Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Clorprenaline-d6 is a deuterated form of Clorprenaline, serving as a stable isotope for metabolic and pharmacokinetic studies. This compound retains the pharmacological properties of its non-deuterated counterpart, enabling researchers to investigate the metabolism and distribution of Clorprenaline in biological systems. Clorprenaline-d6 is valuable for studies involving adrenergic agonists and can aid in the development of novel therapeutic agents. -
Stable Isotope
Phenylethanolamine A-d3 is a deuterium-labeled analogue of Phenylethanolamine A, which functions as a β-adrenergic agonist. This stable isotope is primarily utilized in metabolic studies and pharmacokinetic research to trace and quantify drug behavior in biological systems. It serves as a valuable tool for investigating the mechanisms of action and physiological effects associated with β-adrenergic receptor engagement. Additionally, Phenylethanolamine A is a byproduct of Ractopamine synthesis, highlighting its relevance in both metabolic and synthetic research. -
Stable Isotope
Sotalol-d6 is a deuterium-labeled derivative of Sotalol, a non-selective β-adrenergic receptor antagonist. This compound exhibits potent antiarrhythmic activity, making it valuable for studying pediatric arrhythmias. Additionally, Sotalol-d6 inhibits β-receptors and potassium KCNH2 channels, highlighting its utility in the investigation of cardiac electrophysiology and as a potential antiepileptic agent. -
Stable Isotope
Betaxolol-d5 is a deuterated form of Betaxolol, a selective beta-1 adrenergic receptor antagonist. This stable isotope is primarily utilized in pharmacokinetic studies to investigate hypertension and glaucoma treatment mechanisms. The use of Betaxolol-d5 allows for enhanced studies on drug metabolism, distribution, and elimination in various biological contexts. -
Stable Isotope
DL-Norepinephrine-d3 hydrochloride is a deuterium-labeled form of the racemic catecholamine neurotransmitter, DL-Norepinephrine hydrochloride. This compound serves as a stable isotope tracer, facilitating research applications in neuropharmacology and neurobiology. It enables the study of neurotransmitter dynamics and receptor interactions, contributing valuable insights into conditions such as Parkinson's disease. Researchers can utilize DL-Norepinephrine-d3 hydrochloride to explore pathways associated with catecholamine signaling and its implications in neurological disorders. -
Stable Isotope
(±)-Penbutolol-d9 hydrochloride is a deuterated derivative of (±)-Penbutolol hydrochloride, a selective β-adrenoceptor antagonist. This compound exhibits a reported IC50 of 0.74 μM, demonstrating its potency in modulating β-adrenoceptor activity. It is primarily utilized in pharmacological research to investigate receptor dynamics and bioavailability of β-blockers in various biological systems. -
Stable Isotope
Phenylephrine-d3 hydrochloride is a deuterium-labeled analogue of Phenylephrine hydrochloride, serving as a stable isotope. As a selective α1-adrenoceptor agonist, it exhibits potent activity with pKis of 5.86 for α1D, 4.87 for α1B, and 4.70 for α1A receptors. This reagent is valuable for research involving receptor-ligand interactions and pharmacokinetic studies, enabling precise measurement and analysis in various biological settings. -
Stable Isotope
Ractopamine-d5 hydrochloride is a stable isotope-labeled form of the potent β-adrenergic receptor (βAR) agonist, Ractopamine hydrochloride. It exhibits strong binding affinity to pig β1AR and β2AR, with Kd values approximately 25 nM. This reagent is primarily utilized in research focused on protein metabolism, specifically for studying the enhancement of lean tissue growth and production efficiency in swine. -
Stable Isotope
(R)-Carvedilol-d4 is a deuterium-labeled derivative of (R)-Carvedilol, primarily targeting α-adrenergic receptors. This compound exhibits significant biological activity by inhibiting spontaneous Ca2+ waves and effectively mitigating stress-induced ventricular tachycardia. Furthermore, (R)-Carvedilol-d4 demonstrates potential in research applications related to cardiovascular health and oncology, notably delaying the progression of UV-induced skin tumors and reducing their malignancy. -
Stable Isotope
Clonidine-d4 is a deuterated form of Clonidine, serving as a stable isotope. Its primary mechanism targets the α2-adrenoceptors, functioning as a potent antihypertensive agent. Clonidine-d4 is valuable for pharmacokinetic studies and tracer applications in metabolic experiments, allowing for precise quantification and analysis in research settings. -
