mAChR

Cat. No.

A13761

CAS No.

65-31-6

(-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto).

Cat. No.

A14217

CAS No.

886047-22-9

LY2119620

Synonyms: LY-2219620

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

Cat. No.

A10180

CAS No.

590-63-6

Bethanechol chloride

Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.

Cat. No.

A11372

CAS No.

107233-08-9

Cevimeline (AF-102B)

Synonyms: AF102B

Cevimeline (AF-102B) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

Cat. No.

A11545

CAS No.

15585-43-0

Metanicotine

Synonyms: Rivanicline; RJR 2403

Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM).

Cat. No.

A12264

CAS No.

560083-42-3

AC260584

AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.

Cat. No.

A13685

CAS No.

141064-23-5

Xanomeline oxalate

Synonyms: LY246708

Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively).

Cat. No.

A14205

CAS No.

634616-95-8

TBPB

TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats.

Cat. No.

A14229

CAS No.

150824-47-8

Nitenpyram

Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist.

Cat. No.

A15042

CAS No.

153504-70-2

Cevimeline hydrochloride hemihydrate

Synonyms: Evoxac

Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

Cat. No.

A16669

CAS No.

54-71-7

Pilocarpine Hydrochloride

Synonyms: Pilocarpine HCl; NSC 5746 HCl; (+)-Pilocarpine hydrochloride

Pilocarpine Hydrochloride is a selective agonist for the M3 muscarinic acetylcholine receptor (mAChR). It plays a significant role in stimulating glandular secretion, particularly in the treatment of dry mouth and glaucoma. This compound is valuable in research focused on neuropharmacology, as well as studies investigating cholinergic signaling and its implications in various physiological processes.

Cat. No.

A17285

CAS No.

62-51-1

Methacholine chloride

Synonyms: Acetyl-beta-methylcholine chloride; Provocholine; Mecholyl chloride; Amechol; Methapharma Brand of Methacholine Chloride; Provokit; Roche Brand of Methacholine Chloride

Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.

Cat. No.

A18092

CAS No.

107220-28-0

Cevimeline hydrochloride

Synonyms: Evoxac; Cevimeline HCl

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

Cat. No.

A18571

CAS No.

147025-53-4

Talsaclidine

Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes.

Cat. No.

A19271

CAS No.

120241-31-8

Alvameline

Synonyms: Lu 25-109

Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.

Cat. No.

A20534

CAS No.

56296-18-5

DREADD agonist 21

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM).

Cat. No.

A21095

CAS No.

195615-83-9

Blarcamesine (AVex-73)

Synonyms: AE-37; AVex-73; Anavex-2-73

Blarcamesine, also known as AVex-73 and AE-37, is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. It is an ς receptor ligand.

Cat. No.

A21977

CAS No.

3854-04-4

Oxotremorine M iodide

Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist.

Cat. No.

A22204

CAS No.

1977-11-3

Perlapine

Perlapine is a potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM). This drug exhibits >10,000-fold selectivity for hM3Dq over hM3.

Cat. No.

A57573

CAS No.

1240514-89-9

VU0364572 TFA

VU0364572 TFA is a selective allosteric agonist of the M1 muscarinic receptor, exhibiting an EC50 of 0.11 μM. This compound demonstrates neuroprotective properties, making it a potential candidate for mitigating memory impairments and alleviating neuropathology associated with Alzheimer's Disease. Additionally, VU0364572 TFA is capable of penetrating the central nervous system, thus enabling its application in neurological research.

Cat. No.

A57576

CAS No.

1240514-87-7

VU0364572

VU0364572 is a selective allosteric agonist of the M1 muscarinic receptor, exhibiting an EC50 of 0.11 μM. It demonstrates neuroprotective effects, making it a valuable tool in investigating memory impairments and neuropathological changes associated with Alzheimer’s Disease. Additionally, VU0364572 is orally bioactive and capable of penetrating the central nervous system, enhancing its utility in neuropharmacological research.

Cat. No.

A59853

CAS No.

2250025-93-3

Clozapine N-oxide dihydrochloride

Clozapine N-oxide dihydrochloride is a selective agonist for designer receptors exclusively activated by designer drugs (DREADDs), specifically targeting hM3Dq and hM4Di. This compound plays a crucial role in neuronal circuit manipulation for experimental purposes. It is notable for its inability to cross the blood-brain barrier, making it useful for in vivo studies to modulate neuronal activity without central nervous system effects. Clozapine N-oxide dihydrochloride is integral in research applications related to neuroscience, enabling the dissection of gene function and behavior in animal models.

Cat. No.

A59871

CAS No.

159912-58-0

Sabcomeline hydrochloride

Synonyms: SB-202026 hydrochloride; Memric hydrochloride

Sabcomeline hydrochloride is a muscarinic receptor agonist with the ability to penetrate the blood-brain barrier. It exhibits strong affinity for human muscarinic receptor subtypes hM1 to hM5 (pKi=6.72-7.23) and functions as a near-full agonist at the hM3 receptor, leading to extracellular acidification. This compound also influences dopamine D2 receptor binding kinetics via neural network modulation, while exhibiting minimal effects on cardiovascular parameters. Sabcomeline hydrochloride is valuable in research related to Alzheimer's disease and other neurodegenerative disorders, especially for investigating its effects on spatial memory and taste aversion in rodent models.

Cat. No.

A61259

CAS No.

1364078-75-0

Betovumeline hydrochloride

Betovumeline hydrochloride is an agonist of muscarinic acetylcholine receptors (mAChRs), which play a critical role in various neurological functions. This compound is valuable for research into neurological disorders, facilitating the study of receptor activation and signaling pathways. Its ability to selectively engage mAChRs makes it a useful tool in pharmacological investigations and potential therapeutic applications.

Cat. No.

A61261

CAS No.

131986-45-3

Xanomeline

Synonyms: LY-246708

Xanomeline is a selective agonist of the muscarinic M1 and M4 receptors, known to enhance neuronal excitability. This compound is primarily used in research focused on neurological disorders, including schizophrenia, and offers potential insights into the modulation of cholinergic signaling pathways in the central nervous system.