Fig. 1 · Structure
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Nisoldipine-d4
Stable Isotope
Nisoldipine-d4 is a deuterium-labeled derivative of Nisoldipine, a calcium channel blocker that selectively inhibits L-type calcium channels (Cav1.2) with an IC50 of 10 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling, enabling researchers to investigate the drug's behavior in complex biological systems. Its unique labeling facilitates mass spectrometry detection, making it an ideal choice for studies focused on drug metabolism and pharmacodynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1219795-47-7 |
| Applications | Stable Isotope |
| Formula | C20H20D4N2O6 |
| Molecular Weight | 392.44 |
| SMILES | C(OCC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(N(=O)=O)C(=C(C(=C2[2H])[2H])[2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.