RAFV600E mutation with an IC50 of 31 nM, and c-RAF-1 with an IC50 of 48 nM. This reagent is crucial for studies involving B-RAF signaling pathways and can facilitate the investigation of drug metabolism and pharmacokinetics. Vemurafenib-d5 is especially useful in cancer research, particularly in evaluating autophagy induction and treatment responses in B-RAF mutant tumors. -
Stable Isotope
Fmoc-Pro-OH-1-13C is a stable isotope-labeled derivative of Fmoc-Pro-OH, which serves as a useful tool in various chemical research applications. This compound is particularly valuable for studies involving metabolic tracing and NMR spectroscopy, facilitating the tracking of proline incorporation into peptides and proteins. Its isotopic label enhances the analytical capabilities in understanding biochemical pathways and protein dynamics. -
Stable Isotope
Isradipine-d3 is a deuterium-labeled derivative of Isradipine, an orally active blocker of L-type calcium channels. This compound functions primarily as a peripheral vasodilator and acts as a dihydropyridine calcium antagonist, exhibiting selectivity for both cardiac and peripheral vascular systems. Isradipine-d3 can be used in research applications focused on cardiovascular physiology and offers potential insights into neuroprotective mechanisms in diseases such as Parkinson's disease. -
Stable Isotope
Carprofen-d3 is a deuterium-labeled derivative of Carprofen, a non-steroidal anti-inflammatory drug known for its multi-target inhibition of fatty acid amide hydrolase (FAAH) and cyclooxygenases (COX). It exhibits inhibitory concentrations (IC50) of 3.9 μM for COX-2, 22.3 μM for COX-1, and 78.6 μM for FAAH. This stable isotope is useful in pharmacokinetic studies, facilitating the investigation of drug metabolism and distribution in biological systems. -
Stable Isotope
Desethyl Amiodarone-d4 hydrochloride is a deuterium-labeled analog of Desethylamiodarone hydrochloride, a significant active metabolite of the antiarrhythmic drug Amiodarone. This compound predominantly arises from the metabolic activity of CYP3A isoenzymes. Desethylamiodarone hydrochloride demonstrates potent inhibition of ATP-sensitive potassium channels, with an IC50 value of 19.1 μM, making it a valuable tool for research in cardiac electrophysiology and drug metabolism studies. -
Stable Isotope
Bergapten-d3 is a stable isotope-labeled form of Bergapten, which primarily inhibits cytochrome P450 (CYP) isoforms in both mouse and human models. As a natural compound, Bergapten exhibits notable anti-inflammatory and anti-tumor activities, making it valuable in cancer research and the study of metabolic processes. This isotopically labeled reagent is useful for tracing and quantifying metabolic pathways in preclinical studies. -
Stable Isotope
Nifedipine-d4 is a deuterium-labeled derivative of Nifedipine, a potent calcium channel blocker primarily targeting L-type calcium channels. This stable isotope is utilized in pharmacokinetic studies and metabolic profiling, aiding in research involving cardiovascular diseases and drug metabolism. Its use in labeling experiments enhances the accuracy of quantitative analysis in biological systems. -
Stable Isotope
Lamotrigine-13C2,15N is a stable isotope-labeled form of Lamotrigine, which serves as a potent anticonvulsant and antiepileptic agent. This compound selectively inhibits voltage-gated Na+ channels, leading to the stabilization of presynaptic neuronal membranes and a reduction in glutamate release. Lamotrigine-13C2,15N is valuable in research focused on epilepsy, focal seizures, and related neurological disorders. -
Stable Isotope
Isradipine-d6 is a deuterated form of the calcium channel blocker Isradipine, which selectively inhibits L-type calcium channels. This compound serves as a potent peripheral vasodilator and exhibits significant effects on both cardiac and peripheral circulation. It is under investigation for its potential neuroprotective properties in the treatment of Parkinson's disease. Isradipine-d6 is valuable in research applications requiring stable isotope labeling for pharmacokinetic studies and metabolic tracing. -
Stable Isotope
Homovanillic Acid-13C6 is a stable isotope-labeled form of Homovanillic acid, a significant dopamine metabolite. It has been identified as a biomarker associated with various neurological and metabolic disorders, including aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. This isotope can be utilized in sophisticated analytical techniques such as isotope dilution mass spectrometry to study metabolic pathways and physiological responses in biomedical research. -
Stable Isotope
Pyriproxyfen-d6 is a deuterated form of Pyriproxyfen, a known insect growth regulator that acts as a juvenile hormone analog. This stable isotope is useful for traceability studies in pharmacokinetics and metabolism research, providing insights into the behavioral and biological dynamics of Pyriproxyfen in various organisms. Its application extends to environmental studies investigating the fate and transport of insecticides in ecosystems. -
