Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Dronedarone-d6 is a deuterium-labeled derivative of the antiarrhythmic agent Dronedarone, primarily targeting various ion channels, including potassium, sodium, and L-type calcium channels. This compound is vital for investigating the mechanisms underlying atrial fibrillation (AF) and atrial flutter, as well as for studying its antiadrenergic properties through its noncompetitive binding to β-adrenergic receptors. In addition, Dronedarone-d6 serves as a substrate and moderate inhibitor of CYP3A4, making it relevant for pharmacokinetic studies in cardiovascular research. -
Stable Isotope
Lamotrigine-d3 is a deuterium-labeled analog of Lamotrigine, which functions primarily as an anticonvulsant by selectively blocking voltage-gated Na+ channels. This mechanism stabilizes presynaptic neuronal membranes and reduces glutamate release, making it relevant for research into epilepsy and focal seizures. As a stable isotope, Lamotrigine-d3 is suitable for tracer studies in pharmacokinetics and metabolic research. -
Stable Isotope
Binimetinib-d3 is a deuterated analog of Binimetinib, a selective inhibitor of MEK1/2. It demonstrates potent inhibition of MEK with an IC50 of 12 nM, making it a valuable tool for evaluating MEK signaling pathways. This stable isotope is useful in pharmacokinetic studies and metabolic profiling of Binimetinib in research applications involving cancer therapeutics and signal transduction investigations. -
Stable Isotope
Rosuvastatin-d6 is a deuterium-labeled derivative of Rosuvastatin, a competitive inhibitor of HMG-CoA reductase with an IC50 of 11 nM. This reagent serves as a stable isotope for metabolic studies, allowing for detailed quantification and tracking of Rosuvastatin’s pharmacokinetics. Rosuvastatin is known to effectively reduce low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels, while also influencing cardiac repolarization dynamics through its interaction with hERG channels. This compound is applicable in research focusing on lipid metabolism and cardiovascular pharmacology. -
Stable Isotope
Tolvaptan-d7 is a deuterium-labeled variant of Tolvaptan, a selective antagonist of arginine vasopressin receptor 2 (AVPR2). This compound exhibits an IC50 of 1.28 μM in inhibiting AVP-induced platelet aggregation. Tolvaptan-d7 is utilized in biological research for studying the pharmacokinetics and metabolic pathways of Tolvaptan, providing insights into its therapeutic effects and mechanisms of action. -
Stable Isotope
Retinoic acid-d3-1 is a deuterium-labeled derivative of retinoic acid, a vital metabolite of vitamin A. This compound acts as a natural agonist for retinoic acid receptors (RARs), demonstrating inhibitory effects on transcription factor Nrf2 while also engaging peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) with a Kd of 17 nM. Retinoic acid is integral to various biological processes, including cell growth, differentiation, and organogenesis, making it valuable for research in developmental biology and therapeutic studies. -
Stable Isotope
Efavirenz-d5 is a deuterium-labeled analog of Efavirenz, a potent inhibitor of HIV-1 reverse transcriptase, with a reported Ki of 2.93 nM and an IC95 of 1.5 nM for inhibiting HIV-1 replication. This stable isotope is particularly valuable for applications in metabolic studies and drug metabolism investigations. Additionally, Efavirenz-d5 contains an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating various bioconjugation processes in chemical biology. -
Stable Isotope
Cilostazol-d2 is a deuterium-labeled form of Cilostazol, a selective inhibitor of phosphodiesterase 3A (PDE 3A) with an IC50 of 0.2 μM. This stable isotope is valuable for metabolic studies and pharmacokinetic investigations, enabling more accurate tracking of Cilostazol's biochemical pathways in research. Its utility extends to exploring cardiovascular mechanisms and evaluating therapeutic responses in related studies. -
Stable Isotope
