Catalog No.
Product Name
Application
Product Information
Citations
-
Antibiotic
Thiolactomycin is an antibiotic that targets the FabB enzyme, effectively inhibiting the synthesis of fatty acids and mycolic acids. This compound demonstrates potent activity against Gram-negative anaerobes and exhibits inhibitory effects on malaria parasites and trypanosomes. It is a valuable reagent for researchers investigating antibiotic mechanisms and fatty acid biosynthesis pathways, as well as for studies focused on protozoan infections. -
Polypeptide Antibiotics
Polymyxin B2 is a polypeptide antibiotic that primarily targets the cell membrane of gram-negative bacteria. It exerts its antibacterial effect by binding to lipopolysaccharide components, leading to membrane disruption and subsequent cell lysis. This compound is relevant for antibiotic research and development, particularly in addressing drug-resistant bacterial strains. -
Macrolide Antibiotic
Venturicidin A is a macrolide antibiotic that acts as a potent inhibitor of ATP synthase. Derived from actinomycetes, it enhances the efficacy of the aminoglycoside antibiotic gentamicin against multidrug-resistant strains of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Although Venturicidin A demonstrates significant antibacterial activity, it also exhibits notable toxicity towards human embryonic kidney (HEK) cells, with an IC50 value of 31 μg/mL, making it a valuable compound for research in antibiotic resistance and cellular response assessments. -
Antibiotic
Benzylideneacetone operates as an orally active antibiotic with a primary mechanism of inhibiting tyrosinase and phospholipase A2. It demonstrates antibacterial activity against select gram-negative plant-pathogenic bacteria, making it a valuable compound for agricultural research. Additionally, Benzylideneacetone serves as a versatile starting material in the synthesis of chemicals and pharmaceuticals, and it is utilized as a flavoring additive in certain food applications. -
Bacterial Inhibitor
Flomoxef sodium is an oxacephem antibiotic that primarily targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against a range of Gram-positive bacteria, making it suitable for research in antimicrobial resistance and bacterial infections. Flomoxef sodium can be utilized in studies exploring antibiotic efficacy and drug resistance mechanisms. -
Quinolone Antibiotic
Nemonoxacin malate is a nonfluorinated quinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum antimicrobial activity against Gram-positive, Gram-negative, and atypical pathogens, including drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate is valuable for research focused on community-acquired pneumonia and other infections where antibiotic resistance is a concern. -
Bacterial Inhibitor
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic that inhibits bacterial protein synthesis by targeting aminoacyl-tRNA binding and peptide bond formation. As a type B compound in the streptogramin family, it exhibits potent bactericidal activity against a diverse array of Gram-positive bacteria. Virginiamycin S1, particularly in combination with virginiamycin M1, is valuable in research focused on overcoming multidrug-resistant bacterial infections. Its application is relevant in fields such as microbiology and pharmacology, particularly in the study of antibiotic efficacy and resistance mechanisms. -
Antibacterial Agent
Rosoxacin is an orally active broad-spectrum antibacterial quinolone antibiotic that primarily targets Gram-negative bacteria. It demonstrates effective inhibition against Neisseria gonorrhoeae, with a minimum inhibitory concentration (MIC) range of 0.03-0.125 µg/mL. This compound is valuable in research related to urinary tract infections and various sexually transmitted diseases, providing insights into bacterial resistance and treatment efficacy. -
Linker-Antibiotic Intermediate
MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate specifically designed for use in antibody-antibiotic conjugate (AAC) applications. This compound features a conjugation with the antibiotic Gemcitabine, facilitating targeted delivery and enhancing the therapeutic potential against bacterial infections. Its utility in research encompasses the exploration of immunotherapy strategies and the development of novel antibacterial agents. -
Cephalosporin Antibiotic