Stable Isotope
Retinoic acid-d3 is a deuterium-labeled derivative of retinoic acid that serves as a stable isotope for research applications. Retinoic acid, a key metabolite of vitamin A, is crucial for processes such as cell growth, differentiation, and organogenesis. It functions as a natural agonist of retinoic acid receptors (RARα, RARβ, RARγ) with an IC50 of approximately 14 nM and demonstrates binding to PPARβ/δ with a Kd of 17 nM. Additionally, retinoic acid acts as an inhibitor of the transcription factor Nrf2 by activating retinoic acid receptor alpha, making it valuable for studies related to gene expression and cellular signaling. -
Stable Isotope
Felodipine-d5 is a deuterated form of Felodipine, a dihydropyridine calcium channel antagonist. It exerts potent vasoselective action, effectively lowering blood pressure by targeting vascular smooth muscle, particularly in resistance vessels. In addition to its antihypertensive properties, Felodipine-d5 has been shown to induce autophagy and is capable of crossing the blood-brain barrier, making it valuable for research applications in cardiovascular health and neurobiology. -
Stable Isotope
Pyriproxyfen-d4 is a deuterated stable isotope of Pyriproxyfen, an insect growth regulator. It exhibits similar biological activity to its non-labeled counterpart, enabling the study of insect physiology and detoxification mechanisms. This compound is particularly useful in tracer studies and analytical applications involving metabolic pathways and residue analysis in environmental samples. -
Stable Isotope
Selenomethionine-77Se is a stable isotope-labeled form of the naturally occurring amino acid selenomethionine, which contains selenium. This compound exhibits notable antitumor activity and is utilized in various biological research applications, including studies on selenium metabolism and its implications in cancer therapy. Selenomethionine-77Se serves as a valuable tool for tracing and analyzing selenium's role in cellular processes. -
Stable Isotope
Ezetimibe-13C6 is a stable isotope-labeled derivative of Ezetimibe, designed for use as a tracer in metabolic studies. Ezetimibe functions as a selective inhibitor of cholesterol absorption by targeting the Niemann-Pick C1-like 1 (NPC1L1) transporter, which plays a crucial role in lipid metabolism. This compound is valuable for research applications in studying cholesterol homeostasis and metabolic disorders, as well as for exploring its effects on Nrf2 activation. -
Stable Isotope
Diazoxide-d3 is a deuterium-labeled derivative of Diazoxide, an ATP-sensitive potassium channel activator. This compound is primarily utilized in research to investigate insulin regulation and has potential applications in the treatment of hyperinsulinism. Its unique isotopic labeling allows for enhanced tracking and analysis in various biochemical studies. -
Stable Isotope
Dronedarone-d6 hydrochloride is a deuterium-labeled derivative of Dronedarone, serving as a stable isotope for research applications. This compound functions primarily as a class III antiarrhythmic agent, effective in the study of atrial fibrillation (AF) and atrial flutter. Dronedarone-d6 hydrochloride exhibits potent blockade of various ion currents, including potassium, sodium, and L-type calcium currents, and also demonstrates antiadrenergic activity through noncompetitive binding to β-adrenergic receptors. Additionally, it acts as a substrate and moderate inhibitor of the CYP3A4 enzyme, making it valuable for pharmacokinetic studies. -
Stable Isotope
Maprotiline-d3 hydrochloride is a deuterium-labeled analog of Maprotiline, primarily utilized as a stable isotope in chemical research. This compound serves as an essential tool for metabolic studies and drug trafficking investigations, enabling precise tracking of biological processes. It is particularly valuable in pharmacokinetics and pharmacodynamics research, aiding in the understanding of drug behavior and interactions within biological systems. -
Stable Isotope
Irinotecan-d5 hydrochloride is a deuterated form of Irinotecan hydrochloride, a potent inhibitor of topoisomerase I. This compound is primarily utilized in the treatment of colon and rectal cancers, showing significant efficacy in disrupting DNA replication and repair processes. Its stable isotope labeling allows for advanced research applications, including pharmacokinetic studies and metabolic profiling in cancer research contexts. -
Stable Isotope
