Fig. 1 · Structure
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Ethyl 3,4-dihydroxybenzoate-13C3
Stable Isotope
Ethyl 3,4-Dihydroxybenzoate-13C3 is a stable isotope-labeled form of Ethyl 3,4-dihydroxybenzoate, a competitive inhibitor of prolyl hydroxylase (PHD). This compound effectively penetrates the blood-brain barrier and stabilizes hypoxia-inducible factor (HIF-1α) by inhibiting PHD-mediated hydroxylation. Its biological activities include the activation of autophagy and apoptosis in tumor cells, regulation of inflammatory responses, and promotion of osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate-13C3 is valuable for research in cardiovascular protection, bone metabolism, and the prevention of high-altitude cerebral edema.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1330195-40-8 |
| Applications | Stable Isotope |
| Formula | C613C3H10O4 |
| Molecular Weight | 185.15 |
| Synonyms | Protocatechuic acid ethyl ester-13C3 |
| SMILES | [13CH3][13CH2]O[13C](C1=CC(O)=C(O)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.