Fig. 1 · Structure
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D-α-Hydroxyglutaric acid-13C5 disodium
Stable Isotope
D-α-Hydroxyglutaric acid-13C5 disodium is a stable isotope-labeled analog of D-α-Hydroxyglutaric acid, primarily used in metabolic studies. This compound serves as a weak competitive antagonist of α-ketoglutarate, inhibiting α-ketoglutarate-dependent dioxygenases at a Ki of 10.87 mM. It has been shown to enhance reactive oxygen species (ROS) production and exhibits inhibitory effects on ATP synthase, impacting mTOR signaling pathways. D-α-Hydroxyglutaric acid-13C5 disodium is useful in research focused on neurometabolic disorders and metabolic pathways influenced by α-ketoglutarate metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1648909-80-1 |
| Applications | Stable Isotope |
| Formula | 13C5H6Na2O5 |
| Molecular Weight | 197.04 |
| SMILES | O=[13C](O[Na])[13CH2][13CH2][13C@]([H])([13C](O[Na])=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.