Cabergoline-d6 is a stable isotope-labeled form of Cabergoline, an ergot-derived dopamine D2-like receptor agonist. This compound exhibits high affinity for dopamine receptors D2 and D3, as well as 5-HT2B receptors, with Ki values of 0.7, 1.5, and 1.2 nM respectively. Cabergoline-d6 is utilized in pharmacokinetic studies and metabolic research to investigate the behavior of Cabergoline in biological systems. -
Stable Isotope
Ranolazine-d8 dihydrochloride is a deuterium-labeled analog of Ranolazine dihydrochloride, a compound primarily targeting the late phase of inward sodium current (INa) with an IC50 of 6 μM and IKr with an IC50 of 12 μM. This reagent is primarily utilized in research focused on cardiac physiology and pharmacology, particularly in studies of angina and arrhythmia. Additionally, Ranolazine-d8 serves as a partial fatty acid oxidation inhibitor, providing insights into metabolic modulation in cardiac tissues. -
Stable Isotope
Paroxetine-d4 hydrochloride is a deuterated form of Paroxetine hydrochloride, functioning primarily as a selective serotonin reuptake inhibitor (SSRI). This compound is characterized by its GRK2 inhibitory activity with an IC50 value of 14 µM. Paroxetine-d4 hydrochloride is utilized in biochemical research related to depressive disorders, providing a valuable tool for studies involving serotonin modulation and related pathways. -
Stable Isotope
Pregnenolone monosulfate sodium-13C2,d2 is a stable isotope-labeled derivative of Pregnenolone monosulfate sodium, a neurosteroid that serves as a precursor for various steroid hormones. This compound functions as a selective inhibitor of the cannabinoid CB1 receptor and mitigates the effects of tetrahydrocannabinol (THC), providing neuroprotective benefits against cannabis intoxication. Additionally, Pregnenolone monosulfate sodium-13C2,d2 is known to activate TRPM3 channels and exhibits weak activation of TRPM1 channels, making it a valuable tool for studying cannabinoid signaling and related neurobiological pathways. -
Stable Isotope
Telmisartan-13C,d3 is a stable isotope-labeled version of Telmisartan, a potent and long-acting antagonist of the angiotensin II type 1 receptor (AT1). It selectively inhibits the binding of 125I-AngII to AT1 receptors, exhibiting an IC50 value of 9.2 nM. This reagent is valuable for pharmacological studies and metabolic research, particularly in tracking drug metabolism and pharmacokinetics in biological systems. -
Stable Isotope
Selenomethionine-76Se is a stable isotope-labeled form of selenomethionine, which is a naturally occurring amino acid containing selenium. This compound exhibits notable antitumor activity and plays a significant role in various biological processes. Selenomethionine-76Se is particularly useful in metabolic studies, protein labeling, and research involving selenium's impact on disease mechanisms. Its unique isotopic properties make it an essential tool for researchers investigating the role of selenium in health and disease. -
Stable Isotope
Lamotrigine-13C,d3 is a stable isotope-labeled derivative of the anticonvulsant agent Lamotrigine. It selectively inhibits voltage-gated sodium channels, effectively stabilizing presynaptic neuronal membranes and reducing glutamate release. This compound is valuable for research studies in epilepsy and focal seizures, providing insights into the pharmacokinetics and mechanisms of action of Lamotrigine. -
Stable Isotope
Lamotrigine-13C3,d3 is a stable isotope-labeled derivative of Lamotrigine, a potent anticonvulsant agent that selectively inhibits voltage-gated Na+ channels. This action stabilizes presynaptic neuronal membranes and reduces glutamate release, making it a critical tool in studying the mechanisms of epilepsy and focal seizures. Lamotrigine-13C3,d3 is suitable for applications in metabolic studies and pharmacokinetics, enhancing the understanding of Lamotrigine’s therapeutic effects and its metabolic pathways in neurological research. -
Stable Isotope
Fluoxetine-d6 oxalate is a deuterium-labeled form of Fluoxetine oxalate, functioning as a selective serotonin reuptake inhibitor (SSRI). This stable isotope is instrumental in pharmacokinetic studies and metabolic research, providing valuable insights into the pharmacodynamics and bioavailability of Fluoxetine in biological systems. Its application extends to the investigation of neurotransmitter modulation in various experimental models. -
Stable Isotope
Esmolol-d7 hydrochloride is a deuterated form of Esmolol hydrochloride, a cardioselective β1-adrenergic blocker known for its ultra-short action. This compound exhibits significant antiarrhythmic properties by modulating Neurokinin 1 Receptor activity and is effective in reducing post-resuscitation myocardial dysfunction. Additionally, Esmolol influences diabetic wound healing through the inhibition of aldose reductase and the reduction of advanced glycation end products, while promoting fibroblast migration. Its utility extends to investigating cardiac pathologies, including arrhythmias and diabetic foot ulcers. -
