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Catalog No.
Product Name
Application
Product Information
Citations
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Dengue Virus Inhibitor
Mosnodenvir is an orally active pan-serotype inhibitor of the dengue virus (DENV), exhibiting EC50 values between 0.057 and 11 nM across four DENV serotypes. Its primary mechanism involves inhibiting the interaction between nonstructural proteins NS3 and NS4B, which is critical for preventing the replication of viral RNA. With demonstrated picomolar to nanomolar antiviral activity in vitro, Mosnodenvir also shows antiviral efficacy in murine and non-human primate models, making it a valuable tool for research into dengue virus treatment. -
NS4B Inhibitor
NITD-688 is an orally active inhibitor targeting the NS4B protein of the dengue virus. This compound exhibits pan-serotype activity against various strains of dengue virus (DENV) and is essential for investigating the molecular mechanisms of dengue virus replication. NITD-688 serves as a valuable tool in the development of antiviral strategies and therapeutic interventions for dengue virus infections. -
Translation Elongation Inhibitor
Lactimidomycin is a glutarimide-containing compound that functions as a potent inhibitor of eukaryotic translation elongation. It demonstrates significant antiproliferative effects on various tumor cell lines and selectively disrupts protein synthesis, with an IC50 value of 37.82 nM. Additionally, Lactimidomycin exhibits strong antiviral activity against dengue virus 2 and other RNA viruses, making it a valuable reagent for cancer research and antiviral studies. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-2 is a potent inhibitor of the dengue virus (DENV) NS2B/NS3 protease, demonstrating an IC50 of 6.0 nM and a Ki of 0.66 µM. This covalent inhibitor exhibits no cytotoxicity and significantly enhances cell survival rates, making it an important tool for research in dengue virus therapeutics and antiviral development. -
Dengue Viral Inhibitor
1,8-Dihydroxy-4,5-dinitroanthraquinone is an effective inhibitor of the dengue viral serine proteinase NS2B/3. This compound demonstrates significant antiviral activity with an IC50 of 4.2 μM against viral replication, while also exhibiting proteinase inhibition with an IC50 of 432 μM. Additionally, 1,8-Dihydroxy-4,5-dinitroanthraquinone disrupts NS2B/3 cleavage in BHK-21 cells, providing a valuable tool for research into dengue virus mechanisms and potential therapeutic strategies. -
RdRp Inhibitor
HeE1-2Tyr is a pyridobenzothiazole compound that serves as an inhibitor of RNA-dependent RNA polymerases (RdRp) in flavivirus. It demonstrates significant inhibitory activity against West Nile, Dengue, and SARS-CoV-2 RdRps, with an IC50 value of 27.6 μM in vitro. HeE1-2Tyr is valuable for research investigating viral replication and potential therapeutic strategies targeting RNA polymerase activity. -
RNA Viral Inhibitor
KIN101 is a potent RNA viral inhibitor, demonstrating IC50 values of 2 µM and >5 µM against influenza virus and Dengue virus (DNV), respectively. It acts as an isoflavone agonist of IRF-3 dependent signaling, promoting the nuclear translocation of IRF-3. This compound exhibits broad-spectrum antiviral activity against various RNA viruses, making it a valuable tool for research in virology and antiviral therapeutics. -
Dengue Viru Inhibitor
SP187 is a host-targeted iminosugar that inhibits Dengue virus replication by interfering with viral glycan processing. This compound has demonstrated antiviral activity against both filovirus and influenza infections in vitro and in vivo. SP187 serves as a valuable research tool for studying dengue virus biology and developing therapeutic strategies for viral infections. -
HCV NS3 Helicase Inhibitor
ML283 is a potent inhibitor of the HCV NS3 helicase, with an IC50 value of 2.6 μM. Additionally, ML283 displays inhibitory activity against the dengue virus (DenV) ATPase, with an IC50 of 4.0 μM. This compound is valuable for research focused on hepatitis C virus and dengue virus replication mechanisms, providing a tool for the development of antiviral therapies. -
Influenza Virus Inhibitor
