Catalog No.
Product Name
Application
Product Information
Citations
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Anti-HIV-1 Protease Drug
Ganoderic acid GS-1 is a highly oxygenated lanostane-type triterpenoid that exhibits significant anti-HIV-1 protease activity, with an IC50 value of 58 μM. This compound serves as a valuable tool in research aimed at elucidating the mechanisms of HIV-1 replication and protease function. Its potential role in therapeutic applications makes it a relevant candidate for further investigation in the development of antiviral strategies. -
HIV-1 Protease Substrato Peptídico
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a peptide substrate specific for HIV-1 protease. This compound is utilized in peptidolytic assays to quantify the enzymatic inhibition of HIV-1 protease, providing valuable insights into protease activity and inhibitor efficacy. Its role as a variable substrate enhances the understanding of the protease's function, making it an essential tool in HIV research and drug development. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-8 is a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.32 nM. This compound effectively inhibits wild-type HIV-1 (HIV-1NL4-3) with an IC50 of 0.29 μM and a drug-resistant variant (HIV-1MDR) with an IC50 of 1.90 μM. Its strong antiviral activity against both strains makes HIV-1 protease-IN-8 a valuable tool for research in HIV treatment and drug resistance studies. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-5 is a potent inhibitor of HIV-1 protease, exhibiting an IC50 of 1.64 nM. This compound demonstrates significant efficacy against both wild-type and darunavir-resistant variants of HIV-1, making it a valuable tool for antiviral research. Its mechanism of action is crucial for developing therapeutic strategies to combat HIV-1 infections and resistance. -
HIV-1 Protease Inhibitor
Longipedunin A is a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 50 µg/mL. This compound effectively interferes with the proteolytic processing of viral polyproteins, thereby limiting HIV-1 replication. Longipedunin A is suitable for research applications in virology and studies focused on developing antiviral therapies. -
HIV-1 Inhibitor
U-75875 is an HIV-1 protease inhibitor that effectively impedes the processing of Gag-Pol proteins, thereby disrupting viral maturation and replication. This compound is primarily utilized in research focused on HIV-1 infection, providing valuable insights into viral life cycle mechanisms and potential therapeutic interventions. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-11 is a potent HIV-1 protease inhibitor with an IC50 value of 0.41 nM. This compound demonstrates significant efficacy against drug-resistant variants of the virus, offering opportunities for HIV research and therapeutic development. Its selective targeting of the HIV-1 protease positions it as a valuable tool in the study of HIV replication and infection mechanisms. -
HIV Protease
JG-365 is a potent inhibitor of HIV-1 protease that targets the enzyme's active site, effectively blocking its activity. This compound exhibits significant antiviral activity, making it a valuable tool for research in HIV infection and therapeutic development. Its ability to disrupt the replication cycle of HIV-1 provides insights into potential treatment strategies against HIV-related diseases. -
HIV Proteinase Inhibitor
AG-1284 is an effective HIV proteinase inhibitor, demonstrating an EC50 of 0.5 mg/mL. This compound is utilized in research focused on HIV infection mechanisms and therapeutic strategies aimed at viral suppression. AG-1284's inhibition of HIV proteinase makes it a valuable tool for studying the virus's replication cycle and potential drug development. -
HIV Protease Inhibitor
A-77003 is a potent HIV protease inhibitor, demonstrating an IC50 range of 0.1 to 0.2 μg/ml against both HIV-1 and HIV-2 proteases. This compound exhibits significant antiretroviral activity while maintaining low cytotoxicity in vitro, making it suitable for research applications focused on HIV treatment and therapeutic development. -
HIV-1 Protease Inhibitor
A 74704 is a pseudo C2-symmetric inhibitor targeting HIV-1 protease. This compound effectively disrupts the enzymatic activity of the protease, thereby inhibiting viral replication. It serves as a valuable reagent for studying HIV pathogenesis and developing antiviral therapies. -
HIV-1 Protease Inhibitor
A-80987 is a selective inhibitor of human immunodeficiency virus type 1 (HIV-1) protease. This compound effectively disrupts the proteolytic processing of viral polyproteins, thereby hindering viral replication. A-80987 is valuable for research focused on HIV pathogenesis and therapeutic interventions targeting viral enzyme activity. -
HIV-1 Reverse Transcriptase Inhibitor
Opaviraline is a potent HIV-1 reverse transcriptase inhibitor. It effectively disrupts the viral replication process by targeting the reverse transcriptase enzyme, which is crucial for converting viral RNA into DNA. This compound is utilized in research focused on developing antiviral therapies and understanding HIV-1 resistance mechanisms. -
HIV Protease Inhibitor
