5-Ethynyl-2'-deoxyuridine-13C2 is a stable isotope-labeled analogue of 5-Ethynyl-2'-deoxyuridine, specifically incorporating two carbon-13 atoms. This compound functions primarily in studying DNA replication, as it is incorporated into cellular DNA and subsequently detected through a fluorescent azide in a "Click" reaction. Key applications include cell proliferation assays and the synthesis of PROTACs, leveraging its alkyne functionality for copper-catalyzed azide-alkyne cycloaddition. Its use in research facilitates advanced studies in nucleic acid dynamics and targeted protein degradation.
5-Ethynyl-2'-deoxyuridine-13C2 is a stable isotope-labeled analogue of 5-Ethynyl-2'-deoxyuridine, specifically incorporating two carbon-13 atoms. This compound functions primarily in studying DNA replication, as it is incorporated into cellular DNA and subsequently detected through a fluorescent azide in a "Click" reaction. Key applications include cell proliferation assays and the synthesis of PROTACs, leveraging its alkyne functionality for copper-catalyzed azide-alkyne cycloaddition. Its use in research facilitates advanced studies in nucleic acid dynamics and targeted protein degradation.
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