Glabranine is a flavonoid compound recognized for its inhibitory effects against the influenza virus. Isolated from Tephrosia species, it demonstrates significant interaction with the soluble ectodomain of the dengue virus type 2 (DENV2) E protein, suggesting potential applications in antiviral research. This compound serves as a valuable tool for investigating the mechanisms of viral inhibition and offers insights into therapeutic strategies against influenza and related viral infections. -
Dengue Virus Protease Inhibitor
SP-471 is a potent inhibitor of the dengue virus (DENV) protease, demonstrating an IC50 value of 18 μM. It effectively targets both intermolecular and intramolecular protease activities, making it a valuable tool for research on dengue virus pathogenesis and antiviral drug development. This compound is suitable for studies focused on elucidating viral protease mechanisms and testing potential therapeutic interventions. -
AChE Inhibitor
Temephos is an organophosphate insecticide that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This inhibition leads to cholinergic overactivation, effectively disrupting the larval development of Aedes aegypti and Aedes albopictus, making it a valuable tool in research concerning Dengue Virus, Zika Virus, and other mosquito-borne pathogens. While exhibiting important biological activity, Temephos has been shown to cause genotoxicity, neurodevelopmental toxicity, and potential liver and reproductive system effects in mammals. Additionally, it can accumulate in adipose tissues and aquatic organisms, with its metabolism primarily occurring through oxidation and hydrolysis. Temephos serves as a critical reagent in studies of vector control and viral transmission dynamics. -
Dengue Viru Inhibitor
BP13944 is a small molecule inhibitor that targets the dengue virus (DENV) by inhibiting its NS3 protease. It demonstrates significant antiviral activity, effectively suppressing the replication of all four DENV serotypes with an EC50 value of 1.03±0.09 μM, while showing no toxicity to host cells. Notably, the presence of the E66G mutation in the NS3 protease confers resistance to BP13944. As a promising candidate for dengue virus intervention, BP13944 represents a potential therapeutic agent in the absence of effective vaccines or treatments for dengue. -
Dengue Viru Inhibitor
ST-148 is a novel small molecule compound that acts as a potent inhibitor of all four serotypes of the dengue virus. In studies using a nonlethal AG129 mouse model, ST-148 significantly decreased viremia and viral load in key organs, while also showing a tendency to reduce plasma cytokine levels. The mechanism of action involves direct interaction with the dengue virus capsid protein, indicating that ST-148 interferes with specific stages of the viral replication cycle, which may provide avenues for therapeutic development against dengue virus infections. -
DENV-1/DENV-2 Inhibitor
DENV-IN-12 is a potent inhibitor targeting Dengue Virus serotypes 1 and 2. This compound, a derivative of N-methylcytisine thio, demonstrates significant antiviral activity against DENV-2, with EC50 values ranging from 0.002 to 0.005 μM across various cell lines. DENV-IN-12 serves as a valuable tool for research applications focused on understanding dengue virus pathogenesis and developing antiviral therapeutics. -
DENV2 Inhibitor
DENV-IN-9 (Compound 5f) is a potent inhibitor of the dengue virus serotype 2 (DENV2), exhibiting an EC50 of 0.88 μM. This compound effectively curtails viral replication, making it a valuable tool for research focused on dengue virus pathology and potential antiviral therapeutic strategies. Its potency and specificity position DENV-IN-9 as a significant candidate for studies aimed at understanding DENV2 inhibition mechanisms. -
DENV2 Inhibitor
DENV-IN-8 is a selective DENV2 inhibitor that exhibits an EC50 value of 0.068 μM. This compound effectively disrupts viral replication, making it a valuable tool for research aimed at understanding dengue virus pathogenesis and developing antiviral strategies. Its high potency and specificity for DENV2 facilitate studies in virology and drug discovery. -
RdRp Domain Inhibitor