N-Ethylmaleimide-d5 is a deuterated form of N-Ethylmaleimide, a compound known for its ability to specifically alkylate free sulfhydryl groups. This reagent serves as a cysteine protease inhibitor and plays a critical role in inhibiting phosphate transport in mitochondria. Additionally, N-Ethylmaleimide acts as an inhibitor of deubiquitinating enzymes, making it valuable for studies focused on protein regulation and cellular signaling pathways. -
Stable Isotope
Daidzein-d4 is a deuterium-labeled derivative of Daidzein, a soy isoflavone known for its role as a PPAR activator. This stable isotope variant enables precise tracking and quantification in metabolic studies. It is commonly utilized in research applications that investigate the effects of PPAR activation on cellular metabolism and related signaling pathways. -
Stable Isotope
Dehydroepiandrosterone sulfate sodium-d6 is a deuterium-labeled stable isotope of Dehydroepiandrosterone sulfate (DHEA sulfate). This compound acts as a non-competitive antagonist of the GABAA receptor and an agonist of the σ1 receptor, facilitating neuroactive effects by modulating receptor activity. DHEA sulfate sodium-d6 is utilized in research focused on neuroprotection, neurite growth, and the regulation of catecholamine secretion, making it relevant for studying conditions such as depression, post-traumatic stress disorder, and Alzheimer's disease. Additionally, its concentration may serve as a biomarker for cardiovascular disease mortality. -
Stable Isotope
Fenofibric acid-d6 is a deuterium-labeled derivative of Fenofibric acid, serving as a stable isotope. This compound acts as a potent PPAR activator, demonstrating EC50 values of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ, and PPARδ, respectively. Additionally, Fenofibric acid-d6 inhibits COX-2 enzyme activity with an IC50 of 48 nM, making it valuable for research applications in metabolic diseases, inflammation, and cardiovascular research. -
Stable Isotope
Bezafibrate-d6 is a stable isotope-labeled form of Bezafibrate, functioning as an agonist for peroxisome proliferator-activated receptors (PPARs). It demonstrates varying EC50 values across human and murine PPAR subtypes: 50 μM for PPARα, 60 μM for PPARγ, and 20 μM for PPARδ in humans; and 90 μM, 55 μM, and 110 μM for the respective murine PPARs. Bezafibrate is primarily utilized in research focusing on lipid regulation and metabolic diseases. -
Stable Isotope
5-Aminosalicylic acid-d3 is a deuterium-labeled derivative of 5-Aminosalicylic acid, primarily utilized as a stable isotope in research. This compound acts as a specific agonist of the peroxisome proliferator-activated receptor gamma (PPARγ) and exhibits inhibitory effects on p21-activated kinase 1 (PAK1) and nuclear factor kappa B (NF-κB). Its applications include studying metabolic pathways and investigating inflammatory responses, making it a valuable tool in pharmacological and biochemical research. -
Stable Isotope
15-Deoxy-Δ-12,14-prostaglandin J2-d4 is a deuterium-labeled derivative of 15-Deoxy-Δ-12,14-prostaglandin J2, a cyclopentenone prostaglandin and active metabolite of PGD2. This compound functions as a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ) with an EC50 of 2 μM, and it acts as a covalent agonist of PPARδ. Additionally, 15-Deoxy-Δ-12,14-prostaglandin J2 has been shown to promote the differentiation of C3H10T1/2 fibroblasts into adipocytes, exhibiting an EC50 of 7 μM. It is suitable for various research applications in studying metabolic regulation and adipogenesis. -
Stable Isotope
Oleoylethanolamide-d4 is a deuterated form of Oleoylethanolamide, serving as a stable isotope for research applications. As a potent endogenous agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), Oleoylethanolamide-d4 is instrumental in studying metabolic processes related to obesity and cardiovascular health. This reagent facilitates investigations into the mechanistic actions and physiological effects of PPAR-α activation, contributing to a deeper understanding of lipid metabolism and related disorders. -
Stable Isotope