Stable Isotope
DL-Phenylephrine-d3 hydrochloride is a deuterium-labeled derivative of DL-Phenylephrine hydrochloride, primarily targeting the alpha1-adrenergic receptor. This compound demonstrates significant vasoconstrictive activity, making it useful in the study of adrenergic signaling pathways. Its stable isotope labeling facilitates precise quantitative analyses in pharmacokinetic studies and metabolic research applications. -
Stable Isotope
Phenylephrine-d6 hydrochloride is a deuterated form of Phenylephrine, serving as a stable isotope used in chemical research. It functions primarily as a selective α1-adrenoceptor agonist, exhibiting pKis of 5.86, 4.87, and 4.70 for α1D, α1B, and α1A receptor subtypes, respectively. This reagent is valuable for studies investigating adrenergic signaling and receptor pharmacology, offering insights into cardiovascular and neurophysiological pathways. -
Stable Isotope
Bisoprolol-d7 is a deuterium-labeled analog of Bisoprolol, a selective and orally active β1-adrenergic receptor blocker with minimal β2-receptor activity. This stable isotope is primarily used in pharmacokinetic studies to investigate the metabolism and distribution of Bisoprolol in biological systems. Its applications extend to research involving hypertension, coronary artery disease, and stable ventricular dysfunction. -
Stable Isotope
Salmeterol-d5 is a deuterated analog of Salmeterol, serving as a stable isotope. Salmeterol is a highly selective agonist of the human β2 adrenergic receptor, demonstrating significant stimulation of cAMP accumulation in Chinese Hamster Ovary (CHO) cells expressing β2, β1, and β3 adrenoceptors with pEC50 values of 9.6, 6.1, and 5.9, respectively. This compound is valuable in pharmacological research, particularly in studies investigating β2 adrenergic signaling pathways and respiratory system pharmacotherapy. -
Stable Isotope
Zilpaterol-d7 is a deuterium-labeled variant of Zilpaterol, a selective β-adrenergic agonist. This stable isotope serves as a valuable tool in research involving metabolic studies and pharmacokinetics, particularly in livestock applications. Its use can facilitate investigations into the specific metabolic pathways affected by β-agonists in animal nutrition and performance. -
Stable Isotope
Betaxolol-d7 hydrochloride is a deuterium-labeled analog of Betaxolol hydrochloride, functioning primarily as a selective beta-1 adrenergic receptor blocker. This stable isotope is instrumental in pharmacokinetic studies and metabolic investigations, particularly in the context of hypertension and glaucoma research. Its unique labeling enables precise tracking and quantification in various biological assays, facilitating advanced research into cardiovascular and ocular conditions. -
Stable Isotope
Ractopamine-d6 is a deuterium-labeled analogue of Ractopamine, a potent β-adrenergic receptor (βAR) agonist with a Kd of approximately 25 nM for both pig β1AR and β2AR. This stable isotope enables detailed studies of protein metabolism and is instrumental in research focused on enhancing lean tissue growth and improving production efficiency in swine. Its application is crucial for understanding the biochemical pathways influenced by β-adrenergic signaling in agricultural and animal health settings. -
Stable Isotope
Guanfacine-13C,15N3 is a stable isotope-labeled form of Guanfacine, an orally active noradrenergic α2A adrenergic receptor agonist. This compound exhibits high selectivity for the α2A receptor subtype, contributing to its pharmacological effects such as hypotension and sedation. Guanfacine-13C,15N3 serves as a valuable tool in research applications focused on prefrontal cortex cognitive disorders, including Tourette's syndrome and attention deficit hyperactivity disorder (ADHD). -
Stable Isotope
Paroxetine-d6-1 is a deuterated derivative of Paroxetine, a potent and selective serotonin reuptake inhibitor (SSRI). Primarily, it targets the serotonin transporter, displaying minimal activity as a norepinephrine uptake inhibitor. This stable isotope-labeled reagent is valuable for pharmacokinetic studies, drug metabolism research, and the investigation of SSRIs' mechanism of action. -
Stable Isotope
Meclofenamic acid-d4 is the deuterium-labeled analog of Meclofenamic acid, a non-steroidal anti-inflammatory drug. This compound functions primarily as a selective inhibitor of the fat mass and obesity-associated (FTO) enzyme by competing for its binding to m(6)A-containing nucleic acids. Additionally, Meclofenamic acid exhibits non-selective gap-junction blocking activity, making it valuable for studies in cellular communication and metabolic regulation. Its isotopic labeling enhances its utility in various analytical approaches in chemical biology research. -