NITD-203 is an inhibitor targeting the RNA-dependent RNA polymerase (RdRp) domain. It exhibits potent inhibitory activity against all four serotypes of dengue virus (DENV), as well as yellow fever virus (YFV) and West Nile virus (WNV). This compound is valuable for research applications focusing on the development of antiviral therapies and understanding the molecular mechanisms of viral replication. -
DENV Inhibitor
DENV-IN-10 is a potent tetravalent inhibitor targeting dengue virus (DENV). It demonstrates effective suppression of DENV replication with EC50 values of 1.36, 0.87, 0.94, and 0.95 μM against DENV serotypes 1-4, respectively. This compound functions as a post-entry replication inhibitor, exhibiting specificity for primate-derived cells, making it a valuable tool for research into dengue virus biology and therapeutic intervention. -
DENV Inhibitor
SDM25N is a Dengue virus (DENV) inhibitor that targets the NS4B protein, effectively disrupting genomic RNA replication. With an EC50 of 1.9 µM, SDM25N demonstrates cell type-specific inhibition of DENV. This compound is valuable for research into DENV infection and the mechanisms of viral replication. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
NS4B Inhibitor
JMX0254 is a potent inhibitor of the dengue virus NS4B protein, exhibiting oral bioavailability. It displays effective antiviral activity with EC50 values of 0.78 µM, 0.16 µM, and 0.035 µM against DENV-1, DENV-2, and DENV-3, respectively. This compound is valuable for research applications focused on understanding and combating dengue virus infections. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
DENV MTase Inhibitor
CNP0296775 is a potent inhibitor of dengue virus methyltransferase (DENV MTase), targeting key enzymatic processes involved in viral replication. By disrupting the activity of this enzyme, CNP0296775 shows promise in studying dengue virus pathogenesis and could serve as a valuable tool in antiviral research. Its application in preclinical studies may aid in the development of novel therapeutic strategies for dengue virus infections. -
NS2B-NS3 Inhibitor
NS2B/NS3-IN-9 is a non-competitive inhibitor targeting the NS2B-NS3 protease of Orthoflavivirus, demonstrating broad-spectrum antiviral activity. It exhibits IC50 values of 2.4 μM, 7.2 μM, and 1.9 μM against the Dengue virus DENV2, West Nile virus WNV, and Zika virus ZIKV, respectively. Additionally, NS2B/NS3-IN-9 shows cellular EC50 values of 4.1 μM for DENV2, 4.9 μM for WNV, and 5.0 μM for ZIKV, while exhibiting minimal toxicity to host cells. This compound is suitable for research applications focused on inhibiting Orthoflavivirus infections. -
NS2B·NS3 Protease Inhibitor
CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection. -
NS2B-NS3 Inhibitor
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions. -
AAK1 Inhibitor
AAK1-IN-6 is a potent inhibitor of AP-2-associated protein kinase 1 (AAK1) with an IC50 value of 12 nM. This compound exhibits significant antiviral activity against dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is a valuable tool for researchers investigating antiviral mechanisms and potential therapeutic strategies. -
NS2B-NS3/thrombin Inhibitor
5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione is a potent inhibitor of the dengue virus NS2B-NS3 protease and thrombin. This compound is valuable for studying the mechanisms of viral replication and coagulation processes, making it an essential tool in research focused on infectious diseases and related therapeutic interventions. Its dual activity highlights its potential for investigating the dynamics of viral pathology and thrombotic complications. -
HIV Protease Inhibitor
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is identified as a potent inhibitor of HIV protease, exhibiting significant antiviral activity. Additionally, this compound inhibits the activation of Epstein-Barr virus early antigen (EBV-EA), demonstrating its utility in virology research. Furthermore, it displays inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells, highlighting its potential applications in immunology and inflammation studies. -
EV71 Inhibitor