Pemafibrate-d4 is a deuterated variant of Pemafibrate, a selective agonist of the peroxisome proliferator-activated receptor alpha (PPARα), exhibiting an EC50 value of 1 nM. This stable isotope-labeled compound is ideal for pharmacokinetic studies and metabolic research, allowing for precise tracking of drug metabolites in biological systems. Its application is valuable in studying lipid metabolism and potential therapeutic strategies for dyslipidemia and related metabolic disorders. -
Stable Isotope
Gemfibrozil-d6 is a stable isotope-labeled derivative of Gemfibrozil, primarily known as a PPAR-α activator. This lipid-lowering agent also serves as a nonselective inhibitor of various cytochrome P450 isoforms, exhibiting Ki values of 5.8 μM for CYP2C9, 24 μM for CYP2C19, 69 μM for CYP2C8, and 82 μM for CYP1A2. It is useful in metabolic studies and drug interaction research. -
Stable Isotope
Fmoc-leucine-d10 is a deuterium-labeled derivative of Fmoc-leucine, targeting the peroxisome proliferator-activated receptor gamma (PPARγ). This compound acts as a selective modulator, exhibiting similar maximal efficacy to rosiglitazone but with lower potency. Fmoc-leucine-d10 has been shown to enhance insulin sensitivity in various models, including normal, diet-induced glucose-intolerant, and diabetic db/db mice, while demonstrating reduced adipogenic activity. Its unique isotopic labeling enables advanced studies in metabolic research. -
Stable Isotope
Oleoylethanolamide-d2 is the deuterium-labeled analog of Oleoylethanolamide, an endogenous high-affinity agonist of the peroxisome proliferator-activated receptor alpha (PPAR-α). This compound plays a critical role in lipid metabolism and has been implicated in therapeutic strategies for obesity and arteriosclerosis research. Oleoylethanolamide-d2 is valuable for studies requiring stable isotope labeling in metabolic pathways and receptor interaction investigations. -
Stable Isotope
Fmoc-leucine-d3 is a deuterium-labeled version of Fmoc-leucine, a selective modulator of the peroxisome proliferator-activated receptor gamma (PPARγ). This compound activates PPARγ with reduced potency while exhibiting similar maximal efficacy compared to standard activators. Research has demonstrated that Fmoc-leucine-d3 enhances insulin sensitivity in both normal and diet-induced glucose-intolerant mice, as well as in diabetic db/db mice, all while maintaining lower adipogenic activity. Its stable isotope labeling makes it a valuable tool in metabolic studies and pharmacological research. -
Stable Isotope
Palmitelaidic acid-d13 is a deuterium-labeled derivative of palmitelaidic acid, which is the trans isomer of palmitoleic acid. This stable isotope is utilized in research to trace metabolic pathways and study fatty acid metabolism. Its unique isotopic signature enables scientists to investigate lipid dynamics in biological systems, providing insights into various physiological processes and diseases. -
Stable Isotope
Daidzein-d6 is a deuterated derivative of daidzein, a natural soy isoflavone that functions as a PPAR activator. This stable isotope labeled compound is instrumental for researchers investigating PPAR-mediated pathways in metabolic regulation and disease. Its unique labeling allows for precise tracking and quantification in various biological assays, enhancing studies related to hormone signaling and therapeutic applications. -
Stable Isotope
Fmoc-leucine-13C6,15N is a stable isotope-labeled derivative of Fmoc-leucine, featuring both 15N and 13C isotopes. This compound selectively modulates the peroxisome proliferator-activated receptor gamma (PPARγ), activating it with a lower potency yet exhibiting similar maximal efficacy compared to standard agonists. Fmoc-leucine is utilized in research focused on improving insulin sensitivity and exploring metabolic pathways associated with obesity and type 2 diabetes. -
Stable Isotope
Clofibric acid-d4 is a deuterium-labeled form of Clofibric acid, a well-characterized PPARα agonist. This compound demonstrates significant biological activity, including the inhibition of Escherichia coli fimbriation and the enhancement of superoxide dismutase (SOD) activity. Clofibric acid-d4 is primarily utilized in research related to lipid metabolism, oncological studies, particularly in ovarian and liver cancers, and investigations into obesity and urinary tract infections. The stable isotope labeling facilitates advanced analytical techniques in these areas. -