Stable Isotope
Pentoxifylline-d3 is a deuterium-labeled derivative of Pentoxifylline, primarily serving as a stable isotope for research applications. As a non-selective phosphodiesterase (PDE) inhibitor, it exhibits key biological activities, including immune modulation, anti-inflammatory effects, and improved hemorheological properties. This compound is particularly valuable in studies related to peripheral vascular disease, cerebrovascular disorders, and conditions associated with impaired regional microcirculation. -
Stable Isotope
Fenofibrate-13C6 is a deuterated analogue of Fenofibrate, primarily functioning as a selective PPARα agonist with an EC50 of 30 μM. In addition to its role in activating PPARα, Fenofibrate-13C6 inhibits various human cytochrome P450 isoforms, exhibiting IC50 values of 0.2 μM for CYP2C19, 0.7 μM for CYP2B6, 9.7 μM for CYP2C9, 4.8 μM for CYP2C8, and 142.1 μM for CYP3A4. This reagent is valuable for metabolic studies and understanding lipid metabolism. -
Stable Isotope
Binimetinib-d4 is a deuterium-labeled analogue of Binimetinib, a selective inhibitor of MEK1/2. This stable isotope retains the inhibitory activity of its parent compound, exhibiting an IC50 of 12 nM against MEK. Binimetinib-d4 is primarily utilized in biological research to enable the study of MEK signaling pathways and the pharmacokinetics of MEK inhibitors. Its labeled form allows for enhanced detection and quantification in metabolic studies. -
Stable Isotope
Omeprazole-d6 is a deuterium-labeled form of Omeprazole, a proton pump inhibitor (PPI) primarily targeting gastric acid secretion. It demonstrates competitive inhibition of CYP2C19 with an inhibition constant (Ki) ranging from 2 to 6 μM, making it a valuable tool in drug metabolism studies. In addition to its role in gastrointestinal health, Omeprazole exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria and serves as a potent inhibitor of neutral sphingomyelinase (N-SMase), thereby impacting exosome production and release. This stable isotope variant is useful for pharmacokinetic studies and tracing in biological research applications. -
Stable Isotope
Rel-Paroxetine-d4-1 hydrochloride is a deuterated form of the selective serotonin reuptake inhibitor (SSRI), Paroxetine, which targets the serotonin transporter. This stable isotope-labeled compound is primarily used in pharmacokinetic studies and drug metabolism research, allowing for the precise tracking of Paroxetine in biological systems. Its unique isotopic signature enhances the accuracy of analytical methodologies in scientific investigations. -
Stable Isotope
Pamapimod-d4 is a deuterium-labeled derivative of Pamapimod, a potent and selective inhibitor of p38 MAPK, exhibiting IC50 values of 14 nM and 480 nM for p38α and p38β, respectively. This compound specifically targets the p38 MAPK pathway and demonstrates no activity against p38δ or p38γ isoforms. Pamapimod-d4 is useful for research applications involving the modulation of inflammatory processes and holds potential in studying treatments for rheumatoid arthritis and other autoimmune diseases. -
Stable Isotope
Isosorbide mononitrate-13C6 is a stable isotope-labeled form of Isosorbide mononitrate, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a crucial tool for tracking the metabolism and distribution of Isosorbide mononitrate in biological systems. Its incorporation of the 13C isotope allows for precise monitoring and analysis in various applications, including drug development and biochemical pathway elucidation. -
Stable Isotope
(Rac)-Sitagliptin-d4 is a deuterium-labeled isoform of Sitagliptin, specifically designed as a stable isotope for research applications. As a potent orally active inhibitor of dipeptidyl peptidase IV (DPP4), it exhibits an IC50 of 19 nM in Caco-2 cell extracts. This compound is invaluable for studies involving glucose metabolism, diabetes treatment mechanisms, and metabolic signaling pathways. Its use in isotopic labeling enhances the accuracy of biochemical assays and metabolic studies. -
Stable Isotope
Maprotiline-d5 hydrochloride is a deuterated form of Maprotiline hydrochloride, serving as a stable isotope for analytical applications. It selectively inhibits noradrenaline re-uptake and functions as a tetracyclic antidepressant, making it valuable for research into antidepressant mechanisms and pharmacokinetics. This compound is particularly useful in studies involving neurochemistry and the metabolic pathways of related pharmaceuticals. -
Stable Isotope
Chenodeoxycholic acid-d2 (CDCA-d2) is a deuterium-labeled form of Chenodeoxycholic Acid, a hydrophobic primary bile acid that plays a critical role in the activation of farnesoid X receptor (FXR). This activation is significant for regulating cholesterol metabolism and maintaining bile acid homeostasis. CDCA-d2 serves as a valuable tool for metabolic research, particularly in studies investigating bile acid signaling pathways and lipid metabolism. -