Ceftolozane TFA is a cephalosporin antibiotic that targets Gram-negative bacteria by disrupting cell wall synthesis. Its potent antibacterial activity makes it a valuable tool in combating resistant infections. Ceftolozane TFA can be utilized in research aimed at developing novel antibiotics with improved efficacy and safety profiles. -
Antibiotic Peptide
Aurein 1.2 is an antibiotic peptide derived from amphibian sources, exhibiting potent antimicrobial and anticancer properties. This peptide targets bacterial membranes, leading to disruption and cell death, making it valuable in the study of antibiotic resistance and cancer therapeutics. Aurein 1.2 is ideal for research applications focused on the development of novel antimicrobial agents and exploring mechanisms of cancer cell apoptosis. -
Aminoglycoside Antibiotic
Neamine is an aminoglycoside antibiotic and a degradation product of Neomycin, known for its broad-spectrum antibacterial properties. It exerts anti-angiogenic effects by targeting angiogenin, making it valuable in cancer research. Additionally, Neamine demonstrates neuroprotective and antitumor activities, supporting its potential in diverse biological studies. -
β-Lactam Antibiotic
Cephalothin is a semi-synthetic cephalosporin antibiotic classified as a β-lactam antibiotic. It exerts its antibacterial activity by inhibiting class C β-lactamase AmpC with a Ki of 0.32 µM while also binding to penicillin-binding proteins, thereby disrupting the cross-linking of peptidoglycan in the bacterial cell wall. This mechanism impedes bacterial cell wall synthesis, allowing it to effectively target a broad spectrum of bacteria. Cephalothin is applicable in studies related to hematology and nephrotoxicity. -
Antibacterial Agent
Targocil-II is an ABC transporter inhibitor demonstrating an IC50 value of 137 nM. By binding to allosteric sites within the transmembrane domain, Targocil-II effectively prevents ATP hydrolysis. This compound exhibits antibacterial activity, making it a valuable tool for research focused on combating multidrug resistance in bacterial pathogens. -
Antibacterial Agent
CRS3123 dihydrochloride is a synthetic antibacterial agent that effectively targets methionyl-tRNA synthetase (MetRS) in Clostridioides difficile. By inhibiting MetRS, CRS3123 dihydrochloride reduces toxin production and spore formation associated with Clostridioides difficile infections (CDI). This compound serves as a valuable tool for research into CDI and potential therapeutic strategies. -
Cephem Antibiotic
Cefcapene pivoxil hydrochloride is a pivalate ester prodrug of Cefcapene, functioning as a third-generation cephalosporin antibiotic. It demonstrates a broad spectrum of antibacterial activity, making it valuable in various microbiological studies. Additionally, this compound may hold potential for research applications related to palmoplantar pustulosis (PPP). -
Antitumor Antibiotic/AdoHcy hydrolase Inhibitor
Neplanocin A is an antitumor antibiotic that functions as an irreversible inhibitor of AdoHcy hydrolase, with a Ki of 8.39 nM. It exhibits significant antitumor activity against murine L1210 leukemia cells and also demonstrates antiviral properties, notably against the vaccinia virus. This compound is isolated from the marine-derived organism Ampulariella regularis, making it a valuable reagent for research in cancer therapeutics and virology. -
Antibiotic
Avrainvillamide is a naturally occurring alkaloid that functions as an antibiotic by targeting the nuclear chaperone nucleophosmin (NPM1), which is often overexpressed in various human tumors. This compound exhibits antiproliferative properties by directly binding to NPM1 and Crm1, and disrupting their interactions with native cellular partners. Avrainvillamide demonstrates strong antibacterial activity against multi-drug resistant strains of Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) of 12.5, 12.5, and 25 μg/ml, respectively. Its unique mechanism and efficacy make it a valuable tool in antibiotic research and cancer biology studies. -
Gentamicin-Type Antibiotic
Micronomicin sulfate is a gentamicin-type aminoglycoside antibiotic derived from Micromonospora. It exhibits broad-spectrum antibacterial activity, particularly effective against Pseudomonas, Proteus, Klebsiella pneumoniae, and Serratia, with MIC values ranging from 0.001 to 8.3 μg/ml. This compound is utilized in research focused on bacterial infections and antibiotic resistance mechanisms, making it a valuable tool in microbiological studies and drug development. -
Antibacterial Agent
