mAChR

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  1. Fesoterodine fumarate (Toviaz)

    Catalog No. A10386
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    AChR antagonist
    Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence Learn More
  2. Irsogladine

    Catalog No. A10480
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    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More
  3. Darifenacin

    Catalog No. A11987
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    Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Learn More
  4. Gallamine triethiodide

    Catalog No. A10417
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    mAChR M2 antagonist
    Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. Learn More
  5. Ipratropium bromide

    Catalog No. A10476
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    Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. Learn More
  6. Methscopolamine bromide

    Catalog No. A10579
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    Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M). Learn More
  7. Oxybutynin

    Catalog No. A10684
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    Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties. Learn More
  8. Arecoline

    Catalog No. A13071
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    Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Learn More
  9. BQCA

    Catalog No. A17156
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    BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). Learn More
  10. Metanicotine

    Catalog No. A11545
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    Nicotinic receptor agonist
    Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the ??4??2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM). Learn More
  11. Methoctramine hydrate

    Catalog No. A11975
    Methoctramine hydrate is a selective M2 muscarinic receptor antagonist at nM concentrations Learn More
  12. Bethanechol chloride

    Catalog No. A10180
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    Muscarinic receptor agonist
    Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Learn More
  13. 5-hydroxymethyl tolterodine (PNU 200577)

    Catalog No. A11166
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    muscarinic receptor antagonist

    5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

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  14. Rocuronium bromide

    Catalog No. A10803
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    AchR antagonist
    Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia. Learn More
  15. Biperiden HCl

    Catalog No. A10147
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    muscarinic receptor antagonist
    Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype Learn More
  16. Tolterodine tartrate (Detrol LA)

    Catalog No. A10937
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    muscarinic receptor antagonist
    Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. Learn More
  17. Solifenacin succinate

    Catalog No. A11215
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    muscarinic M3 receptor antagoinst
    Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence. Learn More
  18. Atropine

    Catalog No. A10098
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    mAChR antagonist
    Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. Learn More
  19. SVT-40776 (Tarafenacin)

    Catalog No. A10808
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    muscarinic receptor antagonist
    SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Learn More
  20. Tropicamide

    Catalog No. A11706
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    Tropicamide is an anticholinergic used as a mydriatic. Learn More
  21. Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor antagonist
    Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Learn More
  22. Acetylcholine iodide

    Catalog No. A16390
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    Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. Learn More
  23. Atropine methyl bromide

    Catalog No. A18026
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    mAChR antagonist
    Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine. Learn More
  24. Cevimeline hydrochloride

    Catalog No. A18092
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    mAChR agonist
    Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. Learn More
  25. Anisodamine

    Catalog No. A18215
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    alpha-1 adrenergic receptors / mAChRs inhibitor
    Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. Learn More
  26. Cimetropium Bromide

    Catalog No. A18290
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    mAChR antagonist
    Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. Learn More
  27. Darenzepine

    Catalog No. A12333
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    muscarinic receptor inhibitor
    Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1. Learn More
  28. Tiotropium Bromide

    Catalog No. A10934
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    muscarinic acetylcholine receptor (mAChR) antagonist
    Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. Learn More
  29. Rapacuronium bromide

    Catalog No. A21119
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    mAChR modulator
    Rapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). Learn More
  30. mAChR-IN-1 hydrochloride

    Catalog No. A21398
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    mAChR antagonist
    mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM. Learn More
  31. mAChR-IN-1

    Catalog No. A21518
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    mAChR antagonist
    mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM. Learn More
  32. VU0152100

    Catalog No. A21769
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    mAChR M4 potentiator
    VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ?? 93 nM. Learn More
  33. (Rac)-VU 6008667

    Catalog No. A21939
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    mAChR M5 negative allosteric modulator
    (Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration. Learn More
  34. Oxotremorine M iodide

    Catalog No. A21977
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    mAChR agonist
    Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Learn More
  35. Flavoxate

    Catalog No. A12900
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    muscarinic AChR antagonist
    Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. Learn More
  36. Glycopyrrolate

    Catalog No. A12641
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    muscarinic antagonist
    Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. Learn More
  37. Catharanthine sulfate

    Catalog No. A12161
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    Catharanthine sulfate is a vinblastine-type alkaloid precursor with antitumor activity. It inhibits AChR by ion channel blocking and desensitization. Learn More
  38. LY2119620

    Catalog No. A14217
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    M2/M4 AChR agonist
    LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. Learn More
  39. Diphenidol HCl

    Catalog No. A14244
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    M2/M3 antagonist
    Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02. Learn More
  40. Nitenpyram

    Catalog No. A14229
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    AchR agonist
    Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist. Learn More
  41. AF-DX 384

    Catalog No. A13856
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    mAChR antagonist
    AF-DX 384 is a drug which acts as a selective antagonist of the muscarinic acetylcholine receptors. Learn More
  42. Xanomeline oxalate

    Catalog No. A13685
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    mAChR agonist
    Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively). Learn More
  43. PF-3635659

    Catalog No. A13548
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    muscarinic M(3) receptor antagonist
    PF-3635659 is a potent muscarinic M(3) receptor antagonist. Learn More
  44. Cevimeline hydrochloride hemihydrate

    Catalog No. A15042
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    M1 agonist
    Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. Learn More
  45. Umeclidinium bromide

    Catalog No. A15268
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    Muscarinic receptor antagonist
    Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). Learn More
  46. Imidafenacin

    Catalog No. A15490
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    M3 receptors inhibitor
    Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). Learn More
  47. (-)-Nicotine ditartrate

    Catalog No. A13761
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    (-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto). Learn More
  48. TBPB

    Catalog No. A14205
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    M1 mAChR agonist
    TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats. Learn More
  49. Revefenacin

    Catalog No. A15986
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    muscarinic receptor antagonist
    Revefenacin is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. Learn More
  50. MK7622

    Catalog No. A12835
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    M1 receptor modulator
    MK7622 is a muscarinic M1 receptor positive allosteric modulator. Learn More

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