Stable Isotope
(Rac)-Sitagliptin-d4-1 hydrochloride is a deuterium-labeled derivative of (Rac)-Sitagliptin-1 hydrochloride, a potent and orally bioavailable inhibitor of Dipeptidyl Peptidase-4 (DPP4). With an IC50 value of 19 nM in Caco-2 cell extracts, this compound serves as a valuable research tool for studies investigating the modulation of glucose metabolism and insulin signaling. Its stable isotope labeling offers advantages in pharmacokinetic studies and metabolic profiling in various biological systems. -
Stable Isotope
Fluoxetine-d6 is a deuterium-labeled derivative of fluoxetine, functioning as a selective serotonin reuptake inhibitor (SSRI). This stable isotope compound is valuable in antidepressant research, providing enhanced analytical precision for pharmacokinetic studies and mechanisms of action. Fluoxetine-d6 facilitates investigations into serotonin modulation and its effects on mood disorders. -
Stable Isotope
5-Azacytidine-15N4 is a stable isotope-labeled version of 5-Azacytidine, featuring both 13C and 15N isotopes. As a nucleoside analogue of cytidine, 5-Azacytidine specifically inhibits DNA methylation by being incorporated into DNA, thereby covalently trapping DNA methyltransferases. This process contributes to the reversal of epigenetic modifications. Additionally, 5-Azacytidine has been shown to induce autophagy in cells, making it valuable for research in epigenetics and cellular metabolism. -
Stable Isotope
Ulipristal acetate-d3 is a deuterium-labeled analog of Ulipristal acetate, a selective progesterone receptor modulator (SPRM). It exhibits unique biological activity by stimulating the autophagic response specifically in leiomyoma cells. This reagent is suitable for research applications focused on benign gynecological conditions, including uterine myoma treatment. Its stable isotope labeling allows for advanced studies and precise tracking in biological experiments. -
Stable Isotope
Nifedipine-13C8 is a stable isotope-labeled derivative of Nifedipine, a highly effective calcium channel blocker. It primarily targets L-type calcium channels, playing a critical role in modulating cardiac function and vascular smooth muscle contraction. Nifedipine-13C8 is utilized in pharmacokinetic studies and metabolic research to trace the pharmacodynamics of Nifedipine and its effects on cardiovascular diseases. -
Stable Isotope
Ambroxol-d5 is a stable isotope-labeled derivative of Ambroxol, an active metabolite of the proagent Bromhexine. It functions as a glucocerebrosidase (GCase) chaperone, enhancing GCase activity while exhibiting potent expectorant properties. Additionally, Ambroxol has been shown to induce lung autophagy, making it a valuable tool for research in Parkinson's disease and neuronopathic Gaucher disease. -
Stable Isotope
Taurine-15N (2-Aminoethanesulfonic acid-15N) is a stable isotope-labeled form of taurine, a sulfur-containing amino acid known for its role as an organic osmolyte. It participates in cell volume regulation and serves as a substrate for bile salt synthesis, while also modulating intracellular free calcium levels. This compound is valuable for studies investigating autophagy activation in adipocytes and offers insights into metabolic pathways and cellular responses. -
Stable Isotope
Naproxen-d3 is a deuterated derivative of Naproxen, primarily known for its role as a COX-1 and COX-2 inhibitor, exhibiting IC50 values of 8.72 μM and 5.15 μM, respectively, in cellular assays. This stable isotope is ideal for pharmacokinetic studies and metabolic research, enabling precise tracking of drug metabolism and distribution in biological systems. Its use is critical in the development of therapeutic agents targeting inflammation and pain management. -
Stable Isotope
(Rac)-Efavirenz-d4 is a stable isotope-labeled variant of Efavirenz, a potent inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 2.93 nM and an IC95 of 1.5 nM against HIV-1 replication in cell culture. This compound serves as a valuable tool for quantitative analysis in HIV research. Additionally, (Rac)-Efavirenz-d4 features an alkyne functional group, making it suitable for click chemistry applications, specifically for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
Stable Isotope
Vismodegib-d4 is a deuterated form of Vismodegib, a potent inhibitor of the hedgehog signaling pathway. It exhibits a remarkable IC50 of 3 nM, demonstrating its efficacy in modulating this critical pathway. Additionally, Vismodegib influences P-glycoprotein and ABCG2 transporters with IC50 values of 3.0 μM and 1.4 μM, respectively. This compound is valuable for pharmacokinetic studies and research applications involving hedgehog pathway modulation.