Temafloxacin is an orally active quinolone antibiotic that exhibits broad-spectrum antibacterial activity. Primarily utilized for the treatment of lower respiratory and genitourinary tract infections, Temafloxacin demonstrates favorable tolerability in patients. Its efficacy in combating various bacterial pathogens makes it a valuable tool in microbiological research and infection control studies. -
Antibacterial Agent
Cefpiramide is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against both gram-positive and gram-negative bacteria, making it valuable for combating various bacterial infections. Cefpiramide is also moderately susceptible to β-lactamase, which is relevant in resistance studies and the evaluation of antibacterial efficacy. This reagent is suited for research applications in microbiology and antibiotic resistance. -
Bacterial Inhibitor
PNU-105368 is an antibacterial compound that serves as a metabolite of linezolid. It demonstrates efficacy in inhibiting bacterial growth and is primarily excreted via the kidneys and feces. This compound is relevant for research focusing on bacterial resistance and the pharmacokinetics of oxazolidinones. -
Bacterial Inhibitor
Sisomicin is a broad-spectrum aminoglycoside antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against Gram-positive bacteria, making it valuable in microbiological research. Sisomicin is commonly used in studies investigating bacterial resistance mechanisms and in the evaluation of antibacterial efficacy. -
Carbapenem Antibiotic
Meropenem-vaborbactam is a carbapenem antibiotic combined with a boronic acid-based beta-lactamase inhibitor, designed to effectively combat Enterobacteriaceae, particularly Klebsiella pneumoniae strains producing carbapenemases. This compound demonstrates notable in vitro activity against Pseudomonas aeruginosa, with MIC50 values of 0.5 μg/mL and MIC90 values of 8 μg/mL, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic strategies. -
Antibiotic
Virginiamycin Complex is a synergistic antibiotic comprised of two streptogramins, virginiamycin M (VM) and virginiamycin S (VS), derived from Streptomyces virginiae. This complex effectively irreversibly inhibits protein synthesis in bacteria, leveraging the persistent and catalytic action of VM to enhance the affinity of ribosomes for VS. Virginiamycin Complex exhibits significant antibacterial activity and is applied in research focused on studying bacterial resistance mechanisms and developing novel antimicrobial strategies. -
antibiotic
Etimicin sulfate is a fourth-generation aminoglycoside antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits potent antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria, making it valuable in treating various infections. Etimicin sulfate is particularly useful in clinical settings due to its high efficacy and low toxicity profile. -
Antibiotic for Poultry
Tylosin phosphate is a macrolide antibiotic that targets Gram-positive bacteria, exhibiting significant antimicrobial activity. It is commonly used as a feed additive in veterinary applications to promote growth in poultry, pigs, and cattle. Tylosin phosphate is effective in treating bacterial dysentery and respiratory diseases, making it an essential reagent in veterinary medicine and animal health research. -
Antibiotic
CRS3123 is a potent, orally active narrow-spectrum antibiotic that specifically targets bacterial methionyl-tRNA synthetase. It demonstrates significant efficacy against Clostridium difficile and aerobic Gram-positive bacteria while exhibiting minimal activity against Gram-negative bacteria, including anaerobes. CRS3123 is a valuable reagent for research focused on C. difficile infections and their treatment options. -
Antibiotic
Nemonoxacin is a potent, orally active broad-spectrum antibiotic that primarily targets bacterial infections. It demonstrates significant inhibitory effects against various species, including staphylococci, streptococci, enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. This compound is valuable for research applications related to bacterial infections and the study of community-acquired pneumonia. -
Antibiotic
Cefodizime is a third-generation cephalosporin antibiotic that exhibits a broad spectrum of antibacterial activity. It is characterized by its low renal toxicity and favorable tolerance profile, along with immune modulation capabilities. This compound is particularly useful in the treatment of severe infections affecting the respiratory and urinary tracts. -