Gylongiposide I is a selective inhibitor targeting enterovirus EV71, demonstrating an EC50 of 1.53 μM. It exerts antiviral activity by decreasing the expression of viral protein VP1 and reducing levels of viral genomic RNA. This compound is valuable for research and development of therapeutic agents aimed at combating hand, foot, and mouth disease associated with EV71. -
Enterovirus 71 Inhibitor
Norwogonin is an antiviral compound isolated from Scutellaria baicalensis Georgi that specifically targets Enterovirus 71 (EV71). It demonstrates a potent inhibitory effect, with an IC50 value of 31.83 μg/ml, making it a valuable tool for research in viral infection mechanisms and potential therapeutic strategies against EV71. This compound can contribute to studies focused on antiviral drug development and the exploration of natural product-derived therapeutics. -
EV71 Inhibitor
DMA-135 hydrochloride is a specific inhibitor of enterovirus 71 (EV71) that targets the IRES-dependent translation and replication pathways. It binds to the EV71 SLII domain with a moderately high affinity (KD = 520 nM), effectively suppressing viral activity. This compound exhibits minimal toxicity in cell-based studies, making it an important tool for research in virology and potential therapeutic applications against EV71 infections. -
Monoamine Oxidase Inhibitor
Pirlindole is a selective and reversible inhibitor of monoamine oxidase A (MAO-A). This compound exhibits significant antiviral activity against enterovirus-D68 and coxsackievirus B3 (CV-B3). Pirlindole is primarily utilized in research focusing on the modulation of monoamine levels and the investigation of viral pathologies. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
EV71 3C Protease Inhibitor
DC07090 dihydrochloride is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease. It exhibits low toxicity with an IC50 of 21.72 μM and a Ki value of 23.29 μM. Additionally, DC07090 dihydrochloride effectively inhibits coxsackievirus A16 (CVA16) replication, with an EC50 of 27.76 μM. This compound is valuable for research into enteroviral infections and potential therapeutic interventions against these viruses. -
EV71 Inhibitor
Methyl 3,4-dihydroxyphenylacetate is a potent inhibitor of enterovirus 71 (EV71) replication. This compound effectively reduces viral replication in rhabdomyosarcoma (RD) cells, highlighting its potential as an antiviral agent. Its biological activity makes it valuable for research into therapeutic strategies against EV71 and other enteroviral infections. -
Polioviruses Inhibitor
Disoxaril is a potent inhibitor of polioviruses, effectively impeding the replication of types 1 and 2 within host cells. It operates by binding to virion capsid proteins, facilitating viral uncoating stabilization, while still permitting virus entry through receptor-mediated endocytosis. Additionally, Disoxaril demonstrates inhibitory activity against enterovirus replication, making it a valuable reagent for virology research and studies on enterovirus-related diseases. -
Enterovirus Inhibitor
Antiviral agent 23 is a potent inhibitor of enterovirus 71 (EV71) with an EC50 value of 94 nM. It effectively suppresses the activity of the methyltransferase complex METTL3/METTL14, demonstrating significant antiviral activity. This compound is suitable for research focused on enteroviral infections and the mechanisms of RNA modification in viral pathogenesis. -
HIV/EV-A71 Inhibitor
AL-470 is a potent antiviral compound targeting HIV-1, HIV-2, and EV-A71, exhibiting EC50 values of 0.27 µM, 0.63 µM, and 0.35 µM, respectively. This compound demonstrates significant inhibition of viral replication and is suitable for studies focused on HIV and enterovirus A71 infections. AL-470 serves as a valuable tool for researchers investigating antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Enteroviru Inhibitor
R78206 is an antiviral pyridazinamine compound that targets enteroviruses by providing protection against thermal inactivation. This compound exhibits varied effects on different strains of poliovirus depending on concentration and demonstrates a potent stabilizing effect on Mahoney procapsids. R78206 is valuable for research applications focused on enteroviral pathogenesis and potential therapeutic interventions. -
