Varespladib-d7 is a deuterated derivative of Varespladib, a selective inhibitor of group IIA secretory phospholipase A2 (sPLA2) with an IC50 of 9 nM. This reagent effectively inhibits sPLA2 activity across serum samples from multiple species, demonstrating IC50 values of 8.1 nM in rats, 5.0 nM in rabbits, 3.2 nM in guinea pigs, and 6.2 nM in humans. Varespladib-d7 serves as a valuable tool in pharmacokinetic studies and metabolic research involving sPLA2 pathways.
Varespladib-d7 is a deuterated derivative of Varespladib, a selective inhibitor of group IIA secretory phospholipase A2 (sPLA2) with an IC50 of 9 nM. This reagent effectively inhibits sPLA2 activity across serum samples from multiple species, demonstrating IC50 values of 8.1 nM in rats, 5.0 nM in rabbits, 3.2 nM in guinea pigs, and 6.2 nM in humans. Varespladib-d7 serves as a valuable tool in pharmacokinetic studies and metabolic research involving sPLA2 pathways.
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