Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Monoethyl fumarate-d5 is a deuterium-labeled derivative of monoethyl fumarate, functioning as a stable isotope standard in research applications. It primarily activates the Nrf2 pathway, playing a crucial role in cellular defense mechanisms against oxidative stress. Additionally, monoethyl fumarate serves as an effective preservative and polymerization agent for macromolecular materials, making it valuable in various biochemical and pharmaceutical studies. -
Stable Isotope
(R)-(-)-Ibuprofen-d3 is a deuterium-labeled derivative of the R enantiomer of Ibuprofen. This compound is utilized as a stable isotope in pharmacokinetic and metabolic studies. While the (R)-(-)-Ibuprofen itself is inactive on COX and inhibits NF-κB activation, it is recognized for its anti-inflammatory and antinociceptive properties, making this isotope valuable for research applications focused on drug metabolism and efficacy. -
Isotope-Labeled Compound
Pyridoxine-d3 is a deuterium-labeled derivative of pyridoxine (vitamin B6), primarily used as an isotope-labeled compound for metabolic research. It exhibits antioxidant properties in cellular models of Alzheimer's disease through modulation of the Nrf2/HO-1 signaling pathway. Pyridoxine-d3 serves as a valuable tool in studying vitamin B6 metabolism and its neuroprotective roles in neurodegenerative conditions, facilitating the understanding of its biochemical mechanisms. -
Stable Isotope
Geranylgeraniol-d5 is a deuterated form of geranylgeraniol, which serves as a stable isotope. As an orally active vitamin K2 subtype and an intermediate in the mevalonate pathway, geranylgeraniol primarily targets the NF-kB signaling pathway. Research has demonstrated its potential to alleviate LPS-induced microglial inflammation in animal models, making it a valuable compound for studies focused on inflammatory responses and neurobiology. -
Stable Isotope
TML-6-d3 is a deuterated derivative of the curcumin compound TML-6, demonstrating stability as a labeled isotope. This reagent primarily inhibits the synthesis of β-amyloid precursor protein and β-amyloid (Aβ), contributing to research in neurodegenerative diseases. TML-6-d3 upregulates ApoE, suppresses NF-κB and mTOR signaling pathways, and enhances activities related to neuroprotection. It serves as a valuable tool for studying the molecular mechanisms of Alzheimer's disease and related disorders. -
Stable Isotope
Scyllo-Inositol-d6 is a deuterium-labeled version of Scyllo-Inositol that serves as a stable isotope. This compound acts as an inhibitor targeting the aggregation of misfolded proteins, including α-synuclein and Amyloid-β, effectively crossing the blood-brain barrier. Scyllo-Inositol-d6 selectively binds to and stabilizes non-toxic oligomers, preventing their transformation into harmful aggregates while enhancing mechanisms of protein homeostasis and neuroprotection. It is valuable in research related to neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease. -
Stable Isotope
Glimepiride-d8 is a deuterium-labeled analog of Glimepiride, which primarily targets the sulfonylurea receptor. This stable isotope is utilized in pharmacokinetic studies, allowing for the accurate tracking of drug metabolism and disposition in biological systems. It serves as a valuable tool in research involving diabetes treatment and the investigation of metabolic pathways. -
Stable Isotope
Glimepiride-d4-1 is a deuterium-labeled version of Glimepiride, a medium-to-long acting sulfonylurea antidiabetic agent. This stable isotope is utilized for metabolic studies and pharmacokinetic research, providing insight into the drug's bioavailability and mechanism of action. The compound is valuable in assessing the therapeutic potential and safety profiles of Glimepiride in diabetes management. -
Stable Isotope
Methyl tridecanoate-d25 is a deuterium-labeled derivative of methyl tridecanoate, functioning as a stable isotope. This compound exhibits moderate inhibition of β-amyloid aggregation, making it relevant for studies related to neurodegenerative diseases. Additionally, it shows weak inhibition of acetylcholinesterase (AChE), offering potential applications in enzyme activity assays and the investigation of cholinergic signaling. -
Stable Isotope
Glimepiride-d4-2 is a deuterium-labeled derivative of Glimepiride, a medium-to-long acting sulfonylurea used primarily in the management of type 2 diabetes mellitus. This compound acts by enhancing insulin secretion from pancreatic beta cells, thereby lowering blood glucose levels. Glimepiride-d4-2 is utilized in pharmacokinetic studies and metabolic research to understand the drug's behavior and efficacy in biological systems. -