Stable Isotope
Tonabersat-d6 (SB-220453-d6) is a deuterated form of Tonabersat, a potent gap-junction modulator. This compound has been demonstrated to reduce inflammatory damage in the central nervous system, making it an important tool for research in neuroprotection and neuroinflammation. Tonabersat-d6 can be utilized in studies requiring stable isotope labeling for metabolic tracking or mechanistic investigations of gap-junction communications in various cellular contexts. -
Stable Isotope
Tirofiban-d9 is a deuterium-labeled analogue of Tirofiban, a potent platelet glycoprotein IIb/IIIa inhibitor. This stable isotope can be utilized in pharmacokinetic studies, enabling researchers to investigate the metabolism and distribution of Tirofiban in biological systems. Its design provides enhanced specificity and sensitivity in analytical applications, facilitating a deeper understanding of its pharmacological effects. -
Stable Isotope
Mavacamten-d5 is a deuterated derivative of Mavacamten, specifically designed as a stable isotope for research applications. Mavacamten functions as an orally active modulator of cardiac myosin, displaying IC50 values of 490 nM and 711 nM for bovine and human cardiac myosin, respectively. This compound is utilized in biochemical studies to explore cardiac function and the modulation of myosin activity in heart diseases. -
Stable Isotope
Danicamtiv-d6 is a deuterated variant of Danicamtiv, an inotropic agent that selectively activates cardiac myosin through allosteric modulation. This compound enhances cardiac systolic function while maintaining mechanical efficiency, making it valuable for studying cardiac physiology. Danicamtiv-d6 is suitable for research applications that require stable isotope labeling in metabolic studies and pharmacological investigations of cardiac function. -
Stable Isotope
Danicamtiv-d3 is a deuterated labeled version of the inotropic agent Danicamtiv (MYK-491), targeting cardiac myosin as a selective allosteric activator. This compound enhances cardiac systolic function while maintaining mechanical efficiency, making it valuable for research into heart function and therapies for heart failure. Its stable isotope composition allows for advanced analytical techniques, providing insights into the dynamics of cardiac contractility. -
Stable Isotope
Mavacamten-d6 is a deuterium-labeled analog of Mavacamten, a selective modulator of cardiac myosin. It demonstrates inhibitory activity with IC50 values of 490 nM for bovine cardiac myosin and 711 nM for human cardiac myosin. This stable isotope form is useful in pharmacokinetic studies and metabolic research to trace and quantify drug behavior in biological systems. -
Stable Isotope
Mavacamten-d1 is a deuterium-labeled derivative of Mavacamten, a selective modulator of cardiac myosin that interacts with myosin to reduce cardiac contractility. This compound exhibits significant inhibitory activity with IC50 values of 490 nM for bovine cardiac myosin and 711 nM for human cardiac myosin. Mavacamten-d1 is valuable for metabolic studies, pharmacokinetic assessments, and other research applications requiring stable isotopes in cardiac function investigations. -
Stable Isotope
Bempedoic acid-d5 is a deuterium-labeled analogue of Bempedoic acid, an ATP-citrate lyase (ACL) inhibitor. This compound plays a significant role in the activation of AMP-activated protein kinase (AMPK), which is crucial for regulating energy metabolism. Bempedoic acid-d5 is valuable for applications in metabolic research, facilitating studies on dyslipidemia and cardiometabolic diseases. -
Stable Isotope
5-Methyl-2'-deoxycytidine-d3 is a deuterium-labeled form of the endogenous DNA methylation marker, 5-Methyl-2'-deoxycytidine. This stable isotope serves as a substrate for DNA methyltransferases, facilitating the regulation of DNA methylation patterns by guiding de novo methylation and activating adjacent CpG site methylation. In addition, 5-Methyl-2'-deoxycytidine-d3 plays a critical role in chromatin dynamics and gene expression, as it influences the recruitment of methyltransferases to specific chromatin regions. Its methylation status is essential for understanding cellular processes related to proliferation and differentiation in various biological contexts. -
Stable Isotope
