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Catalog No.
Product Name
Application
Product Information
Citations
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HIV-1 Inhibitor
HIV-1 Inhibitor-43 is a selective inhibitor targeting the HIV-1 virus. It demonstrates potent efficacy with an EC50 of 21.3 nM for Y188L mutants, 6.2 nM for K103N-Y181C, and under 0.7 nM for both K103N and Y181C strains. This compound effectively reduces HIV-1 RNA levels and protein p24 expression, making it a valuable tool for research in HIV pathogenesis and therapeutic development. -
DENV/HIV-1 Inhibitor
DENV-IN-5 is a potent inhibitor targeting both dengue virus (DENV) and HIV-1 replication. It demonstrates effective antiviral activity with half-maximal effective concentration (EC50) values of 1.47, 9.23, 7.08, and 8.91 μM against DENV serotypes I to IV, respectively. Additionally, DENV-IN-5 inhibits the HIV-1 IIIB strain with an EC50 of 0.1512 μM. This compound is valuable for research focused on viral infections and the development of antiviral therapies. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-2 is a potent inhibitor of bacterial DNA gyrase B, demonstrating IC50 values of 3.29-10.49 µM for Escherichia coli and 4.41-5.61 µM for Mycobacterium tuberculosis. This compound exhibits significant anti-tubercular and antibacterial activity, making it valuable for research focused on bacterial replication and antibiotic development. Its specific targeting of DNA gyrase B positions it as a promising candidate for further investigation in treating bacterial infections. -
HIV/HBV Inhibitor
L-2'-Fd4C is an L-nucleoside analogue that acts as an inhibitor of both human immunodeficiency virus (HIV) and hepatitis B virus (HBV). This compound exhibits potent antiviral activity, making it valuable for research focused on the treatment and understanding of these viral infections. Its unique mechanism of action may provide insights into the development of novel therapeutic strategies against HIV and HBV. -
DENV NS5 RdRp Inhibitor
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is a nucleotide analog that serves as a potent inhibitor of DENV NS5 RNA-dependent RNA polymerase (RdRp). Functioning as a chain terminator, it effectively suppresses RNA synthesis, making it a valuable tool in virology research. With an IC50 of 0.02 μM against DENV NS5 RdRp, this compound is crucial for studies focusing on antiviral mechanisms and the development of therapeutic strategies targeting dengue virus infections. -
HIV-1 Inhibitor
SJP-L-5 is an HIV-1 capsid dissociation inhibitor that targets the HIV-1 viral capsid, preventing its normal function. It demonstrates significant inhibitory activity against various HIV-1 strains, with an EC50 ranging from 0.16 to 0.97 μg/mL. By effectively blocking the entry of HIV-1 viral DNA into the nucleus, SJP-L-5 offers valuable potential for applications in HIV-1 infection research and development of antiviral therapies. -
HIV-Ⅰ Inhibitor
HIV-IN-6 is an inhibitor of HIV-1 viral replication, specifically targeting Src family kinases (SFKs) that associate with the viral Nef protein, including Hck. This compound has demonstrated significant antiviral activity by disrupting the functional interactions necessary for viral pathogenesis. Its application in research includes the study of HIV infection mechanisms and the exploration of novel therapeutic strategies against HIV-1. -
BTK/MNK Dual Inhibitor
QL-X-138 is a selective dual inhibitor of Bruton's tyrosine kinase (BTK) and MAPK-interacting kinase (MNK), demonstrating potent covalent binding to BTK and non-covalent binding to MNK. It exhibits IC50 values of 9.4 nM for BTK, and 107.4 nM and 26 nM for MNK1 and MNK2, respectively. Additionally, QL-X-138 displays antiviral activity against dengue virus serotype 2, with an IC50 of 3.5 μM. This compound is valuable for research involving B-cell malignancies and related therapeutic investigations. -
HIV Protease inhibitor
Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). -
HIV Protease inhibitor
Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). -
Protein synthesis inhibitor
Azomycin(2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica, which is active against aerobic Gram-positive and Gram-negative bacteria. -
HIV-1 integrase inhibitor
BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.