Stable Isotope
Bezafibrate-d4 is a deuterium-labeled derivative of Bezafibrate, a potent agonist of peroxisome proliferator-activated receptors (PPARs). It exhibits EC50 values of 50 μM for human PPARα, 60 μM for human PPARγ, and 20 μM for human PPARδ, along with 90 μM for murine PPARα, 55 μM for murine PPARγ, and 110 μM for murine PPARδ. This compound is utilized in hypolipidemic research and aids in the study of metabolic disorders and lipid regulation. -
Stable Isotope
5-Aminosalicylic acid-13C6 is a stable isotope-labeled form of 5-Aminosalicylic acid, commonly known as Mesalamine. This compound functions as a specific agonist for peroxisome proliferator-activated receptor gamma (PPARγ) and exhibits inhibitory activity against p21-activated kinase 1 (PAK1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). It is valuable in biological research for investigating inflammatory pathways and therapeutic mechanisms in conditions such as inflammatory bowel disease. -
Stable Isotope
GW9662-d5 is a deuterium-labeled derivative of the potent PPARγ antagonist GW9662. It exhibits an IC50 of 3.3 nM for PPARγ, demonstrating significant selectivity with 10-fold affinity over PPARα and 1000-fold over PPARδ. This stable isotope variant is ideal for tracer studies and applications in metabolic research, particularly in understanding the role of PPARγ in insulin sensitivity and adipogenesis. -
Stable Isotope
Leriglitazone-d4 is a deuterium-labeled derivative of Leriglitazone, a potent PPARγ agonist capable of crossing the blood-brain barrier. With an EC50 of 9 μM, it modulates mitochondrial function, exhibiting neuroprotective, anti-inflammatory, and antioxidant properties. This stable isotope is valuable for research investigating neuroinflammatory and neurodegenerative diseases, providing insights into the mechanisms of action and therapeutic potential of PPARγ modulation in neurological contexts. -
Stable Isotope
D-Arabinose-d2 is a deuterated form of D-Arabinose, functioning as a stable isotope. This compound exhibits oral antidepressant properties and acts as a growth inhibitor for *Caenorhabditis elegans* with an IC50 value of 7.5 mM. D-Arabinose-d2 is capable of crossing the blood-brain barrier, selectively disrupting the metabolism of D-ribose and D-fructose, and inhibiting nematode growth. Additionally, it has antibacterial activity by disrupting cell biofilm synthesis and activates the ACSS2-PPARγ/TFEB-CRTC1 signaling axis via the lysosomal AXIN-LKB1-AMPK pathway, thereby promoting CRTC1 transcription and an antidepressant-like effect. -
Stable Isotope
D-Arabinose-13C-1 is a stable isotope-labeled form of D-Arabinose. This compound serves as an orally active antidepressant and demonstrates significant growth inhibition of C. elegans, with an IC50 value of 7.5 mM. D-Arabinose-13C-1 can cross the blood-brain barrier, selectively modulating the metabolism of D-ribose and D-fructose, while also inhibiting cell biofilm synthesis and exhibiting antibacterial properties. Its mechanism involves activating the ACSS2-PPARγ/TFEB-CRTC1 axis, influencing CRTC1 transcription through the lysosomal AXIN-LKB1-AMPK pathway, which underlies its antidepressant-like effects. -
Stable Isotope
Fmoc-leucine-13C is a stable isotope-labeled version of leucine, featuring a 13C isotope that allows for precise tracking in biological systems. This reagent is often utilized in protein labeling studies, mass spectrometry analyses, and metabolic pathway investigations to elucidate cellular processes. Its application in stable isotope tracing aids in understanding protein synthesis and turnover, as well as metabolic flux analysis in various biological contexts. -
Stable Isotope