Stable Isotope
Choline-d4 chloride is a stable isotope of choline chloride, a quaternary ammonium salt that acts as an acyl group acceptor and a substrate for choline acetyltransferase. This compound plays a critical role in various biological processes, including neurotransmitter synthesis and lipid metabolism. Research applications of Choline-d4 chloride include metabolic studies, tracer experiments, and investigations into choline's role in growth and development, particularly in animal nutrition. -
Stable Isotope
Choline-d9 chloride is a deuterium-labeled form of choline chloride, classified as a quaternary ammonium salt. It serves as a substrate for choline acetyltransferase and acts as an acyl group acceptor, making it valuable in various biochemical assays. This stable isotope is particularly useful in metabolic studies and tracer experiments, providing insights into choline metabolism and its physiological roles. In addition, it is important as a nutritional supplement in animal feed, especially in promoting growth in poultry. -
Stable Isotope
Pyridostigmine-d6 bromide is a deuterated form of Pyridostigmine, functioning as a reversible cholinesterase inhibitor and parasympathomimetic agent. This stable isotope is useful for metabolic studies and tracking the pharmacokinetics of drugs in biological systems. Its labeling with deuterium allows for enhanced precision in mass spectrometry applications and other analytical techniques in chemical research. -
Stable Isotope
Chlorpyrifos-d10 is a deuterium-labeled variant of Chlorpyrifos, an organophosphate insecticide known for its action as a phosphorothionate. Its active metabolite, Chlorpyrifos oxon, functions as a potent inhibitor of acetylcholinesterase (AChE), thereby disrupting neurological function in a range of organisms, including insects and mammals. This stable isotope is valuable for studying metabolic pathways, neurotoxic effects, and enzyme interactions, particularly in the context of susceptibility to neurotoxicity modulated by plasma enzyme paraoxonase 1 (PON1). -
Stable Isotope
4-Methylbenzylidene camphor-d4 is a deuterated stable isotope of 4-Methylbenzylidene camphor, a compound widely studied for its applications in photoprotection. This labeled compound serves as a valuable tool for tracing and quantifying chemical interactions in biological systems. It is particularly useful in research involving sunscreen formulation studies and the investigation of UV-absorbing properties in various matrices. -
Stable Isotope
Donepezil-d5 hydrochloride is a stable deuterium-labeled analogue of Donepezil, which acts as a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 6.7 nM. Its high selectivity for AChE over butyrylcholinesterase (BuChE) makes it a valuable tool in studying cholinergic signaling. Donepezil-d5 also demonstrates neuroprotective effects against Aβ42-induced neurotoxicity, making it relevant in Alzheimer's disease research and other neurodegenerative studies. -
Stable Isotope
Donepezil-d5 is a deuterium-labeled form of Donepezil, a potent and selective inhibitor of acetylcholinesterase (AChE). It demonstrates inhibitory activities with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in research related to neurodegenerative diseases, particularly Alzheimer's disease. -
Stable Isotope
Physostigmine-d3 is the deuterated form of Physostigmine, a reversible inhibitor of acetylcholinesterase (AChE). This compound effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission, and is utilized in research for its ability to reverse memory deficits in transgenic mouse models of Alzheimer's disease. Additionally, Physostigmine serves as an antidote for anticholinergic poisoning, making it significant for studies in neuropharmacology and toxicology. -
Stable Isotope
Donepezil-d7 hydrochloride is a deuterium-labeled variant of Donepezil, a potent inhibitor of acetylcholinesterase (AChE). This compound exhibits specific inhibition with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. Donepezil-d7 hydrochloride is primarily used in chemical research to trace the metabolism and pharmacokinetics of Donepezil in various biological systems. -
Stable Isotope