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HIV Protease inhibitor
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. -
HIV reverse transcriptase inhibitor
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. -
HIV replication inhibitor
Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus). -
anti-HIV-1 fusion inhibitor
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide. -
LolCDE complex inhibitor
LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity. -
Candida albicans filamentation inhibitor
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. -
neuraminidase inhibitor
Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC50 of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus. -
HIV Reverse Transcriptase Inhibitor
β-Rubromycin is a selective inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 0.27 μM. Additionally, it demonstrates potent telomerase inhibition with an IC50 of 3 μM. β-Rubromycin effectively inhibits the proliferation of K-562 and HeLa cell lines, showing IC50 values of 19.5 µM and 22.7 µM, respectively, making it a valuable tool for research in HIV and telomerase-related studies. -
HIV Protease Inhibitor
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives. -
Bacterial Inhibitor
Cefamandole sodium is a second-generation broad-spectrum cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative bacteria, making it valuable for research into antimicrobial resistance and the mechanisms of bacterial infections. This compound is commonly utilized in studies assessing the efficacy of antibiotic treatments and in exploring bacterial susceptibility profiles. -
Bacterial Inhibitor
Ceftiofur is a cell wall synthesis inhibitor targeting bacterial penicillin-binding proteins (PBPs). It demonstrates bactericidal activity by interfering with the peptidoglycan synthesis in bacterial cell walls, resulting in cell lysis. Additionally, Ceftiofur exhibits anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This makes Ceftiofur a valuable reagent in research investigating bacterial infections and inflammation processes. -
Bacterial Inhibitor
Aeroplysinin 1 is a secondary metabolite with a primary target as a bacterial inhibitor. It exhibits significant antibiotic activity against Gram-positive bacteria and demonstrates antiviral efficacy against HIV-1, with an IC50 of 14.6 μM. Additionally, Aeroplysinin 1 possesses anti-inflammatory, anti-angiogenic, and anti-tumor properties, and has been shown to induce apoptosis in endothelial cells. This compound is valuable for research applications in microbiology, virology, and cancer studies. -
Antibiotic/FOXM1 Inhibitor
Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1), while sparing other Forkhead box family members. It exhibits significant anti-tumor activity and promotes apoptosis, making it a valuable tool for cancer research. This compound is particularly useful for studies focused on the role of FOXM1 in tumorigenesis and therapeutic resistance. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor, primarily functioning as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Research indicates that it may promote the development of atopic dermatitis in murine models by disrupting Th2/Th17 immune responses. Additionally, Methylisothiazolinone hydrochloride has been shown to cause mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its cellular impact. -
Bacterial Inhibitor
K-252c is a staurosporine analog that selectively inhibits protein kinase C (PKC), exhibiting an IC50 value of 2.45 µM. This compound is known for its ability to induce apoptosis in human chronic myelogenous leukemia cells, making it a valuable tool in cancer research. Additionally, K-252c demonstrates inhibitory effects on β-lactamase, chymotrypsin, and malate dehydrogenase, further expanding its utility in studying bacterial resistance and enzyme activity. -
Cytochrome P450 Inhibitor
Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control. -
Antibiotic/DNA Inhibitor
Bleomycin A5 (hydrochloride) is a glycopeptide antibiotic that primarily functions as a DNA inhibitor. This compound exerts its cytotoxic effects by chelating Fe2+, which leads to the formation of reactive species that induce both single-strand and double-strand breaks in DNA, thereby disrupting DNA replication. Additionally, Bleomycin A5 (hydrochloride) inhibits Drp1-mediated mitochondrial fission and modulates the PINK1/Parkin pathway, contributing to mitochondria-mediated apoptosis. It is widely utilized in cancer research applications. -
FASN Inhibitor
Cerulenin is a potent natural inhibitor of fatty acid synthase (FASN), derived from the fungus Cephalosporium caeruleus. It acts by inhibiting topoisomerase I catalytic activity, consequently enhancing apoptosis induced by SN-38. Cerulenin exhibits both antifungal and antitumor properties, making it a valuable tool for research in cancer therapies and fungal infections. -
Antibiotic and APN Inhibitor
Actinonin is a naturally occurring antibiotic that functions primarily as an aminopeptidase N inhibitor. It exhibits potent antimicrobial activity and acts as a reversible peptide deformylase (PDF) inhibitor with a Ki value of 0.28 nM. Additionally, Actinonin shows inhibitory effects on matrix metalloproteinases MMP-1, MMP-3, MMP-8, and MMP-9, with respective Ki values of 300 nM, 1,700 nM, 190 nM, and 330 nM. It also possesses pro-apoptotic properties and has demonstrated antiproliferative and antitumor activities, making it a valuable tool for cancer research and therapeutic exploration. -
Bacterial Agent And Polyamine Transport System Inhibitor
AMXT-1501 is an antibacterial agent and polyamine transport system inhibitor that targets membrane phospholipids. It exhibits significant antibacterial activity against a range of multidrug-resistant Gram-positive and Gram-negative bacteria, specifically inhibiting capsular biosynthesis in Streptococcus pneumoniae. Additionally, AMXT-1501 interferes with ornithine decarboxylase and polyamine pathways, leading to the inhibition of neuroblastoma cell proliferation. Research applications include studies on multidrug-resistant bacterial infections, pneumococcal infections, and neuroblastoma therapeutics. -
actin polymerization inhibitor