Gemfibrozil 1-O-β-glucuronide-d6 is the deuterated form of Gemfibrozil 1-O-β-glucuronide, known for its role as a powerful and competitive inhibitor of the cytochrome P450 isoform CYP2C8, with an IC50 value of 4.07 μM. This metabolite is essential for studying the pharmacokinetics and metabolism of Gemfibrozil, providing insight into its therapeutic mechanisms and potential interactions. Research applications include drug metabolism studies and the investigation of metabolic pathways in pharmacology. -
Stable Isotope
Clofibrate-d4 is a deuterium-labeled derivative of Clofibrate, which targets peroxisome proliferator-activated receptors (PPARs). This compound acts as an agonist with effective concentrations (EC50) of approximately 50 μM for murine PPARα and PPARγ, and around 55 μM for human PPARα and PPARγ. Clofibrate-d4 can be utilized in research applications focused on metabolic disorders, lipid metabolism, and the modulation of gene expression via PPAR activation. -
Stable Isotope
Raspberry ketone-d5 is a stable isotope labeled derivative of raspberry ketone, specifically designated as 4-(4-Hydroxyphenyl)-2-butanone-d5. As a primary aromatic compound found in red raspberries, it is widely utilized for its fragrance in cosmetics and as a flavoring agent in food products. Additionally, raspberry ketone exhibits PPAR-α agonistic activity, making it valuable for research into metabolic regulation and related biological pathways. -
Stable Isotope
DMT-dT Phosphoramidite-13C10,15N2 is a stable isotope-labeled variant of DMT-dT Phosphoramidite, incorporating 13C and 15N isotopes. This reagent is crucial in DNA synthesis, enabling the creation of isotopically enriched oligonucleotides for advanced studies. It serves as a valuable tool in research applications, including metabolomics, tracking molecular dynamics, and studying nucleic acid interactions. -
Stable Isotope
Pyruvic acid-13C3 sodium is a stable isotope of sodium 2-oxopropanoate, a vital three-carbon metabolite derived from glucose through the glycolytic pathway. This compound functions as a free radical scavenger, effectively neutralizing reactive oxygen species (ROS). Pyruvic acid-13C3 sodium is primarily utilized in metabolic studies and isotopic labeling experiments to track substrates and metabolic flux in biological systems. -
Stable Isotope
Uric acid-15N2 is a stable isotope-labeled form of uric acid, which acts as a potent scavenger of reactive oxygen species (ROS) and plays a crucial role in antioxidant defense. This compound helps maintain blood pressure stability and mitigates oxidative stress by effectively neutralizing harmful oxidants, including singlet oxygen and peroxynitrite. Uric acid-15N2 serves as an important tool in metabolic studies and research aimed at understanding oxidative stress pathways in various biological systems. -
Stable Isotope
3-Indolepropionic acid-d2 is a deuterium-labeled analog of 3-Indolepropionic acid, functioning as a stable isotope. This compound exhibits significant antioxidant properties and has been investigated for its potential therapeutic effects in Alzheimer's disease. It serves as a valuable reagent for metabolic studies and tracer experiments in biological research. -
Stable Isotope
L-Carnitine-d3 (hydrochloride) is a deuterated form of L-Carnitine hydrochloride, serving as a stable isotope. This compound is utilized in metabolic studies to trace carnitine metabolism and transport in biological systems. Its application extends to research on mitochondrial function, fatty acid oxidation, and energy metabolism, making it a valuable tool for bioenergetics research. -
Stable Isotope
Dimethyl fumarate-d2 is a deuterated form of Dimethyl fumarate, a recognized Nrf2 activator that enhances antioxidant gene expression via oral administration and effective brain penetration. This compound is known to induce necroptosis in colon cancer cells through mechanisms involving glutathione (GSH) depletion, reactive oxygen species (ROS) accumulation, and MAPK activation, while also promoting autophagy. Dimethyl fumarate-d2 serves as an important tool for research in multiple sclerosis and cellular stress response studies. -
Stable Isotope