EV71 3C Protease Inhibitor
DC07090 is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease, with an IC50 of 21.72 μM and a Ki value of 23.29 μM. This compound also demonstrates inhibitory activity against coxsackievirus A16 (CVA16) replication, exhibiting an EC50 value of 27.76 μM. DC07090 is valuable for research applications focused on the development of antiviral strategies targeting enteroviruses. -
EV-A71 Inhibitor
EV-A71-IN-1 is an inhibitor targeting the human enterovirus A71 (EV-A71) capsid protein, exhibiting an EC50 of 0.27 μM. This compound functions as a capsid binder, effectively interfering with the interaction between the viral VP1 protein and the host receptor hSCARB2. Additionally, EV-A71-IN-1 demonstrates broad inhibitory activity against various human enteroviruses while maintaining low cytotoxicity (CC50 > 56.2 μM), making it a valuable tool for research on enteroviral infections and potential therapeutic interventions. -
MAO-A Inhibitor
Pirlindole mesylate is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), playing a crucial role in the modulation of neurotransmitter metabolism. Additionally, Pirlindole exhibits antiviral activity against enterovirus D68 and coxsackievirus B3 (CV-B3), positioning it as a potential agent in virology research. This compound is valuable for studies focusing on depression, anxiety disorders, and the therapeutic mechanisms of neuronal regulation and viral infections. -
ROC/EV-A71 Inhibitor
Fukinolic acid serves as a receptor-operated Ca2+ channel (ROC) inhibitor, effectively suppressing extracellular Ca2+ influx activated by norepinephrine while preserving the function of voltage-dependent Ca2+ channels. This compound demonstrates notable antiviral activity against enterovirus A71 (EV-A71) replication, making it a valuable tool in research related to enteroviral infections. Additionally, its vasodilatory properties further enhance its potential applications in cardiovascular studies. -
Enteroviruses Replication Inhibitor
MRL-1237 is an enterovirus replication inhibitor that targets the non-structural protein 2C. It demonstrates effective inhibition of poliovirus and other enteroviruses, making it a valuable tool for studying viral infections. Notably, MRL-1237 does not interfere with the NTPase (ATPase) activity of the 2C protein, allowing for specific mechanistic investigations in enteroviral research applications. -
EVs 2C Inhibitor
Jun15716 is an inhibitor of the Enterovirus (EVs) 2C protein, exhibiting dissociation constants (Kis) of 15.9, 44.2, and 17.8 μM for EV-D68, EV-A71, and CVB3, respectively. This compound demonstrates significant antiviral activity, with effective concentrations (EC50) of 1.0 μM against EV-D68 and 0.7 μM against CVB3 in relevant cellular models. Jun15716 is applicable in virology research, particularly in studies related to viral infections such as meningitis, hand, foot and mouth disease (HFMD), and viral myocarditis. -
2C Inhibitor
R523062 is a viral 2C inhibitor that targets the 2C protein of enteroviruses. This compound effectively reduces the levels of the viral VP1 protein, thereby impairing viral replication. R523062 exhibits broad-spectrum antiviral activity against enterovirus D68 (EV-D68) strains, making it a valuable tool for research in antiviral therapeutics and virology. -
CV-B3 2C ATPase Inhibitor
ATPase-IN-8 is a selective inhibitor of CV-B3 2C ATPase, exhibiting an IC50 of 1.4 μM. This compound demonstrates significant anti-enteroviral activity, particularly against coxsackievirus B3 (CV-B3) and enterovirus D68 (EV-D68). ATPase-IN-8 is suitable for research applications focusing on enteroviral infections and their molecular mechanisms. -
EV71 Inhibitor
ZHSI-1 is a potent inhibitor of Enterovirus 71 (EV71), targeting viral replication and mitigating virus-induced pyroptosis linked to pathogenesis. This compound effectively prevents EV71 infection in neonatal and young murine models, making it a valuable tool for research in viral infections, specifically related to hand, foot, and mouth disease (HFMD). Its application may contribute to the understanding of EV71 behavior and aid in developing therapeutic strategies against this virus.