Cytochalasin D (also known as Zygosporin A) is a cell-permeable fungal metabolite and a potent inhibitor of actin polymerization. It binds to G-actin, thereby disrupting the G-actin–cofilin interaction and preventing cofilin association with F-actin. Through this mechanism, Cytochalasin D reduces both actin polymerization and depolymerization rates in living cells, leading to profound effects on cytoskeletal organization and cell morphology. In addition, Cytochalasin D suppresses exosome release, consequently decreasing survivin levels within the tumor microenvironment. It also promotes phosphorylation and cytoplasmic retention of YAP, implicating it in the regulation of mechanotransduction and tumor cell signaling. -
NS3-NS4B interaction inhibitor
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
glutamine amidotransferase inhibitor
Azaserine (CI-337) is a glutamine analog and competitive inhibitor of glutamine amidotransferase, an enzyme involved in nucleotide biosynthesis. It exhibits both antibiotic and antitumor properties by disrupting glutamine-dependent metabolic processes essential for cell proliferation. Azaserine demonstrates antibacterial activity and has shown antitumor effects in various cancer models. However, it has also been reported to possess tumorigenic potential under certain conditions, warranting cautious evaluation. -
GPI/NS2B-NS3/CK1ε Inhibitor
Rhodiolin is a flavonoid that acts as a GPI (glucose 6-phosphate isomerase) and NS2B-NS3 protease inhibitor, with significant implications for cancer and viral research. It demonstrates the ability to inhibit glycolysis in papillary thyroid cancer, leading to suppressed PI3K/AKT/mTOR signaling and induced apoptosis. Additionally, Rhodiolin disrupts dengue viral replication through its action on the NS2B-NS3 protease. With its potential to inhibit CK1ε kinase, it serves as a valuable candidate for developing anticancer strategies and investigating anti-tumor and antiviral mechanisms. -
Bacterial Inhibitor
Vasicine, a quinazoline alkaloid derived from Justicia adhatoda, primarily targets bacterial strains as an inhibitor. This compound is known to activate the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory activities. Its unique biological profile makes Vasicine valuable for research in microbial resistance and inflammation-related studies. -
Bacterial Inhibitor
Vasicine hydrochloride, a quinazoline alkaloid derived from Justicia adhatoda, acts primarily as a bacterial inhibitor. It activates the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory properties. This compound is valuable for research involving antimicrobial activity and cellular signaling pathways, making it a useful tool for studies in infectious disease and inflammation. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
HIV-1 Entry Inhibitor
Trilobatin is a natural sweetener extracted from Lithocarpus polystachyus Rehd, functioning primarily as an HIV-1 entry inhibitor by targeting the HIV-1 Gp41 envelope protein. It demonstrates neuroprotective effects and acts as a selective SGLT1/2 inhibitor, promoting the proliferation of human hepatoblastoma cells. Trilobatin is valuable for research involving HIV-1 entry mechanisms and potential therapeutic applications in hepatoblastoma and neuroprotection studies. -
Bacterial Inhibitor
Lysozyme, also known as Muramidase, is a conserved antimicrobial protein that targets bacterial cell wall peptidoglycan (PG). It exerts a bactericidal effect by hydrolyzing PG, thereby limiting bacterial growth on mucosal surfaces and controlling potential pathogens while preventing dysbiosis through microbiota regulation. Additionally, extracellular lysozyme degrades polymeric PG into soluble fragments, activating NOD receptors in mucosal epithelial cells and stimulating the secretion of chemokines and activating factors by neutrophils and macrophages. This makes lysozyme a valuable reagent for studies involving antimicrobial activity, immune response, and microbiome research. -
Bacterial Inhibitor
Ciclopirox olamine is a synthetic antifungal agent primarily targeting various fungal pathogens. It exhibits a broad spectrum of activity against dermatophytes, yeasts, molds, and multiple Gram-positive and Gram-negative bacteria. In addition to its antibacterial properties, Ciclopirox olamine has demonstrated anticancer and anti-inflammatory effects, making it a valuable reagent for research in superficial mycoses, cancer biology, and inflammation studies. -
Bacterial Inhibitor
X-Neu5Ac sodium is a neuraminidase substrate that facilitates the chromogenic assay of neuraminidase activity in bacterial expression systems. This compound has a Km value of 0.89 mM for neuraminidase, making it an effective tool for studying neuraminidase function and inhibition. Its use in research applications provides insights into bacterial mechanisms and potential therapeutic targets for bacterial infections. -
Bacterial Inhibitor
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic that primarily targets bacterial growth by inhibiting dihydropteroate synthase and disrupting folate synthesis. This compound exhibits significant antibacterial activity and is primarily utilized in research applications focused on understanding bacterial infections and exploring antibiotic resistance mechanisms. Suitable for studies related to dermatological conditions, it aids in exploring therapeutic strategies for diseases like dermatitis herpetiformis. -
Bacterial Inhibitor
Enoxacin hydrate, a fluoroquinolone antibiotic, targets bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication with IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. This compound exhibits significant antibacterial activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin hydrate functions as an activator of miRNA processing, facilitating siRNA-mediated mRNA degradation and enhancing the biogenesis of endogenous miRNAs. Its unique mode of action also includes the inhibition of cancer cell growth through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing. -
Bacterial Inhibitor
Chlorprothixene hydrochloride functions as an antagonist of dopamine and histamine receptors, exhibiting Kis of 18 nM for hD1, 2.96 nM for hD2, 4.56 nM for hD3, 9 nM for hD5, and 3.75 nM for hH1 receptors. This compound demonstrates significant antipsychotic activity, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychotic disorders. Its receptor modulation also indicates potential applications in the study of bacterial inhibition mechanisms, providing insights into the interplay between neurotransmitter systems and microbial pathogenesis.
