Raloxifene 4'-glucuronide-d4 is a deuterated stable isotope of Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene. This compound is primarily formed through the action of UGT1A10 and UGT1A8 enzymes. Raloxifene 4'-glucuronide exhibits binding to the estrogen receptor with an IC50 of 370 μM. It functions as a selective estrogen receptor modulator, activating the TGFβ3 promoter as a full agonist at nanomolar concentrations while also inhibiting expression from the estrogen response element-containing vitellogenin promoter. This makes it a valuable tool for studying estrogen receptor activity and metabolism in chemical research.
Raloxifene 4'-glucuronide-d4 is a deuterated stable isotope of Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene. This compound is primarily formed through the action of UGT1A10 and UGT1A8 enzymes. Raloxifene 4'-glucuronide exhibits binding to the estrogen receptor with an IC50 of 370 μM. It functions as a selective estrogen receptor modulator, activating the TGFβ3 promoter as a full agonist at nanomolar concentrations while also inhibiting expression from the estrogen response element-containing vitellogenin promoter. This makes it a valuable tool for studying estrogen receptor activity and metabolism in chemical research.
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