Ro 31-8588 is a potent HIV protease inhibitor, exhibiting a Ki of 0.3 nM. This compound is essential for studying the role of HIV protease in viral replication and can be utilized in research focused on AIDS treatment and potential therapeutic strategies. Its high affinity makes it a valuable tool for investigating the mechanistic aspects of HIV inhibition. -
HIV Protease Control
Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor darunavir, targeting the HIV protease to inhibit viral replication. It plays a significant role in understanding the pharmacokinetics and metabolism of darunavir and can be utilized in research applications aimed at studying HIV resistance mechanisms and therapeutic efficacy. This compound is essential for investigations into antiviral drug development and optimization strategies. -
HIV-1 Protease Inhibitor
LY-289612 is a potent HIV-1 protease inhibitor, exhibiting an IC50 value of 1.5 nM. This compound effectively disrupts the proteolytic processing of viral polyproteins, thereby inhibiting the replication of HIV-1. It is utilized in research focused on developing antiviral therapies and understanding HIV resistance mechanisms. -
HIV-1 Protease Inhibitor
PL-100 is a powerful inhibitor of HIV-1 protease, exhibiting a Ki of 36 pM and an EC50 of 16 nM. This compound effectively inhibits viral replication by targeting HIV-1 protease activity, showing significant antiviral efficacy against drug-resistant strains of the virus. PL-100 is suitable for research applications focused on understanding and combating drug-resistant HIV infections. -
Anti-Bacterial Agent
Pacidamycin 7 is an anti-bacterial agent primarily targeting Pseudomonas aeruginosa. This compound exhibits inhibitory effects on various bacterial strains, including suppurative Staphylococcus and Escherichia coli. Notably, serum and pH levels can modulate its antibacterial effectiveness, making it relevant for studies focused on resistance mechanisms and antibiotic development. -
Anti-Bacterial Agent
Kibdelin C1 is a potent anti-bacterial agent that exhibits activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It demonstrates similar efficacy to Vancomycin, making it a valuable compound for research aimed at combating resistant bacterial strains. Its unique mechanism offers potential applications in the development of new therapeutic strategies against resistant infections. -
Anti-Bacterial Agent
4"-Demethylgentamicin C1a acts as an anti-bacterial agent with significant efficacy against both Gram-positive and Gram-negative bacteria. Its mechanism involves inhibition of bacterial protein synthesis, making it a valuable tool in studies related to bacterial infections. This compound is relevant for research applications in microbiology and drug development, particularly for understanding antibiotic resistance and enhancing therapeutic strategies. -
Anti-Bacterial Agent
Oganomycin B is an antibacterial agent exhibiting pronounced stability compared to cephalosporin and demonstrating resistance to both Gram-positive and Gram-negative bacteria. Its efficacy is particularly notable in combating Gram-negative bacterial strains, making it a valuable tool for research into antibacterial treatments and mechanisms of resistance. -
Antibacterial Agent
KP 736 sodium is a broad-spectrum antibacterial agent that targets bacterial cell integrity. It demonstrates significant in vitro activity against Gram-negative bacteria, particularly Pseudomonas aeruginosa and other multidrug-resistant strains. This compound is valuable for research focused on bacterial infections and the development of novel antibacterial therapies. -
Anti-Bacterial Agent
Formadicin C is an anti-bacterial agent with notable effectiveness against various strains of Pseudomonas, Proteus, and alkali-producing bacilli. Its potent activity makes it a valuable compound for research focused on combating bacterial infections and understanding microbial resistance mechanisms. Researchers may utilize Formadicin C in studies pertaining to antibiotic efficacy and the development of new antimicrobial therapies. -
Anti-Bacterial Agent
Enaminomycin B is an anti-bacterial agent that exhibits activity against both Gram-positive and Gram-negative bacteria. This compound acts by disrupting bacterial cell wall synthesis, contributing to its potential as a therapeutic agent in combating bacterial infections. Enaminomycin B may be utilized in research applications focused on antibiotic resistance mechanisms and the development of new antibacterial strategies. -
Anti-Bacterial Agent
Kinamycin A is an antibacterial agent primarily targeting mycobacterial infections. It exhibits notable effects against various bacteria, while demonstrating limited efficacy against Gram-negative strains. This compound is valuable for research applications focused on the development of treatments for bacterial infections, particularly those caused by mycobacteria. -
Anti-Bacterial Agent
Quinomycin B is an anti-bacterial agent that exhibits potent activity against Gram-positive bacteria and is also effective against certain Gram-negative strains. Additionally, Quinomycin B demonstrates cytotoxic effects on HeLa cells, making it valuable in cancer research. This compound has also shown protective effects in mouse models inoculated with poliovirus, indicating potential applications in virology studies. -