Chlorpyrifos-oxon-d10 is a deuterium-labeled derivative of Chlorpyrifos-oxon, which serves as a potent inhibitor of acetylcholinesterase (AChE) through phosphorylating action. This compound has been shown to induce cross-linking between tubulin subunits, thereby disrupting microtubule dynamics and function. Its use in research applications includes studying the mechanisms of neurotoxicity and the evaluation of pesticide metabolism. -
Stable Isotope
Profenofos-d3 is a stable isotope-labeled derivative of Profenofos, an insecticide known for its application in field crops, vegetables, and fruit crops. It functions as an acetylcholinesterase (AChE) inhibitor, exhibiting neurotoxic effects that can impact insect populations. This reagent is valuable for research applications involving pharmacokinetics and metabolic studies of insecticides, enabling precise tracking in biological systems. -
Stable Isotope
Acephate-d3 is a deuterated analogue of Acephate, serving as a stable isotope. This compound primarily acts as an anticholinesterase insecticide, exhibiting cholinotoxic effects. While it demonstrates weak inhibition of rat acetylcholinesterase (AChE), it exhibits potent inhibition of AChE in cockroaches, making it valuable for research in insect physiology and pest management studies. -
Stable Isotope
Donepezil-d4 hydrochloride is a deuterium-labeled derivative of Donepezil hydrochloride, a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 6.7 nM. This compound demonstrates a strong selectivity for AChE over butyrylcholinesterase (BuChE) and exhibits neuroprotective effects against Aβ42-induced neurotoxicity. Donepezil-d4 is valuable for studying AChE interactions and pharmacokinetics in neurodegenerative disease research. -
Stable Isotope
Azamethiphos-d6 is a deuterated form of Azamethiphos, an organophosphate insecticide that primarily targets acetylcholinesterase (AChE). This compound is effectively used in research to study the inhibition of AChE activities and its implications in controlling sea lice populations. Azamethiphos-d6 serves as a valuable stable isotope for analytical studies and environmental monitoring of organophosphate residues. -
Stable Isotope
(Rac)-Rivastigmine-d6 is a stable isotope-labeled form of Rivastigmine, a potent inhibitor of cholinesterases, specifically butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC50 values of 0.037 μM and 4.15 μM, respectively. This compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating cholinergic mechanisms.(Rac)-Rivastigmine-d6 is primarily utilized in research focused on mild to moderate Alzheimer's dementia and dementia associated with Parkinson's disease, facilitating studies on neurotransmission and therapeutic interventions. -
Stable Isotope
Acephate-d6 is a deuterium-labeled derivative of Acephate, a widely used anticholinesterase insecticide. It functions by inhibiting acetylcholinesterase (AChE) activity in insects, leading to disruption of their nervous system and effective pest control. This stable isotope variant is useful for research applications involving metabolic studies, pesticide residue analysis, and environmental monitoring in agricultural and horticultural settings. -
Stable Isotope
Protriptyline (N-methyl-d3) hydrochloride is a deuterium-labeled derivative of the tricyclic antidepressant protriptyline, primarily targeting noradrenergic and serotonergic pathways. This compound exhibits key biological activities such as enhancing wakefulness, making it beneficial for research in sleep disorders like narcolepsy, as well as in studies related to depression and attention deficit hyperactivity disorder (ADHD). Its energizing effects distinguish it from other tricyclic antidepressants, providing valuable insights into the pharmacological profiles of psychiatric treatments. -
Stable Isotope
Donepezil-d7 is a deuterium-labeled analog of Donepezil, a selective and potent inhibitor of acetylcholinesterase (AChE). This compound demonstrates impressive inhibitory activity with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE, making it a valuable tool for studying cholinergic signaling and Alzheimer's disease. Researchers can utilize Donepezil-d7 in pharmacokinetic studies and metabolic profiling to better understand the compound's activity and metabolism in various biological contexts. -
Stable Isotope
Desipramine-d4 is a deuterium-labeled derivative of Desipramine, primarily serving as a stable isotope for various analytical applications. This compound is utilized in pharmacokinetic studies and metabolic research to trace the behavior of Desipramine in biological systems. It aids in enhancing the accuracy of quantification methods in mass spectrometry and other analytical techniques. -
Stable Isotope