Bacterial Inhibitor
Thiamphenicol-d3 is a deuterium-labeled variant of the broad-spectrum antibiotic Thiamphenicol, which targets the 50S ribosomal subunit. By binding to this subunit, it inhibits protein synthesis, exhibiting bacteriostatic activity against a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacteria. This reagent is valuable for research applications involving microbiology and the study of antibiotic mechanisms. -
Antibiotic
Platensimycin is an antibiotic derived from Streptomyces platensis that selectively inhibits the biosynthesis of cellular lipids in gram-positive bacteria. It targets the β-ketoacyl-acyl-carrier-protein synthase I/II enzymes, FabF/B, with IC50 values of 48 nM and 160 nM for Staphylococcus aureus and Escherichia coli, respectively. With its unique mechanism of action, Platensimycin shows potential as a therapeutic agent to combat antibiotic resistance. -
Fluoroquinolone Antibiotic
Grepafloxacin hydrochloride is a fluoroquinolone antibiotic that exhibits potent activity against community-acquired respiratory pathogens, particularly Streptococcus pneumoniae. This compound demonstrates high tissue penetration and a favorable pharmacodynamic profile, making it suitable for research applications focused on antimicrobial resistance and respiratory infections. Its unique properties allow for the investigation of effective treatment strategies in microbiology and pharmacology research. -
Antibiotic
Spiramycin I is a macrolide antibiotic that primarily targets bacterial protein synthesis by inhibiting the 50S ribosomal subunit. It exhibits significant antibacterial and antiparasitic activity, making it useful in the treatment of various infections. This reagent is valuable for research applications focused on antimicrobial resistance mechanisms and the development of new therapeutic strategies. -
Antibiotic
Anhydrotetracycline is an antibiotic that functions primarily through the inhibition of tetracycline destructases, thereby preserving the activity of tetracycline antibiotics. This compound demonstrates dose-dependent potency, making it a valuable tool for studying antibiotic resistance mechanisms and enhancing the efficacy of tetracycline-based therapies. Its application in molecular biology and microbiology research helps elucidate bacterial response to antibiotic treatment. -
Antibiotic
Sanfetrinem sodium is a beta-lactamase-stable antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against both gram-positive and gram-negative bacteria, making it a valuable reagent for research applications aimed at understanding bacterial resistance mechanisms and developing new antimicrobial therapies. -
β-Lactam Antibiotic
Loracarbef hydrate is a β-lactam antibiotic that belongs to the carbacephem class, exhibiting a synthetic origin. This second-generation cephalosporin antibiotic demonstrates significant antibacterial activity against a variety of Gram-positive and selected Gram-negative bacteria. It is primarily utilized in research applications focused on microbiology and antibiotic resistance studies. -
Antibiotic
Levonadifloxacin is a broad-spectrum antibiotic that targets bacterial infections, particularly against staphylococcal strains. It exhibits potent antibacterial activity against both Methicillin-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA). This compound is valuable for research applications focused on the mechanisms of antibiotic resistance and the efficacy of therapeutic strategies in treating resistant infections. -
Bacterial Inhibitor
2,2':5',2''-Terthiophene is a heterocyclic oligomer that primarily targets bacterial inhibition. This compound exhibits significant antimicrobial activity, making it a valuable tool for studying bacterial growth and resistance mechanisms. Additionally, 2,2':5',2''-Terthiophene serves as an essential building block in the synthesis of organic semiconductor materials, particularly polythiophene, which has applications in electronic devices and sensors. -
Antibacterial agent
Lascufloxacin is a potent fluoroquinolone antibacterial agent that effectively targets bacterial DNA gyrase and topoisomerase IV, leading to DNA replication inhibition. It demonstrates significant activity against a range of pathogens, including strains resistant to traditional quinolone therapies. Lascufloxacin is primarily applicable in the treatment of various infectious diseases, particularly lower respiratory tract infections. -
Antibiotic