Anti-Bacterial Agent
Kirrothricin is an antibacterial agent that primarily exhibits efficacy against a range of Gram-positive bacteria. It is particularly valuable in research focused on combating bacterial infections, providing insights into its use as a potential therapeutic candidate. However, it shows no activity against Bacillus subtilis, Escherichia coli, or fungal species. This specificity makes Kirrothricin a useful tool for studying antibacterial mechanisms and developing targeted treatments. -
Anti-Bacterial Agent
Cladospolide B is a natural compound derived from the fungal strain Cladosporium sp. FT-0012. It exhibits limited antibacterial activity, making it a potential candidate for further research into its mechanisms and applications in antimicrobial studies. This compound can be of interest for investigations focused on exploring novel antibacterial agents and their modes of action. -
Bacterial Inhibitor
2-C-Methyl-D-erythritol 4-phosphate is an intermediate in the methylerythritol phosphate (MEP) pathway, primarily present in prokaryotes. This compound plays a crucial role as a precursor in the biosynthesis of isoprenoids and non-isoprenoids, including essential vitamins. Its unique presence in bacteria, coupled with its absence in humans, positions it as a promising target for the development of bacterium-specific therapeutic agents for infectious disease treatment. -
Antibacterial Agent
Florfenicol-propanoate-piperidin serves as a potent antibacterial agent targeting various Gram-positive and Gram-negative bacteria. This compound demonstrates significant antibacterial activity, effectively inhibiting the growth of pathogens such as E. coli, Salmonella, S. aureus, B. subtilis, E. faecalis, S. suis, and Haemophilus parasuis, with minimum inhibitory concentrations (MIC) ranging from 2 to 8 μM. It is particularly useful in microbiological research focusing on bacterial resistance and infection control. -
Anti-Bacterial Agent
Ferensimycin B is a polyether antibiotic primarily targeting Gram-positive bacteria. It exhibits significant antibacterial activity while demonstrating weaker effects against Gram-negative bacteria, fungi, and coccidia. This compound is valuable for research applications involving the study of bacterial resistance mechanisms and the development of new antimicrobial agents. -
Anti-Bacterial Agent
Julimycin B2 is an anti-bacterial agent primarily targeting Gram-positive bacteria. This compound demonstrates significant activities against various bacterial strains and exhibits antiviral properties. Additionally, it has been shown to affect Ehrlich ascites carcinoma in murine models, making it a valuable reagent for studies in microbial infections and cancer research. -
Anti-Bacterial Agent
Chloropolysporin B is an anti-bacterial agent that exhibits potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus species. This compound is valuable for research focused on developing treatments for antibiotic-resistant infections and understanding bacterial resistance mechanisms. Its effectiveness against challenging strains makes it a crucial tool in the study of anti-bacterial therapies. -
Anti-Bacterial Agent
Cerexin B1 is an anti-bacterial agent that specifically targets Gram-positive bacteria. It exhibits potent activity against various strains, making it valuable for research in antibiotic efficacy and resistance mechanisms. This compound is suitable for studies focused on developing new antimicrobial therapies and understanding bacterial pathogenesis. -
Anti-Bacterial Agent
Saquayamycin B1 is an anti-bacterial agent primarily known for its antimicrobial properties. It exhibits significant activity against various bacterial strains, with a comparatively weaker effect on Gram-negative bacteria. Additionally, Saquayamycin B1 demonstrates inhibitory effects on leukemia P388 cells, including those resistant to Adriamycin, making it a potential candidate for cancer research and antimicrobial studies. -
Anti-Bacterial Agent
Pacidamycin 3 is an anti-bacterial agent that exhibits inhibitory activity against Pseudomonas aeruginosa and additional bacterial strains, including Staphylococcus aureus and Escherichia coli. This compound is utilized in research focused on understanding bacterial resistance mechanisms and developing new antimicrobial therapies. Its efficacy against a range of pathogenic bacteria makes it a valuable tool for microbiological studies and antibiotic development. -
Anti-Bacterial Agent
Megovalicin A is an anti-bacterial agent that demonstrates potent activity against Bacillus subtilis and Escherichia coli. It is primarily utilized in microbiological research to explore bacterial resistance mechanisms and to develop novel therapeutic strategies targeting bacterial infections. Its efficacy in inhibiting bacterial growth makes it a valuable tool for studies in infectious disease and antibiotic resistance. -
Antibacterial Agent
MBX-1066 is a potent antibacterial agent targeting Mycobacterium tuberculosis. This compound demonstrates significant antibacterial activity in preclinical models, including in vivo efficacy in mice. It is an important tool for research focused on tuberculosis treatment and drug discovery. -
Anti-Bacterial Agent