Miglustat-d9 hydrochloride is a deuterated form of Miglustat hydrochloride, functioning as an inhibitor of glucosylceramide synthase. This compound demonstrates significant biological activity in the modulation of glycosphingolipid metabolism, making it valuable for research related to Type I Gaucher disease (GD1). Its stable isotope labeling allows for enhanced metabolic tracing studies and investigations into enzyme activity in cellular systems. -
Stable Isotope
Miglustat-d9 is a deuterated form of Miglustat, which functions as a selective inhibitor of glucosylceramide synthase. This compound is primarily utilized in the study of Type I Gaucher disease (GD1) and serves as a valuable stable isotope in metabolic research. Its unique deuterium labeling enables advanced analytical applications, aiding in the investigation of metabolic pathways and drug metabolism. -
Stable Isotope
Hydroxylamine-d3 hydrochloride is a deuterium-labeled derivative of hydroxylamine hydrochloride, serving as a selective inhibitor of monoamine oxidase (MAO). This compound is utilized in studies assessing platelet aggregation and plays a role in the nitrogen cycle, particularly among ammonium-oxidizing microorganisms, including ammonium oxidizing bacteria (AOB) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine-d3 hydrochloride is instrumental in investigating the effects of microbial activity on nitrogen oxide emissions and the suppression of nitrite-oxidizing bacteria (NOB). -
Stable Isotope
Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems. -
Stable Isotope
Dabigatran-d4 is a deuterated form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This oral anticoagulant is effective in preventing thrombin-induced platelet aggregation, exhibiting an IC50 value of 10 nM. Dabigatran-d4 can be utilized in pharmacokinetic studies and metabolic research, providing a valuable tool for understanding thrombin inhibition in various biological contexts. -
Stable Isotope
Dabigatran etexilate-d13 is a deuterium-labeled form of Dabigatran etexilate, an orally active prodrug of Dabigatran. This compound exhibits anticoagulant properties and is utilized in the prevention of venous thromboembolism and strokes associated with atrial fibrillation. The stable isotope labeling facilitates pharmacokinetic and metabolic studies, enhancing research applications in drug development and safety assessment. -
Stable Isotope
Argatroban-d3 is a deuterium-labeled analog of Argatroban, a direct and selective inhibitor of thrombin. This stable isotope-labeled compound enables precise tracking and quantification in pharmacokinetic studies. It is particularly valuable for research applications involving anticoagulation therapy and thrombus formation, allowing for improved insights into the pharmacodynamics of thrombin inhibition. -
Stable Isotope
Dabigatran etexilate-d11 is a stable isotope-labeled form of Dabigatran etexilate, a prodrug that acts as a direct inhibitor of thrombin. This compound exhibits potent anticoagulant properties and is primarily utilized in research involving venous thromboembolism and stroke prevention in patients with atrial fibrillation. The deuterium labeling facilitates advanced metabolic studies and pharmacokinetic assessments. -
Stable Isotope
Dabigatran-d7 is a deuterium-labeled analog of Dabigatran, a potent, reversible direct thrombin inhibitor with a Ki of 4.5 nM. This compound effectively inhibits thrombin-induced platelet aggregation, demonstrating an IC50 of 10 nM. Dabigatran-d7 is utilized in pharmacokinetic studies and tracer applications to investigate metabolism and drug interactions in anticoagulation research. -
Stable Isotope
Metolazone-d7 is a deuterium-labeled derivative of Metolazone, primarily utilized in pharmacokinetic studies and tracer experiments. Metolazone functions as a thiazide-like diuretic, effectively lowering blood pressure and managing fluid retention in conditions such as congestive heart failure. The stable isotope labeling enables precise quantification and metabolic tracking in biological assays, facilitating research into drug metabolism and efficacy. -
Stable Isotope
Dabigatran-13C6 is a stable isotope-labeled form of Dabigatran, a potent oral anticoagulant that functions as a reversible, competitive direct thrombin inhibitor with a Ki of 4.5 nM. It effectively inhibits thrombin-induced platelet aggregation, demonstrating an IC50 of 10 nM. This reagent is valuable for pharmacokinetic studies and metabolic profiling in anticoagulant research, enabling precise tracking of drug dynamics in biological systems. -