Levetiracetam-d6 is a deuterium-labeled form of Levetiracetam, an anticonvulsant that targets the synaptic vesicle protein SV2A. This stable isotope is utilized in research to study the pharmacokinetics and dynamics of Levetiracetam. It enhances the efficacy of Temozolomide in glioblastoma stem cells by promoting apoptosis and inhibiting MGMT through modulation of HDAC levels, thus serving as a potential chemosensitizer in cancer therapies. -
Stable Isotope
Levetiracetam-d3 is a deuterated form of Levetiracetam, primarily targeting the synaptic vesicle protein SV2A. This antiepileptic compound enhances the efficacy of Temozolomide by promoting apoptosis and inhibiting the proliferation of glioblastoma stem cells. Levetiracetam-d3 also modulates histone deacetylase (HDAC) levels, leading to the silencing of MGMT and thereby increasing the sensitivity of cancer cells to Temozolomide treatment. This reagent is valuable for chemical research applications related to cancer therapy and neuropharmacology. -
Stable Isotope
2-Undecanone-d5 is a deuterium-labeled analog of 2-Undecanone, serving as a stable isotope. This compound is a volatile organic compound that inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone-d5 is of significant interest in studies related to cellular stress responses and has demonstrated activity in inhibiting lung tumorigenesis. -
Stable Isotope
Lauric acid-13C-1 is a stable isotope-labeled form of lauric acid, a medium-chain fatty acid known for its potent bactericidal activity. This compound exhibits strong antibacterial effects, with EC50 values of 2 μg/mL against P. acnes, 6 μg/mL against S. aureus, and 4 μg/mL against S. epidermidis. Lauric acid-13C-1 is useful in metabolic studies, tracing experiments, and other applications in lipid metabolism and antimicrobial research. -
Stable Isotope
4-Nitrobenzoic acid-d2 is a deuterium-labeled variant of 4-Nitrobenzoic acid, functioning primarily as a redox mediator and electron transfer promoter. This compound effectively accepts electrons from reduced glucose oxidase, subsequently transferring them to electrodes to enhance the glucose oxidation reaction. It is valuable in studies focusing on electron transfer mechanisms and redox cycling, particularly in biosensor applications and metabolic research. -
Stable Isotope
Flurofamide-d4 is a deuterated derivative of Flurofamide, designed for stable isotope labeling. This compound acts as a potent inhibitor of bacterial urease, which plays a critical role in the pathogenesis of infection-induced urinary stones. Flurofamide-d4 is primarily utilized in pharmacokinetic studies and metabolic research to trace and quantify the dynamics of Flurofamide in biological systems. -
Stable?Isotope
Lactate sodium-13C2 is a stable isotope-labeled form of lactic acid sodium, primarily targeting the hydroxycarboxylic acid receptor 1 (HCAR1). It serves as an epigenetic modulator by promoting lysine lactylation, linking glycolysis with oxidative phosphorylation. As an oncometabolite, it plays a significant role in anti-tumor immunity while also demonstrating antimicrobial activity, making it relevant for applications in food preservation and cancer research. -
Stable Isotope
Ethyl acetoacetate-13C4 is a stable isotope-labeled form of Ethyl acetoacetate, which serves as a crucial intermediate in the synthesis of various organic compounds. This compound demonstrates significant biological activity as an inhibitor of bacterial biofilm formation, making it a valuable tool in microbiological research and studies focused on combating biofilm-associated infections. Its labeled form facilitates tracking metabolic pathways and enhancing analytical techniques in chemical research. -
Stable Isotope
3-Methylanisole-d3 is a stable isotope-labeled derivative of 3-Methylanisole, utilized as an intermediate in pharmaceutical synthesis. This compound exhibits properties that contribute to antiseptic and antibacterial activities, as well as enhancing protein stability. It is valuable in research applications involving drug development and metabolic studies. -
Stable Isotope
Methyl paraben-d3 is a deuterated form of Methyl 4-hydroxybenzoate, serving as a stable isotope. This compound is widely recognized as a non-volatile preservative, commonly utilized in biochemical and cosmetic formulations. Methyl paraben-d3 is noted for its capacity to enhance histamine release, modulate immune responses, block sodium channels, and mitigate ischemia-reperfusion injury. Its applications extend to research involving allergenicity, preservation efficacy, and cellular signaling pathways. -
Stable Isotope