Curromycin B is an antibacterial agent primarily targeting Gram-positive bacteria, including Bacillus subtilis. It exhibits notable activity against human immunodeficiency virus (HIV) replication and displays cytotoxic effects on mouse melanoma B16 and leukemia P388 cells. This compound is valuable for research applications in microbiology and oncology, offering insights into antibacterial mechanisms and potential therapeutic strategies. -
Anti-Bacterial Agent
Neoviridogrisein III is an anti-bacterial agent primarily effective against Gram-positive bacteria and mycoplasma. Its mechanism of action involves disrupting bacterial cell function, making it a valuable tool in microbiological research. Neoviridogrisein III is suitable for studies focused on bacterial resistance and the development of new antimicrobial strategies. -
Anti-Bacterial Agent
Baciphelacin is an anti-bacterial agent primarily effective against gram-positive bacteria. It exhibits significant inhibitory activity against Newcastle disease virus and leukemia P-388 cells, making it a valuable tool for research in microbiology and cancer studies. This compound is suitable for investigating bacterial resistance mechanisms and evaluating antiviral and antitumor effects in various experimental models. -
Antibacterial agent
Metallo-β-lactamase-IN-12 is a dual inhibitor targeting both metallo-β-lactamases (MβLs) such as NDM-1 and IMP-1, and serine β-lactamases (SβLs) including OXA-48 and KPC-2. It demonstrates potent antibacterial activity, with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM against these resistant enzymes. This compound is valuable for research applications focused on combating antibiotic resistance and understanding β-lactamase mechanisms. -
Antibacterial
2-Keto-L-gulonic acid is a key precursor in the biosynthesis of vitamin C and exhibits antibacterial activity. It effectively inhibits the growth of Bacillus pumilus and Ketogulonicigenium vulgare, making it valuable in microbiological studies. This compound is useful in research applications focused on antimicrobial agents and vitamin C production processes. -
Anti-Bacterial Agent
Epicillin is a semisynthetic broad-spectrum penicillin that acts as an antibacterial agent by inhibiting the synthesis of bacterial cell walls. It is effective against a variety of Gram-positive and some Gram-negative bacteria, showcasing its potential in treating bacterial infections. Researchers can employ Epicillin in studies focused on antibiotic resistance, mechanisms of bacterial virulence, and the development of new antibacterial therapies. -
Bacterial Inhibitor
Ianthelliformisamine A TFA is a bacterial inhibitor that enhances antibiotic efficacy against resistant Gram-negative bacteria. It demonstrates potent bactericidal activity against Staphylococcus aureus, with an IC50 value of 3.8 μM and a minimum inhibitory concentration of 25 μM. The biological activity is attributed to the structural variations of its synthetic derivatives and their interaction with various amino ester derivatives, making it a valuable tool for research in antibiotic resistance and bacterial infections. -
Anti-Bacterial Agent
Glysperin B is an anti-bacterial agent primarily targeting both Gram-positive and Gram-negative bacteria, including strains resistant to aminoglycoside antibiotics. Its mechanism of action involves disrupting bacterial growth and viability, making it a valuable compound for research in infectious disease studies and antimicrobial resistance. Glysperin B is suitable for applications involving the evaluation of new therapeutic approaches against resistant bacterial pathogens. -
Bacterial
Tetromycin A is a tetronic acid-based antibiotic targeting bacterial pathogens. It exhibits significant antibacterial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Additionally, related tetromycin derivatives have demonstrated anti-trypanosomal properties and inhibit the cysteine protease cathepsin L, with inhibition constants (Ki) in the low micromolar range, making them valuable tools for research into both bacterial and parasitic infections. -
Anti-Bacterial Agent
Olivomycin D is an anti-bacterial agent primarily targeting Gram-positive bacteria. It exhibits potent antimicrobial activity, making it valuable in research focused on bacterial infections and antibiotic resistance. Its limited efficacy against Gram-negative bacteria provides insights into the mechanisms of bacterial susceptibility and resistance. -
Antifungal Agent
Antibacterial agent 230 is an antifungal agent targeting fluconazole-resistant fungi. It exhibits a minimal inhibitory concentration (MIC) ranging from 2.0 to 16.0 μg/mL, demonstrating significant efficacy against resistant strains. This compound is suitable for research applications focused on fungal resistance mechanisms and the development of new antifungal therapies. -
Anti-Bacterial Agent
Olivomycin B is an anti-bacterial agent that exhibits strong activity against Gram-positive bacteria while demonstrating weaker efficacy against Gram-negative bacteria. This compound is significant in research applications focused on bacterial infections and the development of novel antibiotics. Its selective action makes it a valuable tool for studying mechanisms of bacterial resistance and exploring new therapeutic strategies.