Stable Isotope
D-Tyrosine-d7 is a deuterium-labeled derivative of D-Tyrosine, primarily utilized as a stable isotope in scientific research. This compound serves to negatively regulate melanin synthesis through the inhibition of tyrosinase activity. Additionally, D-Tyrosine has demonstrated efficacy in inhibiting biofilm formation and promoting the self-dispersal of established biofilms, all while maintaining bacterial growth levels. Its applications are valuable in studies related to melanin production and biofilm dynamics. -
Stable Isotope
D-Tyrosine-d4 is a deuterium-labeled derivative of D-Tyrosine, functioning primarily as a stable isotope. This compound plays a crucial role in biological research by negatively regulating melanin synthesis through the inhibition of tyrosinase activity. Additionally, D-Tyrosine has been shown to inhibit biofilm formation and induce self-dispersal of biofilms, while not affecting bacterial growth. These properties make it valuable for studies in skin pigmentation and microbial behavior. -
Stable Isotope
D-Tyrosine-d2 is the deuterium-labeled form of D-Tyrosine, an important stable isotope used in chemical research. D-Tyrosine serves as a negative regulator of melanin synthesis by inhibiting the enzymatic activity of tyrosinase. Additionally, it has been shown to inhibit biofilm formation and induce self-dispersal of existing biofilms without adversely affecting bacterial growth. This compound is useful for investigations in biochemical pathways and microbial studies. -
Stable Isotope
β-Tocopherol-d3 is a deuterated analogue of β-Tocopherol, which functions as a stable isotope. This compound exhibits notable antioxidant properties and has been shown to inhibit tyrosinase activity, thereby affecting melanin synthesis. Additionally, β-Tocopherol can counteract the suppression of cell growth and protein kinase C (PKC) activity induced by d-alpha-tocopherol, making it valuable for research in cellular signaling and pigmentation studies. -
Stable Isotope
Febuxostat-d7 is a deuterated analog of Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace drug metabolism and evaluate chemical reactions involving Febuxostat. Its application in labeling studies enhances the understanding of drug metabolism and its interactions in biological systems. -
Stable Isotope
Allopurinol-d2 is a deuterium-labeled derivative of Allopurinol, primarily functioning as a xanthine oxidase inhibitor, with reported IC50 values ranging from 0.2 to 50 μM. This reagent is widely utilized in research on hyperuricemia and gout, facilitating studies on uric acid metabolism. Additionally, Allopurinol has demonstrated antileishmanial properties, making it relevant for investigations into leishmaniasis treatment strategies. -
Stable Isotope
Oxypurinol-13C,15N2-1 is a stable isotope-labeled form of Oxypurinol, the primary active metabolite of Allopurinol, functioning as an effective inhibitor of xanthine oxidase. This compound plays a critical role in regulating blood urate levels, making it valuable for the treatment of gout. Its isotopic labeling allows for advanced research applications, including metabolic studies and drug metabolism investigations. -
Stable Isotope
Tramiprosate-d6 is a deuterium-labeled derivative of Tramiprosate, a naturally occurring amino acid with notable brain-penetrant properties. This compound primarily targets soluble amyloid-beta (Aβ) peptides, effectively maintaining them in a non-fibrillar configuration. Tramiprosate shows significant biological activities, including neuroprotection, anticonvulsant, and antihypertensive effects, making it valuable for research on neurodegenerative diseases and neurological disorders. -
Stable Isotope
Glimepiride-d5 is a deuterated derivative of Glimepiride, a medium-to-long acting sulfonylurea antidiabetic agent. This stable isotope is primarily used in pharmacokinetic studies to trace the compound's metabolic pathways and evaluate its biological efficacy. With an ED50 of 182 μg/kg, Glimepiride effectively stimulates insulin secretion from pancreatic beta cells, making it relevant for diabetes research and therapeutic investigations. -
Stable Isotope
Protriptyline-d3 is a deuterated analog of the tricyclic antidepressant Protriptyline, serving as a stable isotope for research applications. It exerts potent inhibition of acetylcholinesterase (AChE) with an IC50 value of 0.06 mM and effectively inhibits amyloid beta (Aβ) self-assembly. This compound is valuable for studying the mechanisms underlying depression and Alzheimer's disease.