Antibacterial agent 265-13C,d3 is a deuterium and 13C-labeled derivative of Antibacterial agent 265, primarily targeting bacterial pathogens. This compound exhibits potent antibacterial activity against a range of organisms, including Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Flavobacterium devorans. Its stable isotope labeling makes it suitable for pharmacokinetic studies and metabolic research applications in microbiology and drug development. -
Stable Isotope
Levulinic acid-13C3 is a stable isotope-labeled form of Levulinic acid, primarily utilized as a precursor for the synthesis of biofuels, including ethyl levulinate. As a 5-keto-pentanoic acid, it serves as a valuable cosubstrate in biopolymer synthesis, facilitating metabolic studies. Additionally, Levulinic acid's antibacterial properties make it a relevant compound for research in antimicrobial applications. -
Stable Isotope
4-Nitrobenzoic acid-d4 is a deuterium-labeled derivative of 4-Nitrobenzoic acid, functioning as an oxidoreduction mediator and electron transfer promoter. This compound facilitates the transfer of electrons from reduced glucose oxidase to the electrode, enhancing the glucose oxidation reaction while reducing the generation of protonated amine groups. It serves as a valuable tool in studies involving electron transfer mechanisms and the design of biosensors. -
Stable Isotope
Furaltadone-d5 is a deuterium-labeled derivative of Furaltadone, a nitrofuran compound. It exhibits antibacterial properties, demonstrating both inhibitory and bactericidal activity against Staphylococcus species in vitro. This reagent is suitable for research applications focused on studying infections, particularly those involving Salmonella enteritidis in poultry, facilitating enhanced tracking and analysis in biochemical assays. -
Stable Isotope
Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections. -
Stable Isotope
Captan-d6 is a deuterium-labeled analog of Captan, a widely used agricultural fungicide. Its primary mechanism involves inhibiting fungal growth through its action on various pathogens, including Botrytis, Fusarium, Fusicoccum, and Pythium. Captan-d6 is valuable in research applications focused on understanding the environmental fate of fungicides, studying microbial interactions, and assessing the effects of fungicides on soil microbial communities. -
Stable Isotope
p-Anisic acid-d7 is a deuterated form of p-Anisic acid, a well-known tyrosinase inhibitor. This stable isotope can be utilized in analytical studies to investigate biological pathways involving p-Anisic acid, which is recognized for its antioxidant, anti-inflammatory, and anti-diabetic activities. Additionally, it serves as a preservative in the cosmetic industry, making it relevant for research focused on dermatological applications and formulations. -
Stable Isotope
Ethyl acetoacetate-13C is a stable isotope-labeled variant of ethyl acetoacetate, an important ester utilized as an intermediate in various synthetic pathways. This compound exhibits biological activity as an inhibitor of bacterial biofilm formation, making it valuable in microbiological studies. Its isotopic labeling facilitates tracing and quantification in metabolic research and various analytical applications. -
Isotope-Labeled Compounds
Veratraldehyde-d3 is a deuterium-labeled derivative of veratraldehyde, which primarily targets the PilY1 protein. This aromatic compound exhibits notable antibacterial activity against Pseudomonas aeruginosa and demonstrates repellent effects against mosquitoes and ticks. Veratraldehyde-d3 is valuable in research applications involving microbial resistance and may also be utilized as a flavoring agent in various settings. -
Stable Isotope
3,4,5-Trimethoxybenzaldehyde-d3 is a deuterated analogue of 3,4,5-Trimethoxybenzaldehyde, serving as a stable isotope labeled compound. This reagent exhibits antimicrobial activity and acts as a crucial intermediate in the synthesis of various pharmaceuticals, including the antibiotic Trimethoprim. Its unique isotopic labeling makes it valuable for tracing studies in chemical research, metabolic profiling, and pathway elucidation. -
Stable Isotope
Calindol hydrochloride-13C,D2 is a deuterium and 13C-labeled variant of Calindol hydrochloride, a positive allosteric modulator of the calcium-sensing receptor (CaSR) with an EC50 value of 132 nM. This stable isotope-labeled compound is invaluable for mechanistic studies in calcium signaling and receptor pharmacology. It can be utilized in various research applications, including drug metabolism and kinetics, as well as in the development of novel calcimimetic agents.