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic primarily targeting bacterial growth inhibition. It exhibits significant antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 5 μg/mL. In addition to its antibacterial properties, Kendomycin acts as a potent antagonist of the endothelin receptor and a calcitonin receptor agonist, highlighting its potential applications in anti-osteoporotic research. -
Antibiotic
AMOZ, a metabolite associated with Furaltadone, functions as an antibiotic by forming stable tissue residues through covalent binding to proteins. This property allows for the coupling of AMOZ with carrier proteins, such as BSA or OVA, to elicit an immune response and release upon acid hydrolysis. AMOZ is instrumental in monitoring antibiotic residues in animal-derived foods, with detection capabilities via competitive ELISA methods achieving limits as low as 0.16 μg/kg in shrimp samples. Its utility makes it a critical marker in food safety research. -
Antibiotic
PAMAM Dendrimer G0.0 amine is an antibiotic targeting pore-forming toxins, specifically acting as an antagonist to anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, it demonstrates protective effects against C2 toxin-induced cytotoxicity in HeLa cells. Additionally, this compound acts as a nickel chelator and has been employed in the selective capture and storage of carbon dioxide in gas-feed systems when used in conjunction with polysulfone membrane-bound chitosan. PAMAM Dendrimer G0.0 amine serves as a valuable reagent in research focused on infectious diseases, cancer biology, and drug delivery systems. -
Glycopeptide Antibiotic
A40926 is a glycopeptide antibiotic that targets the bacterial cell wall peptidoglycan precursor D-alanyl-D-alanine (D-Ala-D-Ala). It functions by irreversibly inhibiting cell wall synthesis through competitive binding, demonstrating significant bactericidal activity against Gram-positive bacteria, including Staphylococcus and Streptococcus, as well as Neisseria gonorrhoeae, with MIC values ranging from 0.06 to 2 μg/mL. Additionally, A40926 is effective against penicillin-resistant strains, disrupting peptidoglycan cross-linking and leading to bacterial lysis and death. The compound's fat-soluble fatty acid structure enhances serum concentrations and extends its duration of action, with a terminal half-life of 61.22 hours in rats. -
Antibiotic Peptide
Dermcidin-1L (human) is an antibiotic peptide that targets microbial pathogens with its inherent antimicrobial activity. Secreted by sweat glands, it plays a crucial role in skin defense mechanisms. Research applications include studies of inflammatory skin disorders and the investigation of innate immune responses. -
Antibiotic
Indolmycin is a competitive inhibitor of prokaryotic tryptophanyl-tRNA synthetase (TrpS), serving as an effective antibiotic. This compound exhibits significant antibacterial and antiviral properties, making it valuable in various research applications focused on microbial resistance and viral infection mechanisms. Its unique mode of action allows for exploration into strategies for combating infectious diseases. -
Antibiotic
Ristocetin A sulfate is an antibiotic primarily targeting staphylococcal infections. Its biological activity includes promoting thrombocytopenia and platelet agglutination. Ristocetin A sulfate is instrumental in two important assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay, both of which are utilized in diagnosing von Willebrand disease and various bleeding disorders. -
Antibiotic
trans-Clopenthixol dihydrochloride is an antibiotic agent that exhibits activity against Pseudomonas aeruginosa and Plasmodium falciparum in vitro, while lacking neuroleptic effects. This compound is valuable for research applications focusing on bacterial and parasitic infections. Its structural properties enable investigations into potential therapeutic pathways for managing these pathogens. -
Antibiotics
Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism. -
Bacteriostatic Antibiotic
Trimethoprim hydrochloride is a bacteriostatic antibiotic that functions primarily as a dihydrofolate reductase inhibitor. It exhibits efficacy against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, making it valuable in the study of urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, trimethoprim hydrochloride has been shown to inhibit Influenza A virus infection in chick embryos when combined with zinc, highlighting its potential for further virological research applications.