(±)-Carnitine-d9 chloride is a deuterium-labeled derivative of (±)-Carnitine chloride. This stable isotope isomers, D and L, are critical in biochemical studies, particularly in the β-oxidation of fatty acids, and also exhibit antioxidant and anti-inflammatory properties. It is particularly useful in metabolic research and tracer studies, enabling precise investigation of carnitine's role in cellular energy metabolism and lipid metabolism. -
Stable Isotope
Glutathione oxidized-13C4,15N2 is a stable isotope-labeled derivative of oxidized glutathione, incorporating four carbon-13 and two nitrogen-15 isotopes. This compound plays a critical role in cellular antioxidant defense mechanisms, particularly in the detoxification of reactive oxygen species. Its unique isotopic labeling enables advanced research applications, particularly in studies of oxidative stress in sickle cells and erythrocytes, facilitating enhanced metabolic tracing and biomarker identification. -
Stable Isotope
Diuron-d6 is a deuterium-labeled derivative of the phenylurea herbicide Diuron, which primarily targets photosynthesis inhibition in plants. It functions by disrupting ATP and NADH production, leading to increased reactive oxygen species (ROS) levels. This compound is relevant for studying herbicidal activity against both annual and perennial broadleaf and grass weeds. Additionally, Diuron-d6 is utilized in cancer research, notably in examining breast cancer and evaluating the mechanisms underlying DMBA/BBN-induced bladder cancer. -
Stable Isotope
Pyruvic acid-13C-1 sodium is a stable isotope-labeled form of sodium pyruvate, a pivotal three-carbon intermediate in the glycolytic pathway. It is recognized for its role in cellular metabolism and as an effective free radical scavenger, capable of mitigating reactive oxygen species (ROS). This reagent is valuable for research applications in metabolic studies, oxidative stress investigations, and isotopic tracing in biochemical pathways. -
Stable Isotope
Phthalic acid-d4 is a deuterated form of phthalic acid, a key stable isotope used in various research applications. As a final common metabolite of phthalic acid esters (PAEs), it plays a crucial role in synthesis pathways for synthetic agents, including isophthalic acid (IPA) and terephthalic acid (TPA). This compound is utilized in the production of phthalate ester plasticizers and has been studied for its mutagenic effects and potential to cause genetic damage in mammalian germ cells. -
Stable Isotope
Resorufin-d6 is a deuterium-labeled derivative of Resorufin, functioning as a stable isotope for research applications. This fluorescent compound is widely used for the sensitive detection of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in biological samples. Its high fluorescence enables precise analytical measurements, making it essential for studies focused on oxidative stress, cellular signaling, and related biological processes. -
Stable Isotope
Pyruvic acid-d3 sodium is a deuterium-labeled derivative of sodium 2-oxopropanoate, also known as sodium pyruvate. This three-carbon metabolite plays a critical role in the glycolytic pathway and acts as a free radical scavenger, effectively neutralizing reactive oxygen species (ROS). Pyruvic acid-d3 sodium is useful in metabolic studies, isotopic tracing, and research involving cellular respiration and oxidative stress. -
Stable Isotope
Vitamin E-13C2,d6 is a stable isotope-labeled form of Vitamin E, featuring both carbon-13 and deuterium modifications. This compound serves as a valuable tracer in metabolic studies, allowing researchers to investigate the role of Vitamin E in biological systems. Its unique isotopic composition can facilitate the understanding of metabolic pathways and biochemical interactions involving this antioxidant. -
Stable Isotope
Uric acid-13C,15N3 is a stable isotope-labeled form of uric acid, specifically incorporating 13C and 15N isotopes. This compound functions as a potent antioxidant, effectively scavenging reactive oxygen species (ROS), including singlet oxygen and peroxynitrite. Its ability to inhibit lipid peroxidation underscores its significance in research applications related to oxidative stress, blood pressure regulation, and cellular antioxidant defense mechanisms.
