Fig. 1 · Structure
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SN-38-d3
Stable Isotope
SN-38-d3 is a deuterium-labeled derivative of SN-38, the active metabolite of the topoisomerase I inhibitor Irinotecan. SN-38 exhibits potent activity against DNA and RNA synthesis, with IC50 values of 0.077 μM and 1.3 μM, respectively. This stable isotope is instrumental in pharmacokinetic studies, mass spectrometry applications, and tracer studies involving cancer research and drug metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 718612-49-8 |
| Applications | Stable Isotope |
| Formula | C22H17D3N2O5 |
| Molecular Weight | 395.42 |
| Synonyms | NK012-d3 |
| SMILES | [2H]C([2H])([2H])CC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(O)C=C51 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.